The Experts below are selected from a list of 15420 Experts worldwide ranked by ideXlab platform
Mattawan Japa - One of the best experts on this subject based on the ideXlab platform.
-
simple preparation of nitrogen doped tio2 and its performance in selective oxidation of benzyl alcohol and Benzylamine under visible light
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021Co-Authors: Mattawan Japa, Doldet Tantraviwat, Witchaya Phasayavan, Andrew Nattestad, Jun Chen, Burapat InceesungvornAbstract:Abstract N-doped TiO2, denoted as T_400, was prepared simply by the facile thermal hydrolysis of TiOSO4 using NH4OH as both a precipitating agent and a nitrogen source. Compared to TiO2 without nitrogen doping, T_400 provides superior photocatalytic activity toward the selective oxidation of benzyl alcohol and Benzylamine under visible light irradiation, with >85% conversion and >95% selectivity to benzaldehyde and N-benzylideneBenzylamine products, respectively. The increased photoactivity of T_400 is ascribed to enhanced visible-light absorption and efficient photogenerated charge transfer and separation as supported by UV-vis DRS, photoelectrochemical and VB-XPS results. The catalyst can tolerate the presence of substituent groups in benzyl alcohol and benzelamine molecules as > 80% conversion and > 95% selectivity are still achieved, which expands the scope of substrates and catalyst utilization. Band energy level of N-doped TiO2 compared to that of undoped TiO2 is determined using Mott-Schottky and UV-vis DRS measurements. Possible mechanisms for the formation of benzaldehyde and N-benzylideneBenzylamine over N-doped TiO2 are proposed. This work presents a simple synthesis of N-doped TiO2, using a low-cost and easily handled inorganic titanium salt instead of air/moisture-sensitive alkoxide precursors and reveals its potential application toward photocatalytic synthesis of organic fine chemicals under visible light.
Vadim A Soloshonok - One of the best experts on this subject based on the ideXlab platform.
-
thermal 1 3 proton shift reaction and its application for operationally convenient and improved synthesis of α trifluoromethyl Benzylamine
Journal of Fluorine Chemistry, 2007Co-Authors: Manabu Yasumoto, Hisanori Ueki, Vadim A SoloshonokAbstract:Abstract This paper describes a synthesis of α-(trifluoromethyl)Benzylamine via a novel base-free biomimetic reductive amination of α,α,α-trifluoroacetophenone with Benzylamine. When the corresponding imine, derived from α,α,α-trifluoroacetophenone and Benzylamine was heated at 200 °C under N2 for 1 day, the thermal 1,3-proton shift reaction took place giving rise to the N-(benzylidene)-α-(trifluoromethyl)Benzylamine in quantitative yield. This thermal 1,3-proton shift reaction was used a key step in the development of new and substantially simplified, practical and operationally convenient procedure for preparation of the target α-(trifluoromethyl)Benzylamine on large scale.
-
simple and convenient synthesis of 3 5 bis trifluoromethyl Benzylamine via biomimetic 1 3 proton shift reaction
Journal of Fluorine Chemistry, 2006Co-Authors: Vadim A Soloshonok, Manabu YasumotoAbstract:Abstract This paper describes an efficient, practical synthesis of 3,5-bis(trifluoromethyl)Benzylamine via biomimetic transamination of 3,5-bis(trifluoromethyl)benzaldehyde with Benzylamine. From a synthetic standpoint the reported procedure is highly operationally convenient and scalable as it does not require any chromatographic purification of the intermediate products.
Manabu Yasumoto - One of the best experts on this subject based on the ideXlab platform.
-
thermal 1 3 proton shift reaction and its application for operationally convenient and improved synthesis of α trifluoromethyl Benzylamine
Journal of Fluorine Chemistry, 2007Co-Authors: Manabu Yasumoto, Hisanori Ueki, Vadim A SoloshonokAbstract:Abstract This paper describes a synthesis of α-(trifluoromethyl)Benzylamine via a novel base-free biomimetic reductive amination of α,α,α-trifluoroacetophenone with Benzylamine. When the corresponding imine, derived from α,α,α-trifluoroacetophenone and Benzylamine was heated at 200 °C under N2 for 1 day, the thermal 1,3-proton shift reaction took place giving rise to the N-(benzylidene)-α-(trifluoromethyl)Benzylamine in quantitative yield. This thermal 1,3-proton shift reaction was used a key step in the development of new and substantially simplified, practical and operationally convenient procedure for preparation of the target α-(trifluoromethyl)Benzylamine on large scale.
-
simple and convenient synthesis of 3 5 bis trifluoromethyl Benzylamine via biomimetic 1 3 proton shift reaction
Journal of Fluorine Chemistry, 2006Co-Authors: Vadim A Soloshonok, Manabu YasumotoAbstract:Abstract This paper describes an efficient, practical synthesis of 3,5-bis(trifluoromethyl)Benzylamine via biomimetic transamination of 3,5-bis(trifluoromethyl)benzaldehyde with Benzylamine. From a synthetic standpoint the reported procedure is highly operationally convenient and scalable as it does not require any chromatographic purification of the intermediate products.
Burapat Inceesungvorn - One of the best experts on this subject based on the ideXlab platform.
-
simple preparation of nitrogen doped tio2 and its performance in selective oxidation of benzyl alcohol and Benzylamine under visible light
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021Co-Authors: Mattawan Japa, Doldet Tantraviwat, Witchaya Phasayavan, Andrew Nattestad, Jun Chen, Burapat InceesungvornAbstract:Abstract N-doped TiO2, denoted as T_400, was prepared simply by the facile thermal hydrolysis of TiOSO4 using NH4OH as both a precipitating agent and a nitrogen source. Compared to TiO2 without nitrogen doping, T_400 provides superior photocatalytic activity toward the selective oxidation of benzyl alcohol and Benzylamine under visible light irradiation, with >85% conversion and >95% selectivity to benzaldehyde and N-benzylideneBenzylamine products, respectively. The increased photoactivity of T_400 is ascribed to enhanced visible-light absorption and efficient photogenerated charge transfer and separation as supported by UV-vis DRS, photoelectrochemical and VB-XPS results. The catalyst can tolerate the presence of substituent groups in benzyl alcohol and benzelamine molecules as > 80% conversion and > 95% selectivity are still achieved, which expands the scope of substrates and catalyst utilization. Band energy level of N-doped TiO2 compared to that of undoped TiO2 is determined using Mott-Schottky and UV-vis DRS measurements. Possible mechanisms for the formation of benzaldehyde and N-benzylideneBenzylamine over N-doped TiO2 are proposed. This work presents a simple synthesis of N-doped TiO2, using a low-cost and easily handled inorganic titanium salt instead of air/moisture-sensitive alkoxide precursors and reveals its potential application toward photocatalytic synthesis of organic fine chemicals under visible light.
J J Leyden - One of the best experts on this subject based on the ideXlab platform.
-
overview of topical therapy for common superficial fungal infections and the role of new topical agents update on topical therapy for superficial fungal infections focus on butenafine
Journal of The American Academy of Dermatology, 1997Co-Authors: B Brennan, J J LeydenAbstract:Until recently the treatment options for superficial fungal infections have been limited mainly to the use of fungistatic drugs of the imidazole class, discovered in the 1960s. The recent development of allylamine and Benzylamine compounds provides antifungal agents with fungicidal mechanisms of action. Both imidazole and allylamine/Benzylamine drugs interfere with the production of ergosterol, an essential component of the fungal cell membrane; however, the newer drugs act at an earlier stage of the metabolic pathway than the azoles and cause an accumulation of squalene in the fungal cell, which leads to cell death. In vitro test results show that allylamine/Benzylamine minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) are lower than the MICS and MFCs of azoles tested by the same methods. In studies using animal models of dermatophytosis, results have shown the efficacy of the allylamine/Benzylamine drugs to be superior to that of azole drugs. Clinical trials have also shown significant differences favoring allylamine/Benzylamine drugs over imidazoles in the treatment of dermatophytosis. The fungicidal drugs provide earlier evidence of efficacy, higher cure rates with shorter treatment periods, and lower relapse rates than imidazoles in direct-comparison studies. The allylamine/Benzylamine drugs have also shown high cure rates in patients with candidiasis.