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Beta Casomorphine

The Experts below are selected from a list of 30 Experts worldwide ranked by ideXlab platform

M. Kurek – 1st expert on this subject based on the ideXlab platform

  • Exorphins derived from cow’s milk casein elicit pseudo-allergic wheal-and-flare reactions in healthy children*
    Revue Francaise D Allergologie Et D Immunologie Clinique, 1996
    Co-Authors: M. Kurek, F. Ruëff, M. Czerwionka-szaflarska, G. Doroszewska, B. Przybilla

    Abstract:

    Les exorphines provenant de la caseine du lait de vache provoquent des reactions urticariennes pseudo-allergiques chez les enfants sains. – La BetaCasomorphine-7 et l’alpha-caseine (90-95) sont des peptides opioides retrouves dans les produits de digestion de la caseine du lait de vache. Le but de ce travail est d’etudier les proprietes histamino-liberatrices directes de ces peptides in vivo. Des tests intradermiques ont ete pratiques avec la BetaCasomorphine-7, l’alpha-caseine (90-95) et un extrait de lait de vache chez 25 enfants bien portants n’ayant aucun signe d’allergie ou d’intolerance au lait de vache. Les reactions papuleuses immediates ont ete mesurees et comparees avec les reactions cutanees a l’histamine et a la codeine. Les tests ont ete refaits apres administration de 10 mg de cetirizine, antihistaminique H1. Chez tous les enfants, les peptides opioides ont induit des reactions erythemato-papuleuses. Elles etaient concentration-dependantes et similaires a celles provoquees par l’histamine ou la codeine. Un pretraitement avec la cetirizine inhibait la reactivite des deux peptides opioides. Sauf dans un cas, les tests cutanes au lait de vache resterent negatifs. Les biopsies de la zone cutanee injectee avec l’alpha-caseine (90-95) mirent en evidence la degranulation des mastocytes cutanes. La BetaCasomorphine-7 et l’alpha-caseine (90-95) provoquent des reactions cutanees pseudo-allergiques immediates dues a une histamino-liberation directe. Cette constatation peut avoir de l’interet pour la comprehension des reactions cliniques au lait de vache.

  • a naturally occurring opioid peptide from cow s milk Beta Casomorphine 7 is a direct histamine releaser in man
    International Archives of Allergy and Immunology, 1992
    Co-Authors: M. Kurek, B. Przybilla, K Hermann, J Ring

    Abstract:

    β-Casomorphine-7, a naturally occurring product of cow’s milk with opiate-like activity, was studied for possible direct histamine liberation activities in humans. It was found to cause concentration-

B. Przybilla – 2nd expert on this subject based on the ideXlab platform

  • Exorphins derived from cow’s milk casein elicit pseudo-allergic wheal-and-flare reactions in healthy children*
    Revue Francaise D Allergologie Et D Immunologie Clinique, 1996
    Co-Authors: M. Kurek, F. Ruëff, M. Czerwionka-szaflarska, G. Doroszewska, B. Przybilla

    Abstract:

    Les exorphines provenant de la caseine du lait de vache provoquent des reactions urticariennes pseudo-allergiques chez les enfants sains. – La BetaCasomorphine-7 et l’alpha-caseine (90-95) sont des peptides opioides retrouves dans les produits de digestion de la caseine du lait de vache. Le but de ce travail est d’etudier les proprietes histamino-liberatrices directes de ces peptides in vivo. Des tests intradermiques ont ete pratiques avec la BetaCasomorphine-7, l’alpha-caseine (90-95) et un extrait de lait de vache chez 25 enfants bien portants n’ayant aucun signe d’allergie ou d’intolerance au lait de vache. Les reactions papuleuses immediates ont ete mesurees et comparees avec les reactions cutanees a l’histamine et a la codeine. Les tests ont ete refaits apres administration de 10 mg de cetirizine, antihistaminique H1. Chez tous les enfants, les peptides opioides ont induit des reactions erythemato-papuleuses. Elles etaient concentration-dependantes et similaires a celles provoquees par l’histamine ou la codeine. Un pretraitement avec la cetirizine inhibait la reactivite des deux peptides opioides. Sauf dans un cas, les tests cutanes au lait de vache resterent negatifs. Les biopsies de la zone cutanee injectee avec l’alpha-caseine (90-95) mirent en evidence la degranulation des mastocytes cutanes. La BetaCasomorphine-7 et l’alpha-caseine (90-95) provoquent des reactions cutanees pseudo-allergiques immediates dues a une histamino-liberation directe. Cette constatation peut avoir de l’interet pour la comprehension des reactions cliniques au lait de vache.

  • a naturally occurring opioid peptide from cow s milk Beta Casomorphine 7 is a direct histamine releaser in man
    International Archives of Allergy and Immunology, 1992
    Co-Authors: M. Kurek, B. Przybilla, K Hermann, J Ring

    Abstract:

    β-Casomorphine-7, a naturally occurring product of cow’s milk with opiate-like activity, was studied for possible direct histamine liberation activities in humans. It was found to cause concentration-

İbrahim Aytekin – 3rd expert on this subject based on the ideXlab platform

  • A1 and A2 Bovine Milk, the Risk of Beta-casomorphin-7 and Its Possible Effects on Human Health:(I) A1 and A2 Milk and the Risk of Beta-casomorphin-7
    Selcuk Journal of Agricultural and Food Sciences, 2018
    Co-Authors: Özcan Şahin, Saim Boztepe, İbrahim Aytekin

    Abstract:

    Milk proteins are generally composed of proteins such as casein, lactalbumin, lactoglobulin, blood serum albumin, and immunoglobulin. One of them, casein from milk proteins consists of fractions such as alpha, Beta, kappa and gamma. Beta casein gene in cattle consists of 209 amino acids and contains proline amino acid (CCT) at position 67 of the amino acid sequence. The milk obtained from animals with this genotype is defined as the original A2 milk. Proline/Histidine amino acid substitution (C/A) at position 67 of the amino acid sequence results in the BetaCasomorphine-7 (BCM-7) which is a naturally occurring opioid peptide from cow’s milk. By this substitution (CAT), the milk obtained from animals with genotypes (A1A1 or A1A2) is defined as the A1 milk. BCM-7 is a polypeptide consisting of seven amino acids and is produced from A1 milk during digestion of Beta-casein protein. As a result, BCM-7 has harmful effects on human health. The aim of this study is to raise awareness in the field of animal science as well as to contribute to the taking of professional measures by using the literature on A1 / A2 milk and BetaCasomorphine-7.

  • A1 and A2 Bovine Milk, the Risk of Beta-casomorphin-7 and Its Possible Effects on Human Health: (II) Possible Effects of Beta-casomorphin-7 on Human Health
    Selcuk Journal of Agricultural and Food Sciences, 2018
    Co-Authors: Özcan Şahin, Saim Boztepe, İbrahim Aytekin

    Abstract:

    BetaCasomorphine-7 (BCM-7), which is an opioid peptide during digestion of A1 milk, has been claimed as a possible cause of some health problems. There are some studies about the role of β- Casomorphine-7 in some diseases such as type 1 diabetes, cardiovascular diseases, autism, schizophrenia, sudden infant death syndrome, apnea, constipation. For example, β- Casomorphine-7 destroys pancreatic β cells, leading to the emergence of type 1 diabetes. It affects T and B cells related to immunity and negatively affects the autoimmune system. The aim of this study is to reveal the diseases that can caused by β- Casomorphine-7 in terms of both animal and human health, in this way to contribute to the reduction of the costs of animal and human health and to create an awareness.