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Siamak Sabour - One of the best experts on this subject based on the ideXlab platform.

  • serum hypercoagulability states in coats disease
    Clinical Ophthalmology, 2017
    Co-Authors: Fariba Ghassemi, Masoumeh Mohebbi, Mehdi Nili Ahmadabadi, Fatemeh Morsali, Carol L. Shields, Siamak Sabour
    Abstract:

    PURPOSE: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' disease versus a normal control group. MATERIALS AND METHODS: In this comparative case series, 22 consecutive patients with Coats' disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. RESULTS: The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoGlobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum Beta Globulin (P<0.001) were associated with Coats' disease. In those older than 10 years, higher serum protein S (P=0.04), Beta Globulin (P=0.05), and gamma Globulin (P=0.04) were related to Coats' diagnosis. After adjusting for sex and age as confounding factors, only Beta Globulin was found to be associated with Coats' disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0-3.1, P=0.02). CONCLUSION: Serum Beta Globulin levels appear to be elevated in patients with Coats' disease.

  • Serum hypercoagulability states in Coats’ disease
    Clinical Ophthalmology, 2017
    Co-Authors: Fariba Ghassemi, Masoumeh Mohebbi, Mehdi Nili Ahmadabadi, Fatemeh Morsali, Carol L. Shields, Siamak Sabour
    Abstract:

    PURPOSE: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' disease versus a normal control group. MATERIALS AND METHODS: In this comparative case series, 22 consecutive patients with Coats' disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. RESULTS: The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoGlobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum Beta Globulin (P

Kimberley Hart - One of the best experts on this subject based on the ideXlab platform.

  • familial pulmonary hypertension in association with an abnormal hemoglobin insights into the pathogenesis of primary pulmonary hypertension
    Chest, 1991
    Co-Authors: Stuart Rich, Kimberley Hart
    Abstract:

    A kindred with a familial hemoglobinopathy and familial primary pulmonary hypertension with autosomal dominant transmission has been identified. Affected family members were obvious from their cyanosis due to a reduced affinity for oxygen by the hemoglobin variant. The mother and one child had clinical pulmonary hypertension, whereas two siblings had cyanosis and preclinical pulmonary vascular disease as evidenced by abnormal perfusion lung scans and elevated levels of fibrinopeptide A in the face of normal pulmonary hemodynamics. In one, pulmonary hypertension could be induced with exercise. The studies on this family support the hypothesis that primary pulmonary hypertension may be initiated by abnormalities of the pulmonary vascular bed that predispose to in situ thrombosis. The possible common genetic transmission of the two diseases offers the speculation that the gene that confers predisposition to pulmonary hypertension may be located near the gene responsible for Beta Globulin. (Chest 1991; 99:1208-10)

Fariba Ghassemi - One of the best experts on this subject based on the ideXlab platform.

  • serum hypercoagulability states in coats disease
    Clinical Ophthalmology, 2017
    Co-Authors: Fariba Ghassemi, Masoumeh Mohebbi, Mehdi Nili Ahmadabadi, Fatemeh Morsali, Carol L. Shields, Siamak Sabour
    Abstract:

    PURPOSE: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' disease versus a normal control group. MATERIALS AND METHODS: In this comparative case series, 22 consecutive patients with Coats' disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. RESULTS: The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoGlobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum Beta Globulin (P<0.001) were associated with Coats' disease. In those older than 10 years, higher serum protein S (P=0.04), Beta Globulin (P=0.05), and gamma Globulin (P=0.04) were related to Coats' diagnosis. After adjusting for sex and age as confounding factors, only Beta Globulin was found to be associated with Coats' disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0-3.1, P=0.02). CONCLUSION: Serum Beta Globulin levels appear to be elevated in patients with Coats' disease.

  • Serum hypercoagulability states in Coats’ disease
    Clinical Ophthalmology, 2017
    Co-Authors: Fariba Ghassemi, Masoumeh Mohebbi, Mehdi Nili Ahmadabadi, Fatemeh Morsali, Carol L. Shields, Siamak Sabour
    Abstract:

    PURPOSE: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' disease versus a normal control group. MATERIALS AND METHODS: In this comparative case series, 22 consecutive patients with Coats' disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. RESULTS: The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoGlobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum Beta Globulin (P

Miguel A Tesouro - One of the best experts on this subject based on the ideXlab platform.

  • effects of meloxicam on hematologic and plasma biochemical analyte values and results of histologic examination of kidney biopsy specimens of african grey parrots psittacus erithacus
    Journal of Avian Medicine and Surgery, 2015
    Co-Authors: Andres Montesinos, Maria Ardiaca, Carles Juansalles, Miguel A Tesouro
    Abstract:

    Abstract In this study we evaluated the effects of meloxicam administered at 0.5 mg/kg IM q12h for 14 days on hematologic and plasma biochemical values and on kidney tissue in 11 healthy African grey parrots (Psittacus erithacus). Before treatment with meloxicam, blood samples were collected and renal biopsy samples were obtained from the cranial portion of the left kidney from each of the birds. On day 14 of treatment, a second blood sample and biopsy from the middle portion of the left kidney were obtained from each bird. All birds remained clinically normal throughout the study period. No significant differences were found between hematologic and plasma biochemical values before and after 14 days of treatment with meloxicam, except for a slight increase in median Beta Globulin and corresponding total Globulin concentrations, and a slight decrease in median phosphorus concentration. Renal lesions were absent in 9 of 10 representative posttreatment biopsy samples. On the basis of these results, meloxicam...

  • effects of meloxicam on hematologic and plasma biochemical analyte values and results of histologic examination of kidney biopsy specimens of african grey parrots psittacus erithacus
    Journal of Avian Medicine and Surgery, 2015
    Co-Authors: Andres Montesinos, Maria Ardiaca, Carles Juansalles, Miguel A Tesouro
    Abstract:

    In this study we evaluated the effects of meloxicam administered at 0.5 mg/kg IM q12h for 14 days on hematologic and plasma biochemical values and on kidney tissue in 11 healthy African grey parrots (Psittacus erithacus). Before treatment with meloxicam, blood samples were collected and renal biopsy samples were obtained from the cranial portion of the left kidney from each of the birds. On day 14 of treatment, a second blood sample and biopsy from the middle portion of the left kidney were obtained from each bird. All birds remained clinically normal throughout the study period. No significant differences were found between hematologic and plasma biochemical values before and after 14 days of treatment with meloxicam, except for a slight increase in median Beta Globulin and corresponding total Globulin concentrations, and a slight decrease in median phosphorus concentration. Renal lesions were absent in 9 of 10 representative posttreatment biopsy samples. On the basis of these results, meloxicam administered at the dosage used in this study protocol does not appear to cause renal disease in African grey parrots.

Carol L. Shields - One of the best experts on this subject based on the ideXlab platform.

  • serum hypercoagulability states in coats disease
    Clinical Ophthalmology, 2017
    Co-Authors: Fariba Ghassemi, Masoumeh Mohebbi, Mehdi Nili Ahmadabadi, Fatemeh Morsali, Carol L. Shields, Siamak Sabour
    Abstract:

    PURPOSE: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' disease versus a normal control group. MATERIALS AND METHODS: In this comparative case series, 22 consecutive patients with Coats' disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. RESULTS: The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoGlobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum Beta Globulin (P<0.001) were associated with Coats' disease. In those older than 10 years, higher serum protein S (P=0.04), Beta Globulin (P=0.05), and gamma Globulin (P=0.04) were related to Coats' diagnosis. After adjusting for sex and age as confounding factors, only Beta Globulin was found to be associated with Coats' disease in logistic regression analysis (odds ratio: 1.8, 95% confidence interval: 1.0-3.1, P=0.02). CONCLUSION: Serum Beta Globulin levels appear to be elevated in patients with Coats' disease.

  • Serum hypercoagulability states in Coats’ disease
    Clinical Ophthalmology, 2017
    Co-Authors: Fariba Ghassemi, Masoumeh Mohebbi, Mehdi Nili Ahmadabadi, Fatemeh Morsali, Carol L. Shields, Siamak Sabour
    Abstract:

    PURPOSE: The purpose of this study was to investigate the serum hypercoagulability state and common viral and protozoan infections in Coats' disease versus a normal control group. MATERIALS AND METHODS: In this comparative case series, 22 consecutive patients with Coats' disease and 19 non-Coats' patients undergoing lensectomy for congenital, traumatic, or senile cataract between January 2011 and June 2014 were included. Laboratory data for hypercoagulability states and common viral and protozoan infections were investigated. RESULTS: The mean age for the Coats' group was 14.5 years (median 8 years, range: 2 months to 59 years), and for the control group it was 30.6 years (median 17 years, range: 2-82 years). In patients aged 10 years or younger, anticytomegalovirus immunoGlobulin G (IgG) (P≤0.01), homocysteine (P=0.03), and serum Beta Globulin (P