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Luan D Truong - One of the best experts on this subject based on the ideXlab platform.
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are gadolinium based contrast media nephrotoxic a Renal Biopsy study
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Hulya Akgun, Gulfiliz Gonlusen, Joiner Cartwright, Wadi N Suki, Luan D TruongAbstract:Gadolinium-based contrast media were originally introduced as alternatives to iodinated media for magnetic resonance imaging. Although originally thought to be nonnephrotoxic, gadolinium-based contrast media have recently been reported to be associated with acute Renal failure; the mechanism and the underlying Renal injury are not completely understood. We report what is, to our knowledge, the first Renal Biopsy in this context. A 56-year-old patient underwent 2 consecutive vascular imaging procedures in conjunction with gadolinium-based contrast medium administration. A few days later, the patient developed acute Renal failure. A Renal Biopsy showed acute tubular cell injury including patchy tubular cell necrosis, tubular cell degeneration, and marked proliferation of tubular cells, together with mild interstitial edema and interstitial inflammation, but without significant glomerular or vascular changes. During supportive therapy, Renal function was partially regained. This case emphasizes the potential nephrotoxicity of gadolinium-based contrast media and suggests that the nephrotoxicity is related to potentially reversible acute tubular cell injury.
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:c Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases. (Arch Pathol Lab Med. 2006;130:101‐106)
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases.
Hulya Akgun - One of the best experts on this subject based on the ideXlab platform.
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are gadolinium based contrast media nephrotoxic a Renal Biopsy study
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Hulya Akgun, Gulfiliz Gonlusen, Joiner Cartwright, Wadi N Suki, Luan D TruongAbstract:Gadolinium-based contrast media were originally introduced as alternatives to iodinated media for magnetic resonance imaging. Although originally thought to be nonnephrotoxic, gadolinium-based contrast media have recently been reported to be associated with acute Renal failure; the mechanism and the underlying Renal injury are not completely understood. We report what is, to our knowledge, the first Renal Biopsy in this context. A 56-year-old patient underwent 2 consecutive vascular imaging procedures in conjunction with gadolinium-based contrast medium administration. A few days later, the patient developed acute Renal failure. A Renal Biopsy showed acute tubular cell injury including patchy tubular cell necrosis, tubular cell degeneration, and marked proliferation of tubular cells, together with mild interstitial edema and interstitial inflammation, but without significant glomerular or vascular changes. During supportive therapy, Renal function was partially regained. This case emphasizes the potential nephrotoxicity of gadolinium-based contrast media and suggests that the nephrotoxicity is related to potentially reversible acute tubular cell injury.
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:c Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases. (Arch Pathol Lab Med. 2006;130:101‐106)
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases.
Gulfiliz Gonlusen - One of the best experts on this subject based on the ideXlab platform.
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are gadolinium based contrast media nephrotoxic a Renal Biopsy study
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Hulya Akgun, Gulfiliz Gonlusen, Joiner Cartwright, Wadi N Suki, Luan D TruongAbstract:Gadolinium-based contrast media were originally introduced as alternatives to iodinated media for magnetic resonance imaging. Although originally thought to be nonnephrotoxic, gadolinium-based contrast media have recently been reported to be associated with acute Renal failure; the mechanism and the underlying Renal injury are not completely understood. We report what is, to our knowledge, the first Renal Biopsy in this context. A 56-year-old patient underwent 2 consecutive vascular imaging procedures in conjunction with gadolinium-based contrast medium administration. A few days later, the patient developed acute Renal failure. A Renal Biopsy showed acute tubular cell injury including patchy tubular cell necrosis, tubular cell degeneration, and marked proliferation of tubular cells, together with mild interstitial edema and interstitial inflammation, but without significant glomerular or vascular changes. During supportive therapy, Renal function was partially regained. This case emphasizes the potential nephrotoxicity of gadolinium-based contrast media and suggests that the nephrotoxicity is related to potentially reversible acute tubular cell injury.
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:c Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases. (Arch Pathol Lab Med. 2006;130:101‐106)
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases.
Atilla Ertan - One of the best experts on this subject based on the ideXlab platform.
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:c Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases. (Arch Pathol Lab Med. 2006;130:101‐106)
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases.
J J Olivero - One of the best experts on this subject based on the ideXlab platform.
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:c Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases. (Arch Pathol Lab Med. 2006;130:101‐106)
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Renal failure and nephrocalcinosis associated with oral sodium phosphate bowel cleansing clinical patterns and Renal Biopsy findings
Archives of Pathology & Laboratory Medicine, 2006Co-Authors: Gulfiliz Gonlusen, Hulya Akgun, Atilla Ertan, J J Olivero, Luan D TruongAbstract:Acute Renal failure (ARF) is rarely reported after bowel preparation with sodium phosphate. We report a patient with mild Crohn disease (in remission), without history of Renal disease, and with normal baseline Renal function, who developed ARF 14 days after bowel preparation for colonoscopy with oral sodium phosphate. A Renal Biopsy showed multifocal calcium phosphate deposition in the Renal tubules against a background of diffuse chronic tubulointerstitial injury. Review of the literature suggested 2 distinct patterns of ARF in the context of sodium phosphate bowel cleansing. One pattern is characterized by ARF, which develops a few hours or days after sodium phosphate administration, as a component of a systemic syndrome associated with severe hyperphosphatemia and hypocalcemia. Correction of these electrolyte abnormalities was frequently associated with rapid recovery of Renal function. The cause of ARF in this context was not clear because the favorable outcome negated the need for Renal Biopsy. In the second pattern, exemplified by the current patient, ARF was identified incidentally. These patients did not have any features of an acute syndrome immediately after sodium phosphate administration and presented much later (usually weeks) with mild, nonspecific symptoms. At the time of presentation, the serum calcium and phosphate levels were normal. The Renal biopsies in each of these patients showed nephrocalcinosis as the possible cause of ARF. The Renal failure improved at least partially in most of these patients, but persisted in rare cases.
