The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
M Kumar - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 7 chloro 5 trifluoromethyl 7 fluoro 7 trifluoromethyl 4h 1 4 benzothiazines as antimicrobial agents
Bioorganic & Medicinal Chemistry, 2006Co-Authors: Bhawani Singh Rathore, M KumarAbstract:7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/Beta-Ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.
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Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents.
Bioorganic & medicinal chemistry, 2006Co-Authors: Bhawani Singh Rathore, M KumarAbstract:7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/Beta-Ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.
Caroline H Lee - One of the best experts on this subject based on the ideXlab platform.
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Consecutive Alkene Cross-Metathesis/Oxonium Ylide Formation—Rearrangement: Synthesis of the anti-HIV Agent Hyperolactone C.
ChemInform, 2009Co-Authors: David M Hodgson, Deepshikha Angrish, Stephanie P Erickson, Johannes Kloesges, Caroline H LeeAbstract:Alpha-diazo-Beta-Ketoesters bearing allylic ether functionality undergo highly stereoselective Ru-carbene-catalyzed alkene cross-metathesis followed by Rh(2)(OAc)(4)-catalyzed oxonium ylide formation/[2,3] sigmatropic rearrangement in a one-flask operation and in a highly diastereoselective manner. The methodology has been demonstrated in a concise synthesis of the anti-HIV agent hyperolactone C.
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Consecutive alkene cross-metathesis/oxonium ylide formation-rearrangement: synthesis of the anti-HIV agent hyperolactone C.
Organic letters, 2008Co-Authors: David M Hodgson, Deepshikha Angrish, Stephanie P Erickson, Johannes Kloesges, Caroline H LeeAbstract:Alpha-diazo-Beta-Ketoesters bearing allylic ether functionality undergo highly stereoselective Ru-carbene-catalyzed alkene cross-metathesis followed by Rh(2)(OAc)(4)-catalyzed oxonium ylide formation/[2,3] sigmatropic rearrangement in a one-flask operation and in a highly diastereoselective manner. The methodology has been demonstrated in a concise synthesis of the anti-HIV agent hyperolactone C.
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consecutive alkene cross metathesis oxonium ylide formation rearrangement synthesis of the anti hiv agent hyperolactone c
Organic Letters, 2008Co-Authors: David M Hodgson, Deepshikha Angrish, Stephanie P Erickson, Johannes Kloesges, Caroline H LeeAbstract:Alpha-diazo-Beta-Ketoesters bearing allylic ether functionality undergo highly stereoselective Ru-carbene-catalyzed alkene cross-metathesis followed by Rh(2)(OAc)(4)-catalyzed oxonium ylide formation/[2,3] sigmatropic rearrangement in a one-flask operation and in a highly diastereoselective manner. The methodology has been demonstrated in a concise synthesis of the anti-HIV agent hyperolactone C.
Bhawani Singh Rathore - One of the best experts on this subject based on the ideXlab platform.
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synthesis of 7 chloro 5 trifluoromethyl 7 fluoro 7 trifluoromethyl 4h 1 4 benzothiazines as antimicrobial agents
Bioorganic & Medicinal Chemistry, 2006Co-Authors: Bhawani Singh Rathore, M KumarAbstract:7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/Beta-Ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.
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Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents.
Bioorganic & medicinal chemistry, 2006Co-Authors: Bhawani Singh Rathore, M KumarAbstract:7-Chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/Beta-Ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included.
David M Hodgson - One of the best experts on this subject based on the ideXlab platform.
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Consecutive Alkene Cross-Metathesis/Oxonium Ylide Formation—Rearrangement: Synthesis of the anti-HIV Agent Hyperolactone C.
ChemInform, 2009Co-Authors: David M Hodgson, Deepshikha Angrish, Stephanie P Erickson, Johannes Kloesges, Caroline H LeeAbstract:Alpha-diazo-Beta-Ketoesters bearing allylic ether functionality undergo highly stereoselective Ru-carbene-catalyzed alkene cross-metathesis followed by Rh(2)(OAc)(4)-catalyzed oxonium ylide formation/[2,3] sigmatropic rearrangement in a one-flask operation and in a highly diastereoselective manner. The methodology has been demonstrated in a concise synthesis of the anti-HIV agent hyperolactone C.
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Consecutive alkene cross-metathesis/oxonium ylide formation-rearrangement: synthesis of the anti-HIV agent hyperolactone C.
Organic letters, 2008Co-Authors: David M Hodgson, Deepshikha Angrish, Stephanie P Erickson, Johannes Kloesges, Caroline H LeeAbstract:Alpha-diazo-Beta-Ketoesters bearing allylic ether functionality undergo highly stereoselective Ru-carbene-catalyzed alkene cross-metathesis followed by Rh(2)(OAc)(4)-catalyzed oxonium ylide formation/[2,3] sigmatropic rearrangement in a one-flask operation and in a highly diastereoselective manner. The methodology has been demonstrated in a concise synthesis of the anti-HIV agent hyperolactone C.
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consecutive alkene cross metathesis oxonium ylide formation rearrangement synthesis of the anti hiv agent hyperolactone c
Organic Letters, 2008Co-Authors: David M Hodgson, Deepshikha Angrish, Stephanie P Erickson, Johannes Kloesges, Caroline H LeeAbstract:Alpha-diazo-Beta-Ketoesters bearing allylic ether functionality undergo highly stereoselective Ru-carbene-catalyzed alkene cross-metathesis followed by Rh(2)(OAc)(4)-catalyzed oxonium ylide formation/[2,3] sigmatropic rearrangement in a one-flask operation and in a highly diastereoselective manner. The methodology has been demonstrated in a concise synthesis of the anti-HIV agent hyperolactone C.
Antonio Togni - One of the best experts on this subject based on the ideXlab platform.
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Titanium(IV)‐Catalyzed Enantioselective Sulfenylation of β‐Ketoesters.
ChemInform, 2006Co-Authors: Marjan Jereb, Antonio TogniAbstract:A [Ti(TADDOLato)] complex (1) catalyzes the enantioselective sulfenylation of Beta-Ketoesters using phenylsulfenyl chloride, giving ees of up to 88% and yields of up to 95%. The reaction does not require the presence of a base. [reaction: see text]
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Titanium(IV)-Catalyzed Enantioselective Sulfenylation of β-Ketoesters
Organic letters, 2005Co-Authors: Marjan Jereb, Antonio TogniAbstract:A [Ti(TADDOLato)] complex (1) catalyzes the enantioselective sulfenylation of Beta-Ketoesters using phenylsulfenyl chloride, giving ees of up to 88% and yields of up to 95%. The reaction does not require the presence of a base. [reaction: see text]
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expanding the scope of asymmetric electrophilic atom transfer reactions titanium and ruthenium catalyzed hydroxylation of β ketoesters
Proceedings of the National Academy of Sciences of the United States of America, 2004Co-Authors: Patrick Y Toullec, Cristina Bonaccorsi, Antonio Mezzetti, Antonio TogniAbstract:The enantioselective formation of a quaternary stereogenic center coinciding with a hydroxylation process is a very rare reaction from a homogeneous catalysis point of view. Indeed, to our knowledge, no asymmetric transition-metal-catalyzed direct hydroxylation has been reported before. We describe here our initial study concerning the enantioselective alpha-hydroxylation of various Beta-Ketoesters catalyzed by Lewis-acidic complexes. Specifically, it was found that the Ti complex [TiCl(2)((R,R)-1-Np-TADDOLato)(MeCN)(2)] affords the hydroxylated products in high yield and enantioselectivities up to 94% enantiomeric excess when using 2-(phenylsulphonyl)-3-(4-nitrophenyl)oxaziridine as the oxidizing agent. Chiral enantiopure compounds of the latter type have been used previously in stoichiometric asymmetric hydroxylation reactions. We also show that, in a complementary approach with H(2)O(2) as the oxidant, the Ru(II) complex [RuCl(OE(2))((S,S)-PNNP)]PF(6) catalyzes the same type of transformation in a case of substrates showing a very substantial extent of enolization under reaction conditions; being, however, unreactive toward only weakly enolized Beta-Ketoesters.