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The Experts below are selected from a list of 87 Experts worldwide ranked by ideXlab platform
E. H. Mccraw – 1st expert on this subject based on the ideXlab platform
Extractives from the New Zealand myrtaceae. IV.—Triterpene Acids from the bark of Leptospermum ericoidesJournal of the Science of Food and Agriculture, 2006Co-Authors: R. E. Corbett, E. H. MccrawAbstract:
Betulic Acid, ursolic Acid, acetate, and a new triterpene Acid, C30H48O4, have been isolated from the outer bark of L. ericoides. Chromatography on silica gel has proved an effective method for the separation of these Acids.
Zhang Qian-qia – 2nd expert on this subject based on the ideXlab platform
Isolation and identification of chemical constituents from Ziziphi Spinosae Branch and FoliumJournal of Shenyang Pharmaceutical University, 2020Co-Authors: Zhang Qian-qiaAbstract:
Objective To study the chemical constituents from branches and leaves of Z.jujubavar.spinosa.Methods The chemical constituents were isolated and purified by silica gel,polyamide,SephadexLH-20,ODS as well as PR-HPLC and so on.The chemical structures were elucidated on the basis of physic-chemical properties and spectral data.Results Eight compounds were obtained from branches and leaves of Z.jujubavar.spinosa.Their structures were identified as:3-phenyl lactic Acid methyl ester(1),3-(3-indolyl)lactic Acid methyl ester(2),catechin(3),2R,3R-3,5,7,3′,5′-pentahydroxyflavane(4),quercetin-3-O-β-D-glucoside(5),quercetin(6),Betulic Acid(7)and rutin(8).Conclusions Compounds 1-5 are isolated from this genus for the first time.
Huijie Wang – 3rd expert on this subject based on the ideXlab platform
study on absorption kinetics of Betulic Acid in rat s intestinesChina journal of Chinese materia medica, 2012Co-Authors: Huijun Xu, Yingfeng Du, Lantong Zhang, Tao Li, Ying Ge, Huijie WangAbstract:
OBJECTIVE: To establish a HPLC-DAD method for determining concentrations of Betulic Acid and phenol red in intestinal circulation liquid, and probe into the absorption kinetic characteristics of Betulic Acid at different intestine segments in rats and the effect of different drug concentrations on absorption. METHOD: The rat intestinal absorption model was established to detect the impact of absorption site, drug concentration and pH value on drug absorption. RESULT: Within the range from 75-125 mg x L(-1), the absorption rate and the quality concentration of Betulic Acid had a linear relation, with Ka value keeping unchanged. The absorption rate for each intestinal segment showed no remarkable difference, with Ka values in duodenum, jejunum, ileum and colon being (0.151 +/- 0.0049), (0.159 +/- 0.0056), (0.156 +/- 6.0083), (0.149 +/- 0.0041) h(-1), respectively. CONCLUSION: Betulic Acid is proved to be well absorbed in intestines marked by no specific absorption site in the intestine. The absorption mechanism of the drug conforms to passive transport mechanism and first-order kinetics. The bioavailability of Betulic Acid preparation can be increased by enhancing the dissolution rate and the solubility.