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The Experts below are selected from a list of 7101 Experts worldwide ranked by ideXlab platform
Simone Fulda – 1st expert on this subject based on the ideXlab platform
Betulinic Acid for cancer treatment and preventionInternational Journal of Molecular Sciences, 2008Co-Authors: Simone FuldaAbstract:
Betulinic Acid is a natural product with a range of biological effects, for example potent antitumor activity. This anticancer property is linked to its ability to induce apoptotic cell death in cancer cells by triggering the mitochondrial pathway of apoptosis. In contrast to the cytotoxicity of Betulinic Acid against a variety of cancer types, normal cells and tissue are relatively resistant to Betulinic Acid, pointing to a therapeutic window. Compounds that exert a direct action on mitochondria present promising experimental cancer therapeutics, since they may trigger cell death under circumstances in which standard chemotherapeutics fail. Thus, mitochondrion-targeted agents such as Betulinic Acid hold great promise as a novel therapeutic strategy in the treatment of human cancers.
Yin Zhiqi – 2nd expert on this subject based on the ideXlab platform
Determination of Betulinic Acid in Semen Ziziphi Spinosae by HPLCPharmaceutical biotechnology, 2020Co-Authors: Yin ZhiqiAbstract:
To establish a HPLC method for the determination of the content of Betulinic Acid in Semen Ziziphi Spinosae,the Alltech C18(4.6mm × 250mm,5μm)column was used with the acetonitrile:water containing 0.4% phosphoric Acid(85∶15) as mobile phase,with the flow rate at 1.0mL/min and UV detector at 205nm.The linear range of Betulinic Acid was 0.4462～6.693μg(r=0.9998).The average recovery of Betulinic Acid was 100.3%(RSD=1.7%).The method is simple and accurate,it can be used for the quality control of Betulinic Acid in Semen Ziziphi Spinosae.
Yang Guang – 3rd expert on this subject based on the ideXlab platform
HPLC determination of Betulinic Acid in Semen Ziziphi SpinosaeChinese Journal of Pharmaceutical Analysis, 2020Co-Authors: Yang GuangAbstract:
Objective:To establish an HPLC method for the determination of Betulinic Acid in Semen Ziziphi Spi- nosae.Method:The separation was achieved on a ALCHROM~(TM)Hyper Sil C_(18)column(250mm×4.6mm,5μm) at 25℃.The mobile phase composition was methanol-water-triethylamine-glacial acetic Acid(85:15:0.05: 0.03)with a flow rate of 0.8mL·min~(-1).The detection wavelength was 210nm.Result:The cahbration curves was linear in the rang of 0.8-4.0μg,r=0.9995 and the resolution of Betulinic Acid was more than 1.5.The recovery rate was 102.5%,RSD=2.0%.Conclusion:This method is sensitive,rapid and accurate with good reproducibility for quantitative analysis of Betulinic Acid in Semen Ziziphi Spinosae.