Biflavonoid - Explore the Science & Experts | ideXlab

Scan Science and Technology

Contact Leading Edge Experts & Companies

Biflavonoid

The Experts below are selected from a list of 2676 Experts worldwide ranked by ideXlab platform

Hyeun Wook Chang – One of the best experts on this subject based on the ideXlab platform.

  • New anti-inflammatory synthetic Biflavonoid with C-C (6-6″) linkage: Differential effects on cyclooxygenase-2 and inducible nitric oxide synthase
    Archives of Pharmacal Research, 2009
    Co-Authors: Haeil Park, Hyeun Wook Chang

    Abstract:

    Previously, a synthetic biflavone having a C-C (6–6″) linkage ([6,6″]biflavone, BF6-6) was shown to possess considerable anti-inflammatory activity. The present investigation was conducted to develop more active anti-inflammatory Biflavonoids having unique mechanisms of action based on the BF6-6 molecule. For this purpose, 5,7-dihydroxy[6,6″]biflavone (G168) was synthesized using Suzuki-Miyaura C-C cross coupling reaction. The anti-inflammatory activities of G168 were then examined on lipopolysaccharide-treated RAW 264.7 cells, carrageenaninduced paw edema and acetic acid-induced writhing in mice. It was found that G168 showed much stronger inhibition against cyclooxygenase-2-mediated PGE_2 production than the original molecule, BF6-6. It also demonstrated inhibitory activity against inducible nitric oxide synthase (iNOS)-mediated NO production at least partly by the down-regulation of iNOS. Furthermore, G168, administered intraperitoneally at a dosage of 1–5 mg/kg, showed a potent in vivo anti-inflammatory activity on carrageenan-induced paw edema and analgesic activity on acetic acid-induced writhing in mice. Therefore, the newly synthesized Biflavonoid, G168, may be used as a synthetic lead for new anti-inflammatory drug development.

  • new anti inflammatory synthetic Biflavonoid with c c 6 6 linkage differential effects on cyclooxygenase 2 and inducible nitric oxide synthase
    Archives of Pharmacal Research, 2009
    Co-Authors: Hyun Lim, Hyeun Wook Chang, Haeil Park, Soo Bae Kim, Hyun Pyo Kim

    Abstract:

    Previously, a synthetic biflavone having a C-C (6–6″) linkage ([6,6″]biflavone, BF6-6) was shown to possess considerable anti-inflammatory activity. The present investigation was conducted to develop more active anti-inflammatory Biflavonoids having unique mechanisms of action based on the BF6-6 molecule. For this purpose, 5,7-dihydroxy[6,6″]biflavone (G168) was synthesized using Suzuki-Miyaura C-C cross coupling reaction. The anti-inflammatory activities of G168 were then examined on lipopolysaccharide-treated RAW 264.7 cells, carrageenaninduced paw edema and acetic acid-induced writhing in mice. It was found that G168 showed much stronger inhibition against cyclooxygenase-2-mediated PGE2 production than the original molecule, BF6-6. It also demonstrated inhibitory activity against inducible nitric oxide synthase (iNOS)-mediated NO production at least partly by the down-regulation of iNOS. Furthermore, G168, administered intraperitoneally at a dosage of 1–5 mg/kg, showed a potent in vivo anti-inflammatory activity on carrageenan-induced paw edema and analgesic activity on acetic acid-induced writhing in mice. Therefore, the newly synthesized Biflavonoid, G168, may be used as a synthetic lead for new anti-inflammatory drug development.

  • Biochemical pharmacology of Biflavonoids: Implications for anti-inflammatory action
    Archives of Pharmacal Research, 2008
    Co-Authors: Haeil Park, Hyeun Wook Chang, Sam-sik Kang

    Abstract:

    Biflavonoids belong to a subclass of the plant flavonoid family. Distribution of Biflavonoids in the plant kingdom is limited to several species. Previously, some pharmacological activities of Biflavonoids were described such as inhibition of histamine release from mast cells and inhibition of lymphocyte proliferation, suggesting the anti-inflammatory/antiallergic potential of the Biflavonoids. Furthermore, several natural Biflavonoids including ochnaflavone and ginkgetin inhibit phospholipase A_2. Most importantly, certain Biflavonoids exhibit anti-inflammatory activity through the regulation of proinflammatory gene expression in vitro and in vivo . Recently, several synthetic approaches yielded new Biflavonoid molecules with anti-inflammatory potential. These molecules also exhibit phospholipase A_2 and cyclooxygenase-2 inhibitory activity. Although the bioavailability needs be improved, certain Biflavonoids may have potential as new anti-inflammatory agents. This is the first review of Biflavonoid pharmacology to date.

Joseph J Karchesy – One of the best experts on this subject based on the ideXlab platform.

  • [5′,5′]-bisdihydroquercetin: A B-ring linked Biflavonoid from Pseudotsuga menziesii
    Phytochemistry, 1992
    Co-Authors: Richard F Helm, Joseph J Karchesy

    Abstract:

    Abstract The isolation of [5′,5′]-bisdihydroquercetin from the outer bark of Douglas-fir, as the first example of a true Biflavonoid linked exclusively via the B-rings, broadens the known heterogeneity of interflavonoid- linkage modes among natural Biflavonoids, and supports the concept that the constitution of phlobaphenes is primarily derived by oxidative coupling of dihydroquercetin and other co-occurring components.

  • 5 5 bisdihydroquercetin a b ring linked Biflavonoid from pseudotsuga menziesii
    Phytochemistry, 1992
    Co-Authors: Yeap Foo Lai, Richard F Helm, Joseph J Karchesy

    Abstract:

    Abstract The isolation of [5′,5′]-bisdihydroquercetin from the outer bark of Douglas-fir, as the first example of a true Biflavonoid linked exclusively via the B-rings, broadens the known heterogeneity of interflavonoid- linkage modes among natural Biflavonoids, and supports the concept that the constitution of phlobaphenes is primarily derived by oxidative coupling of dihydroquercetin and other co-occurring components.

Haeil Park – One of the best experts on this subject based on the ideXlab platform.

  • New anti-inflammatory synthetic Biflavonoid with C-C (6-6″) linkage: Differential effects on cyclooxygenase-2 and inducible nitric oxide synthase
    Archives of Pharmacal Research, 2009
    Co-Authors: Haeil Park, Hyeun Wook Chang

    Abstract:

    Previously, a synthetic biflavone having a C-C (6–6″) linkage ([6,6″]biflavone, BF6-6) was shown to possess considerable anti-inflammatory activity. The present investigation was conducted to develop more active anti-inflammatory Biflavonoids having unique mechanisms of action based on the BF6-6 molecule. For this purpose, 5,7-dihydroxy[6,6″]biflavone (G168) was synthesized using Suzuki-Miyaura C-C cross coupling reaction. The anti-inflammatory activities of G168 were then examined on lipopolysaccharide-treated RAW 264.7 cells, carrageenaninduced paw edema and acetic acid-induced writhing in mice. It was found that G168 showed much stronger inhibition against cyclooxygenase-2-mediated PGE_2 production than the original molecule, BF6-6. It also demonstrated inhibitory activity against inducible nitric oxide synthase (iNOS)-mediated NO production at least partly by the down-regulation of iNOS. Furthermore, G168, administered intraperitoneally at a dosage of 1–5 mg/kg, showed a potent in vivo anti-inflammatory activity on carrageenan-induced paw edema and analgesic activity on acetic acid-induced writhing in mice. Therefore, the newly synthesized Biflavonoid, G168, may be used as a synthetic lead for new anti-inflammatory drug development.

  • new anti inflammatory synthetic Biflavonoid with c c 6 6 linkage differential effects on cyclooxygenase 2 and inducible nitric oxide synthase
    Archives of Pharmacal Research, 2009
    Co-Authors: Hyun Lim, Hyeun Wook Chang, Haeil Park, Soo Bae Kim, Hyun Pyo Kim

    Abstract:

    Previously, a synthetic biflavone having a C-C (6–6″) linkage ([6,6″]biflavone, BF6-6) was shown to possess considerable anti-inflammatory activity. The present investigation was conducted to develop more active anti-inflammatory Biflavonoids having unique mechanisms of action based on the BF6-6 molecule. For this purpose, 5,7-dihydroxy[6,6″]biflavone (G168) was synthesized using Suzuki-Miyaura C-C cross coupling reaction. The anti-inflammatory activities of G168 were then examined on lipopolysaccharide-treated RAW 264.7 cells, carrageenaninduced paw edema and acetic acid-induced writhing in mice. It was found that G168 showed much stronger inhibition against cyclooxygenase-2-mediated PGE2 production than the original molecule, BF6-6. It also demonstrated inhibitory activity against inducible nitric oxide synthase (iNOS)-mediated NO production at least partly by the down-regulation of iNOS. Furthermore, G168, administered intraperitoneally at a dosage of 1–5 mg/kg, showed a potent in vivo anti-inflammatory activity on carrageenan-induced paw edema and analgesic activity on acetic acid-induced writhing in mice. Therefore, the newly synthesized Biflavonoid, G168, may be used as a synthetic lead for new anti-inflammatory drug development.

  • Biochemical pharmacology of Biflavonoids: Implications for anti-inflammatory action
    Archives of Pharmacal Research, 2008
    Co-Authors: Haeil Park, Hyeun Wook Chang, Sam-sik Kang

    Abstract:

    Biflavonoids belong to a subclass of the plant flavonoid family. Distribution of Biflavonoids in the plant kingdom is limited to several species. Previously, some pharmacological activities of Biflavonoids were described such as inhibition of histamine release from mast cells and inhibition of lymphocyte proliferation, suggesting the anti-inflammatory/antiallergic potential of the Biflavonoids. Furthermore, several natural Biflavonoids including ochnaflavone and ginkgetin inhibit phospholipase A_2. Most importantly, certain Biflavonoids exhibit anti-inflammatory activity through the regulation of proinflammatory gene expression in vitro and in vivo . Recently, several synthetic approaches yielded new Biflavonoid molecules with anti-inflammatory potential. These molecules also exhibit phospholipase A_2 and cyclooxygenase-2 inhibitory activity. Although the bioavailability needs be improved, certain Biflavonoids may have potential as new anti-inflammatory agents. This is the first review of Biflavonoid pharmacology to date.