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Bifurcation

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D Lenstra – One of the best experts on this subject based on the ideXlab platform.

  • the dynamical complexity of optically injected semiconductor lasers
    Physics Reports, 2005
    Co-Authors: Sebastian Wieczorek, D Lenstra, Bernd Krauskopf, T B Simpson

    Abstract:

    Abstract This report presents a modern approach to the theoretical and experimental study of complex nonlinear behavior of a semiconductor laser with optical injection—an example of a widely applied and technologically relevant forced nonlinear oscillator. We show that the careful Bifurcation analysis of a rate equation model yields (i) a deeper understanding of already studied physical phenomena, and (ii) the discovery of new dynamical effects, such as multipulse excitability. Different instabilities, cascades of Bifurcations, multistability, and sudden chaotic transitions, which are often viewed as independent, are in fact logically connected into a consistent web of Bifurcations via special points called organizing centers. This theoretical Bifurcation analysis has predictive power, which manifests itself in good agreement with experimental measurements over a wide range of parameters and diversity of dynamics. While it is dealing with the specific system of an optically injected laser, our work constitutes the state-of-the-art in the understanding and modeling of a nonlinear physical system in general.

Antonio Colombo – One of the best experts on this subject based on the ideXlab platform.

  • Bifurcation stenting current strategies and new devices
    Heart, 2009
    Co-Authors: Azeem Latib, Antonio Colombo, Giuseppe Sangiorgi

    Abstract:

    Based on the results of numerous randomised trials, the provisional approach of implanting one stent on the main branch has become the default approach to most Bifurcation lesions. However, Bifurcation intervention still remains technically challenging. Dedicated Bifurcation stents have been designed to specifically treat coronary Bifurcations with the aim of dealing with some of the shortcomings of the conventional percutaneous approach to Bifurcation intervention. Most of the devices are aimed at facilitating the provisional approach. They are an exciting and innovative technology that may further simplify the management and current approach to Bifurcation treatment. Currently, 11 devices are available that have either completed or are currently undergoing First-In-Man trials. The development of more drug-eluting platforms and larger studies with control groups demonstrating their clinical applicability, efficacy and safety are required before they are widely incorporated into daily practice.

  • Bifurcation disease what do we know what should we do
    Jacc-cardiovascular Interventions, 2008
    Co-Authors: Azeem Latib, Antonio Colombo

    Abstract:

    The percutaneous treatment of coronary Bifurcations has moved past an important milestone in that the 1- versus 2-stent debate appears to have been resolved. The provisional approach of implanting one stent on the main branch should be the default approach in most Bifurcations lesions. Selection of the most appropriate strategy for an individual Bifurcation is important. Some Bifurcations require 1 stent, whereas others require the stenting of both branches. Irrespective of whether a 1- or 2-stent strategy is chosen, the results after Bifurcation percutaneous coronary intervention (PCI) have dramatically improved. Dedicated Bifurcation stents are an exciting new technology that may further simplify the management of Bifurcation PCI and change some of these concepts.

  • the clinical outcome of percutaneous treatment of Bifurcation lesions in multivessel coronary artery disease with the sirolimus eluting stent insights from the arterial revascularization therapies study part ii arts ii
    European Heart Journal, 2007
    Co-Authors: Keiichi Tsuchida, Antonio Colombo, Thierry Lefevre, Keith G Oldroyd, Victo Guetta, Giulio Guagliumi, Wolfgang Von Scheid, Witold Ruzyllo, Christia W Hamm, Marco Essers

    Abstract:

    Aims Little is known about the impact of treating Bifurcations on the overall outcome of multivessel coronary artery disease treated with stenting. This analysis was made to investigate the 1 year clinical outcome of the treatment of Bifurcation lesions using sirolimus-eluting stents (SES) in patients with multivessel disease.

    Methods and results Among a total of 607 patients (2160 lesions) in the Arterial Revascularization Therapies Study part II (ARTS II), there were 324 patients in whom at least one Bifurcation lesion was treated (465 lesions). Patients with Bifurcations were compared with those without Bifurcations in terms of baseline characteristics and major adverse cardiac and cerebrovascular events (MACCE). Patients with ‘true’ (200 patients) vs. ‘partial’ Bifurcations (124 patients) and usage of a one- (263 patients) vs. two-stent strategy (61 patients) were also evaluated. The Bifurcation group was associated with more complex lesion and procedural characteristics than the non-Bifurcation group. However, there was no significant difference in 1 year MACCE rates between the Bifurcation group and the non-Bifurcation group (13.3 vs. 11.0%, P = 0.46). MACCE in patients with true Bifurcations was 13.0 vs. 13.7% for partial Bifurcations ( P = 0.87) and 14.1 vs. 9.8% for one- vs. two-stent strategy ( P = 0.53).

    Conclusions In this trial without angiographic follow-up, the presence of Bifurcations did not affect 1 year outcomes after SES implantation. The outcomes in true vs. partial Bifurcations and using one vs. two stents were similar when the treatment strategies were left to the operator’s discretion.

Bernd Krauskopf – One of the best experts on this subject based on the ideXlab platform.

  • the dynamical complexity of optically injected semiconductor lasers
    Physics Reports, 2005
    Co-Authors: Sebastian Wieczorek, D Lenstra, Bernd Krauskopf, T B Simpson

    Abstract:

    Abstract This report presents a modern approach to the theoretical and experimental study of complex nonlinear behavior of a semiconductor laser with optical injection—an example of a widely applied and technologically relevant forced nonlinear oscillator. We show that the careful Bifurcation analysis of a rate equation model yields (i) a deeper understanding of already studied physical phenomena, and (ii) the discovery of new dynamical effects, such as multipulse excitability. Different instabilities, cascades of Bifurcations, multistability, and sudden chaotic transitions, which are often viewed as independent, are in fact logically connected into a consistent web of Bifurcations via special points called organizing centers. This theoretical Bifurcation analysis has predictive power, which manifests itself in good agreement with experimental measurements over a wide range of parameters and diversity of dynamics. While it is dealing with the specific system of an optically injected laser, our work constitutes the state-of-the-art in the understanding and modeling of a nonlinear physical system in general.