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Andreas Seidelmorgenstern - One of the best experts on this subject based on the ideXlab platform.

  • the Binary Phase Diagram of propranolol hydrochloride and crystallization based enantioseparation
    Journal of Pharmaceutical Sciences, 2010
    Co-Authors: D Polenske, Heike Lorenz, Andreas Seidelmorgenstern
    Abstract:

    Inconsistent results were reported for the solid-state nature of the racemic species of the pharmaceutical relevant compound propranolol hydrochloride. In this work the Binary Phase Diagram of the propranolol hydrochloride enantiomers is studied. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and high performance liquid chromatography (HPLC) were used as analytical methods. The type of the racemic species, the presence and extent of partial solid solutions and the stability regions of polymorphic forms in the system were investigated. The identified Binary Phase Diagram is sketched. Finally, the feasibility of crystallization-based resolution is discussed.

  • the Binary Phase Diagram of propranolol hydrochloride and crystallization based enantioseparation
    Journal of Pharmaceutical Sciences, 2010
    Co-Authors: D Polenske, Heike Lorenz, Andreas Seidelmorgenstern
    Abstract:

    Abstract Inconsistent results were reported for the solid‐state nature of the racemic species of the pharmaceutical relevant compound propranolol hydrochloride. In this work the Binary Phase Diagram of the propranolol hydrochloride enantiomers is studied. Differential scanning calorimetry (DSC), X‐ray powder diffraction (XRPD), and high performance liquid chromatography (HPLC) were used as analytical methods. The type of the racemic species, the presence and extent of partial solid solutions and the stability regions of polymorphic forms in the system were investigated. The identified Binary Phase Diagram is sketched. Finally, the feasibility of crystallization‐based resolution is discussed. © 2009 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1762–1773, 2010

Kazuo Watanabe - One of the best experts on this subject based on the ideXlab platform.

  • fe fe3c Binary Phase Diagram in high magnetic fields
    Journal of Alloys and Compounds, 2015
    Co-Authors: Yoshifuru Mitsui, Kohki Takahashi, Yuki Ikehara, Goro Miyamoto, Kazuo Watanabe, Shojiro Kimura, Tadashi Furuhara, Keiichi Koyama
    Abstract:

    Abstract The Fe-Fe 3 C Binary Phase Diagram under high magnetic fields up to 21 T was investigated by a differential thermal analysis. Applying a magnetic field of 18 T, the α–γ transformation temperature T α–γ for pure iron increased quadratically from 1181 K (a zero field) to 1206 K. With increasing magnetic field strength, the transformation temperature A c1 (α-Fe + cementite → α-Fe + γ-Fe) increased linearly from ∼1000 K to ∼1030 K at the rate of 1.4–1.5 K T −1 . The transformation temperature A c3 (α-Fe + γ-Fe → γ-Fe) for Fe–0.18 wt.%C and Fe–0.38 wt.%C increased quadratically by 27 K under a 18-T field. The A c1 and A c3 lines shifted to higher temperatures by the magnetic field, resulting in a change in the Fe-Fe 3 C Phase Diagram. The results obtained suggest that the transformation temperatures mainly arose because of the Zeeman energy of α-Fe under high magnetic fields.

  • thermodynamic assessment for the bi mn Binary Phase Diagram in high magnetic fields
    Journal of Alloys and Compounds, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, K Oikawa, Kazuo Watanabe
    Abstract:

    Abstract The thermodynamic calculations of the Bi–Mn Binary Phase Diagram in high magnetic fields are carried out by the Computer Coupling of Phase Diagrams (CALPHAD) method. The magnetic total energy E mag was estimated by calculating magnetization on the basis of the mean field theory. The calculated results show the significant change of the Bi–Mn Phase Diagram under magnetic fields, which were in good agreement with the experimental results of in-field thermal analysis performed by Mitsui et al. The calculation shows that the peritectic temperature T p1 (BiMn + liquid → BiMn 1.08  + liquid) reached another peritectic temperature T p2 (BiMn 1.08  + liquid → Mn + liquid) at 49 T, suggesting that BiMn will form directly from Mn + liquid without forming BiMn 1.08 by the heat treatment in B  ⩾ 49 T.

  • bi mn Binary Phase Diagram in high magnetic fields
    Materials Transactions, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, Kazuo Watanabe
    Abstract:

    To examine magnetic field effects on the Bi­Mn equilibrium Phase, a high-magnetic fields differential thermal analysis (HF-DTA) was performed for fields up to 18T and temperatures ranging from 300 to 753K. For zero field, the peritectic temperatures Tp1 (BiMn1.08 + Bi-rich liquid1⁄4 BiMn) and Tp2 (iMn + Bi-rich liquid1⁄4 BiMn1.08), and the eutectic temperature TE (the Bi-rich liquid 1⁄4 Bi solid + BiMn) were determined to be 632, 721 and 538K, respectively. The Bi­Mn Phase Diagram at 18T was obtained, which showed that Tp1 increases with increasing magnetic fields at the rate of 2KT11. Furthermore, the liquidus boundary temperature Tliq between BiMn1.08 + liquid and Bi-rich liquid was found to increase nonlinearly with increasing magnetic field. [doi:10.2320/matertrans.M2012310]

  • bi mn Binary Phase Diagram in high magnetic fields
    Materials Transactions, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, Kazuo Watanabe
    Abstract:

    To examine magnetic field effects on the Bi­Mn equilibrium Phase, a high-magnetic fields differential thermal analysis (HF-DTA) was performed for fields up to 18T and temperatures ranging from 300 to 753K. For zero field, the peritectic temperatures Tp1 (BiMn1.08 + Bi-rich liquid1⁄4 BiMn) and Tp2 (iMn + Bi-rich liquid1⁄4 BiMn1.08), and the eutectic temperature TE (the Bi-rich liquid 1⁄4 Bi solid + BiMn) were determined to be 632, 721 and 538K, respectively. The Bi­Mn Phase Diagram at 18T was obtained, which showed that Tp1 increases with increasing magnetic fields at the rate of 2KT11. Furthermore, the liquidus boundary temperature Tliq between BiMn1.08 + liquid and Bi-rich liquid was found to increase nonlinearly with increasing magnetic field. [doi:10.2320/matertrans.M2012310]

Yoshifuru Mitsui - One of the best experts on this subject based on the ideXlab platform.

  • fe fe3c Binary Phase Diagram in high magnetic fields
    Journal of Alloys and Compounds, 2015
    Co-Authors: Yoshifuru Mitsui, Kohki Takahashi, Yuki Ikehara, Goro Miyamoto, Kazuo Watanabe, Shojiro Kimura, Tadashi Furuhara, Keiichi Koyama
    Abstract:

    Abstract The Fe-Fe 3 C Binary Phase Diagram under high magnetic fields up to 21 T was investigated by a differential thermal analysis. Applying a magnetic field of 18 T, the α–γ transformation temperature T α–γ for pure iron increased quadratically from 1181 K (a zero field) to 1206 K. With increasing magnetic field strength, the transformation temperature A c1 (α-Fe + cementite → α-Fe + γ-Fe) increased linearly from ∼1000 K to ∼1030 K at the rate of 1.4–1.5 K T −1 . The transformation temperature A c3 (α-Fe + γ-Fe → γ-Fe) for Fe–0.18 wt.%C and Fe–0.38 wt.%C increased quadratically by 27 K under a 18-T field. The A c1 and A c3 lines shifted to higher temperatures by the magnetic field, resulting in a change in the Fe-Fe 3 C Phase Diagram. The results obtained suggest that the transformation temperatures mainly arose because of the Zeeman energy of α-Fe under high magnetic fields.

  • thermodynamic assessment for the bi mn Binary Phase Diagram in high magnetic fields
    Journal of Alloys and Compounds, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, K Oikawa, Kazuo Watanabe
    Abstract:

    Abstract The thermodynamic calculations of the Bi–Mn Binary Phase Diagram in high magnetic fields are carried out by the Computer Coupling of Phase Diagrams (CALPHAD) method. The magnetic total energy E mag was estimated by calculating magnetization on the basis of the mean field theory. The calculated results show the significant change of the Bi–Mn Phase Diagram under magnetic fields, which were in good agreement with the experimental results of in-field thermal analysis performed by Mitsui et al. The calculation shows that the peritectic temperature T p1 (BiMn + liquid → BiMn 1.08  + liquid) reached another peritectic temperature T p2 (BiMn 1.08  + liquid → Mn + liquid) at 49 T, suggesting that BiMn will form directly from Mn + liquid without forming BiMn 1.08 by the heat treatment in B  ⩾ 49 T.

  • bi mn Binary Phase Diagram in high magnetic fields
    Materials Transactions, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, Kazuo Watanabe
    Abstract:

    To examine magnetic field effects on the Bi­Mn equilibrium Phase, a high-magnetic fields differential thermal analysis (HF-DTA) was performed for fields up to 18T and temperatures ranging from 300 to 753K. For zero field, the peritectic temperatures Tp1 (BiMn1.08 + Bi-rich liquid1⁄4 BiMn) and Tp2 (iMn + Bi-rich liquid1⁄4 BiMn1.08), and the eutectic temperature TE (the Bi-rich liquid 1⁄4 Bi solid + BiMn) were determined to be 632, 721 and 538K, respectively. The Bi­Mn Phase Diagram at 18T was obtained, which showed that Tp1 increases with increasing magnetic fields at the rate of 2KT11. Furthermore, the liquidus boundary temperature Tliq between BiMn1.08 + liquid and Bi-rich liquid was found to increase nonlinearly with increasing magnetic field. [doi:10.2320/matertrans.M2012310]

  • bi mn Binary Phase Diagram in high magnetic fields
    Materials Transactions, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, Kazuo Watanabe
    Abstract:

    To examine magnetic field effects on the Bi­Mn equilibrium Phase, a high-magnetic fields differential thermal analysis (HF-DTA) was performed for fields up to 18T and temperatures ranging from 300 to 753K. For zero field, the peritectic temperatures Tp1 (BiMn1.08 + Bi-rich liquid1⁄4 BiMn) and Tp2 (iMn + Bi-rich liquid1⁄4 BiMn1.08), and the eutectic temperature TE (the Bi-rich liquid 1⁄4 Bi solid + BiMn) were determined to be 632, 721 and 538K, respectively. The Bi­Mn Phase Diagram at 18T was obtained, which showed that Tp1 increases with increasing magnetic fields at the rate of 2KT11. Furthermore, the liquidus boundary temperature Tliq between BiMn1.08 + liquid and Bi-rich liquid was found to increase nonlinearly with increasing magnetic field. [doi:10.2320/matertrans.M2012310]

Keiichi Koyama - One of the best experts on this subject based on the ideXlab platform.

  • fe fe3c Binary Phase Diagram in high magnetic fields
    Journal of Alloys and Compounds, 2015
    Co-Authors: Yoshifuru Mitsui, Kohki Takahashi, Yuki Ikehara, Goro Miyamoto, Kazuo Watanabe, Shojiro Kimura, Tadashi Furuhara, Keiichi Koyama
    Abstract:

    Abstract The Fe-Fe 3 C Binary Phase Diagram under high magnetic fields up to 21 T was investigated by a differential thermal analysis. Applying a magnetic field of 18 T, the α–γ transformation temperature T α–γ for pure iron increased quadratically from 1181 K (a zero field) to 1206 K. With increasing magnetic field strength, the transformation temperature A c1 (α-Fe + cementite → α-Fe + γ-Fe) increased linearly from ∼1000 K to ∼1030 K at the rate of 1.4–1.5 K T −1 . The transformation temperature A c3 (α-Fe + γ-Fe → γ-Fe) for Fe–0.18 wt.%C and Fe–0.38 wt.%C increased quadratically by 27 K under a 18-T field. The A c1 and A c3 lines shifted to higher temperatures by the magnetic field, resulting in a change in the Fe-Fe 3 C Phase Diagram. The results obtained suggest that the transformation temperatures mainly arose because of the Zeeman energy of α-Fe under high magnetic fields.

  • thermodynamic assessment for the bi mn Binary Phase Diagram in high magnetic fields
    Journal of Alloys and Compounds, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, K Oikawa, Kazuo Watanabe
    Abstract:

    Abstract The thermodynamic calculations of the Bi–Mn Binary Phase Diagram in high magnetic fields are carried out by the Computer Coupling of Phase Diagrams (CALPHAD) method. The magnetic total energy E mag was estimated by calculating magnetization on the basis of the mean field theory. The calculated results show the significant change of the Bi–Mn Phase Diagram under magnetic fields, which were in good agreement with the experimental results of in-field thermal analysis performed by Mitsui et al. The calculation shows that the peritectic temperature T p1 (BiMn + liquid → BiMn 1.08  + liquid) reached another peritectic temperature T p2 (BiMn 1.08  + liquid → Mn + liquid) at 49 T, suggesting that BiMn will form directly from Mn + liquid without forming BiMn 1.08 by the heat treatment in B  ⩾ 49 T.

  • bi mn Binary Phase Diagram in high magnetic fields
    Materials Transactions, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, Kazuo Watanabe
    Abstract:

    To examine magnetic field effects on the Bi­Mn equilibrium Phase, a high-magnetic fields differential thermal analysis (HF-DTA) was performed for fields up to 18T and temperatures ranging from 300 to 753K. For zero field, the peritectic temperatures Tp1 (BiMn1.08 + Bi-rich liquid1⁄4 BiMn) and Tp2 (iMn + Bi-rich liquid1⁄4 BiMn1.08), and the eutectic temperature TE (the Bi-rich liquid 1⁄4 Bi solid + BiMn) were determined to be 632, 721 and 538K, respectively. The Bi­Mn Phase Diagram at 18T was obtained, which showed that Tp1 increases with increasing magnetic fields at the rate of 2KT11. Furthermore, the liquidus boundary temperature Tliq between BiMn1.08 + liquid and Bi-rich liquid was found to increase nonlinearly with increasing magnetic field. [doi:10.2320/matertrans.M2012310]

  • bi mn Binary Phase Diagram in high magnetic fields
    Materials Transactions, 2013
    Co-Authors: Yoshifuru Mitsui, Keiichi Koyama, Kazuo Watanabe
    Abstract:

    To examine magnetic field effects on the Bi­Mn equilibrium Phase, a high-magnetic fields differential thermal analysis (HF-DTA) was performed for fields up to 18T and temperatures ranging from 300 to 753K. For zero field, the peritectic temperatures Tp1 (BiMn1.08 + Bi-rich liquid1⁄4 BiMn) and Tp2 (iMn + Bi-rich liquid1⁄4 BiMn1.08), and the eutectic temperature TE (the Bi-rich liquid 1⁄4 Bi solid + BiMn) were determined to be 632, 721 and 538K, respectively. The Bi­Mn Phase Diagram at 18T was obtained, which showed that Tp1 increases with increasing magnetic fields at the rate of 2KT11. Furthermore, the liquidus boundary temperature Tliq between BiMn1.08 + liquid and Bi-rich liquid was found to increase nonlinearly with increasing magnetic field. [doi:10.2320/matertrans.M2012310]

D Polenske - One of the best experts on this subject based on the ideXlab platform.

  • the Binary Phase Diagram of propranolol hydrochloride and crystallization based enantioseparation
    Journal of Pharmaceutical Sciences, 2010
    Co-Authors: D Polenske, Heike Lorenz, Andreas Seidelmorgenstern
    Abstract:

    Inconsistent results were reported for the solid-state nature of the racemic species of the pharmaceutical relevant compound propranolol hydrochloride. In this work the Binary Phase Diagram of the propranolol hydrochloride enantiomers is studied. Differential scanning calorimetry (DSC), X-ray powder diffraction (XRPD), and high performance liquid chromatography (HPLC) were used as analytical methods. The type of the racemic species, the presence and extent of partial solid solutions and the stability regions of polymorphic forms in the system were investigated. The identified Binary Phase Diagram is sketched. Finally, the feasibility of crystallization-based resolution is discussed.

  • the Binary Phase Diagram of propranolol hydrochloride and crystallization based enantioseparation
    Journal of Pharmaceutical Sciences, 2010
    Co-Authors: D Polenske, Heike Lorenz, Andreas Seidelmorgenstern
    Abstract:

    Abstract Inconsistent results were reported for the solid‐state nature of the racemic species of the pharmaceutical relevant compound propranolol hydrochloride. In this work the Binary Phase Diagram of the propranolol hydrochloride enantiomers is studied. Differential scanning calorimetry (DSC), X‐ray powder diffraction (XRPD), and high performance liquid chromatography (HPLC) were used as analytical methods. The type of the racemic species, the presence and extent of partial solid solutions and the stability regions of polymorphic forms in the system were investigated. The identified Binary Phase Diagram is sketched. Finally, the feasibility of crystallization‐based resolution is discussed. © 2009 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1762–1773, 2010