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Isabel C.f.r. Ferreira - One of the best experts on this subject based on the ideXlab platform.
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Chemical composition and Bioactive Properties of byproducts from two different kiwi varieties.
Food Research International, 2019Co-Authors: Murilo Dias, Carla Pereira, Ricardo C. Calhelha, Lillian Barros, Cristina Caleja, Marina Kostić, Marina Soković, Débora Tavares, Ilton José Baraldi, Isabel C.f.r. FerreiraAbstract:Abstract Kiwis are an example of fruits with excellent Bioactive Properties worldwide appreciated and consumed generating tons of waste. Thus, the objective of this work was to compare two varieties of kiwi: Actinidia deliciosa cv. “Hayward” (green) and Actinidia spp. (red) regarding the nutritional value of their pulps, chemical composition and bioactivities of each pulp and peel. The results revealed that pulps have a high water content and low amount of other macronutrients. Both parts of red kiwi presented the highest tocopherols content and red kiwi pulp presented the highest content in ascorbic acid. In general, the peels exhibited the highest antioxidant activity and green kiwi peels showed cytotoxicity and anti-inflammatory activity, which could be related to its higher content in phenolic compounds, especially B-type (epi)catechin dimer. Therefore, kiwi components currently underutilized may be indicated as a source of natural functionalizing ingredients with several benefits for human health.
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Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with Bioactive Properties.
Food Chemistry, 2019Co-Authors: Bianca R. Albuquerque, Carla Pereira, Ricardo C. Calhelha, Maria José Alves, Rui M.v. Abreu, Lillian Barros, M. Beatriz P.p. Oliveira, Isabel C.f.r. FerreiraAbstract:Jabuticaba (Myrciaria jaboticaba (Vell.) Berg) is a Brazilian berry, very appreciated for in natura consumption. However, its epicarp is not normally consumed due to its stiffness and astringent taste, and in manufacture of products from jabuticaba fruit, it is responsible for the generation of large amounts of residues. The exploration of by-products is becoming important for the obtainment of valuable Bioactive compounds for food and pharmaceutical industries. In this context, jabuticaba epicarp was studied regarding its chemical composition, namely in terms of phenolic compounds, tocopherols, and organic acids, and its Bioactive Properties, such as antioxidant, anti-proliferate, anti-inflammatory, and antimicrobial activities. A total of sixteen phenolic compounds, four tocopherols and six organic acids were identified in jabuticaba epicarp. Regarding Bioactive Properties, it showed high antioxidant activity, also presenting moderate anti-inflammatory, anti-proliferative, and antimicrobial activities. The extract did not present hepatotoxicity, confirming the possibility of its applications without toxicity issues.
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Challenges of traditional herbal teas: plant infusions and their mixtures with Bioactive Properties
Food & Function, 2019Co-Authors: Cristina Caleja, Carla Pereira, Ricardo C. Calhelha, Lillian Barros, Ana Maria Carvalho, Marina Soković, Tiane C. Finimundy, Marija Ivanov, Eduardo A. S. Rosa, Isabel C.f.r. FerreiraAbstract:In order to characterize and study the bioactivities of individual plant species and to determine how these characteristics are modified when preparing blends, five different plant species were selected: Erica australis L., Genista tridentata L., Melissa officinalis L., Mentha spicata L., and Prunella vulgaris L. Infusions prepared from each plant species and from three selected mixtures were analyzed in terms of nutritional values, phenolic compositions, and Bioactive Properties (antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities). The major compound detected in M. officinalis, M. spicata, and P. vulgaris infusions was rosmarinic acid, whilst in E. australis and G. tridentata flavonoid derivatives such as quercetin and genistein were identified. P. vulgaris and M. officinalis presented the best results in TBARS and OxHLIA assays, respectively. M. spicata and all mixtures presented anti-inflammatory activity. M. spicata showed the best cytotoxic Properties and antimicrobial activity, and none of the infusions showed hepatotoxicity for non-tumour cells.
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Bioactive Properties of greenhouse cultivated green beans (Phaseolus vulgaris L.) under biostimulants and water‐stress effect
Journal of the Science of Food and Agriculture, 2019Co-Authors: Spyridon A. Petropoulos, Lillian Barros, Ângela Fernandes, Marina Soković, Oludemi Taofiq, Nikos Tzortzakis, Ana Ćirić, Isabel C.f.r. FerreiraAbstract:BACKGROUND: The scarcity of irrigation water is severely affecting global crop production. In this context, biostimulants are increasingly used as alternatives means against abiotic stress conditions. In this study, phenolic compounds composition and Bioactive Properties of common bean (Phaseolus vulgaris L.) plants grown under water stress conditions and biostimulants application were investigated. RESULTS: Sixteen individual phenolic compounds were detected in both pods and seeds with a notable difference in their compositional profile. A significant effect on phenolic compounds content and composition was also observed for the biostimulants tested. Regarding the antibacterial activity, pods of the second harvest and seed extracts showed significant efficacy against Bacillus cereus, especially in water‐stressed plants, where all biostimulant treatments were more effective than positive controls. Moreover, all biostimulant treatments for seed extracts of water‐stressed plants were more effective against Staphylococcus aureus compared with ampicillin, whereas streptomycin showed the best results. Extracts from pods of the second harvest from normally irrigated plants showed the best results against the fungi tested, except for Penicillium verrucosum var. cyclopium. Finally, no significant cytotoxic effects were detected. CONCLUSION: In conclusion, the biostimulants tested increased total phenolic compounds content compared with control treatment, especially in pods of the first harvest and seeds of water‐stressed plants. Moreover, Bioactive Properties showed a varied response in regard to irrigation and biostimulant treatment. Therefore, biostimulants can be considered as a useful means towards increasing phenolic compounds content, and they may also affect the antimicrobial Properties of pods and seeds extracts. © 2019 Society of Chemical Industry
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Phenolic Profile and Bioactive Properties of Carissa macrocarpa (Eckl.) A.DC.: An In Vitro Comparative Study between Leaves, Stems, and Flowers
Molecules, 2019Co-Authors: Fedia Souilem, Ricardo C. Calhelha, Maria José Alves, Lillian Barros, Maria Inês Dias, Fethia Harzallah-skhiri, Isabel C.f.r. FerreiraAbstract:The present work aimed to characterize leaves, stems, and flowers of Carissa macrocarpa (Eckl.) A.DC., by performing an analysis of the phenolic compounds by HPLC-DAD/ESI-MS, correlating them with Bioactive Properties, such as antioxidant, anti-inflammatory, cytotoxic, and antimicrobial activities. Thirty polyphenols were identified in the hydroethanolic extract, including phenolic acids, flavan-3-ols, and flavonol glycosides derivatives (which presented the highest number of identified compounds). However, flavan-3-ols showed the highest concentration in stems (mainly owing to the presence of dimers, trimmers, and tetramers of type B (epi)catechin). Leaves were distinguished by their high antioxidant and anti-inflammatory activities, as well as their bactericidal effect against E. coli, while stems presented a higher cytotoxic activity and bactericidal effect against Gram-positive bacteria. Moreover, a high correlation between the studied bioactivities and the presence of phenolic compounds was also verified. The obtained results bring added value to the studied plant species.
A. Navarro-ocaña - One of the best experts on this subject based on the ideXlab platform.
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Valuable medicinal plants and resins: Commercial phytochemicals with Bioactive Properties
Industrial Crops and Products, 2010Co-Authors: Liliana Hernández-vázquez, Javier Palazon, Susana Mangas, A. Navarro-ocañaAbstract:Abstract A simple, fast and efficient method was developed for the isolation of phytochemicals with Bioactive Properties from valuable resins and medicinal plants. The method involves rapid qualitative detection of triterpenes by thin-layer chromatography (TLC), efficient extraction with n-hexane, quantitative analysis by HPLC and preparative separation (preparative TLC and crystallization) to obtain high-purity α-amyrin (98.5%), 3-epi-lupeol (98.0%) and β-amyrin (82.0%). The presence of α- and β-amyrin, or a mixture of both, was detected by TLC on silica gel in all the sources investigated, while 3-epi-lupeol was only found in the Mexican Copal resins. The results demonstrated that HPLC is a selective method for the analysis of α- and β-amyrin and 3-epi-lupeol, and that the best source of α-amyrin was Mexican Copal Tepoztlan, that of β-amyrin was Nance wastes and that of 3-epi-lupeol was Mexican Copal Sonora.
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Valuable medicinal plants and resins: Commercial phytochemicals with Bioactive Properties
Industrial Crops and Products, 2010Co-Authors: Liliana Hernández-vázquez, Javier Palazon, Susana Mangas, A. Navarro-ocañaAbstract:A simple, fast and efficient method was developed for the isolation of phytochemicals with Bioactive Properties from valuable resins and medicinal plants. The method involves rapid qualitative detection of triterpenes by thin-layer chromatography (TLC), efficient extraction with n-hexane, quantitative analysis by HPLC and preparative separation (preparative TLC and crystallization) to obtain high-purity ??-amyrin (98.5%), 3-epi-lupeol (98.0%) and ??-amyrin (82.0%). The presence of ??- and ??-amyrin, or a mixture of both, was detected by TLC on silica gel in all the sources investigated, while 3-epi-lupeol was only found in the Mexican Copal resins. The results demonstrated that HPLC is a selective method for the analysis of ??- and ??-amyrin and 3-epi-lupeol, and that the best source of ??-amyrin was Mexican Copal Tepoztlan, that of ??-amyrin was Nance wastes and that of 3-epi-lupeol was Mexican Copal Sonora. ?? 2010 Elsevier B.V. All rights reserved.
Liliana Hernández-vázquez - One of the best experts on this subject based on the ideXlab platform.
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Valuable medicinal plants and resins: Commercial phytochemicals with Bioactive Properties
Industrial Crops and Products, 2010Co-Authors: Liliana Hernández-vázquez, Javier Palazon, Susana Mangas, A. Navarro-ocañaAbstract:Abstract A simple, fast and efficient method was developed for the isolation of phytochemicals with Bioactive Properties from valuable resins and medicinal plants. The method involves rapid qualitative detection of triterpenes by thin-layer chromatography (TLC), efficient extraction with n-hexane, quantitative analysis by HPLC and preparative separation (preparative TLC and crystallization) to obtain high-purity α-amyrin (98.5%), 3-epi-lupeol (98.0%) and β-amyrin (82.0%). The presence of α- and β-amyrin, or a mixture of both, was detected by TLC on silica gel in all the sources investigated, while 3-epi-lupeol was only found in the Mexican Copal resins. The results demonstrated that HPLC is a selective method for the analysis of α- and β-amyrin and 3-epi-lupeol, and that the best source of α-amyrin was Mexican Copal Tepoztlan, that of β-amyrin was Nance wastes and that of 3-epi-lupeol was Mexican Copal Sonora.
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Valuable medicinal plants and resins: Commercial phytochemicals with Bioactive Properties
Industrial Crops and Products, 2010Co-Authors: Liliana Hernández-vázquez, Javier Palazon, Susana Mangas, A. Navarro-ocañaAbstract:A simple, fast and efficient method was developed for the isolation of phytochemicals with Bioactive Properties from valuable resins and medicinal plants. The method involves rapid qualitative detection of triterpenes by thin-layer chromatography (TLC), efficient extraction with n-hexane, quantitative analysis by HPLC and preparative separation (preparative TLC and crystallization) to obtain high-purity ??-amyrin (98.5%), 3-epi-lupeol (98.0%) and ??-amyrin (82.0%). The presence of ??- and ??-amyrin, or a mixture of both, was detected by TLC on silica gel in all the sources investigated, while 3-epi-lupeol was only found in the Mexican Copal resins. The results demonstrated that HPLC is a selective method for the analysis of ??- and ??-amyrin and 3-epi-lupeol, and that the best source of ??-amyrin was Mexican Copal Tepoztlan, that of ??-amyrin was Nance wastes and that of 3-epi-lupeol was Mexican Copal Sonora. ?? 2010 Elsevier B.V. All rights reserved.
Lillian Barros - One of the best experts on this subject based on the ideXlab platform.
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Nutritional value, physicochemical characterization and Bioactive Properties of Brazilian quinoa BRS Piabiru
Food & Function, 2020Co-Authors: Shirley L. Sampaio, Carla Pereira, Ricardo C. Calhelha, Lillian Barros, Marina Soković, A. Fernandes, Celestino Santos-buelga, Icfr FerreiraAbstract:Chenopodium quinoa Willd. is an ancient food crop that has provided nutrition to Andean populations for thousands of years. BRS Piabiru is a quinoa genotype developed and adapted to tropical climate by the Brazilian Agriculture Research Corporation. In this work, BRS Piabiru quinoa was evaluated concerning its nutritional, physicochemical and phenolic composition, as also its Bioactive Properties. This variety showed high carbohydrate and protein contents and a low-fat level, composed of 86% of unsaturated fatty acids, 60% of which polyunsaturated fatty acids. Four organic acids were detected, with quinic acid as the most abundant, while α- and γ-tocopherols were the vitamin E isoforms found. Quercetin and kaempferol glycosides were the main phenolic compounds in the quinoa extract, which also revealed relevant antioxidant and antimicrobial activities, with no toxic effect. These results support the potential of BRS Piabiru quinoa as a nutritious food crop and a source of Bioactive compounds.
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Chemical composition and Bioactive Properties of byproducts from two different kiwi varieties.
Food Research International, 2019Co-Authors: Murilo Dias, Carla Pereira, Ricardo C. Calhelha, Lillian Barros, Cristina Caleja, Marina Kostić, Marina Soković, Débora Tavares, Ilton José Baraldi, Isabel C.f.r. FerreiraAbstract:Abstract Kiwis are an example of fruits with excellent Bioactive Properties worldwide appreciated and consumed generating tons of waste. Thus, the objective of this work was to compare two varieties of kiwi: Actinidia deliciosa cv. “Hayward” (green) and Actinidia spp. (red) regarding the nutritional value of their pulps, chemical composition and bioactivities of each pulp and peel. The results revealed that pulps have a high water content and low amount of other macronutrients. Both parts of red kiwi presented the highest tocopherols content and red kiwi pulp presented the highest content in ascorbic acid. In general, the peels exhibited the highest antioxidant activity and green kiwi peels showed cytotoxicity and anti-inflammatory activity, which could be related to its higher content in phenolic compounds, especially B-type (epi)catechin dimer. Therefore, kiwi components currently underutilized may be indicated as a source of natural functionalizing ingredients with several benefits for human health.
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Jabuticaba residues (Myrciaria jaboticaba (Vell.) Berg) are rich sources of valuable compounds with Bioactive Properties.
Food Chemistry, 2019Co-Authors: Bianca R. Albuquerque, Carla Pereira, Ricardo C. Calhelha, Maria José Alves, Rui M.v. Abreu, Lillian Barros, M. Beatriz P.p. Oliveira, Isabel C.f.r. FerreiraAbstract:Jabuticaba (Myrciaria jaboticaba (Vell.) Berg) is a Brazilian berry, very appreciated for in natura consumption. However, its epicarp is not normally consumed due to its stiffness and astringent taste, and in manufacture of products from jabuticaba fruit, it is responsible for the generation of large amounts of residues. The exploration of by-products is becoming important for the obtainment of valuable Bioactive compounds for food and pharmaceutical industries. In this context, jabuticaba epicarp was studied regarding its chemical composition, namely in terms of phenolic compounds, tocopherols, and organic acids, and its Bioactive Properties, such as antioxidant, anti-proliferate, anti-inflammatory, and antimicrobial activities. A total of sixteen phenolic compounds, four tocopherols and six organic acids were identified in jabuticaba epicarp. Regarding Bioactive Properties, it showed high antioxidant activity, also presenting moderate anti-inflammatory, anti-proliferative, and antimicrobial activities. The extract did not present hepatotoxicity, confirming the possibility of its applications without toxicity issues.
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Challenges of traditional herbal teas: plant infusions and their mixtures with Bioactive Properties
Food & Function, 2019Co-Authors: Cristina Caleja, Carla Pereira, Ricardo C. Calhelha, Lillian Barros, Ana Maria Carvalho, Marina Soković, Tiane C. Finimundy, Marija Ivanov, Eduardo A. S. Rosa, Isabel C.f.r. FerreiraAbstract:In order to characterize and study the bioactivities of individual plant species and to determine how these characteristics are modified when preparing blends, five different plant species were selected: Erica australis L., Genista tridentata L., Melissa officinalis L., Mentha spicata L., and Prunella vulgaris L. Infusions prepared from each plant species and from three selected mixtures were analyzed in terms of nutritional values, phenolic compositions, and Bioactive Properties (antioxidant, antimicrobial, cytotoxic, and anti-inflammatory activities). The major compound detected in M. officinalis, M. spicata, and P. vulgaris infusions was rosmarinic acid, whilst in E. australis and G. tridentata flavonoid derivatives such as quercetin and genistein were identified. P. vulgaris and M. officinalis presented the best results in TBARS and OxHLIA assays, respectively. M. spicata and all mixtures presented anti-inflammatory activity. M. spicata showed the best cytotoxic Properties and antimicrobial activity, and none of the infusions showed hepatotoxicity for non-tumour cells.
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Bioactive Properties of greenhouse cultivated green beans (Phaseolus vulgaris L.) under biostimulants and water‐stress effect
Journal of the Science of Food and Agriculture, 2019Co-Authors: Spyridon A. Petropoulos, Lillian Barros, Ângela Fernandes, Marina Soković, Oludemi Taofiq, Nikos Tzortzakis, Ana Ćirić, Isabel C.f.r. FerreiraAbstract:BACKGROUND: The scarcity of irrigation water is severely affecting global crop production. In this context, biostimulants are increasingly used as alternatives means against abiotic stress conditions. In this study, phenolic compounds composition and Bioactive Properties of common bean (Phaseolus vulgaris L.) plants grown under water stress conditions and biostimulants application were investigated. RESULTS: Sixteen individual phenolic compounds were detected in both pods and seeds with a notable difference in their compositional profile. A significant effect on phenolic compounds content and composition was also observed for the biostimulants tested. Regarding the antibacterial activity, pods of the second harvest and seed extracts showed significant efficacy against Bacillus cereus, especially in water‐stressed plants, where all biostimulant treatments were more effective than positive controls. Moreover, all biostimulant treatments for seed extracts of water‐stressed plants were more effective against Staphylococcus aureus compared with ampicillin, whereas streptomycin showed the best results. Extracts from pods of the second harvest from normally irrigated plants showed the best results against the fungi tested, except for Penicillium verrucosum var. cyclopium. Finally, no significant cytotoxic effects were detected. CONCLUSION: In conclusion, the biostimulants tested increased total phenolic compounds content compared with control treatment, especially in pods of the first harvest and seeds of water‐stressed plants. Moreover, Bioactive Properties showed a varied response in regard to irrigation and biostimulant treatment. Therefore, biostimulants can be considered as a useful means towards increasing phenolic compounds content, and they may also affect the antimicrobial Properties of pods and seeds extracts. © 2019 Society of Chemical Industry
Mehrdad Yazdanipedram - One of the best experts on this subject based on the ideXlab platform.
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preparation and Bioactive Properties of novel bone repair bionanocomposites based on hydroxyapatite and Bioactive glass nanoparticles
Journal of Biomedical Materials Research Part B, 2012Co-Authors: Francisco Valenzuela, Cristian Covarrubias, Constanza Martinez, Patricio C Smith, Mario Diazdosque, Mehrdad YazdanipedramAbstract:Bionanocomposites based on ceramic nanoparticles and a biodegradable porous matrix represent a promising strategy for bone repair applications. The preparation and Bioactive Properties of bionanocomposites based on hydroxyapatite (nHA) and Bioactive glass (nBG) nanoparticles were presented. nHA and nBG were synthesized with nanometric particle size using sol–gel/precipitation methods. Composite scaffolds were prepared by incorporating nHA and nBG into a porous alginate (ALG) matrix at different particle loads. The ability of the bionanocomposites to induce the crystallization of the apatite phase from simulated body fluid (SBF) was systematically evaluated using X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray analysis, and Fourier transform infrared spectroscopy. Both nHA/ALG and nBG/ALG composites were shown to notably accelerate the process of crystallization and growth of the apatite phase on the scaffold surfaces. For short immersion times in SBF, nBG (25%)-based nanocomposites induced a higher degree of apatite crystallization than nHA (25%)-based nanocomposites, probably due to the more reactive nature of the BG particles. Through a reinforcement effect, the nanoparticles also improve the mechanical Properties and stability in SBF of the polymer scaffold matrix. In addition, in vitro biocompatibility tests demonstrated that osteoblast cells are viable and adhere well on the surface of the bionanocomposites. These results indicate that nHA- and nBG-based bionanocomposites present potential Properties for bone repair applications, particularly oriented to accelerate the bone mineralization process. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 100B: 1672–1682, 2012.