The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Motomu Tanaka - One of the best experts on this subject based on the ideXlab platform.
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at...
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities inplasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
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nanofocused scanning x ray fluorescence microscopyrevealing an effect of heterozygous hemoglobin s and c on Biochemicalactivities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
Yang Yang - One of the best experts on this subject based on the ideXlab platform.
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at...
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities inplasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
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nanofocused scanning x ray fluorescence microscopyrevealing an effect of heterozygous hemoglobin s and c on Biochemicalactivities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
Benjamin Frohlich - One of the best experts on this subject based on the ideXlab platform.
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at...
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities inplasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
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nanofocused scanning x ray fluorescence microscopyrevealing an effect of heterozygous hemoglobin s and c on Biochemicalactivities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
Youjun Zhang - One of the best experts on this subject based on the ideXlab platform.
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cross resistance study and Biochemical Mechanisms of thiamethoxam resistance in b biotype bemisia tabaci hemiptera aleyrodidae
Pest Management Science, 2010Co-Authors: Yuntao Feng, Qingjun Wu, Shaoli Wang, Xiaoli Chang, Baoyun Xu, Youjun ZhangAbstract:BACKGROUND: B-biotype Bemisia tabaci (Gennadius) has invaded China over the past two decades. To understand the risks and to determine possible Mechanisms of resistance to thiamethoxam in B. tabaci, a resistant strain was selected in the laboratory. Cross-resistance and the Biochemical Mechanisms of thiamethoxam resistance were investigated in the present study. RESULTS: A 66.3-fold thiamethoxam-resistant B. tabaci strain (TH-R) was established after selection for 36 generations. Compared with the susceptible strain (TH-S), the selected TH-R strain showed obvious cross-resistance to imidacloprid (47.3-fold), acetamiprid (35.8-fold), nitenpyram (9.99-fold), abamectin (5.33-fold) and carbosulfan (4.43-fold). No cross-resistance to fipronil, chlorpyrifos or deltamethrin was seen. Piperonyl butoxide (PBO) and triphenyl phosphate (TPP) exhibited significant synergism on thiamethoxam effects in the TH-R strain (3.14- and 2.37-fold respectively). However, diethyl maleate (DEM) did not act synergistically with thiamethoxam. Biochemical assays showed that cytochrome P450 monooxygenase activities increased 1.21- and 1.68-fold respectively, and carboxylesterase activity increased 2.96-fold in the TH-R strain. However, no difference was observed for glutathione S-transferase between the two strains. CONCLUSION: B-biotype B. tabaci develops resistance to thiamethoxam. Cytochrome P450 monooxygenase and carboxylesterase appear to be responsible for the resistance. Reasonable resistance management that avoids the use of cross-resistance insecticides may delay the development of resistance to thiamethoxam in this species.
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cross resistance study and Biochemical Mechanisms of thiamethoxam resistance in b biotype bemisia tabaci hemiptera aleyrodidae
Pest Management Science, 2010Co-Authors: Yuntao Feng, Shaoli Wang, Xiaoli Chang, Wen Xie, Youjun ZhangAbstract:BACKGROUND: B-biotype Bemisia tabaci (Gennadius) has invaded China over the past two decades. To understand the risks and to determine possible Mechanisms of resistance to thiamethoxam in B. tabaci, a resistant strain was selected in the laboratory. Cross-resistance and the Biochemical Mechanisms of thiamethoxam resistance were investigated in the present study. RESULTS: A 66.3-fold thiamethoxam-resistant B. tabaci strain (TH-R) was established after selection for 36 generations. Compared with the susceptible strain (TH-S), the selected TH-R strain showed obvious cross-resistance to imidacloprid (47.3-fold), acetamiprid (35.8-fold), nitenpyram (9.99-fold), abamectin (5.33-fold) and carbosulfan (4.43-fold). No cross-resistance to fipronil, chlorpyrifos or deltamethrin was seen. Piperonyl butoxide (PBO) and triphenyl phosphate (TPP) exhibited significant synergism on thiamethoxam effects in the TH-R strain (3.14- and 2.37-fold respectively). However, diethyl maleate (DEM) did not act synergistically with thiamethoxam. Biochemical assays showed that cytochrome P450 monooxygenase activities increased 1.21- and 1.68-fold respectively, and carboxylesterase activity increased 2.96-fold in the TH-R strain. However, no difference was observed for glutathione S-transferase between the two strains. CONCLUSION: B-biotype B. tabaci develops resistance to thiamethoxam. Cytochrome P450 monooxygenase and carboxylesterase appear to be responsible for the resistance. Reasonable resistance management that avoids the use of cross-resistance insecticides may delay the development of resistance to thiamethoxam in this species. Copyright © 2009 Society of Chemical Industry
Judith Thoma - One of the best experts on this subject based on the ideXlab platform.
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at...
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities inplasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
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nanofocused scanning x ray fluorescence microscopy revealing an effect of heterozygous hemoglobin s and c on Biochemical activities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.
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nanofocused scanning x ray fluorescence microscopyrevealing an effect of heterozygous hemoglobin s and c on Biochemicalactivities in plasmodium falciparum infected erythrocytes
Analytical Chemistry, 2020Co-Authors: Benjamin Frohlich, Yang Yang, Judith Thoma, Julian Czajor, Christine Lansche, Cecilia P Sanchez, Michael Lanzer, Peter Cloetens, Motomu TanakaAbstract:While there is ample evidence suggesting that carriers of heterozygous hemoglobin S and C are protected from life-threatening malaria, little is known about the underlying Biochemical Mechanisms at the single cell level. Using nanofocused scanning X-ray fluorescence microscopy, we quantify the spatial distribution of individual elements in subcellular compartments, including Fe, S, P, Zn, and Cu, in Plasmodium falciparum-infected (P. falciparum-infected) erythrocytes carrying the wild type or variant hemoglobins. Our data indicate that heterozygous hemoglobin S and C significantly modulate Biochemical reactions in parasitized erythrocytes, such as aberrant hemozoin mineralization and a delay in hemoglobin degradation. The label-free scanning X-ray fluorescence imaging has great potential to quantify the spatial distribution of elements in subcellular compartments of P. falciparum-infected erythrocytes and unravel the Biochemical Mechanisms underpinning disease and protective traits.