The Experts below are selected from a list of 6084 Experts worldwide ranked by ideXlab platform

Dora I A Pereira - One of the best experts on this subject based on the ideXlab platform.

  • mammalian gastrointestinal tract parameters modulating the integrity surface properties and absorption of food relevant nanomaterials
    Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology, 2015
    Co-Authors: Susann Bellmann, David Carlander, Alessio Fasano, Dragan Momcilovic, Joseph Scimeca, James W Waldman, Lourdes Gombau, Lyubov Tsytsikova, Richard Canady, Dora I A Pereira
    Abstract:

    Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid-based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous Biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food-relevant engineered NMs for risk assessment.

  • mammalian gastrointestinal tract parameters modulating the integrity surface properties and absorption of food relevant nanomaterials
    Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology, 2015
    Co-Authors: Susann Bellmann, David Carlander, Alessio Fasano, Dragan Momcilovic, Joseph Scimeca, James W Waldman, Lourdes Gombau, Lyubov Tsytsikova, Richard Canady, Dora I A Pereira
    Abstract:

    Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid-based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous Biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food-relevant engineered NMs for risk assessment. WIREs Nanomed Nanobiotechnol 2015, 7:609–622. doi: 10.1002/wnan.1333 For further resources related to this article, please visit the WIREs website.

Zhengxiang Wang - One of the best experts on this subject based on the ideXlab platform.

  • metabolic engineering of escherichia coli a sustainable industrial platform for bio based chemical production
    Biotechnology Advances, 2013
    Co-Authors: Xianzhong Chen, Li Zhou, Kangming Tian, Ashwani Kumar, Suren Singh, Bernard A Prior, Zhengxiang Wang
    Abstract:

    In order to decrease carbon emissions and negative environmental impacts of various pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the traditional energy and fossil based intensive route. The Gram-negative rod-shaped bacterium, Escherichia coli has been studied extensively on a fundamental and applied level and has become a predominant host microorganism for industrial applications. Furthermore, metabolic engineering of E. coli for the enhanced biochemical production has been significantly promoted by the integrated use of recent developments in systems biology, synthetic biology and evolutionary engineering. In this review, we focus on recent efforts devoted to the use of genetically engineered E. coli as a sustainable platform for the production of industrially important Biochemicals such as biofuels, organic acids, amino acids, sugar alcohols and biopolymers. In addition, representative secondary metabolites produced by E. coli will be systematically discussed and the successful strategies for strain improvements will be highlighted. Moreover, this review presents guidelines for future developments in the bio-based chemical production using E. coli as an industrial platform.

  • metabolic engineering of escherichia coli a sustainable industrial platform for bio based chemical production
    Biotechnology Advances, 2013
    Co-Authors: Xianzhong Chen, Li Zhou, Kangming Tian, Ashwani Kumar, Suren Singh, Bernard A Prior, Zhengxiang Wang
    Abstract:

    article i nfo In order to decrease carbon emissions and negative environmental impacts of various pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the traditional energy and fossil based inten- sive route. The Gram-negative rod-shaped bacterium, Escherichia coli has been studied extensively on a fundamental and applied level and has become a predominant host microorganism for industrial applications. Furthermore, metabolic engineering of E. coli for the enhanced biochemical production has been significantly promoted by the integrated use of recent developments in systems biology, synthetic biology and evolutionary engineering. In this review, we focus on recent efforts devoted to the use of genetically engineered E. coli as a sustainable platform for the production of industrially important Biochemicals such as biofuels, organic acids, amino acids, sugar alcohols and biopolymers. In addition, representative secondary metabolites produced by E. coli will be systematically discussed and the successful strategies for strain improvements will be highlighted. Moreover, this review presents guidelines for future developments in the bio-based chemical production using E. coli as an industrial platform.

Susann Bellmann - One of the best experts on this subject based on the ideXlab platform.

  • mammalian gastrointestinal tract parameters modulating the integrity surface properties and absorption of food relevant nanomaterials
    Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology, 2015
    Co-Authors: Susann Bellmann, David Carlander, Alessio Fasano, Dragan Momcilovic, Joseph Scimeca, James W Waldman, Lourdes Gombau, Lyubov Tsytsikova, Richard Canady, Dora I A Pereira
    Abstract:

    Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid-based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous Biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food-relevant engineered NMs for risk assessment.

  • mammalian gastrointestinal tract parameters modulating the integrity surface properties and absorption of food relevant nanomaterials
    Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology, 2015
    Co-Authors: Susann Bellmann, David Carlander, Alessio Fasano, Dragan Momcilovic, Joseph Scimeca, James W Waldman, Lourdes Gombau, Lyubov Tsytsikova, Richard Canady, Dora I A Pereira
    Abstract:

    Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid-based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous Biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food-relevant engineered NMs for risk assessment. WIREs Nanomed Nanobiotechnol 2015, 7:609–622. doi: 10.1002/wnan.1333 For further resources related to this article, please visit the WIREs website.

Xianzhong Chen - One of the best experts on this subject based on the ideXlab platform.

  • metabolic engineering of escherichia coli a sustainable industrial platform for bio based chemical production
    Biotechnology Advances, 2013
    Co-Authors: Xianzhong Chen, Li Zhou, Kangming Tian, Ashwani Kumar, Suren Singh, Bernard A Prior, Zhengxiang Wang
    Abstract:

    In order to decrease carbon emissions and negative environmental impacts of various pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the traditional energy and fossil based intensive route. The Gram-negative rod-shaped bacterium, Escherichia coli has been studied extensively on a fundamental and applied level and has become a predominant host microorganism for industrial applications. Furthermore, metabolic engineering of E. coli for the enhanced biochemical production has been significantly promoted by the integrated use of recent developments in systems biology, synthetic biology and evolutionary engineering. In this review, we focus on recent efforts devoted to the use of genetically engineered E. coli as a sustainable platform for the production of industrially important Biochemicals such as biofuels, organic acids, amino acids, sugar alcohols and biopolymers. In addition, representative secondary metabolites produced by E. coli will be systematically discussed and the successful strategies for strain improvements will be highlighted. Moreover, this review presents guidelines for future developments in the bio-based chemical production using E. coli as an industrial platform.

  • metabolic engineering of escherichia coli a sustainable industrial platform for bio based chemical production
    Biotechnology Advances, 2013
    Co-Authors: Xianzhong Chen, Li Zhou, Kangming Tian, Ashwani Kumar, Suren Singh, Bernard A Prior, Zhengxiang Wang
    Abstract:

    article i nfo In order to decrease carbon emissions and negative environmental impacts of various pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the traditional energy and fossil based inten- sive route. The Gram-negative rod-shaped bacterium, Escherichia coli has been studied extensively on a fundamental and applied level and has become a predominant host microorganism for industrial applications. Furthermore, metabolic engineering of E. coli for the enhanced biochemical production has been significantly promoted by the integrated use of recent developments in systems biology, synthetic biology and evolutionary engineering. In this review, we focus on recent efforts devoted to the use of genetically engineered E. coli as a sustainable platform for the production of industrially important Biochemicals such as biofuels, organic acids, amino acids, sugar alcohols and biopolymers. In addition, representative secondary metabolites produced by E. coli will be systematically discussed and the successful strategies for strain improvements will be highlighted. Moreover, this review presents guidelines for future developments in the bio-based chemical production using E. coli as an industrial platform.

David Carlander - One of the best experts on this subject based on the ideXlab platform.

  • mammalian gastrointestinal tract parameters modulating the integrity surface properties and absorption of food relevant nanomaterials
    Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology, 2015
    Co-Authors: Susann Bellmann, David Carlander, Alessio Fasano, Dragan Momcilovic, Joseph Scimeca, James W Waldman, Lourdes Gombau, Lyubov Tsytsikova, Richard Canady, Dora I A Pereira
    Abstract:

    Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid-based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous Biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food-relevant engineered NMs for risk assessment.

  • mammalian gastrointestinal tract parameters modulating the integrity surface properties and absorption of food relevant nanomaterials
    Wiley Interdisciplinary Reviews-nanomedicine and Nanobiotechnology, 2015
    Co-Authors: Susann Bellmann, David Carlander, Alessio Fasano, Dragan Momcilovic, Joseph Scimeca, James W Waldman, Lourdes Gombau, Lyubov Tsytsikova, Richard Canady, Dora I A Pereira
    Abstract:

    Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid-based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous Biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food-relevant engineered NMs for risk assessment. WIREs Nanomed Nanobiotechnol 2015, 7:609–622. doi: 10.1002/wnan.1333 For further resources related to this article, please visit the WIREs website.