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Ke Yang - One of the best experts on this subject based on the ideXlab platform.
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corrosion and biological performance of Biodegradable magnesium alloys mediated by low copper addition and processing
Materials Science and Engineering: C, 2018Co-Authors: Xudong Yan, Peng Wan, Lili Tan, Mingchun Zhao, Ling Qin, Ke YangAbstract:Abstract Mg-Cu alloys were designed by introducing the well-known antibacterial property of copper into magnesium alloy to solve the infection problem especially under the neutralised environment in vitro. In this paper, the Mg-Cu alloys with further processing by solution and extrusion were studied to optimise the corrosion-related performance for their future application. It was shown that the differences in the property profile of Mg-Cu alloys are dependent on different compositions as well as on different microstructures that are obtained by the different processing routes. Galvanic corrosion can be significantly relieved by solution treatment and extrusion due to decrease and well distribution of cathodic Mg2Cu phases. Negligible cytotoxicity were observed with rBMSCs incubation. Antibacterial assays proved that the alloys reduced the viability of Staphylococcus aureus by high alkalinity and copper ions releasing, especially in comparison with pure magnesium. Finally, the as-solutionized Mg-0.1Cu alloy showed the optimal corrosion properties and promising antibacterial activity, which warranted its potentials as antibacterial Biodegradable Implant materials.
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study on microstructure and properties of extruded mg 2nd 0 2zn alloy as potential Biodegradable Implant material
Materials Science and Engineering: C, 2015Co-Authors: Junlei Li, Xiaoming Yu, Ke YangAbstract:Abstract Mg–2Nd–0.2Zn (NZ20) alloy was prepared for the application as Biodegradable Implant material in this study. The effects of the extrusion process on microstructure, mechanical and corrosion properties of the alloy were investigated. The as-cast alloy was composed of α-Mg matrix and Mg12Nd eutectic compound. The solution treatment could lead to the Mg12Nd phase dissolution and the grain coarsening. The alloy (E1) preheated at 380 °C for 1 h and extruded at 390 °C presents fine grains with amounts of tiny Mg12Nd particles uniformly dispersed throughout the boundaries and the interior of the grains. The alloy (E2) preheated at 480 °C for 1 h and extruded at 500 °C exhibits relatively larger grains with few nano-scale Mg12Nd phase particles dispersed. The alloy of E1, compared with E2, showed relatively lower corrosion rate, higher yield strength and slightly lower elongation.
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study on microstructure and properties of extruded mg 2nd 0 2zn alloy as potential Biodegradable Implant material
Materials Science and Engineering: C, 2015Co-Authors: Ke YangAbstract:Mg-2Nd-0.2Zn (NZ20) alloy was prepared for the application as Biodegradable Implant material in this study. The effects of the extrusion process on microstructure, mechanical and corrosion properties of the alloy were investigated. The as-cast alloy was composed of alpha-Mg matrix and Mg12Nd eutectic compound. The solution treatment could lead to the Mg12Nd phase dissolution and the grain coarsening. The alloy (E1) preheated at 380 degrees C for 1 h and extruded at 390 degrees C presents fine grains with amounts of tiny Mg12Nd particles uniformly dispersed throughout the boundaries and the interior of the grains. The alloy (E2) preheated at 480 degrees C for 1 h and extruded at 500 degrees C exhibits relatively larger grains with few nano-scale Mg12Nd phase particles dispersed. The alloy of E1, compared with E2, showed relatively lower corrosion rate, higher yield strength and slightly lower elongation. (C) 2015 Elsevier B.V. All rights reserved.
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in vitro degradation and biocompatibility of a strontium containing micro arc oxidation coating on the Biodegradable zk60 magnesium alloy
Applied Surface Science, 2014Co-Authors: Xiao Lin, Ke Yang, Lili Tan, Xiaoming Yang, Xin Wang, Yu Zhang, Jianhong QiuAbstract:Abstract Magnesium alloys are promising Biodegradable Implant candidates for orthopedic application. In the present study, a phosphate-based micro-arc oxidation (MAO) coating was applied on the ZK60 alloy to decrease its initial degradation rate. Strontium (Sr) was incorporated into the coating in order to improve the bioactivity of the coating. The in vitro degradation studies showed that the MAO coating containing Sr owned a better initial corrosion resistance, which was mainly attributed to the superior inner barrier layer, and a better long-term protective ability, probably owning to its larger thickness, superior inner barrier layer and the superior apatite formation ability. The degradation of MAO coating was accompanied by the formation of degradation layer and Ca-P deposition layer. The in vitro cell tests demonstrated that the incorporation of Sr into the MAO coating enhanced both the proliferation of preosteoblast cells and the alkaline phosphatase activity of the murine bone marrow stromal cells. In conclusion, the MAO coating with Sr is a promising surface treatment for the Biodegradable magnesium alloys.
Yufeng Zheng - One of the best experts on this subject based on the ideXlab platform.
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mechanical properties in vitro degradation behavior hemocompatibility and cytotoxicity evaluation of zn 1 2mg alloy for Biodegradable Implants
RSC Advances, 2016Co-Authors: Chao Shen, F Y Zhou, Zhongjie Pu, L Li, Yufeng Zheng, Xiaokang Li, Hailiang Wang, Xin Xiao, Shen ZhaoAbstract:Zn, which is a promising alternative candidate as a Biodegradable Implant material, possesses excellent biocompatibility and biodegradability. However, the insufficiency of its strength and hardness has largely limited its application. Nevertheless, adding alloying elements and mechanical forming by extrusion have generally enhanced its mechanical properties. In the present work, Zn–1.2Mg alloy has been designed and treated by extrusion. Experimental results demonstrated that the studied alloys were composed of a matrix of Zn and a precipitated phase of Mg2Zn11, and the grain size became smaller and more homogeneous after extrusion. The as-extruded alloy exhibited much higher yield strength (YS 219.61 MPa), ultimate tensile strength (UTS 362.64 MPa), elongation (21.31%) and hardness (96.01 HV). The corrosion rates of the as-extruded alloy were higher compared with those of the as-cast alloy and reached values of 0.19 mm per year in electrochemical tests and 0.11 mm per year after exposure in Hank's solution for 30 days, respectively. Moreover, the as-extruded alloy displayed excellent hemocompatibility (hemolysis rate of 1.85%, superior thromboresistance and no signs of thrombogenicity). The viability of human osteosarcoma HOS cells and MG63 cells cultured in diluted extracts of the alloy exceeded 70%, which demonstrated no potential cytotoxicity and tolerance in cellular applications.
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microstructure mechanical properties in vitro degradation behavior and hemocompatibility of novel zn mg sr alloys as Biodegradable metals
Materials Letters, 2016Co-Authors: Yinghong Yang, F Y Zhou, Zhongjie Pu, L Li, Yufeng ZhengAbstract:Abstract The microstructure, mechanical properties, in vitro degradation behavior and hemocompatibility of novel Zn–1Mg–0.1Sr and Zn–1Mg–0.5Sr (wt%) ternary alloys were evaluated with pure Zn as control. The results indicated that Zn–Mg–Sr alloys exhibited much higher yield strength (YS), ultimate tensile strength (UTS), hardness and corrosion rate than those of pure Zn. But their elongation and hemolysis rates were reduced. Furthermore, the hot-rolled Zn–1Mg–0.1Sr alloy presented the superior mechanics performance (196.84±13.20 MPa, 300.08±6.09 MPa, 22.49±2.52%, 104.31±10.18 for YS, UTS, Elongation and hardness, respectively), appropriate corrosion rate (0.15±0.05 mm/year) and excellent hemocompatibility (hematolysis rate of 1.10±0.2% and no signs of thrombogenicity), showing a preferable candidate as the Biodegradable Implant material.
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Corrosion fatigue behaviors of two biomedical Mg alloys - AZ91D and WE43 - In simulated body fluid.
Acta biomaterialia, 2010Co-Authors: W.r. Zhou, Yufeng Zheng, Shicheng Wei, Y. Cheng, Shengping Zhong, L.j. ChenAbstract:Magnesium alloys have been recently developed as Biodegradable Implant materials, yet there has been no study concerning their corrosion fatigue properties under cyclic loading. In this study the die-cast AZ91D (A for aluminum 9%, Z for zinc 1% and D for a fourth phase) and extruded WE43 (W for yttrium 4%, E for rare earth mischmetal 3%) alloys were chosen to evaluate their fatigue and corrosion fatigue behaviors in simulated body fluid (SBF). The die-cast AZ91D alloy indicated a fatigue limit of 50MPa at 10⁷ cycles in air compared to 20MPa at 10⁶ cycles tested in SBF at 37°C. A fatigue limit of 110MPa at 10⁷ cycles in air was observed for extruded WE43 alloy compared to 40MPa at 10⁷ cycles tested in SBF at 37°C. The fatigue cracks initiated from the micropores when tested in air and from corrosion pits when tested in SBF, respectively. The overload zone of the extruded WE43 alloy exhibited a ductile fracture mode with deep dimples, in comparison to a brittle fracture mode for the die-cast AZ91D. The corrosion rate of the two experimental alloys increased under cyclic loading compared to that in the static immersion test.
Ana Santoscoquillat - One of the best experts on this subject based on the ideXlab platform.
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hierarchical functionalized polymeric ceramic coatings on mg ca alloys for Biodegradable Implant applications
Macromolecular Bioscience, 2019Co-Authors: Ana Santoscoquillat, Enrique Martinezcampos, Nelson Vargasalfredo, Juan Rodriguezhernandez, Raul Arrabal, Endzhe MatykinaAbstract:This work was funded by ADITIMAT-CM Programme (S2018/NMT-4411) via Regional Government of Madrid and EU Structural Funds. A.S.-C. is grateful to Regional Government of Madrid and European Social Fund for financial support (PEJD-2018-POST/BMD-9592). The authors gratefully acknowledge financial support from the Spanish National Science Foundation (CSIC) and the Ministerio de Ciencia, Innovacion y Universidades grant number MAT2016-78437-R, FONDOS FEDER
Minfang Chen - One of the best experts on this subject based on the ideXlab platform.
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the influence of zn content on the corrosion and wear performance of mg zn ca alloy in simulated body fluid
Journal of Materials Engineering and Performance, 2016Co-Authors: Debao Liu, Yue Zhao, Feng Jin, Minfang ChenAbstract:Mg-Zn-Ca alloy has been attracting increasing attention as a potential Biodegradable Implant material. In this paper, Mg-3Zn-0.2Ca and Mg-4Zn-0.2Ca alloys were prepared by means of vacuum melting and subsequent hot extrusion process. The influences of Zn content on the microstructure, mechanical properties, and corrosion and wear behavior of Mg-Zn-Ca alloys in simulated body fluid (SBF) were studied. The results show that with increased Zn content, the grain size and corrosion resistance were decreased, while the mechanical strength and wear resistance were increased, under both dry sliding and SBF-lubricated conditions. For the same Mg-Zn-Ca alloy, the wear loss rate under SBF lubrication was higher than dry sliding condition, indicating a strong corrosion-assisted wear effect of SBF to the Mg-Zn-Ca alloy.
Bobby M Kannan - One of the best experts on this subject based on the ideXlab platform.
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electrochemical deposition of calcium phosphates on magnesium and its alloys for improved biodegradation performance a review
Surface & Coatings Technology, 2016Co-Authors: Bobby M KannanAbstract:Magnesium and its alloys have been widely studied in recent years for load-bearing Biodegradable Implant applications due to their biodegradability and biocompatibility. Unfortunately, there are two major concerns with these materials, i.e., high degradation rate and localized degradation susceptibility which can affect the in-service mechanical integrity. This review paper focuses on the potential use of calcium phosphates as biocompatible coatings on magnesium-based materials to control their degradation rates and also delay their localized degradation tendency.
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influence of microstructure on the in vitro degradation behaviour of magnesium alloys
Materials Letters, 2010Co-Authors: Bobby M KannanAbstract:The study shows that the microstructural difference between the fine-grained die-cast and coarse-grained sand-cast magnesium-based alloys has no significant effect on the in-vitro degradation behaviour. However, the post-degradation analysis of the alloys suggest that the high volume fraction of secondary phase particles in the die-cast alloy may not be suitable for Biodegradable Implant applications, primarily due to the high stability of the secondary phase particles in physiological conditions.