The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform

A. V. Leonov - One of the best experts on this subject based on the ideXlab platform.

  • Estimation of Biogenic Substance transport by water masses in Tatar Strait
    Water Resources, 2011
    Co-Authors: A. V. Leonov, V. M. Pishchal’nik, V. S. Arkhipkin
    Abstract:

    The conditions of transformations of Biogenic Substances and the redistribution of their concentrations in the shelf water of Sakhalin Island are studied. Preliminary works have given the results for the water area of La Perouse Strait and Aniva Bay (the Sea of Okhotsk), while this paper gives such results for Tatar Strait (the Sea of Japan). Three electronic instruments of oceanographic studies are applied: an adapted version of Bergen Oceanic Model (for the reconstruction of the space and time distribution of seawater temperature, salinity, and density; the circulation intensity of water masses; and water exchange parameters with nearby water areas and within the strait); GIS “Sakhalin Shelf” (for the reconstruction of annual variations in thermohaline characteristics on a standard grid and horizons of oceanographic stations, and the parameters of the aquatic environment); hydroecological CNPSi-model (for studying the annual dynamics of Biogenic element compounds, the biomasses, biohydrochemical activity and bioproduction of microorganisms—bacteria, phytoplankton, and zooplankton, taking part in transformation of Biogenic Substances and petroleum hydrocarbons, as well as the internal fluxes of Biogenic Substances governed by the activity of microorganisms and the external load on the marine ecosystem). The results of modeling the spatial transport of Biogenic Substances through the outer boundaries of Tatar Strait water area and the boundaries of the three areas identified within it are presented and discussed.

  • Specific features of water circulation and Biogenic Substance transformation and transport in Tatar Strait (Sea of Japan): Assessment based on the results of mathematical modeling
    Water Resources, 2010
    Co-Authors: A. V. Leonov, V. M. Pishchal’nik, V. S. Arkhipkin, O. V. Chicherina
    Abstract:

    This study has no analogues in terms of methodology, as it uses three electronic instruments for studying the oceanographic regime of Tatar Strait. GIS “Sakhalin Shelf” was used to reconstruct annual variations in hydrological and hydrochemical characteristics of the marine environment at standard horizons of oceanographic stations in fixed geographic coordinates. An adapted version of the Oceanic Model created in Bergen University was used to reconstruct the spatial and temporal distribution of seawater temperature and salinity, to calculate the density and the circulation rate of water masses and water exchange parameters between the strait and nearby water areas and between regions within the strait. The hydroecological CNPSi-model was next used to assess the annual dynamics of concentrations of Biogenic element compounds; the biomasses, biohydrochemical activity, and bioproductivity of microorganisms (heterotrophic bacteria, three phytoplankton and two zooplankton groups), involved in transformation of Biogenic Substances, as well as the internal fluxes of Biogenic Substances, governed by microorganism activity and the external load onto the marine ecosystem. Analysis of calculation results made it possible to reveal new features in water circulation in the strait (including those for winter) and, for the first time, to analyze the transport regime of Biogenic Substances through the external boundaries of Tatar Strait and through the boundaries of three regions identified within the strait.

  • Transformations of Biogenic Substances in Tatar Strait water (the Sea of Japan): Analysis of mathematical modeling results
    Water Resources, 2010
    Co-Authors: A. V. Leonov, V. M. Pishchal’nik, O. V. Chicherina
    Abstract:

    The state of the marine environment (the temperature, light intensity, transparency, Biogenic load) in Tatar Strait was assessed based on mean annual data from literary sources and with the use of GIS “Sakhalin Shelf.” The entire strait was divided into three regions (northern, southwestern, and southeastern), and water exchange between them for each month was estimated by using Bergen Oceanic Model. The information about the state of the marine environment and water exchange characteristics was used as input data for a hydroecological model, which enabled the assessment of annual variations of Biogenic Substance concentrations and biomasses of microorganisms (heterotrophic bacteria, three groups of phytoplankton, and two groups of zooplankton) in the strait regions chosen. The development conditions of microorganism biomasses within the year can be characterized by their activity indices (specific growth rates), the values of internal fluxes of Biogenic Substances, and calculated bioproductivity values. The calculated Biogenic Substance concentrations and phytoplankton bioproductivity values showed good agreement with the estimates for the Sea of Japan and Tatar Strait available from the literature.

  • WATER QUALITY AND PROTECTIOIN: ENVIRONMENTAL ASPECTS Transformations of Biogenic Substances in Tatar Strait Water (the Sea of Japan): Analysis of Mathematical Modeling Results
    2010
    Co-Authors: A. V. Leonov, O. V. Chicherina
    Abstract:

    The state of the marine environment (the temperature, light intensity, transparency, Biogenic load) in Tatar Strait was assessed based on mean annual data from literary sources and with the use of GIS "Sakhalin Shelf." The entire strait was divided into three regions (northern, southwestern, and southeastern), and water exchange between them for each month was estimated by using Bergen Oceanic Model. The infor� mation about the state of the marine environment and water exchange characteristics was used as input data for a hydroecological model, which enabled the assessment of annual variations of Biogenic Substance con� centrations and biomasses of microorganisms (heterotrophic bacteria, three groups of phytoplankton, and two groups of zooplankton) in the strait regions chosen. The development conditions of microorganism bio� masses within the year can be characterized by their activity indices (specific growth rates), the values of internal fluxes of Biogenic Substances, and calculated bioproductivity values. The calculated Biogenic sub� stance concentrations and phytoplankton bioproductivity values showed good agreement with the estimates for the Sea of Japan and Tatar Strait available from the literature.

  • Biomass development and production created by microorganisms of lower trophic levels in the caspian sea ecosystem: Analysis of mathematical modeling results
    Water Resources, 2009
    Co-Authors: A. V. Leonov, O. V. Chicherina
    Abstract:

    The biohydrochemical features of the Caspian Sea ecosystem were estimated for its ten water areas with the use of a mathematical model describing the transformation of compounds of organogenic elements (C, Si, N, and P) and taking into account the morphometric characteristics of the water areas and long-term mean monthly values of the major characteristics of the aquatic environment. Variations in the estimated concentrations of mineral and aggregated Biogenic Substance fractions, microorganism biomasses (heterotrophic bacteria, three phytoplankton groups and two zooplankton groups) in different water areas of the sea were analyzed. The formation conditions of microorganism biomasses in different water areas are characterized by the analysis of their bioproductivity estimates based on evaluated internal Biogenic Substance fluxes.

Jack R Harkema - One of the best experts on this subject based on the ideXlab platform.

  • Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and Biogenic Substances: enhancement of toxicant-induced airway injury.
    Experimental and Toxicologic Pathology, 2005
    Co-Authors: Jack R Harkema, James G Wagner
    Abstract:

    People are often concurrently exposed to more than one air pollutant whether they are in outdoor or indoor environments. Therefore, inhalation studies that are designed to examine the toxicity of coexposures to two or more airborne toxicants may be more relevant for assessing human health risks than those studies that investigate the toxic effects of only one airborne toxicant at a time. Furthermore, airborne Biogenic Substances such as pollens, bacteria, fungi, and microbial toxins often coexist with common air pollutants in the ambient air, and when inhaled may also cause specific adverse effects on the respiratory tract. One such Biogenic Substance, bacterial endotoxin, is a potent stimulus of airway inflammation and is commonly found in domestic, agricultural, and industrial settings. Little is known about the interaction of exposures to Biogenic Substances and common air pollutants, such as ozone or airborne particulate matter. In the last few years, we have performed a series of in vivo studies using laboratory rodents that examined how airway surface epithelial cells are altered by coexposure to ozone and a Biogenic Substance, either bacterial endotoxin or a commonly used experimental aeroallergen (ovalbumin). Results from these studies indicate that the ozone-induced epithelial and inflammatory responses in laboratory rodents may be markedly enhanced by coexposure to an inhaled Biogenic Substance. Conversely, the adverse airway alterations caused by exposure to Biogenic Substances may be enhanced by coexposure to ozone. The results from these initial studies have also suggested some of the cellular and molecular mechanisms underlying the phenotypic epithelial alterations induced by these coexposures. Many more studies are needed to fully elucidate the potential risk to human health from coexposure to air pollutants and airborne Biogenic Substances.

  • ozone exposure enhances endotoxin induced mucous cell metaplasia in rat pulmonary airways
    Toxicological Sciences, 2003
    Co-Authors: James G Wagner, Jon A Hotchkiss, Steven J Van Dyken, Janelle R Wierenga, Jack R Harkema
    Abstract:

    : Coexposure to different airborne pollutants can be more toxic to airway epithelium than an inhalation exposure to a single pollutant. We have previously reported that coexposure to ozone, the primary oxidant gas in photochemical smog, and unique inflammatory Biogenic Substances such as allergens or bacterial endotoxin, results in augmented epithelial and inflammatory responses in rat nasal airways (M. V. Fanucchi et al., 1998, Toxicol. Appl. Pharmacol. 152, 1-9; J. G. Wagner et al., 2002a, Toxicol. Sci.67, 284-294). In the present study, we investigated the toxic interaction of ozone and endotoxin on the respiratory epithelium in the pulmonary airways of laboratory rodents. F344 rats were intranasally instilled with 0, 2, or 20 microg endotoxin dissolved in sterile saline (150 microl/nasal passage). Six h after instillation rats were exposed to air or 1 ppm ozone for 8 h. One day later, endotoxin and ozone exposures were repeated. Three days after the last exposure, rats were sacrificed, the lungs were lavaged with saline, and the collected bronchoalveolar lavage fluid (BALF) was analyzed for inflammatory cells and secreted mucoSubstances (mucin 5AC). Lung tissues were processed for light microscopic examination and morphometric analysis of numeric density of epithelial cell populations and volume densities of intraepithelial mucoSubstances (IM). Conducting airways were microdissected and analyzed by quantitative RT-PCR to determine steady-state mucin gene (rMuc5AC) mRNA levels in respiratory epithelium. Endotoxin instillation caused a dose-dependent increase in BALF neutrophils that was further increased twofold in ozone-exposed rats given 20 microg endotoxin. Mucin glycoprotein 5AC was elevated in BALF from rats exposed to 20 microg, but not 2 microg endotoxin. Exposure to ozone alone did not cause mucus hypersecretion, but ozone potentiated mucus secretion in rats given 2 or 20 microg endotoxin. Airways of rats exposed to air or ozone alone had scant amounts of IM. Endotoxin instillation induced a dose-dependent increase in IM in airway epithelium that was significantly increased (twofold) in rats that were also exposed to ozone. Expression of rMuc5AC was induced in axial pulmonary airways by 2 and 20 microg endotoxin, and was increased further by ozone-exposure in rats instilled with 20 microg endotoxin. These data demonstrate that ozone exposure potentiates neutrophilic inflammation and mucus production and secretion elicited by a Biogenic Substance in rat pulmonary airways.

O. V. Chicherina - One of the best experts on this subject based on the ideXlab platform.

  • Specific features of water circulation and Biogenic Substance transformation and transport in Tatar Strait (Sea of Japan): Assessment based on the results of mathematical modeling
    Water Resources, 2010
    Co-Authors: A. V. Leonov, V. M. Pishchal’nik, V. S. Arkhipkin, O. V. Chicherina
    Abstract:

    This study has no analogues in terms of methodology, as it uses three electronic instruments for studying the oceanographic regime of Tatar Strait. GIS “Sakhalin Shelf” was used to reconstruct annual variations in hydrological and hydrochemical characteristics of the marine environment at standard horizons of oceanographic stations in fixed geographic coordinates. An adapted version of the Oceanic Model created in Bergen University was used to reconstruct the spatial and temporal distribution of seawater temperature and salinity, to calculate the density and the circulation rate of water masses and water exchange parameters between the strait and nearby water areas and between regions within the strait. The hydroecological CNPSi-model was next used to assess the annual dynamics of concentrations of Biogenic element compounds; the biomasses, biohydrochemical activity, and bioproductivity of microorganisms (heterotrophic bacteria, three phytoplankton and two zooplankton groups), involved in transformation of Biogenic Substances, as well as the internal fluxes of Biogenic Substances, governed by microorganism activity and the external load onto the marine ecosystem. Analysis of calculation results made it possible to reveal new features in water circulation in the strait (including those for winter) and, for the first time, to analyze the transport regime of Biogenic Substances through the external boundaries of Tatar Strait and through the boundaries of three regions identified within the strait.

  • WATER QUALITY AND PROTECTIOIN: ENVIRONMENTAL ASPECTS Transformations of Biogenic Substances in Tatar Strait Water (the Sea of Japan): Analysis of Mathematical Modeling Results
    2010
    Co-Authors: A. V. Leonov, O. V. Chicherina
    Abstract:

    The state of the marine environment (the temperature, light intensity, transparency, Biogenic load) in Tatar Strait was assessed based on mean annual data from literary sources and with the use of GIS "Sakhalin Shelf." The entire strait was divided into three regions (northern, southwestern, and southeastern), and water exchange between them for each month was estimated by using Bergen Oceanic Model. The infor� mation about the state of the marine environment and water exchange characteristics was used as input data for a hydroecological model, which enabled the assessment of annual variations of Biogenic Substance con� centrations and biomasses of microorganisms (heterotrophic bacteria, three groups of phytoplankton, and two groups of zooplankton) in the strait regions chosen. The development conditions of microorganism bio� masses within the year can be characterized by their activity indices (specific growth rates), the values of internal fluxes of Biogenic Substances, and calculated bioproductivity values. The calculated Biogenic sub� stance concentrations and phytoplankton bioproductivity values showed good agreement with the estimates for the Sea of Japan and Tatar Strait available from the literature.

  • Transformations of Biogenic Substances in Tatar Strait water (the Sea of Japan): Analysis of mathematical modeling results
    Water Resources, 2010
    Co-Authors: A. V. Leonov, V. M. Pishchal’nik, O. V. Chicherina
    Abstract:

    The state of the marine environment (the temperature, light intensity, transparency, Biogenic load) in Tatar Strait was assessed based on mean annual data from literary sources and with the use of GIS “Sakhalin Shelf.” The entire strait was divided into three regions (northern, southwestern, and southeastern), and water exchange between them for each month was estimated by using Bergen Oceanic Model. The information about the state of the marine environment and water exchange characteristics was used as input data for a hydroecological model, which enabled the assessment of annual variations of Biogenic Substance concentrations and biomasses of microorganisms (heterotrophic bacteria, three groups of phytoplankton, and two groups of zooplankton) in the strait regions chosen. The development conditions of microorganism biomasses within the year can be characterized by their activity indices (specific growth rates), the values of internal fluxes of Biogenic Substances, and calculated bioproductivity values. The calculated Biogenic Substance concentrations and phytoplankton bioproductivity values showed good agreement with the estimates for the Sea of Japan and Tatar Strait available from the literature.

  • Biomass development and production created by microorganisms of lower trophic levels in the caspian sea ecosystem: Analysis of mathematical modeling results
    Water Resources, 2009
    Co-Authors: A. V. Leonov, O. V. Chicherina
    Abstract:

    The biohydrochemical features of the Caspian Sea ecosystem were estimated for its ten water areas with the use of a mathematical model describing the transformation of compounds of organogenic elements (C, Si, N, and P) and taking into account the morphometric characteristics of the water areas and long-term mean monthly values of the major characteristics of the aquatic environment. Variations in the estimated concentrations of mineral and aggregated Biogenic Substance fractions, microorganism biomasses (heterotrophic bacteria, three phytoplankton groups and two zooplankton groups) in different water areas of the sea were analyzed. The formation conditions of microorganism biomasses in different water areas are characterized by the analysis of their bioproductivity estimates based on evaluated internal Biogenic Substance fluxes.

  • Transformations of Organogenic Substances in the White Sea Ecosystem: Assessment Based on the Results of Mathematical Modeling
    Water Resources, 2005
    Co-Authors: A. V. Leonov, N. N. Filatov, O. V. Chicherina
    Abstract:

    Methods of systems analysis and mathematical modeling are used to generalize hydrological, hydrochemical, and hydrobiological observational data with the aim to study the biohydrochemical conditions of organic and Biogenic Substance transformations in eight water areas in the White Sea. A hydroecological model describing transformations of N, P, and Si compounds and dissolved organic C, as well as the regime of O_2 was used as a means of the study. Water exchange between water areas was evaluated using a hydrodynamic model. Averaged data on annual variations in water temperature, illumination, and transparency, as well as run-off characteristics (water flow in river mouths and organic and Biogenic matter concentrations in the river water entering the sea) were used to calculate the dynamics of organic and mineral compounds of nutrients in different areas of the sea. The principal attention is paid to the verification of the model against field observational data, assessment of the biomass development conditions of aquatic animals, analysis of model results regarding the turnover time of organic and mineral components, and the evaluation of balances of organic dissolved and particulate N and P forms.

James G Wagner - One of the best experts on this subject based on the ideXlab platform.

  • Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and Biogenic Substances: enhancement of toxicant-induced airway injury.
    Experimental and Toxicologic Pathology, 2005
    Co-Authors: Jack R Harkema, James G Wagner
    Abstract:

    People are often concurrently exposed to more than one air pollutant whether they are in outdoor or indoor environments. Therefore, inhalation studies that are designed to examine the toxicity of coexposures to two or more airborne toxicants may be more relevant for assessing human health risks than those studies that investigate the toxic effects of only one airborne toxicant at a time. Furthermore, airborne Biogenic Substances such as pollens, bacteria, fungi, and microbial toxins often coexist with common air pollutants in the ambient air, and when inhaled may also cause specific adverse effects on the respiratory tract. One such Biogenic Substance, bacterial endotoxin, is a potent stimulus of airway inflammation and is commonly found in domestic, agricultural, and industrial settings. Little is known about the interaction of exposures to Biogenic Substances and common air pollutants, such as ozone or airborne particulate matter. In the last few years, we have performed a series of in vivo studies using laboratory rodents that examined how airway surface epithelial cells are altered by coexposure to ozone and a Biogenic Substance, either bacterial endotoxin or a commonly used experimental aeroallergen (ovalbumin). Results from these studies indicate that the ozone-induced epithelial and inflammatory responses in laboratory rodents may be markedly enhanced by coexposure to an inhaled Biogenic Substance. Conversely, the adverse airway alterations caused by exposure to Biogenic Substances may be enhanced by coexposure to ozone. The results from these initial studies have also suggested some of the cellular and molecular mechanisms underlying the phenotypic epithelial alterations induced by these coexposures. Many more studies are needed to fully elucidate the potential risk to human health from coexposure to air pollutants and airborne Biogenic Substances.

  • ozone exposure enhances endotoxin induced mucous cell metaplasia in rat pulmonary airways
    Toxicological Sciences, 2003
    Co-Authors: James G Wagner, Jon A Hotchkiss, Steven J Van Dyken, Janelle R Wierenga, Jack R Harkema
    Abstract:

    : Coexposure to different airborne pollutants can be more toxic to airway epithelium than an inhalation exposure to a single pollutant. We have previously reported that coexposure to ozone, the primary oxidant gas in photochemical smog, and unique inflammatory Biogenic Substances such as allergens or bacterial endotoxin, results in augmented epithelial and inflammatory responses in rat nasal airways (M. V. Fanucchi et al., 1998, Toxicol. Appl. Pharmacol. 152, 1-9; J. G. Wagner et al., 2002a, Toxicol. Sci.67, 284-294). In the present study, we investigated the toxic interaction of ozone and endotoxin on the respiratory epithelium in the pulmonary airways of laboratory rodents. F344 rats were intranasally instilled with 0, 2, or 20 microg endotoxin dissolved in sterile saline (150 microl/nasal passage). Six h after instillation rats were exposed to air or 1 ppm ozone for 8 h. One day later, endotoxin and ozone exposures were repeated. Three days after the last exposure, rats were sacrificed, the lungs were lavaged with saline, and the collected bronchoalveolar lavage fluid (BALF) was analyzed for inflammatory cells and secreted mucoSubstances (mucin 5AC). Lung tissues were processed for light microscopic examination and morphometric analysis of numeric density of epithelial cell populations and volume densities of intraepithelial mucoSubstances (IM). Conducting airways were microdissected and analyzed by quantitative RT-PCR to determine steady-state mucin gene (rMuc5AC) mRNA levels in respiratory epithelium. Endotoxin instillation caused a dose-dependent increase in BALF neutrophils that was further increased twofold in ozone-exposed rats given 20 microg endotoxin. Mucin glycoprotein 5AC was elevated in BALF from rats exposed to 20 microg, but not 2 microg endotoxin. Exposure to ozone alone did not cause mucus hypersecretion, but ozone potentiated mucus secretion in rats given 2 or 20 microg endotoxin. Airways of rats exposed to air or ozone alone had scant amounts of IM. Endotoxin instillation induced a dose-dependent increase in IM in airway epithelium that was significantly increased (twofold) in rats that were also exposed to ozone. Expression of rMuc5AC was induced in axial pulmonary airways by 2 and 20 microg endotoxin, and was increased further by ozone-exposure in rats instilled with 20 microg endotoxin. These data demonstrate that ozone exposure potentiates neutrophilic inflammation and mucus production and secretion elicited by a Biogenic Substance in rat pulmonary airways.

Ichirou Ishimaru - One of the best experts on this subject based on the ideXlab platform.

  • Novel algorithm for background correction of the quantitative spectroscopic tomography of the Biogenic-Substances
    Optical Diagnostics and Sensing XIII: Toward Point-of-Care Diagnostics, 2013
    Co-Authors: Pradeep K. W. Abeygunawardhana, Daisuke Kojima, Satoru Suzuki, Akira Nishiyama, Ichirou Ishimaru
    Abstract:

    The non-invasive blood sugar sensor by using imaging-type 2-dimensional Fourier spectroscopy is to be realized in this work. The spectroscopic imaging, that observes the biological tissue by the dark-field image, can measure the Biogenic Substance quantitatively such as the glucose concentration. For the quantitative analysis with high accuracy, the correction of the background such as the light-source fluctuation and the phase-shift uncertainty is inevitable issue. Thus, the quantitative band-pass plate on which the grating is locally formed has been already proposed by [1]. In that paper, the diffractive light, whose diffraction angle depends on the wavelength, has been used as the reference light. Object lens is used to narrow down the reference light and narrowed band pass diffraction light is obtained. The changes of imaging intensities with interference phenomenon on whole area of the observation image can be confirmed using the quantitative band pass filter. This paper proposed background correction method of the interferogram in spectroscopic tomography. Correction algorithm mainly contained two parts as light source fluctuation error correction and phase shift error correction.

  • Spectroscopic tomography of biological tissues with the near-infrared radiation for the non-invasive measurement of the Biogenic-Substances
    Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Opti, 2012
    Co-Authors: Daisuke Kojima, Akira Nishiyama, Takashi Takuma, Asuka Inui, Ryosuke Tsutsumi, Takehiko Yuzuriha, Hiroyasu Kagiyama, Ichirou Ishimaru
    Abstract:

    We are aiming at the realization of the non-invasive measurement of the Biogenic-Substance, such as the blood glucose concentration, by the proposed imaging-type 2-dimensional Fourier spectroscopy. We had successfully obtained the spectroscopic tomography of the mouse's ear with the near-infrared radiation. The proposed Fourier-spectroscopic imaging can limit the measuring depth into the focal plane. So, we can set the focal plane as the measurement plane near the skin surface that is not affected by the optical diffusion of the biological tissues. To analyze the absorption coefficient in the specific wavelength at the vessel area, we can expect to acquire the blood glucose concentration in high accuracy. In the proposed method, we install the variable phase-filter into the optical Fourier transform plane of the imaging optics to give the arbitrary phase-shift to the half flux of objective beams. Because of the imaging optics, only the rays from the focal plane can contribute the formation of the interferogram. Thus, we can obtain the 2-dimensional spectra only on the focal plane. We had successfully obtained the distribution of the spectroscopic-absorption near the skin surface. We are trying to convert the absorptance into the glucose concentration by the quantitative spectroscopic image-processing.

  • Quantitative spectroscopic tomography for the non-invasive measurement of the Biogenic-Substances
    2012 9th France-Japan & 7th Europe-Asia Congress on Mechatronics (MECATRONICS) 13th Int'l Workshop on Research and Education in Mechatronics (REM), 2012
    Co-Authors: Daisuke Kojima, Pradeep K. W. Abeygunawardhana, Satoru Suzuki, Akira Nishiyama, Shun Sato, Ichirou Ishimaru
    Abstract:

    The non-invasive blood sugar sensor by using imaging-type 2-dimensional Fourier spectroscopy is to be realized in this work. The spectroscopic imaging, that observes the biological tissue by the dark-field image, can measure the Biogenic Substance quantitatively such as the glucose concentration. For the quantitative analysis with high accuracy, the correction of the background such as the light-source fluctuation and the phase-shift uncertainty is inevitable issue. Thus, the quantitative bandpass plate on which the grating is locally formed has been proposed in this paper. Here, the diffractive light, whose diffraction angle depends on the wavelength, has been used as the reference light Object lens is used to narrow down the reference light and narrowed band pass diffraction light is obtained. The changes of imaging intensities with interference phenomenon on whole area of the observation image can be confirmed using the quantitative band pass filter. Thus, the light-source fluctuation from the amplitude of the reference light intensity and the phase-shift uncertainly from the interference-phase can be corrected respectively. In this paper, the theoretical accuracy of Fourier spectroscopy calculated with the numerical simulation and the background correction method of the spectral-absorption-index image by the diffraction grating type quantitative bandpass plate are presented.