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Biohazard

The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform

Leopoldo Paolo Pucillo – 1st expert on this subject based on the ideXlab platform

  • diagnostic performances of clinical laboratory tests using triton x 100 to reduce the Biohazard associated with routine testing of ebola virus infected patients
    Clinical Chemistry and Laboratory Medicine, 2015
    Co-Authors: Massimo Tempestilli, Luigia Pucci, Stefania Notari, Antonino Di Caro, Concetta Castilletti, Maria Rosaria Rivelli, Chiara Agrati, Leopoldo Paolo Pucillo

    Abstract:

    BACKGROUND: Ebola virus, an enveloped virus, is the cause of the largest and most complex Ebola virus disease (EVD) outbreak in West Africa. Blood or body fluids of an infected person may represent a Biohazard to laboratory workers. Laboratory tests of virus containing specimens should be conducted in referral centres at biosafety level 4, but based on the severity of clinical symptoms, basic laboratories might be required to execute urgent tests for patients suspected of EVD. The aim of this work was to compare the analytical performances of laboratory tests when Triton X-100, a chemical agent able to inactivate other enveloped viruses, was added to specimens. METHODS: Results of clinical chemistry, coagulation and haematology parameters on samples before and after the addition of 0.1% (final concentration) of Triton X-100 and 1 h of incubation at room temperature were compared. RESULTS: Overall, results showed very good agreement by all statistical analyses. Triton X-100 at 0.1% did not significantly affect the results for the majority of the analytes tested. CONCLUSIONS: Triton X-100 at 0.1% can be used to reduce the Biohazard in performing laboratory tests on samples from patients with EVD without affecting clinical decisions.

P Tenning – 2nd expert on this subject based on the ideXlab platform

  • inventory of microbial species with a rationale a comparison of the idf effca inventory of microbial food cultures with the efsa Biohazard panel qualified presumption of safety
    Fems Microbiology Letters, 2019
    Co-Authors: F Bourdichon, S Laulund, P Tenning

    Abstract:

    : In order to provide a harmonised preassessment to support risk assessment performed by the European Food Safety Authority (EFSA), the Biohazard Panel in 2007 published guidelines for evaluation of the safety of a strain included in the food chain, the Qualified Presumption of Safety (QPS). Since 2008, the Biohazard Panel has published on a regular basis an update of the microbial strains submitted for approval and extends the list of species which have been granted QPS status. The International Dairy Federation (IDF) and the European Food and Feed Cultures Association (EFFCA) have, since 2002, been conducting a project on the safety demonstration of microbial food cultures (MFCs). Following the publication of IDF Bulletin 377-2002, an inventory of MFCs was published in IDF Bulletin 455-2012 and updated most recently in IDF Bulletin 495-2018. These two lists developed by EFSA (QPS) and IDF/EFFCA both propose as an outcome an inventory of microbial species that are safe for human consumption. To avoid confusion when these two inventories are compared, this review attempts to explain the rationale that was used to develop them and explain how the two lists should be understood.

  • Inventory of microbial species with a rationale: a comparison of the IDF/EFFCA inventory of microbial food cultures with the EFSA Biohazard Panel qualified presumption of safety.
    Fems Microbiology Letters, 2019
    Co-Authors: F Bourdichon, S Laulund, P Tenning

    Abstract:

    : In order to provide a harmonised preassessment to support risk assessment performed by the European Food Safety Authority (EFSA), the Biohazard Panel in 2007 published guidelines for evaluation of the safety of a strain included in the food chain, the Qualified Presumption of Safety (QPS). Since 2008, the Biohazard Panel has published on a regular basis an update of the microbial strains submitted for approval and extends the list of species which have been granted QPS status. The International Dairy Federation (IDF) and the European Food and Feed Cultures Association (EFFCA) have, since 2002, been conducting a project on the safety demonstration of microbial food cultures (MFCs). Following the publication of IDF Bulletin 377-2002, an inventory of MFCs was published in IDF Bulletin 455-2012 and updated most recently in IDF Bulletin 495-2018. These two lists developed by EFSA (QPS) and IDF/EFFCA both propose as an outcome an inventory of microbial species that are safe for human consumption. To avoid confusion when these two inventories are compared, this review attempts to explain the rationale that was used to develop them and explain how the two lists should be understood.

Wlodzimierz Kutner – 3rd expert on this subject based on the ideXlab platform

  • molecular imprinting for selective chemical sensing of hazardous compounds and drugs of abuse
    Trends in Analytical Chemistry, 2012
    Co-Authors: Piyush Sindhu Sharma, Wlodzimierz Kutner, Francis Dsouza

    Abstract:

    Abstract Environmental and health safety requires thorough determination of hazardous compounds and drugs of abuse. In determinations of these analytes, traditional instrumental analytical techniques often suffer from tedious assay procedures. Biosensors are simpler to construct and faster in use, so they can better meet the analytical demands in determination of these Biohazards. However, their stability and reproducibility when operating under harsh conditions are poor, so artificial recognition units have become attractive as replacements for natural receptors in sensing applications. Molecular imprinting is one of the most powerful tools for preparing materials that can bind analytes reversibly and selectively in the presence of their interferents. This review critically evaluates the development of chemical sensing of Biohazards and drugs of abuse using the molecular-imprinting approach to recognition in combination with different ways of analytical signal transduction. We compile analytical parameters of the molecularly-imprinted receptors, identify difficulties in the determinations encountered and highlight proposed solutions to problems.