The Experts below are selected from a list of 7947 Experts worldwide ranked by ideXlab platform

Ruszymah Bt Hj Idrus - One of the best experts on this subject based on the ideXlab platform.

  • polylactic co glycolic acid mesh coated with fibrin or collagen and Biological Adhesive substance as a prefabricated degradable biocompatible and functional scaffold for regeneration of the urinary bladder wall
    Journal of Biomedical Materials Research Part A, 2013
    Co-Authors: Salah Abood Salem, Ng Min Hwei, Aminuddin Bin Saim, Ismail Sagap, Rajesh Singh, Mohd Reusmaazran Yusof, Zulkifili Md Zainuddin, Ruszymah Bt Hj Idrus
    Abstract:

    The chief obstacle for reconstructing the bladder is the absence of a biomaterial, either permanent or biodegradable, that will function as a suitable scaffold for the natural process of regeneration. In this study, polylactic-co-glycolic acid (PLGA) plus collagen or fibrin was evaluated for its suitability as a scaffold for urinary bladder construct. Human adipose-derived stem cells (HADSCs) were cultured, followed by incubation in smooth muscle cells differentiation media. Differentiated HADSCs were then seeded onto PLGA mesh supported with collagen or fibrin. Evaluation of cell-seeded PLGA composite immersed in culture medium was performed under a light and scanning microscope. To determine if the composite is compatible with the urodynamic properties of urinary bladder, porosity and leaking test was performed. The PLGA samples were subjected to tensile testing was pulled until PLGA fibers break. The results showed that the PLGA composite is biocompatible to differentiated HADSCs. PLGA-collagen mesh appeared to be optimal as a cell carrier while the three-layered PLGA-fibrin composite is better in relation to its leaking/ porosity property. A biomechanical test was also performed for three-layered PLGA with Biological Adhesive and three-layered PLGA alone. The tensile stress at failure was 30.82 ± 3.80 (MPa) and 34.36 ± 2.57 (MPa), respectively. Maximum tensile strain at failure was 19.42 ± 2.24 (mm) and 23.06 ± 2.47 (mm), respectively. Young's modulus was 0.035 ± 0.0083 and 0.043 ± 0.012, respectively. The maximum load at break was 58.55 ± 7.90 (N) and 65.29 ± 4.89 (N), respectively. In conclusion, PLGA-Fibrin fulfils the criteria as a scaffold for urinary bladder reconstruction. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

  • Polylactic‐co‐glycolic acid mesh coated with fibrin or collagen and Biological Adhesive substance as a prefabricated, degradable, biocompatible, and functional scaffold for regeneration of the urinary bladder wall
    Journal of biomedical materials research. Part A, 2013
    Co-Authors: Salah Abood Salem, Ng Min Hwei, Ismail Sagap, Rajesh Singh, Mohd Reusmaazran Yusof, Zulkifili Md Zainuddin, Aminuddin Bin Saim, Ruszymah Bt Hj Idrus
    Abstract:

    The chief obstacle for reconstructing the bladder is the absence of a biomaterial, either permanent or biodegradable, that will function as a suitable scaffold for the natural process of regeneration. In this study, polylactic-co-glycolic acid (PLGA) plus collagen or fibrin was evaluated for its suitability as a scaffold for urinary bladder construct. Human adipose-derived stem cells (HADSCs) were cultured, followed by incubation in smooth muscle cells differentiation media. Differentiated HADSCs were then seeded onto PLGA mesh supported with collagen or fibrin. Evaluation of cell-seeded PLGA composite immersed in culture medium was performed under a light and scanning microscope. To determine if the composite is compatible with the urodynamic properties of urinary bladder, porosity and leaking test was performed. The PLGA samples were subjected to tensile testing was pulled until PLGA fibers break. The results showed that the PLGA composite is biocompatible to differentiated HADSCs. PLGA-collagen mesh appeared to be optimal as a cell carrier while the three-layered PLGA-fibrin composite is better in relation to its leaking/ porosity property. A biomechanical test was also performed for three-layered PLGA with Biological Adhesive and three-layered PLGA alone. The tensile stress at failure was 30.82 ± 3.80 (MPa) and 34.36 ± 2.57 (MPa), respectively. Maximum tensile strain at failure was 19.42 ± 2.24 (mm) and 23.06 ± 2.47 (mm), respectively. Young's modulus was 0.035 ± 0.0083 and 0.043 ± 0.012, respectively. The maximum load at break was 58.55 ± 7.90 (N) and 65.29 ± 4.89 (N), respectively. In conclusion, PLGA-Fibrin fulfils the criteria as a scaffold for urinary bladder reconstruction. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

Salah Abood Salem - One of the best experts on this subject based on the ideXlab platform.

  • polylactic co glycolic acid mesh coated with fibrin or collagen and Biological Adhesive substance as a prefabricated degradable biocompatible and functional scaffold for regeneration of the urinary bladder wall
    Journal of Biomedical Materials Research Part A, 2013
    Co-Authors: Salah Abood Salem, Ng Min Hwei, Aminuddin Bin Saim, Ismail Sagap, Rajesh Singh, Mohd Reusmaazran Yusof, Zulkifili Md Zainuddin, Ruszymah Bt Hj Idrus
    Abstract:

    The chief obstacle for reconstructing the bladder is the absence of a biomaterial, either permanent or biodegradable, that will function as a suitable scaffold for the natural process of regeneration. In this study, polylactic-co-glycolic acid (PLGA) plus collagen or fibrin was evaluated for its suitability as a scaffold for urinary bladder construct. Human adipose-derived stem cells (HADSCs) were cultured, followed by incubation in smooth muscle cells differentiation media. Differentiated HADSCs were then seeded onto PLGA mesh supported with collagen or fibrin. Evaluation of cell-seeded PLGA composite immersed in culture medium was performed under a light and scanning microscope. To determine if the composite is compatible with the urodynamic properties of urinary bladder, porosity and leaking test was performed. The PLGA samples were subjected to tensile testing was pulled until PLGA fibers break. The results showed that the PLGA composite is biocompatible to differentiated HADSCs. PLGA-collagen mesh appeared to be optimal as a cell carrier while the three-layered PLGA-fibrin composite is better in relation to its leaking/ porosity property. A biomechanical test was also performed for three-layered PLGA with Biological Adhesive and three-layered PLGA alone. The tensile stress at failure was 30.82 ± 3.80 (MPa) and 34.36 ± 2.57 (MPa), respectively. Maximum tensile strain at failure was 19.42 ± 2.24 (mm) and 23.06 ± 2.47 (mm), respectively. Young's modulus was 0.035 ± 0.0083 and 0.043 ± 0.012, respectively. The maximum load at break was 58.55 ± 7.90 (N) and 65.29 ± 4.89 (N), respectively. In conclusion, PLGA-Fibrin fulfils the criteria as a scaffold for urinary bladder reconstruction. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

  • Polylactic‐co‐glycolic acid mesh coated with fibrin or collagen and Biological Adhesive substance as a prefabricated, degradable, biocompatible, and functional scaffold for regeneration of the urinary bladder wall
    Journal of biomedical materials research. Part A, 2013
    Co-Authors: Salah Abood Salem, Ng Min Hwei, Ismail Sagap, Rajesh Singh, Mohd Reusmaazran Yusof, Zulkifili Md Zainuddin, Aminuddin Bin Saim, Ruszymah Bt Hj Idrus
    Abstract:

    The chief obstacle for reconstructing the bladder is the absence of a biomaterial, either permanent or biodegradable, that will function as a suitable scaffold for the natural process of regeneration. In this study, polylactic-co-glycolic acid (PLGA) plus collagen or fibrin was evaluated for its suitability as a scaffold for urinary bladder construct. Human adipose-derived stem cells (HADSCs) were cultured, followed by incubation in smooth muscle cells differentiation media. Differentiated HADSCs were then seeded onto PLGA mesh supported with collagen or fibrin. Evaluation of cell-seeded PLGA composite immersed in culture medium was performed under a light and scanning microscope. To determine if the composite is compatible with the urodynamic properties of urinary bladder, porosity and leaking test was performed. The PLGA samples were subjected to tensile testing was pulled until PLGA fibers break. The results showed that the PLGA composite is biocompatible to differentiated HADSCs. PLGA-collagen mesh appeared to be optimal as a cell carrier while the three-layered PLGA-fibrin composite is better in relation to its leaking/ porosity property. A biomechanical test was also performed for three-layered PLGA with Biological Adhesive and three-layered PLGA alone. The tensile stress at failure was 30.82 ± 3.80 (MPa) and 34.36 ± 2.57 (MPa), respectively. Maximum tensile strain at failure was 19.42 ± 2.24 (mm) and 23.06 ± 2.47 (mm), respectively. Young's modulus was 0.035 ± 0.0083 and 0.043 ± 0.012, respectively. The maximum load at break was 58.55 ± 7.90 (N) and 65.29 ± 4.89 (N), respectively. In conclusion, PLGA-Fibrin fulfils the criteria as a scaffold for urinary bladder reconstruction. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

Peibiao Zhang - One of the best experts on this subject based on the ideXlab platform.

Ido Didi Fabian - One of the best experts on this subject based on the ideXlab platform.

  • A Biological tissue Adhesive and dissolvent system for intraocular tumor plaque radiotherapy: an in vivo animal model experiment
    Graefe's Archive for Clinical and Experimental Ophthalmology, 2015
    Co-Authors: Ofira Zloto, Dror Alezra, Oded Sagiv, Michael Belkin, Vicktoria Vishnevskia Dai, Iris Moroz, Gahl Greenberg, Elad Ben-artsi, Ido Didi Fabian
    Abstract:

    Purpose To examine a novel Biological Adhesive and dissolvent system for plaque placement and removal using fibrin glue and urokinase, respectively, in an in vivo animal model. Methods The study was performed on 23 rabbit eyes. Of these, eight underwent a technical feasibility study and ultrasonographic plaque displacement measurements, nine were examined clinically and by magnetic resonance imaging and histopathology for tissue reaction to the Biological substances used, and in six the impact of fibrin glue as an orbital space occupier on intraocular pressure was assessed. In an additional ex vivo experiment, the glue's radiation attenuating properties were tested using an oncology EDR2 film. Results Plaque horizontal movement throughout follow-up (7–10 days) was negligible (0.5 ± 0.2 mm), and there was no tilting whatsoever. In the tissue response experiment, no adverse effects were recorded after application of fibrin or urokinase throughout the 21-day follow-up period. Interestingly, a circumscribed local inflammatory response was noted in tissue surrounding the fibrin glue, and persisted at 21 days. In the orbital space-occupying experiment, application of 1 cc fibrin glue did not cause a significant elevation in intraocular pressure (IOP) ( P  = 0.06), and in the ex vivo experiment, there was no significant difference between radiation readings with and without glue separation of the radioactive sources and film ( P  = 0.065). Conclusions The Adhesive and dissolvent system was feasible and safe for plaque placement and removal. It may be superior to conventional surgical plaque placement methods in eliminating the relatively common risk of plaque tilting and complications due to scleral suturing.

  • Erratum to: A Biological tissue Adhesive and dissolvent system for intraocular tumor plaque radiotherapy: an in vivo animal model experiment
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2015
    Co-Authors: Ofira Zloto, Dror Alezra, Oded Sagiv, Michael Belkin, Vicktoria Vishnevskia Dai, Iris Moroz, Gahl Greenberg, Elad Ben-artsi, Ido Didi Fabian
    Abstract:

    Purpose To examine a novel Biological Adhesive and dissolvent system for plaque placement and removal using fibrin glue and urokinase, respectively, in an in vivo animal model.

Ng Min Hwei - One of the best experts on this subject based on the ideXlab platform.

  • polylactic co glycolic acid mesh coated with fibrin or collagen and Biological Adhesive substance as a prefabricated degradable biocompatible and functional scaffold for regeneration of the urinary bladder wall
    Journal of Biomedical Materials Research Part A, 2013
    Co-Authors: Salah Abood Salem, Ng Min Hwei, Aminuddin Bin Saim, Ismail Sagap, Rajesh Singh, Mohd Reusmaazran Yusof, Zulkifili Md Zainuddin, Ruszymah Bt Hj Idrus
    Abstract:

    The chief obstacle for reconstructing the bladder is the absence of a biomaterial, either permanent or biodegradable, that will function as a suitable scaffold for the natural process of regeneration. In this study, polylactic-co-glycolic acid (PLGA) plus collagen or fibrin was evaluated for its suitability as a scaffold for urinary bladder construct. Human adipose-derived stem cells (HADSCs) were cultured, followed by incubation in smooth muscle cells differentiation media. Differentiated HADSCs were then seeded onto PLGA mesh supported with collagen or fibrin. Evaluation of cell-seeded PLGA composite immersed in culture medium was performed under a light and scanning microscope. To determine if the composite is compatible with the urodynamic properties of urinary bladder, porosity and leaking test was performed. The PLGA samples were subjected to tensile testing was pulled until PLGA fibers break. The results showed that the PLGA composite is biocompatible to differentiated HADSCs. PLGA-collagen mesh appeared to be optimal as a cell carrier while the three-layered PLGA-fibrin composite is better in relation to its leaking/ porosity property. A biomechanical test was also performed for three-layered PLGA with Biological Adhesive and three-layered PLGA alone. The tensile stress at failure was 30.82 ± 3.80 (MPa) and 34.36 ± 2.57 (MPa), respectively. Maximum tensile strain at failure was 19.42 ± 2.24 (mm) and 23.06 ± 2.47 (mm), respectively. Young's modulus was 0.035 ± 0.0083 and 0.043 ± 0.012, respectively. The maximum load at break was 58.55 ± 7.90 (N) and 65.29 ± 4.89 (N), respectively. In conclusion, PLGA-Fibrin fulfils the criteria as a scaffold for urinary bladder reconstruction. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.

  • Polylactic‐co‐glycolic acid mesh coated with fibrin or collagen and Biological Adhesive substance as a prefabricated, degradable, biocompatible, and functional scaffold for regeneration of the urinary bladder wall
    Journal of biomedical materials research. Part A, 2013
    Co-Authors: Salah Abood Salem, Ng Min Hwei, Ismail Sagap, Rajesh Singh, Mohd Reusmaazran Yusof, Zulkifili Md Zainuddin, Aminuddin Bin Saim, Ruszymah Bt Hj Idrus
    Abstract:

    The chief obstacle for reconstructing the bladder is the absence of a biomaterial, either permanent or biodegradable, that will function as a suitable scaffold for the natural process of regeneration. In this study, polylactic-co-glycolic acid (PLGA) plus collagen or fibrin was evaluated for its suitability as a scaffold for urinary bladder construct. Human adipose-derived stem cells (HADSCs) were cultured, followed by incubation in smooth muscle cells differentiation media. Differentiated HADSCs were then seeded onto PLGA mesh supported with collagen or fibrin. Evaluation of cell-seeded PLGA composite immersed in culture medium was performed under a light and scanning microscope. To determine if the composite is compatible with the urodynamic properties of urinary bladder, porosity and leaking test was performed. The PLGA samples were subjected to tensile testing was pulled until PLGA fibers break. The results showed that the PLGA composite is biocompatible to differentiated HADSCs. PLGA-collagen mesh appeared to be optimal as a cell carrier while the three-layered PLGA-fibrin composite is better in relation to its leaking/ porosity property. A biomechanical test was also performed for three-layered PLGA with Biological Adhesive and three-layered PLGA alone. The tensile stress at failure was 30.82 ± 3.80 (MPa) and 34.36 ± 2.57 (MPa), respectively. Maximum tensile strain at failure was 19.42 ± 2.24 (mm) and 23.06 ± 2.47 (mm), respectively. Young's modulus was 0.035 ± 0.0083 and 0.043 ± 0.012, respectively. The maximum load at break was 58.55 ± 7.90 (N) and 65.29 ± 4.89 (N), respectively. In conclusion, PLGA-Fibrin fulfils the criteria as a scaffold for urinary bladder reconstruction. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.