The Experts below are selected from a list of 193386 Experts worldwide ranked by ideXlab platform
Hongbing Zhang - One of the best experts on this subject based on the ideXlab platform.
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abstract 3551 a microrna 1280 jag2 network comprises a novel Biological Target in high risk medulloblastoma
Cancer Research, 2015Co-Authors: Fengfei Wang, Kruttika Bhat, Saeed Salem, Adrian M Dubuc, Marc Remke, Ekokobe Fonkem, Vijay Ramaswamy, Eric T Wong, Shuang Zhou, Hongbing ZhangAbstract:Over-expression of PDGF receptors (PDGFRs) has been previously implicated in high-risk medulloblastoma (MB) pathogenesis. However, the exact Biological functions of PDGFRα and PDGFRβ signaling in MB biology remain poorly understood. Here, we report the subgroup specific expression of PDGFRα and PDGFRβ and their associated Biological pathways in MB tumors. c-MYC, a downstream Target of PDGFRβ but not PDGFRα, is involved in PDGFRβ signaling associated with cell proliferation, cell death, and invasion. Concurrent inhibition of PDGFRβ and c-MYC blocks MB cell proliferation and migration synergistically. Integrated analysis of miRNA and miRNA Targets regulated by both PDGFRβ and c-MYC reveals that increased expression of JAG2, a Target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in MB patients. Our study may resolve the controversy on the role of PDGFRs in MB and unveils JAG2 as a key downstream effector of a PDGFRβ-driven signaling cascade and a potential therapeutic Target. Citation Format: Fengfei Wang, Marc Remke, Kruttika Bhat, Eric Wong, Shuang Zhou, Vijay Ramaswamy, Adrian Dubuc, Ekokobe Fonkem, Saeed Salem, Hongbing Zhang, Tze-chen Hsieh, Stephen O9Rourke, Lizi Wu, David Li, Cynthia Hawkins, Isaac Kohane, Joseph Wu, Min Wu, Michael Taylor, Erxi Wu. A microRNA-1280/JAG2 network comprises a novel Biological Target in high-risk medulloblastoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3551. doi:10.1158/1538-7445.AM2015-3551
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a microrna 1280 jag2 network comprises a novel Biological Target in high risk medulloblastoma
Oncotarget, 2015Co-Authors: Fengfei Wang, Kruttika Bhat, Saeed Salem, Adrian M Dubuc, Marc Remke, Ekokobe Fonkem, Vijay Ramaswamy, Eric T Wong, Shuang Zhou, Hongbing ZhangAbstract:Over-expression of PDGF receptors (PDGFRs) has been previously implicated in high-risk medulloblastoma (MB) pathogenesis. However, the exact Biological functions of PDGFRα and PDGFRβ signaling in MB biology remain poorly understood. Here, we report the subgroup specific expression of PDGFRα and PDGFRβ and their associated Biological pathways in MB tumors. c-MYC, a downstream Target of PDGFRβ but not PDGFRα, is involved in PDGFRβ signaling associated with cell proliferation, cell death, and invasion. Concurrent inhibition of PDGFRβ and c-MYC blocks MB cell proliferation and migration synergistically. Integrated analysis of miRNA and miRNA Targets regulated by both PDGFRβ and c-MYC reveals that increased expression of JAG2, a Target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in MB patients. Our study may resolve the controversy on the role of PDGFRs in MB and unveils JAG2 as a key downstream effector of a PDGFRβ-driven signaling cascade and a potential therapeutic Target.
Federico Caobelli - One of the best experts on this subject based on the ideXlab platform.
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positron emission tomography with computed tomography imaging pet ct for the radiotherapy planning definition of the Biological Target volume part 1
Critical Reviews in Oncology Hematology, 2019Co-Authors: Pierpaolo Alongi, Riccardo Laudicella, Laura Evangelista, Lorenza Marino, Isacco Desideri, Agostino Chiaravalloti, Paolo Borghetti, Natale Quartuccio, M Fiore, Federico CaobelliAbstract:Abstract Aim Functional and molecular imaging, including positron emission tomography with computed tomography imaging (PET/CT) is increasing for radiotherapy (RT) definition of the Target volume. This expert review summarizes existing data of functional imaging modalities and RT management, in terms of Target volume delineation, for the following anatomical districts: brain (for primary and secondary tumors), head/neck and lung. Materials and methods A collection of available published data was made, by PubMed a search. Only original articles were carefully and critically revised. Results For primary and secondary brain tumors, amino acid PET radiotracers could be useful to identify microscopic residual areas and to differ between recurrence and treatment-related alterations in case of re-irradiation. As for head and neck neoplasms may benefit from precise PET/CT-based Target delineation, due to the major capability to identify high-risk RT areas. In primary and secondary lung cancer, PET/CT could be useful both to delimit a tumor and collapsed lungs and as a predictive parameter of treatment response. Conclusion Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic care going forward. Nevertheless, several uncertainties remain on the standard method to properly assess the Target volume definition including PET information for primary and secondary brain tumors.
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positron emission tomography with computed tomography imaging pet ct for the radiotherapy planning definition of the Biological Target volume part 2
Critical Reviews in Oncology Hematology, 2019Co-Authors: Alba Fiorentino, Riccardo Laudicella, Elisa Ciurlia, Salvatore Annunziata, Valentina Lancellotta, Paola Mapelli, Carmelo Tuscano, Federico Caobelli, Laura Evangelista, Lorenza MarinoAbstract:Abstract Aim Positron Emission Tomography with Computed Tomography (PET/CT) has been proven to be useful in the definition of Radiotherapy (RT) Target volume. In this regard, the present expert review summarizes existing data for pancreas, prostate, gynecological and rectum/anal cancer. Methods A comprehensive search of published original article was made, based on SCOPUS and PubMed database, selecting the paper that evaluated the role of PET/CT in the definition of RT volume. Results FDG-PET has an important and promising role for pancreatic cancer. Choline PET/CT could be useful for identifying high-risk volumes for prostate cancer; while PSMA PET/CT is still under evaluation. FDG PET/CT in gynecological cancers has been shown to impact external-beam RT planning. The role of FDG-PET for Gross Tumor volume identification is crucial, representing a useful and powerful tool for anal and rectal cancer. Conclusion Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic approach.
Lorenza Marino - One of the best experts on this subject based on the ideXlab platform.
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positron emission tomography with computed tomography imaging pet ct for the radiotherapy planning definition of the Biological Target volume part 1
Critical Reviews in Oncology Hematology, 2019Co-Authors: Pierpaolo Alongi, Riccardo Laudicella, Laura Evangelista, Lorenza Marino, Isacco Desideri, Agostino Chiaravalloti, Paolo Borghetti, Natale Quartuccio, M Fiore, Federico CaobelliAbstract:Abstract Aim Functional and molecular imaging, including positron emission tomography with computed tomography imaging (PET/CT) is increasing for radiotherapy (RT) definition of the Target volume. This expert review summarizes existing data of functional imaging modalities and RT management, in terms of Target volume delineation, for the following anatomical districts: brain (for primary and secondary tumors), head/neck and lung. Materials and methods A collection of available published data was made, by PubMed a search. Only original articles were carefully and critically revised. Results For primary and secondary brain tumors, amino acid PET radiotracers could be useful to identify microscopic residual areas and to differ between recurrence and treatment-related alterations in case of re-irradiation. As for head and neck neoplasms may benefit from precise PET/CT-based Target delineation, due to the major capability to identify high-risk RT areas. In primary and secondary lung cancer, PET/CT could be useful both to delimit a tumor and collapsed lungs and as a predictive parameter of treatment response. Conclusion Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic care going forward. Nevertheless, several uncertainties remain on the standard method to properly assess the Target volume definition including PET information for primary and secondary brain tumors.
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positron emission tomography with computed tomography imaging pet ct for the radiotherapy planning definition of the Biological Target volume part 2
Critical Reviews in Oncology Hematology, 2019Co-Authors: Alba Fiorentino, Riccardo Laudicella, Elisa Ciurlia, Salvatore Annunziata, Valentina Lancellotta, Paola Mapelli, Carmelo Tuscano, Federico Caobelli, Laura Evangelista, Lorenza MarinoAbstract:Abstract Aim Positron Emission Tomography with Computed Tomography (PET/CT) has been proven to be useful in the definition of Radiotherapy (RT) Target volume. In this regard, the present expert review summarizes existing data for pancreas, prostate, gynecological and rectum/anal cancer. Methods A comprehensive search of published original article was made, based on SCOPUS and PubMed database, selecting the paper that evaluated the role of PET/CT in the definition of RT volume. Results FDG-PET has an important and promising role for pancreatic cancer. Choline PET/CT could be useful for identifying high-risk volumes for prostate cancer; while PSMA PET/CT is still under evaluation. FDG PET/CT in gynecological cancers has been shown to impact external-beam RT planning. The role of FDG-PET for Gross Tumor volume identification is crucial, representing a useful and powerful tool for anal and rectal cancer. Conclusion Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic approach.
Fengfei Wang - One of the best experts on this subject based on the ideXlab platform.
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abstract 3551 a microrna 1280 jag2 network comprises a novel Biological Target in high risk medulloblastoma
Cancer Research, 2015Co-Authors: Fengfei Wang, Kruttika Bhat, Saeed Salem, Adrian M Dubuc, Marc Remke, Ekokobe Fonkem, Vijay Ramaswamy, Eric T Wong, Shuang Zhou, Hongbing ZhangAbstract:Over-expression of PDGF receptors (PDGFRs) has been previously implicated in high-risk medulloblastoma (MB) pathogenesis. However, the exact Biological functions of PDGFRα and PDGFRβ signaling in MB biology remain poorly understood. Here, we report the subgroup specific expression of PDGFRα and PDGFRβ and their associated Biological pathways in MB tumors. c-MYC, a downstream Target of PDGFRβ but not PDGFRα, is involved in PDGFRβ signaling associated with cell proliferation, cell death, and invasion. Concurrent inhibition of PDGFRβ and c-MYC blocks MB cell proliferation and migration synergistically. Integrated analysis of miRNA and miRNA Targets regulated by both PDGFRβ and c-MYC reveals that increased expression of JAG2, a Target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in MB patients. Our study may resolve the controversy on the role of PDGFRs in MB and unveils JAG2 as a key downstream effector of a PDGFRβ-driven signaling cascade and a potential therapeutic Target. Citation Format: Fengfei Wang, Marc Remke, Kruttika Bhat, Eric Wong, Shuang Zhou, Vijay Ramaswamy, Adrian Dubuc, Ekokobe Fonkem, Saeed Salem, Hongbing Zhang, Tze-chen Hsieh, Stephen O9Rourke, Lizi Wu, David Li, Cynthia Hawkins, Isaac Kohane, Joseph Wu, Min Wu, Michael Taylor, Erxi Wu. A microRNA-1280/JAG2 network comprises a novel Biological Target in high-risk medulloblastoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3551. doi:10.1158/1538-7445.AM2015-3551
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a microrna 1280 jag2 network comprises a novel Biological Target in high risk medulloblastoma
Oncotarget, 2015Co-Authors: Fengfei Wang, Kruttika Bhat, Saeed Salem, Adrian M Dubuc, Marc Remke, Ekokobe Fonkem, Vijay Ramaswamy, Eric T Wong, Shuang Zhou, Hongbing ZhangAbstract:Over-expression of PDGF receptors (PDGFRs) has been previously implicated in high-risk medulloblastoma (MB) pathogenesis. However, the exact Biological functions of PDGFRα and PDGFRβ signaling in MB biology remain poorly understood. Here, we report the subgroup specific expression of PDGFRα and PDGFRβ and their associated Biological pathways in MB tumors. c-MYC, a downstream Target of PDGFRβ but not PDGFRα, is involved in PDGFRβ signaling associated with cell proliferation, cell death, and invasion. Concurrent inhibition of PDGFRβ and c-MYC blocks MB cell proliferation and migration synergistically. Integrated analysis of miRNA and miRNA Targets regulated by both PDGFRβ and c-MYC reveals that increased expression of JAG2, a Target of miR-1280, is associated with high metastatic dissemination at diagnosis and a poor outcome in MB patients. Our study may resolve the controversy on the role of PDGFRs in MB and unveils JAG2 as a key downstream effector of a PDGFRβ-driven signaling cascade and a potential therapeutic Target.
Kichiro Koshida - One of the best experts on this subject based on the ideXlab platform.
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the use of positron emission tomography computed tomography imaging in radiation therapy a phantom study for setting internal Target volume of Biological Target volume
Radiation Oncology, 2015Co-Authors: Wataru Kawakami, Akihiro Takemura, Kunihiko Yokoyama, Kenichi Nakajima, Syoichi Yokoyama, Kichiro KoshidaAbstract:Background Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is an important method for detecting tumours, planning radiotherapy treatment, and evaluating treatment responses. However, using the standardized uptake value (SUV) threshold with PET imaging may be suitable not to determine gross tumour volume but to determine Biological Target volume (BTV). The aim of this study was to extract internal Target volume of BTV from PET images.
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the use of positron emission tomography computed tomography imaging in radiation therapy a phantom study for setting internal Target volume of Biological Target volume
Radiation Oncology, 2015Co-Authors: Wataru Kawakami, Akihiro Takemura, Kunihiko Yokoyama, Kenichi Nakajima, Syoichi Yokoyama, Kichiro KoshidaAbstract:Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) is an important method for detecting tumours, planning radiotherapy treatment, and evaluating treatment responses. However, using the standardized uptake value (SUV) threshold with PET imaging may be suitable not to determine gross tumour volume but to determine Biological Target volume (BTV). The aim of this study was to extract internal Target volume of BTV from PET images. Three spherical densities of 18F-FDG were employed in a phantom with an air or water background with repetitive motion amplitudes of 0–30 mm. The PET data were reconstructed with attenuation correction (AC) based on CT images obtained by slow CT scanning (SCS) or helical CT scanning (HCS). The errors in measured SUVmax and volumes calculated using SUV threshold values based on SUVmax (THmax) in experiments performed with varying extents of respiratory motion and AC were analysed. A partial volume effect (PVE) was not observed in spheres with diameters of ≥ 28 mm. When calculating SUVmax and THmax, using SCS for AC yielded smaller variance than using HCS (p < 0.05). For spheres of 37- and 28-mm diameters in the phantom with either an air or water background, significant differences were observed when mean THmax of 30-, 20-, or 10-mm amplitude were compared with the stationary conditions (p < 0.05). The average THmax values for 37-mm and 28-mm spheres with an air background were 0.362 and 0.352 in non-motion, respectively, and the mean THmax values for 37-mm and 28-mm spheres with a water background were 0.404 and 0.387 in non-motion and 0.244 and 0.263 in motion, respectively. When the phantom background was air, regardless of sphere concentration or size, THmax was dependent only on motion amplitude. We found that there was no PVE for spheres with ≥ 28-mm diameters, and differences between SUVmax and THmax were reduced by using SCS for AC. In the head-and-neck and the abdomen, the standard values of THmax were 0.25 and 0.40 with and without respiratory movement, respectively. In the lungs, the value of THmax became the approximate expression depending on motion amplitude.