Biomedical Application

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Erlin Zhang - One of the best experts on this subject based on the ideXlab platform.

  • the antibacterial properties and biocompatibility of a ti cu sintered alloy for Biomedical Application
    Biomedical Materials, 2014
    Co-Authors: Xinxin Zhang, Erlin Zhang, Ke Yang, Hongying Wang, Fangbing Li, Muqin Li
    Abstract:

    The antibacterial activity, the cytotoxicity and the cell function of a sintered Ti-10?wt% Cu alloy were investigated in order to assess the suitability of the alloy for Biomedical Application. The antibacterial activity of the alloy was investigated by a plate-count method and the cytotoxicity was studied by examining the MG63 cell response by CCK8 assessment. The cell function was monitored by measuring the AKP activity. The Cu ion released from the Ti?Cu alloy was also measured by an inductively coupled plasma spectrometer at different immersion durations. The results show that the antibacterial rates of the alloy against Escherichia coli and Staphylococcus aureus increase with an increase in the incubation duration. After 7?h of incubation, the alloy showed an antibacterial rate of 91.66% against S. aureus and 99. 01% against E. coli. With a further extension of incubation time to 24?h, the antibacterial rate increased to 100% against S. aureus and 99.93% against E. coli. No cytotoxicity was observed on the alloy by a CKK8 test during three days of incubation in comparison with commercially available pure titanium (cp-Ti). AKP test results showed a significantly high AKP value (p = 0.001 < 0.01) on the Ti?Cu alloy on day 1. The Cu ion release was thought to contribute to the strong antibacterial property, but the Cu ion did not lead to cell cytotoxicity. Strong antibacterial activity and good cell biocompatibility suggest that the Ti?Cu alloy could reduce bacterial infection and have a potential Application as an implant material.

  • microstructure corrosion properties and bio compatibility of calcium zinc phosphate coating on pure iron for Biomedical Application
    Materials Science and Engineering: C, 2014
    Co-Authors: Haiyan Chen, Erlin Zhang, Ke Yang
    Abstract:

    Abstract In order to improve the biocompatibility and the corrosion resistance in the initial stage of implantation, a phosphate (CaZn2(PO4)2 · 2H2O) coating was obtained on the surface of pure iron by a chemical reaction method. The anti-corrosion property, the blood compatibility and the cell toxicity of the coated pure iron specimens were investigated. The coating was composed of some fine phosphate crystals and the surface of coating was flat and dense enough. The electrochemical data indicated that the corrosion resistance of the coated pure iron was improved with the increase of phosphating time. When the specimen was phosphated for 30 min, the corrosion resistance (Rp) increased to 8006 Ω. Compared with that of the naked pure iron, the anti-hemolysis property and cell compatibility of the coated specimen was improved significantly, while the anti-coagulant property became slightly worse due to the existence of element calcium. It was thought that phosphating treatment might be an effective method to improve the biocompatibility of pure iron for Biomedical Application.

  • effects of zn on the microstructure mechanical property and bio corrosion property of mg 3ca alloys for Biomedical Application
    Materials Chemistry and Physics, 2011
    Co-Authors: Hui Du, Erlin Zhang
    Abstract:

    Abstract The effects of the addition of Zn element on the microstructures, mechanical properties and bio-corrosion properties of Mg–3Ca alloys are investigated. The microstructure and X-ray diffraction topography indicate that as-cast Mg–3Ca alloys are composed of primary Mg and eutectic (α-Mg + Mg2Ca) phases, while Mg–3Ca–2Zn alloys are constituted of primary Mg and eutectic (α-Mg + Mg2Ca + Ca2Mg6Zn3) phases. Mechanical properties results show that the element Zn could improve both tensile strength and elongation of Mg–3Ca alloys. The ultimate tensile strength is enhanced by 22%. Meanwhile, the corrosion resistance is increased by the addition of Zn element. It is thought that the presence of Ca2Mg6Zn3 phase mainly contributes to these improvements. Mg–3Ca–2Zn alloy provides moderate strength and excellent corrosion resistance for Biomedical Application.

  • biocorrosion behavior of magnesium alloy in different simulated fluids for Biomedical Application
    Materials Science and Engineering: C, 2009
    Co-Authors: Lei Yang, Erlin Zhang
    Abstract:

    Abstract The biocorrosion behavior of a magnesium alloy in two simulated body solutions, Hank's solution and simulated blood plasma (SBP) solution was investigated by electrochemical and weight loss testing for Biomedical Application. The solution volume/surface area (SV/SA) ratio was changed to reveal the effect of immersion condition on the biocorrosion behavior. A same tendency was observed in the corrosion rate of magnesium alloy in all testing conditions: a high corrosion rate at the initial stage, and rapid decrease in the first 2–3 days followed by a stable corrosion rate in the following stage. A higher corrosion rate was observed in Hank's solution than in SBP solution due to high Cl−, low Ca2+ and PO43− concentration in Hank's solution. However, no difference in the surface reaction product was observed between the samples immersed in Hank's solution and in SBP solution. It was found that the SV/SA ratio significantly affected the corrosion rate of magnesium alloy. Low ratio resulted in a high pH, which resisted the corrosion. But when the ratio was high enough, 6.7 for example, the influence was negligible. By changing the ratio, the biocorrosion behavior of magnesium implant in different implantation sites can be simulated, for example, low ratio for the case of in muscle and high ratio for the case of in marrow cavity. It is suggested that selection of the simulated solution and the SV/SA ratio would be very necessary to simulate different the in-vivo biodegradation behavior of magnesium in different implantation environment.

  • microstructure mechanical and corrosion properties and biocompatibility of mg zn mn alloys for Biomedical Application
    Materials Science and Engineering: C, 2009
    Co-Authors: Erlin Zhang, Liping Xu, Lei Yang, Ke Yang
    Abstract:

    Mn and Zn were selected to develop a Mg-Zn-Mn magnesium alloy for Biomedical Application due to the good biocompatibility of Zn and Mn elements. Microstructure, mechanical properties, corrosion properties and biocompatibility of the Mg-Zn-Mn alloys have been investigated by use of optical microscope, scanning electron microscope, tensile testing, and blood hemolysis and cell toxicity. Microstructure observation has shown that the addition of Zn and the extrusion significantly refined the grain size of both the as-cast and the extruded magnesium alloys, which mainly contributes to the high tensile strength and good elongation. Polarization test has shown Zn could accelerate the formation of a passivation film, which provides good protection to the magnesium alloy against simulate body fluid. Cell culture and hemolysis tests have shown that the magnesium alloy did not have cell toxicity, showing good cytocompatibility, but the alloy caused hemolysis to blood system. It was suggested that surface modification have to be adopted to improve the blood compatibility of the magnesium alloy for the Application in blood environment. (C) 2008 Elsevier B.V. All rights reserved.

Xiabin Jing - One of the best experts on this subject based on the ideXlab platform.

  • biodegradable synthetic polymers preparation functionalization and Biomedical Application
    Progress in Polymer Science, 2012
    Co-Authors: Huayu Tian, Xiuli Zhuang, Xuesi Chen, Zhaohui Tang, Xiabin Jing
    Abstract:

    Abstract Biodegradable polymers have been widely used and have greatly promoted the development of Biomedical fields because of their biocompatibility and biodegradability. The development of biotechnology and medical technology has set higher requirements for Biomedical materials. Novel biodegradable polymers with specific properties are in great demand. Biodegradable polymers can be classified as natural or synthetic polymers according to the source. Synthetic biodegradable polymers have found more versatile and diverse Biomedical Applications owing to their tailorable designs or modifications. This review presents a comprehensive introduction to various types of synthetic biodegradable polymers with reactive groups and bioactive groups, and further describes their structure, preparation procedures and properties. The focus is on advances in the past decade in functionalization and responsive strategies of biodegradable polymers and their Biomedical Applications. The possible future developments of the materials are also discussed.

  • Biodegradable synthetic polymers: Preparation, functionalization and Biomedical Application
    Progress in Polymer Science (Oxford), 2012
    Co-Authors: Huayu Tian, Xiuli Zhuang, Xuesi Chen, Zhaohui Tang, Xiabin Jing
    Abstract:

    Biodegradable polymers have been widely used and have greatly promoted the development of Biomedical fields because of their biocompatibility and biodegradability. The development of biotechnology and medical technology has set higher requirements for Biomedical materials. Novel biodegradable polymers with specific properties are in great demand. Biodegradable polymers can be classified as natural or synthetic polymers according to the source. Synthetic biodegradable polymers have found more versatile and diverse Biomedical Applications owing to their tailorable designs or modifications. This review presents a comprehensive introduction to various types of synthetic biodegradable polymers with reactive groups and bioactive groups, and further describes their structure, preparation procedures and properties. The focus is on advances in the past decade in functionalization and responsive strategies of biodegradable polymers and their Biomedical Applications. The possible future developments of the materials are also discussed. © 2011 Elsevier Ltd. All rights reserved.

Huayu Tian - One of the best experts on this subject based on the ideXlab platform.

  • biodegradable synthetic polymers preparation functionalization and Biomedical Application
    Progress in Polymer Science, 2012
    Co-Authors: Huayu Tian, Xiuli Zhuang, Xuesi Chen, Zhaohui Tang, Xiabin Jing
    Abstract:

    Abstract Biodegradable polymers have been widely used and have greatly promoted the development of Biomedical fields because of their biocompatibility and biodegradability. The development of biotechnology and medical technology has set higher requirements for Biomedical materials. Novel biodegradable polymers with specific properties are in great demand. Biodegradable polymers can be classified as natural or synthetic polymers according to the source. Synthetic biodegradable polymers have found more versatile and diverse Biomedical Applications owing to their tailorable designs or modifications. This review presents a comprehensive introduction to various types of synthetic biodegradable polymers with reactive groups and bioactive groups, and further describes their structure, preparation procedures and properties. The focus is on advances in the past decade in functionalization and responsive strategies of biodegradable polymers and their Biomedical Applications. The possible future developments of the materials are also discussed.

  • Biodegradable synthetic polymers: Preparation, functionalization and Biomedical Application
    Progress in Polymer Science (Oxford), 2012
    Co-Authors: Huayu Tian, Xiuli Zhuang, Xuesi Chen, Zhaohui Tang, Xiabin Jing
    Abstract:

    Biodegradable polymers have been widely used and have greatly promoted the development of Biomedical fields because of their biocompatibility and biodegradability. The development of biotechnology and medical technology has set higher requirements for Biomedical materials. Novel biodegradable polymers with specific properties are in great demand. Biodegradable polymers can be classified as natural or synthetic polymers according to the source. Synthetic biodegradable polymers have found more versatile and diverse Biomedical Applications owing to their tailorable designs or modifications. This review presents a comprehensive introduction to various types of synthetic biodegradable polymers with reactive groups and bioactive groups, and further describes their structure, preparation procedures and properties. The focus is on advances in the past decade in functionalization and responsive strategies of biodegradable polymers and their Biomedical Applications. The possible future developments of the materials are also discussed. © 2011 Elsevier Ltd. All rights reserved.

Denni Kurniawan - One of the best experts on this subject based on the ideXlab platform.

  • development of highly porous biodegradable γ fe2o3 polyvinyl alcohol nanofiber mats using electrospinning process for Biomedical Application
    Materials Science and Engineering: C, 2017
    Co-Authors: Nor Hasrul Akhmal Ngadiman, Noordin Mohd Yusof, Ani Idris, Effaliza Misran, Denni Kurniawan
    Abstract:

    The use of electrospinning process in fabricating tissue engineering scaffolds has received great attention in recent years due to its simplicity. The nanofibers produced via electrospinning possessed morphological characteristics similar to extracellular matrix of most tissue components. Porosity plays a vital role in developing tissue engineering scaffolds because it influences the biocompatibility performance of the scaffolds. In this study, maghemite (γ-Fe2O3) was mixed with polyvinyl alcohol (PVA) and subsequently electrospun to produce nanofibers. Five factors; nanoparticles content, voltage, flow rate, spinning distance, and rotating speed were varied to produce the electrospun nanofibrous mats with high porosity value. Empirical model was developed using response surface methodology to analyze the effect of these factors to the porosity. The results revealed that the optimum porosity (90.85%) was obtained using 5% w/v nanoparticle content, 35 kV of voltage, 1.1 ml/h volume flow rate of solution, 8 cm spinning distance and 2455 rpm of rotating speed. The empirical model was verified successfully by performing confirmation experiments. The properties of optimum PVA/γ-Fe2O3 nanofiber mats such as fiber diameter, mechanical properties, and contact angle were investigated. In addition, cytocompatibility test, in vitro degradation rate, and MTT assay were also performed. Results revealed that high porosity biodegradable γ-Fe2O3/polyvinyl alcohol nanofiber mats have low mechanical properties but good degradation rates and cytocompatibility properties. Thus, they are suitable for low load bearing Biomedical Application or soft tissue engineering scaffold.

  • Development of highly porous biodegradable γ-Fe2O3/polyvinyl alcohol nanofiber mats using electrospinning process for Biomedical Application.
    Materials Science and Engineering: C, 2016
    Co-Authors: Nor Hasrul Akhmal Ngadiman, Noordin Mohd Yusof, Ani Idris, Effaliza Misran, Denni Kurniawan
    Abstract:

    The use of electrospinning process in fabricating tissue engineering scaffolds has received great attention in recent years due to its simplicity. The nanofibers produced via electrospinning possessed morphological characteristics similar to extracellular matrix of most tissue components. Porosity plays a vital role in developing tissue engineering scaffolds because it influences the biocompatibility performance of the scaffolds. In this study, maghemite (γ-Fe2O3) was mixed with polyvinyl alcohol (PVA) and subsequently electrospun to produce nanofibers. Five factors; nanoparticles content, voltage, flow rate, spinning distance, and rotating speed were varied to produce the electrospun nanofibrous mats with high porosity value. Empirical model was developed using response surface methodology to analyze the effect of these factors to the porosity. The results revealed that the optimum porosity (90.85%) was obtained using 5% w/v nanoparticle content, 35 kV of voltage, 1.1 ml/h volume flow rate of solution, 8 cm spinning distance and 2455 rpm of rotating speed. The empirical model was verified successfully by performing confirmation experiments. The properties of optimum PVA/γ-Fe2O3 nanofiber mats such as fiber diameter, mechanical properties, and contact angle were investigated. In addition, cytocompatibility test, in vitro degradation rate, and MTT assay were also performed. Results revealed that high porosity biodegradable γ-Fe2O3/polyvinyl alcohol nanofiber mats have low mechanical properties but good degradation rates and cytocompatibility properties. Thus, they are suitable for low load bearing Biomedical Application or soft tissue engineering scaffold.

Lei Yang - One of the best experts on this subject based on the ideXlab platform.

  • biocorrosion behavior of magnesium alloy in different simulated fluids for Biomedical Application
    Materials Science and Engineering: C, 2009
    Co-Authors: Lei Yang, Erlin Zhang
    Abstract:

    Abstract The biocorrosion behavior of a magnesium alloy in two simulated body solutions, Hank's solution and simulated blood plasma (SBP) solution was investigated by electrochemical and weight loss testing for Biomedical Application. The solution volume/surface area (SV/SA) ratio was changed to reveal the effect of immersion condition on the biocorrosion behavior. A same tendency was observed in the corrosion rate of magnesium alloy in all testing conditions: a high corrosion rate at the initial stage, and rapid decrease in the first 2–3 days followed by a stable corrosion rate in the following stage. A higher corrosion rate was observed in Hank's solution than in SBP solution due to high Cl−, low Ca2+ and PO43− concentration in Hank's solution. However, no difference in the surface reaction product was observed between the samples immersed in Hank's solution and in SBP solution. It was found that the SV/SA ratio significantly affected the corrosion rate of magnesium alloy. Low ratio resulted in a high pH, which resisted the corrosion. But when the ratio was high enough, 6.7 for example, the influence was negligible. By changing the ratio, the biocorrosion behavior of magnesium implant in different implantation sites can be simulated, for example, low ratio for the case of in muscle and high ratio for the case of in marrow cavity. It is suggested that selection of the simulated solution and the SV/SA ratio would be very necessary to simulate different the in-vivo biodegradation behavior of magnesium in different implantation environment.

  • microstructure mechanical and corrosion properties and biocompatibility of mg zn mn alloys for Biomedical Application
    Materials Science and Engineering: C, 2009
    Co-Authors: Erlin Zhang, Liping Xu, Lei Yang, Ke Yang
    Abstract:

    Mn and Zn were selected to develop a Mg-Zn-Mn magnesium alloy for Biomedical Application due to the good biocompatibility of Zn and Mn elements. Microstructure, mechanical properties, corrosion properties and biocompatibility of the Mg-Zn-Mn alloys have been investigated by use of optical microscope, scanning electron microscope, tensile testing, and blood hemolysis and cell toxicity. Microstructure observation has shown that the addition of Zn and the extrusion significantly refined the grain size of both the as-cast and the extruded magnesium alloys, which mainly contributes to the high tensile strength and good elongation. Polarization test has shown Zn could accelerate the formation of a passivation film, which provides good protection to the magnesium alloy against simulate body fluid. Cell culture and hemolysis tests have shown that the magnesium alloy did not have cell toxicity, showing good cytocompatibility, but the alloy caused hemolysis to blood system. It was suggested that surface modification have to be adopted to improve the blood compatibility of the magnesium alloy for the Application in blood environment. (C) 2008 Elsevier B.V. All rights reserved.

  • microstructure mechanical properties and bio corrosion properties of mg zn mn ca alloy for Biomedical Application
    Materials Science and Engineering A-structural Materials Properties Microstructure and Processing, 2008
    Co-Authors: Erlin Zhang, Lei Yang
    Abstract:

    Abstract Microstructure, mechanical properties and bio-corrosion properties of as-cast Mg–Zn–Mn–Ca alloys were investigated for Biomedical Application in detail by optical microscopy, scanning electronic microscopy (SEM), mechanical properties testing and electrochemical measurement. SEM and optical microscopy observation indicated that the grain size of the as-cast alloys significantly decreased with the increasing of Ca content up to 0.5 wt.%. Further increasing of Ca content did not refine the grain more. The phase constitute was mainly controlled by the atomic ratio of Zn to Ca. When the ratio was more than 1.0–1.2, the alloy was mainly composed of primary Mg and lamellar eutectic (α-Mg + Ca 2 Mg 6 Zn 3 ), while the alloy was composed of primary Mg and divorced eutectic (α-Mg + Mg 2 Ca + Ca 2 Mg 6 Zn 3 ) when the atomic ratio was less than 1.0–1.2. The yield strength of the as-cast alloy increased but the elongation and the tensile strength increased first and then decreased with the increasing of Ca content. It was thought that Mg 2 Ca phase deteriorated the tensile strength and ductility. Electrochemical measurements indicated that Mg 2 Ca phase improved the corrosion resistance of the as-cast alloy.