The Experts below are selected from a list of 2454 Experts worldwide ranked by ideXlab platform

Xiurong Yang - One of the best experts on this subject based on the ideXlab platform.

  • establishment of logic gates based on conformational changes in a multiple factor Biomolecule Interaction process by dual polarization interferometry
    Analytical Chemistry, 2019
    Co-Authors: Shuang Wang, Jiahui Zhao, Jianshe Huang, Xiurong Yang
    Abstract:

    DNA-based logic gates stimulate the development of molecular scale computers and show enormous potential in nanotechnology, biotechnology, and medicine. However, the reported detectors to date usually require one to label appropriate signal probes, resulting in not only a high cost but also potentially tedious manipulation. For the first time, we established a label-free logic gate by regarding the structure-related signal as output. Dual polarization interferometry (DPI) was employed to reveal the detailed conformational transitions occurring in the multiple-factor Biomolecule Interactions and then was utilized as a detection tool of logic gate. As a vital merit of this system, the dependence of the density output signal on the Interaction with multiple-factor input can mimic the function of signal communication in OR, INHIBIT, and IDENTITY logic gates and the INHIBIT-OR cascade circuit. Additionally, the DPI signal with logic stringency can unambiguously distinguish conformational polymorphisms and compare structural stability. This study provides a new way for the construction of a label-free logic gate, supplements information deficiency of reaction details, and extends the application of DPI in logic operation.

  • Establishment of Logic Gates Based on Conformational Changes in a Multiple-Factor Biomolecule Interaction Process by Dual Polarization Interferometry
    2019
    Co-Authors: Shuang Wang, Jiahui Zhao, Jianshe Huang, Xiurong Yang
    Abstract:

    DNA-based logic gates stimulate the development of molecular scale computers and show enormous potential in nanotechnology, biotechnology, and medicine. However, the reported detectors to date usually require one to label appropriate signal probes, resulting in not only a high cost but also potentially tedious manipulation. For the first time, we established a label-free logic gate by regarding the structure-related signal as output. Dual polarization interferometry (DPI) was employed to reveal the detailed conformational transitions occurring in the multiple-factor Biomolecule Interactions and then was utilized as a detection tool of logic gate. As a vital merit of this system, the dependence of the density output signal on the Interaction with multiple-factor input can mimic the function of signal communication in OR, INHIBIT, and IDENTITY logic gates and the INHIBIT–OR cascade circuit. Additionally, the DPI signal with logic stringency can unambiguously distinguish conformational polymorphisms and compare structural stability. This study provides a new way for the construction of a label-free logic gate, supplements information deficiency of reaction details, and extends the application of DPI in logic operation

Shuang Wang - One of the best experts on this subject based on the ideXlab platform.

  • establishment of logic gates based on conformational changes in a multiple factor Biomolecule Interaction process by dual polarization interferometry
    Analytical Chemistry, 2019
    Co-Authors: Shuang Wang, Jiahui Zhao, Jianshe Huang, Xiurong Yang
    Abstract:

    DNA-based logic gates stimulate the development of molecular scale computers and show enormous potential in nanotechnology, biotechnology, and medicine. However, the reported detectors to date usually require one to label appropriate signal probes, resulting in not only a high cost but also potentially tedious manipulation. For the first time, we established a label-free logic gate by regarding the structure-related signal as output. Dual polarization interferometry (DPI) was employed to reveal the detailed conformational transitions occurring in the multiple-factor Biomolecule Interactions and then was utilized as a detection tool of logic gate. As a vital merit of this system, the dependence of the density output signal on the Interaction with multiple-factor input can mimic the function of signal communication in OR, INHIBIT, and IDENTITY logic gates and the INHIBIT-OR cascade circuit. Additionally, the DPI signal with logic stringency can unambiguously distinguish conformational polymorphisms and compare structural stability. This study provides a new way for the construction of a label-free logic gate, supplements information deficiency of reaction details, and extends the application of DPI in logic operation.

  • Establishment of Logic Gates Based on Conformational Changes in a Multiple-Factor Biomolecule Interaction Process by Dual Polarization Interferometry
    2019
    Co-Authors: Shuang Wang, Jiahui Zhao, Jianshe Huang, Xiurong Yang
    Abstract:

    DNA-based logic gates stimulate the development of molecular scale computers and show enormous potential in nanotechnology, biotechnology, and medicine. However, the reported detectors to date usually require one to label appropriate signal probes, resulting in not only a high cost but also potentially tedious manipulation. For the first time, we established a label-free logic gate by regarding the structure-related signal as output. Dual polarization interferometry (DPI) was employed to reveal the detailed conformational transitions occurring in the multiple-factor Biomolecule Interactions and then was utilized as a detection tool of logic gate. As a vital merit of this system, the dependence of the density output signal on the Interaction with multiple-factor input can mimic the function of signal communication in OR, INHIBIT, and IDENTITY logic gates and the INHIBIT–OR cascade circuit. Additionally, the DPI signal with logic stringency can unambiguously distinguish conformational polymorphisms and compare structural stability. This study provides a new way for the construction of a label-free logic gate, supplements information deficiency of reaction details, and extends the application of DPI in logic operation

Jiahui Zhao - One of the best experts on this subject based on the ideXlab platform.

  • establishment of logic gates based on conformational changes in a multiple factor Biomolecule Interaction process by dual polarization interferometry
    Analytical Chemistry, 2019
    Co-Authors: Shuang Wang, Jiahui Zhao, Jianshe Huang, Xiurong Yang
    Abstract:

    DNA-based logic gates stimulate the development of molecular scale computers and show enormous potential in nanotechnology, biotechnology, and medicine. However, the reported detectors to date usually require one to label appropriate signal probes, resulting in not only a high cost but also potentially tedious manipulation. For the first time, we established a label-free logic gate by regarding the structure-related signal as output. Dual polarization interferometry (DPI) was employed to reveal the detailed conformational transitions occurring in the multiple-factor Biomolecule Interactions and then was utilized as a detection tool of logic gate. As a vital merit of this system, the dependence of the density output signal on the Interaction with multiple-factor input can mimic the function of signal communication in OR, INHIBIT, and IDENTITY logic gates and the INHIBIT-OR cascade circuit. Additionally, the DPI signal with logic stringency can unambiguously distinguish conformational polymorphisms and compare structural stability. This study provides a new way for the construction of a label-free logic gate, supplements information deficiency of reaction details, and extends the application of DPI in logic operation.

  • Establishment of Logic Gates Based on Conformational Changes in a Multiple-Factor Biomolecule Interaction Process by Dual Polarization Interferometry
    2019
    Co-Authors: Shuang Wang, Jiahui Zhao, Jianshe Huang, Xiurong Yang
    Abstract:

    DNA-based logic gates stimulate the development of molecular scale computers and show enormous potential in nanotechnology, biotechnology, and medicine. However, the reported detectors to date usually require one to label appropriate signal probes, resulting in not only a high cost but also potentially tedious manipulation. For the first time, we established a label-free logic gate by regarding the structure-related signal as output. Dual polarization interferometry (DPI) was employed to reveal the detailed conformational transitions occurring in the multiple-factor Biomolecule Interactions and then was utilized as a detection tool of logic gate. As a vital merit of this system, the dependence of the density output signal on the Interaction with multiple-factor input can mimic the function of signal communication in OR, INHIBIT, and IDENTITY logic gates and the INHIBIT–OR cascade circuit. Additionally, the DPI signal with logic stringency can unambiguously distinguish conformational polymorphisms and compare structural stability. This study provides a new way for the construction of a label-free logic gate, supplements information deficiency of reaction details, and extends the application of DPI in logic operation

Jianshe Huang - One of the best experts on this subject based on the ideXlab platform.

  • establishment of logic gates based on conformational changes in a multiple factor Biomolecule Interaction process by dual polarization interferometry
    Analytical Chemistry, 2019
    Co-Authors: Shuang Wang, Jiahui Zhao, Jianshe Huang, Xiurong Yang
    Abstract:

    DNA-based logic gates stimulate the development of molecular scale computers and show enormous potential in nanotechnology, biotechnology, and medicine. However, the reported detectors to date usually require one to label appropriate signal probes, resulting in not only a high cost but also potentially tedious manipulation. For the first time, we established a label-free logic gate by regarding the structure-related signal as output. Dual polarization interferometry (DPI) was employed to reveal the detailed conformational transitions occurring in the multiple-factor Biomolecule Interactions and then was utilized as a detection tool of logic gate. As a vital merit of this system, the dependence of the density output signal on the Interaction with multiple-factor input can mimic the function of signal communication in OR, INHIBIT, and IDENTITY logic gates and the INHIBIT-OR cascade circuit. Additionally, the DPI signal with logic stringency can unambiguously distinguish conformational polymorphisms and compare structural stability. This study provides a new way for the construction of a label-free logic gate, supplements information deficiency of reaction details, and extends the application of DPI in logic operation.

  • Establishment of Logic Gates Based on Conformational Changes in a Multiple-Factor Biomolecule Interaction Process by Dual Polarization Interferometry
    2019
    Co-Authors: Shuang Wang, Jiahui Zhao, Jianshe Huang, Xiurong Yang
    Abstract:

    DNA-based logic gates stimulate the development of molecular scale computers and show enormous potential in nanotechnology, biotechnology, and medicine. However, the reported detectors to date usually require one to label appropriate signal probes, resulting in not only a high cost but also potentially tedious manipulation. For the first time, we established a label-free logic gate by regarding the structure-related signal as output. Dual polarization interferometry (DPI) was employed to reveal the detailed conformational transitions occurring in the multiple-factor Biomolecule Interactions and then was utilized as a detection tool of logic gate. As a vital merit of this system, the dependence of the density output signal on the Interaction with multiple-factor input can mimic the function of signal communication in OR, INHIBIT, and IDENTITY logic gates and the INHIBIT–OR cascade circuit. Additionally, the DPI signal with logic stringency can unambiguously distinguish conformational polymorphisms and compare structural stability. This study provides a new way for the construction of a label-free logic gate, supplements information deficiency of reaction details, and extends the application of DPI in logic operation

Niall Barron - One of the best experts on this subject based on the ideXlab platform.

  • Interaction of plasma deposited hmdso based coatings with fibrinogen and human blood plasma the correlation between bulk plasma surface characteristics and Biomolecule Interaction
    Plasma Processes and Polymers, 2010
    Co-Authors: Ram P Gandhiraman, Mohan Kumar Muniyappa, Magdalena M Dudek, Conor Coyle, Cedric Volcke, Anthony J Killard, Paul Burham, Stephen Daniels, Niall Barron
    Abstract:

    The success of a biomaterial depends on the nature of Interaction and the progressive reaction between the biological components and the surface of the biomaterial. In order to control the Interaction between the biomaterial and biological component, it is necessary to understand the factors that influence the protein adsorption and cell proliferation. Surface chemistry plays a crucial role in the success of any blood contacting biomaterial. Plasma enhanced chemical vapour deposition (PECVD) is an interesting commonly used technique for tailoring surface characteristics while retaining bulk material properties. Two different films, namely polymer-like and silica-like coatings, with varying surface characteristics have been deposited from hexamethyldisiloxane, by PECVD, on 316L stainless steel. A correlation between the bulk plasma, interfacial adhesion of the coating to 316L steel, surface characteristics and Biomolecule Interaction is presented in this work The interfacial adhesion strength analysis demonstrated that silica-like coatings have higher adhesion strength to 316L stainless steel than polymer-like coatings, caused due to the formation of a strong Fe-O-Si and Cr-O-Si bonds. It was observed that the effect of nanoscale surface roughness (dose to 6 nm) was less significant, and that the surface chemistry played a significant role in governing the fibrinogen adsorption. Highest fibrinogen adsorption on plain steel was due to the electrostatic Interaction of the metal oxide layer with the protein Hydrophobicity of the polymer like film resulted in a higher fibrinogen binding than the silica-like films.