The Experts below are selected from a list of 99 Experts worldwide ranked by ideXlab platform
R De Crevoisier - One of the best experts on this subject based on the ideXlab platform.
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2020Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:International audienceBackground: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2016Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Background: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution.
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SU-E-P-42: Benefit of Equivalent Uniform Dose in Prostate IMRT Planning to Reduce Bladder Toxicity
Medical Physics, 2015Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Purpose: To assess the benefit of Bladder wall sub-volume equivalent uniform dose (EUD) constrains in prostate cancer IMRT planning Methods: The Bladder wall was defined by the volume between the external manually delineated wall and a contraction of 7 mm from this external wall. This Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. Two IMRT plans, with and without using EUD constraints, were generated and compared for 53 prostate cancer patients, to deliver 80Gy to the prostate PTV (V95>95%). In the plan with EUD constraints, the values of the “a” parameter of the EUD models were: 10.0 for bla-in and 2.3 for bla-ex., and 5 for the rectum. Results: The use of Bladder EUD objectives increased significantly the conformal index (0.73±0.04 vs. 0.93±0.02) and decreased both the doses in the Bladder wall (V70: 22.66% vs. 18.88%, Dmean: 39.40Gy vs. 35.04Gy) and the Bladder wall NTCP values (NTCP at 3 years Bladder toxicity >= LENT/SOMA Grade2: 16.68% vs. 14.48%, NTCP at 3 years Bladder Bleeding: 7.16% vs. 5.88%, NTCP at 5 years Bladder toxicity >= LENT/SOMA Grade2: 20.15% vs. 17.75%, NTCP at 5 years Bladder Bleeding: 10.38% vs. 8.36%). The use of Bladder EUD objectives, although slightly decreasing the dose to the rectum wall (Dmax: 75.19Gy vs. 75.05Gy, V72: 12.95Gy vs. 12.72Gy) as well, increased however the dose in the femoral heads (V55-femoral head left: 0.06% vs. 0.30%, V55-femoral head right: 0.04% vs. 0.21%). Conclusion: Separating Bladder wall into two parts with appropriate Bladder EUD objectives may reduce Bladder toxicity, while keeping high dose to the prostate.
A Simon - One of the best experts on this subject based on the ideXlab platform.
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2020Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:International audienceBackground: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2016Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Background: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution.
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SU-E-P-42: Benefit of Equivalent Uniform Dose in Prostate IMRT Planning to Reduce Bladder Toxicity
Medical Physics, 2015Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Purpose: To assess the benefit of Bladder wall sub-volume equivalent uniform dose (EUD) constrains in prostate cancer IMRT planning Methods: The Bladder wall was defined by the volume between the external manually delineated wall and a contraction of 7 mm from this external wall. This Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. Two IMRT plans, with and without using EUD constraints, were generated and compared for 53 prostate cancer patients, to deliver 80Gy to the prostate PTV (V95>95%). In the plan with EUD constraints, the values of the “a” parameter of the EUD models were: 10.0 for bla-in and 2.3 for bla-ex., and 5 for the rectum. Results: The use of Bladder EUD objectives increased significantly the conformal index (0.73±0.04 vs. 0.93±0.02) and decreased both the doses in the Bladder wall (V70: 22.66% vs. 18.88%, Dmean: 39.40Gy vs. 35.04Gy) and the Bladder wall NTCP values (NTCP at 3 years Bladder toxicity >= LENT/SOMA Grade2: 16.68% vs. 14.48%, NTCP at 3 years Bladder Bleeding: 7.16% vs. 5.88%, NTCP at 5 years Bladder toxicity >= LENT/SOMA Grade2: 20.15% vs. 17.75%, NTCP at 5 years Bladder Bleeding: 10.38% vs. 8.36%). The use of Bladder EUD objectives, although slightly decreasing the dose to the rectum wall (Dmax: 75.19Gy vs. 75.05Gy, V72: 12.95Gy vs. 12.72Gy) as well, increased however the dose in the femoral heads (V55-femoral head left: 0.06% vs. 0.30%, V55-femoral head right: 0.04% vs. 0.21%). Conclusion: Separating Bladder wall into two parts with appropriate Bladder EUD objectives may reduce Bladder toxicity, while keeping high dose to the prostate.
Baosheng Li - One of the best experts on this subject based on the ideXlab platform.
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2020Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:International audienceBackground: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2016Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Background: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution.
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SU-E-P-42: Benefit of Equivalent Uniform Dose in Prostate IMRT Planning to Reduce Bladder Toxicity
Medical Physics, 2015Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Purpose: To assess the benefit of Bladder wall sub-volume equivalent uniform dose (EUD) constrains in prostate cancer IMRT planning Methods: The Bladder wall was defined by the volume between the external manually delineated wall and a contraction of 7 mm from this external wall. This Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. Two IMRT plans, with and without using EUD constraints, were generated and compared for 53 prostate cancer patients, to deliver 80Gy to the prostate PTV (V95>95%). In the plan with EUD constraints, the values of the “a” parameter of the EUD models were: 10.0 for bla-in and 2.3 for bla-ex., and 5 for the rectum. Results: The use of Bladder EUD objectives increased significantly the conformal index (0.73±0.04 vs. 0.93±0.02) and decreased both the doses in the Bladder wall (V70: 22.66% vs. 18.88%, Dmean: 39.40Gy vs. 35.04Gy) and the Bladder wall NTCP values (NTCP at 3 years Bladder toxicity >= LENT/SOMA Grade2: 16.68% vs. 14.48%, NTCP at 3 years Bladder Bleeding: 7.16% vs. 5.88%, NTCP at 5 years Bladder toxicity >= LENT/SOMA Grade2: 20.15% vs. 17.75%, NTCP at 5 years Bladder Bleeding: 10.38% vs. 8.36%). The use of Bladder EUD objectives, although slightly decreasing the dose to the rectum wall (Dmax: 75.19Gy vs. 75.05Gy, V72: 12.95Gy vs. 12.72Gy) as well, increased however the dose in the femoral heads (V55-femoral head left: 0.06% vs. 0.30%, V55-femoral head right: 0.04% vs. 0.21%). Conclusion: Separating Bladder wall into two parts with appropriate Bladder EUD objectives may reduce Bladder toxicity, while keeping high dose to the prostate.
J Castelli - One of the best experts on this subject based on the ideXlab platform.
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2020Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:International audienceBackground: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2016Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Background: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution.
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SU-E-P-42: Benefit of Equivalent Uniform Dose in Prostate IMRT Planning to Reduce Bladder Toxicity
Medical Physics, 2015Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Purpose: To assess the benefit of Bladder wall sub-volume equivalent uniform dose (EUD) constrains in prostate cancer IMRT planning Methods: The Bladder wall was defined by the volume between the external manually delineated wall and a contraction of 7 mm from this external wall. This Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. Two IMRT plans, with and without using EUD constraints, were generated and compared for 53 prostate cancer patients, to deliver 80Gy to the prostate PTV (V95>95%). In the plan with EUD constraints, the values of the “a” parameter of the EUD models were: 10.0 for bla-in and 2.3 for bla-ex., and 5 for the rectum. Results: The use of Bladder EUD objectives increased significantly the conformal index (0.73±0.04 vs. 0.93±0.02) and decreased both the doses in the Bladder wall (V70: 22.66% vs. 18.88%, Dmean: 39.40Gy vs. 35.04Gy) and the Bladder wall NTCP values (NTCP at 3 years Bladder toxicity >= LENT/SOMA Grade2: 16.68% vs. 14.48%, NTCP at 3 years Bladder Bleeding: 7.16% vs. 5.88%, NTCP at 5 years Bladder toxicity >= LENT/SOMA Grade2: 20.15% vs. 17.75%, NTCP at 5 years Bladder Bleeding: 10.38% vs. 8.36%). The use of Bladder EUD objectives, although slightly decreasing the dose to the rectum wall (Dmax: 75.19Gy vs. 75.05Gy, V72: 12.95Gy vs. 12.72Gy) as well, increased however the dose in the femoral heads (V55-femoral head left: 0.06% vs. 0.30%, V55-femoral head right: 0.04% vs. 0.21%). Conclusion: Separating Bladder wall into two parts with appropriate Bladder EUD objectives may reduce Bladder toxicity, while keeping high dose to the prostate.
O Acosta - One of the best experts on this subject based on the ideXlab platform.
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2020Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:International audienceBackground: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution
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The benefit of using Bladder sub-volume equivalent uniform dose constraints in prostate intensity-modulated radiotherapy planning
OncoTargets and Therapy, 2016Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Background: To assess the benefits of Bladder wall sub-volume equivalent uniform dose (EUD) constraints in prostate cancer intensity-modulated radiotherapy (IMRT) planning. Methods: Two IMRT plans, with and without EUD constraints on the Bladder wall, were generated using beams that deliver 80 Gy to the prostate and 46 Gy to the seminal vesicles and were compared in 53 prostate cancer patients. The Bladder wall was defined as the volume between the external manually delineated wall and a contraction of 7 mm apart from it. The Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. In the IMRT plan with EUD constraints, the values of "a" parameter for the EUD models were 10.0 for bla-in and 2.3 for bla-ex. The plans with and without EUD constraints were compared in terms of dose-volume histograms, 5-year Bladder and rectum normal tissue complication probability values, as well as tumor control probability (TCP) values. Results: The use of Bladder sub-volume EUD constraints decreased both the doses to the Bladder wall (V-70: 22.76% vs 19.65%, D-mean: 39.82 Gy vs 35.45 Gy) and the 5-year Bladder complication probabilities (>= LENT/SOMA Grade 2: 20.35% vs 17.96%; Bladder Bleeding: 10.63% vs 8.64%). The doses to the rectum wall and the rectum complication probabilities were also slightly decreased by the EUD constraints compared to physical constraints only. The minimal dose and the V-76Gy of PTVprostate were, however, slightly decreased by EUD optimization, nevertheless without significant difference in TCP values between the two plans, and the PTV parameters finally respected the Groupe d'Etude des Tumeurs Uro-Genitales recommendations. Conclusion: Separating the Bladder wall into two parts with appropriate EUD optimization may reduce Bladder toxicity in prostate IMRT. Combining biological constraints with physical constraints in the organs at risk at the inverse planning step of IMRT may improve the dose distribution.
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SU-E-P-42: Benefit of Equivalent Uniform Dose in Prostate IMRT Planning to Reduce Bladder Toxicity
Medical Physics, 2015Co-Authors: A Simon, P Haigron, C Lafond, O Acosta, J Castelli, Baosheng Li, R De CrevoisierAbstract:Purpose: To assess the benefit of Bladder wall sub-volume equivalent uniform dose (EUD) constrains in prostate cancer IMRT planning Methods: The Bladder wall was defined by the volume between the external manually delineated wall and a contraction of 7 mm from this external wall. This Bladder wall was then separated into two parts: the internal-Bladder wall (bla-in) represented by the portion of the Bladder wall that intersected with the planning target volume (PTV) plus 5 mm extension; the external-Bladder wall (bla-ex) represented by the remaining part of the Bladder wall. Two IMRT plans, with and without using EUD constraints, were generated and compared for 53 prostate cancer patients, to deliver 80Gy to the prostate PTV (V95>95%). In the plan with EUD constraints, the values of the “a” parameter of the EUD models were: 10.0 for bla-in and 2.3 for bla-ex., and 5 for the rectum. Results: The use of Bladder EUD objectives increased significantly the conformal index (0.73±0.04 vs. 0.93±0.02) and decreased both the doses in the Bladder wall (V70: 22.66% vs. 18.88%, Dmean: 39.40Gy vs. 35.04Gy) and the Bladder wall NTCP values (NTCP at 3 years Bladder toxicity >= LENT/SOMA Grade2: 16.68% vs. 14.48%, NTCP at 3 years Bladder Bleeding: 7.16% vs. 5.88%, NTCP at 5 years Bladder toxicity >= LENT/SOMA Grade2: 20.15% vs. 17.75%, NTCP at 5 years Bladder Bleeding: 10.38% vs. 8.36%). The use of Bladder EUD objectives, although slightly decreasing the dose to the rectum wall (Dmax: 75.19Gy vs. 75.05Gy, V72: 12.95Gy vs. 12.72Gy) as well, increased however the dose in the femoral heads (V55-femoral head left: 0.06% vs. 0.30%, V55-femoral head right: 0.04% vs. 0.21%). Conclusion: Separating Bladder wall into two parts with appropriate Bladder EUD objectives may reduce Bladder toxicity, while keeping high dose to the prostate.
