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Zine-eddine Khene - One of the best experts on this subject based on the ideXlab platform.
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Urinary TIMP‐2 and MMP‐2 are significantly associated with poor Bladder Compliance in adult patients with spina bifida
Neurourology and urodynamics, 2019Co-Authors: B. Peyronnet, C. Richard, Claude Bendavid, Florian Naudet, J. Hascoet, Charlène Brochard, Nelly Senal, M. Jezequel, Quentin Alimi, Zine-eddine KheneAbstract:AIMS To assess the predictive values of six urinary markers (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], matrix metalloproteinase 2 [MMP-2], tissue inhibitor metalloproteinase 2 [TIMP-2], transformation growth factor β-1 [TGF-B1], and prostaglandin 2 [PGE2]) for adverse urodynamic features and for upper urinary tract damage in adult patients with spina bifida. MATERIALS AND METHODS A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult patients with spina bifida seen for urodynamic testing. The urine was collected and stored at -80°C. A urodynamic and an upper urinary tract were systematically performed. At the end of the inclusion period, urines were defrosted and urinary nerve growth factor, BDNF, TIMP-2, and TGF-B1 were assessed using validated ELISA kits. The urinary markers levels were adjusted on the urinary creatinine level. Urinary MMP-2 levels were assessed by zymography. RESULTS Fourty patients were included. Only TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance (P = .043 and P = .039, respectively). TIMP-2 was also the only urinary marker significantly associated with upper urinary tract damage on imaging (OR = 19.81; P = .02). Of all urodynamic parameters, Bladder Compliance and maximum detrusor pressure were the only ones associated with upper urinary tract damage on imaging (P = .01 and P = .02), The diagnostic performances of urinary TIMP-2 for upper urinary tract damage were slightly superior to PdetMax and Bladder Compliance with an area under the curve of 0.72. CONCLUSION Urinary TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance and urinary TIMP-2 was significantly associated with upper urinary tract damage. These findings support a pathophysiological role of extracellular matrix remodeling in poor Bladder Compliance of adult patients with spina bifida.
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urinary timp 2 and mmp 2 are significantly associated with poor Bladder Compliance in adult patients with spina bifida
Neurourology and Urodynamics, 2019Co-Authors: B. Peyronnet, C. Richard, Claude Bendavid, Florian Naudet, J. Hascoet, Charlène Brochard, Nelly Senal, M. Jezequel, Quentin Alimi, Zine-eddine KheneAbstract:AIMS To assess the predictive values of six urinary markers (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], matrix metalloproteinase 2 [MMP-2], tissue inhibitor metalloproteinase 2 [TIMP-2], transformation growth factor β-1 [TGF-B1], and prostaglandin 2 [PGE2]) for adverse urodynamic features and for upper urinary tract damage in adult patients with spina bifida. MATERIALS AND METHODS A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult patients with spina bifida seen for urodynamic testing. The urine was collected and stored at -80°C. A urodynamic and an upper urinary tract were systematically performed. At the end of the inclusion period, urines were defrosted and urinary nerve growth factor, BDNF, TIMP-2, and TGF-B1 were assessed using validated ELISA kits. The urinary markers levels were adjusted on the urinary creatinine level. Urinary MMP-2 levels were assessed by zymography. RESULTS Fourty patients were included. Only TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance (P = .043 and P = .039, respectively). TIMP-2 was also the only urinary marker significantly associated with upper urinary tract damage on imaging (OR = 19.81; P = .02). Of all urodynamic parameters, Bladder Compliance and maximum detrusor pressure were the only ones associated with upper urinary tract damage on imaging (P = .01 and P = .02), The diagnostic performances of urinary TIMP-2 for upper urinary tract damage were slightly superior to PdetMax and Bladder Compliance with an area under the curve of 0.72. CONCLUSION Urinary TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance and urinary TIMP-2 was significantly associated with upper urinary tract damage. These findings support a pathophysiological role of extracellular matrix remodeling in poor Bladder Compliance of adult patients with spina bifida.
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Contrast-enhanced CT texture parameters as predictive markers of high-risk urodynamic features in adult patients with spina bifida
Urology, 2019Co-Authors: Zine-eddine Khene, Charlène Brochard, Quentin Alimi, Claire Richard, Juliette Hascoet, Anis Gasmi, Anna Goujon, Magali Jezequel, Laurent Siproudhis, Guillaume BouguenAbstract:OBJECTIVE : To investigate computed tomography (CT) texture analysis of the Bladder wall as a predictor of urodynamics findings in adult patient with spina bifida. METHODS : A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult spina bifida patients seen for urodynamic testing. A contrast-enhanced abdominal CT was systematically performed in all patients during the same visit. Texture features of the Bladder wall related to the gray-level histogram and gray-level co-occurrence were evaluated on CT images. Multivariate analysis was performed to identify independent predictors of poor Bladder Compliance and detrusor overactivity among clinical and texture parameters. RESULTS : Fourty patients were included. The Lasso penalized logistic regression analysis identified 2 texture parameters as potential predictors of poor Bladder Compliance: Skewness (coefficient weight, -1.81) and S.1.1.SumVarnc (coefficient weight, -3.52). Multivariate logistic regression analysis confirmed skewness (odds ratio [confidence interval 95%] = 0.40 [0.14, 0.97], P = .04) as an independent predictor of poor Bladder Compliance. The Lasso penalized logistic regression analysis identified one texture parameters as potential predictor of detrusor overactivity: Kurtosis (coefficient weight, -3.52), which was confirmed in multivariate logistic regression analysis (odds ratio [confidence interval 95%] = 1.12 [1.01, 1.55], P = .02). CONCLUSION : Our findings demonstrate that CT texture analysis of the Bladder wall might be an interesting tool to identify spina bifida patients with high risk urodynamic features.
Edward J Mcguire - One of the best experts on this subject based on the ideXlab platform.
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obstructive uropathy induced Bladder dysfunction can be reversible Bladder Compliance measures before and after treatment
The Journal of Urology, 2003Co-Authors: Wendy W Leng, Edward J McguireAbstract:ABSTRACT Purpose We demonstrated that abnormal Bladder Compliance in the setting of obstructive uropathy can be improved by relief of Bladder outlet obstruction. Materials and Methods A cohort of 9 men with nonneurogenic lower urinary tract symptoms and videourodynamics proven Bladder outlet obstruction were identified prospectively from a university urology practice. Study exclusion criteria ensured absence of active urinary infection, hematuria and neurourological pathology. Testing specifically focused on assessment of the Bladder Compliance curve, and a Compliance value was calculated (ml./cm. H 2 O). Treatment intervention consisted of transurethral incisions or resection of the prostate in 8 cases and transurethral balloon dilation of a urethral stricture in 1. Followup videourodynamics testing was performed 1 month after treatment to confirm relief of outlet obstruction and reassess Bladder Compliance. Results Mean patient age was 75.2 ± 6.16 years. Pretreatment mean Bladder Compliance ± SE was 3.06 ± 0.45 ml./cm. H 2 O. At 1 month after treatment videourodynamics testing confirmed relief of obstruction in the cohort. Posttreatment mean Bladder Compliance ± SE was 13.53 ± 0.45 ml./cm. H 2 O. Nonparametric paired t test analysis determined that the difference between pretreatment and posttreatment Bladder Compliance was statistically significant at p=0.0117. Conclusions This pilot study suggests that relief of obstructive uropathy even in elderly patients with long-standing lower urinary tract symptoms, can significantly improve Bladder Compliance.
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Decreased Bladder Compliance in patients with myelomeningocele treated with radiological observation
The Journal of urology, 1996Co-Authors: Ariel Kaufman, Michael L. Ritchey, Andrew C. Roberts, Delbert C. Rudy, Edward J McguireAbstract:AbstractPurpose: Recently others advocated frequent radiological surveillance to detect upper urinary tract deterioration in children with neurogenic Bladder secondary to spina bifida. We reviewed the consequences of such expectant management on Bladder Compliance and urinary continence.Materials and Methods: We retrospectively reviewed the records of 214 children presenting to our spina bifida clinic in a 13-year period. Followup is available for 95 girls and 86 boys. Imaging studies of the kidneys were repeated at 6 to 12-month intervals. Urodynamics were performed when upper urinary tracts deteriorated or in incontinent school age children.Results: On radiographic study there was evidence of upper urinary tract deterioration in 79 children, including hydronephrosis in 34, hydronephrosis and vesicoureteral reflux in 19, and reflux only in 26. Followup studies performed after clean intermittent catheterization and pharmacological therapy were instituted revealed resolution or improvement of upper tract d...
Quentin Alimi - One of the best experts on this subject based on the ideXlab platform.
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Urinary TIMP‐2 and MMP‐2 are significantly associated with poor Bladder Compliance in adult patients with spina bifida
Neurourology and urodynamics, 2019Co-Authors: B. Peyronnet, C. Richard, Claude Bendavid, Florian Naudet, J. Hascoet, Charlène Brochard, Nelly Senal, M. Jezequel, Quentin Alimi, Zine-eddine KheneAbstract:AIMS To assess the predictive values of six urinary markers (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], matrix metalloproteinase 2 [MMP-2], tissue inhibitor metalloproteinase 2 [TIMP-2], transformation growth factor β-1 [TGF-B1], and prostaglandin 2 [PGE2]) for adverse urodynamic features and for upper urinary tract damage in adult patients with spina bifida. MATERIALS AND METHODS A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult patients with spina bifida seen for urodynamic testing. The urine was collected and stored at -80°C. A urodynamic and an upper urinary tract were systematically performed. At the end of the inclusion period, urines were defrosted and urinary nerve growth factor, BDNF, TIMP-2, and TGF-B1 were assessed using validated ELISA kits. The urinary markers levels were adjusted on the urinary creatinine level. Urinary MMP-2 levels were assessed by zymography. RESULTS Fourty patients were included. Only TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance (P = .043 and P = .039, respectively). TIMP-2 was also the only urinary marker significantly associated with upper urinary tract damage on imaging (OR = 19.81; P = .02). Of all urodynamic parameters, Bladder Compliance and maximum detrusor pressure were the only ones associated with upper urinary tract damage on imaging (P = .01 and P = .02), The diagnostic performances of urinary TIMP-2 for upper urinary tract damage were slightly superior to PdetMax and Bladder Compliance with an area under the curve of 0.72. CONCLUSION Urinary TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance and urinary TIMP-2 was significantly associated with upper urinary tract damage. These findings support a pathophysiological role of extracellular matrix remodeling in poor Bladder Compliance of adult patients with spina bifida.
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urinary timp 2 and mmp 2 are significantly associated with poor Bladder Compliance in adult patients with spina bifida
Neurourology and Urodynamics, 2019Co-Authors: B. Peyronnet, C. Richard, Claude Bendavid, Florian Naudet, J. Hascoet, Charlène Brochard, Nelly Senal, M. Jezequel, Quentin Alimi, Zine-eddine KheneAbstract:AIMS To assess the predictive values of six urinary markers (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], matrix metalloproteinase 2 [MMP-2], tissue inhibitor metalloproteinase 2 [TIMP-2], transformation growth factor β-1 [TGF-B1], and prostaglandin 2 [PGE2]) for adverse urodynamic features and for upper urinary tract damage in adult patients with spina bifida. MATERIALS AND METHODS A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult patients with spina bifida seen for urodynamic testing. The urine was collected and stored at -80°C. A urodynamic and an upper urinary tract were systematically performed. At the end of the inclusion period, urines were defrosted and urinary nerve growth factor, BDNF, TIMP-2, and TGF-B1 were assessed using validated ELISA kits. The urinary markers levels were adjusted on the urinary creatinine level. Urinary MMP-2 levels were assessed by zymography. RESULTS Fourty patients were included. Only TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance (P = .043 and P = .039, respectively). TIMP-2 was also the only urinary marker significantly associated with upper urinary tract damage on imaging (OR = 19.81; P = .02). Of all urodynamic parameters, Bladder Compliance and maximum detrusor pressure were the only ones associated with upper urinary tract damage on imaging (P = .01 and P = .02), The diagnostic performances of urinary TIMP-2 for upper urinary tract damage were slightly superior to PdetMax and Bladder Compliance with an area under the curve of 0.72. CONCLUSION Urinary TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance and urinary TIMP-2 was significantly associated with upper urinary tract damage. These findings support a pathophysiological role of extracellular matrix remodeling in poor Bladder Compliance of adult patients with spina bifida.
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Contrast-enhanced CT texture parameters as predictive markers of high-risk urodynamic features in adult patients with spina bifida
Urology, 2019Co-Authors: Zine-eddine Khene, Charlène Brochard, Quentin Alimi, Claire Richard, Juliette Hascoet, Anis Gasmi, Anna Goujon, Magali Jezequel, Laurent Siproudhis, Guillaume BouguenAbstract:OBJECTIVE : To investigate computed tomography (CT) texture analysis of the Bladder wall as a predictor of urodynamics findings in adult patient with spina bifida. METHODS : A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult spina bifida patients seen for urodynamic testing. A contrast-enhanced abdominal CT was systematically performed in all patients during the same visit. Texture features of the Bladder wall related to the gray-level histogram and gray-level co-occurrence were evaluated on CT images. Multivariate analysis was performed to identify independent predictors of poor Bladder Compliance and detrusor overactivity among clinical and texture parameters. RESULTS : Fourty patients were included. The Lasso penalized logistic regression analysis identified 2 texture parameters as potential predictors of poor Bladder Compliance: Skewness (coefficient weight, -1.81) and S.1.1.SumVarnc (coefficient weight, -3.52). Multivariate logistic regression analysis confirmed skewness (odds ratio [confidence interval 95%] = 0.40 [0.14, 0.97], P = .04) as an independent predictor of poor Bladder Compliance. The Lasso penalized logistic regression analysis identified one texture parameters as potential predictor of detrusor overactivity: Kurtosis (coefficient weight, -3.52), which was confirmed in multivariate logistic regression analysis (odds ratio [confidence interval 95%] = 1.12 [1.01, 1.55], P = .02). CONCLUSION : Our findings demonstrate that CT texture analysis of the Bladder wall might be an interesting tool to identify spina bifida patients with high risk urodynamic features.
Charlène Brochard - One of the best experts on this subject based on the ideXlab platform.
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Urinary TIMP‐2 and MMP‐2 are significantly associated with poor Bladder Compliance in adult patients with spina bifida
Neurourology and urodynamics, 2019Co-Authors: B. Peyronnet, C. Richard, Claude Bendavid, Florian Naudet, J. Hascoet, Charlène Brochard, Nelly Senal, M. Jezequel, Quentin Alimi, Zine-eddine KheneAbstract:AIMS To assess the predictive values of six urinary markers (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], matrix metalloproteinase 2 [MMP-2], tissue inhibitor metalloproteinase 2 [TIMP-2], transformation growth factor β-1 [TGF-B1], and prostaglandin 2 [PGE2]) for adverse urodynamic features and for upper urinary tract damage in adult patients with spina bifida. MATERIALS AND METHODS A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult patients with spina bifida seen for urodynamic testing. The urine was collected and stored at -80°C. A urodynamic and an upper urinary tract were systematically performed. At the end of the inclusion period, urines were defrosted and urinary nerve growth factor, BDNF, TIMP-2, and TGF-B1 were assessed using validated ELISA kits. The urinary markers levels were adjusted on the urinary creatinine level. Urinary MMP-2 levels were assessed by zymography. RESULTS Fourty patients were included. Only TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance (P = .043 and P = .039, respectively). TIMP-2 was also the only urinary marker significantly associated with upper urinary tract damage on imaging (OR = 19.81; P = .02). Of all urodynamic parameters, Bladder Compliance and maximum detrusor pressure were the only ones associated with upper urinary tract damage on imaging (P = .01 and P = .02), The diagnostic performances of urinary TIMP-2 for upper urinary tract damage were slightly superior to PdetMax and Bladder Compliance with an area under the curve of 0.72. CONCLUSION Urinary TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance and urinary TIMP-2 was significantly associated with upper urinary tract damage. These findings support a pathophysiological role of extracellular matrix remodeling in poor Bladder Compliance of adult patients with spina bifida.
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urinary timp 2 and mmp 2 are significantly associated with poor Bladder Compliance in adult patients with spina bifida
Neurourology and Urodynamics, 2019Co-Authors: B. Peyronnet, C. Richard, Claude Bendavid, Florian Naudet, J. Hascoet, Charlène Brochard, Nelly Senal, M. Jezequel, Quentin Alimi, Zine-eddine KheneAbstract:AIMS To assess the predictive values of six urinary markers (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], matrix metalloproteinase 2 [MMP-2], tissue inhibitor metalloproteinase 2 [TIMP-2], transformation growth factor β-1 [TGF-B1], and prostaglandin 2 [PGE2]) for adverse urodynamic features and for upper urinary tract damage in adult patients with spina bifida. MATERIALS AND METHODS A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult patients with spina bifida seen for urodynamic testing. The urine was collected and stored at -80°C. A urodynamic and an upper urinary tract were systematically performed. At the end of the inclusion period, urines were defrosted and urinary nerve growth factor, BDNF, TIMP-2, and TGF-B1 were assessed using validated ELISA kits. The urinary markers levels were adjusted on the urinary creatinine level. Urinary MMP-2 levels were assessed by zymography. RESULTS Fourty patients were included. Only TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance (P = .043 and P = .039, respectively). TIMP-2 was also the only urinary marker significantly associated with upper urinary tract damage on imaging (OR = 19.81; P = .02). Of all urodynamic parameters, Bladder Compliance and maximum detrusor pressure were the only ones associated with upper urinary tract damage on imaging (P = .01 and P = .02), The diagnostic performances of urinary TIMP-2 for upper urinary tract damage were slightly superior to PdetMax and Bladder Compliance with an area under the curve of 0.72. CONCLUSION Urinary TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance and urinary TIMP-2 was significantly associated with upper urinary tract damage. These findings support a pathophysiological role of extracellular matrix remodeling in poor Bladder Compliance of adult patients with spina bifida.
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Contrast-enhanced CT texture parameters as predictive markers of high-risk urodynamic features in adult patients with spina bifida
Urology, 2019Co-Authors: Zine-eddine Khene, Charlène Brochard, Quentin Alimi, Claire Richard, Juliette Hascoet, Anis Gasmi, Anna Goujon, Magali Jezequel, Laurent Siproudhis, Guillaume BouguenAbstract:OBJECTIVE : To investigate computed tomography (CT) texture analysis of the Bladder wall as a predictor of urodynamics findings in adult patient with spina bifida. METHODS : A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult spina bifida patients seen for urodynamic testing. A contrast-enhanced abdominal CT was systematically performed in all patients during the same visit. Texture features of the Bladder wall related to the gray-level histogram and gray-level co-occurrence were evaluated on CT images. Multivariate analysis was performed to identify independent predictors of poor Bladder Compliance and detrusor overactivity among clinical and texture parameters. RESULTS : Fourty patients were included. The Lasso penalized logistic regression analysis identified 2 texture parameters as potential predictors of poor Bladder Compliance: Skewness (coefficient weight, -1.81) and S.1.1.SumVarnc (coefficient weight, -3.52). Multivariate logistic regression analysis confirmed skewness (odds ratio [confidence interval 95%] = 0.40 [0.14, 0.97], P = .04) as an independent predictor of poor Bladder Compliance. The Lasso penalized logistic regression analysis identified one texture parameters as potential predictor of detrusor overactivity: Kurtosis (coefficient weight, -3.52), which was confirmed in multivariate logistic regression analysis (odds ratio [confidence interval 95%] = 1.12 [1.01, 1.55], P = .02). CONCLUSION : Our findings demonstrate that CT texture analysis of the Bladder wall might be an interesting tool to identify spina bifida patients with high risk urodynamic features.
B. Peyronnet - One of the best experts on this subject based on the ideXlab platform.
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Urinary TIMP‐2 and MMP‐2 are significantly associated with poor Bladder Compliance in adult patients with spina bifida
Neurourology and urodynamics, 2019Co-Authors: B. Peyronnet, C. Richard, Claude Bendavid, Florian Naudet, J. Hascoet, Charlène Brochard, Nelly Senal, M. Jezequel, Quentin Alimi, Zine-eddine KheneAbstract:AIMS To assess the predictive values of six urinary markers (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], matrix metalloproteinase 2 [MMP-2], tissue inhibitor metalloproteinase 2 [TIMP-2], transformation growth factor β-1 [TGF-B1], and prostaglandin 2 [PGE2]) for adverse urodynamic features and for upper urinary tract damage in adult patients with spina bifida. MATERIALS AND METHODS A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult patients with spina bifida seen for urodynamic testing. The urine was collected and stored at -80°C. A urodynamic and an upper urinary tract were systematically performed. At the end of the inclusion period, urines were defrosted and urinary nerve growth factor, BDNF, TIMP-2, and TGF-B1 were assessed using validated ELISA kits. The urinary markers levels were adjusted on the urinary creatinine level. Urinary MMP-2 levels were assessed by zymography. RESULTS Fourty patients were included. Only TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance (P = .043 and P = .039, respectively). TIMP-2 was also the only urinary marker significantly associated with upper urinary tract damage on imaging (OR = 19.81; P = .02). Of all urodynamic parameters, Bladder Compliance and maximum detrusor pressure were the only ones associated with upper urinary tract damage on imaging (P = .01 and P = .02), The diagnostic performances of urinary TIMP-2 for upper urinary tract damage were slightly superior to PdetMax and Bladder Compliance with an area under the curve of 0.72. CONCLUSION Urinary TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance and urinary TIMP-2 was significantly associated with upper urinary tract damage. These findings support a pathophysiological role of extracellular matrix remodeling in poor Bladder Compliance of adult patients with spina bifida.
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urinary timp 2 and mmp 2 are significantly associated with poor Bladder Compliance in adult patients with spina bifida
Neurourology and Urodynamics, 2019Co-Authors: B. Peyronnet, C. Richard, Claude Bendavid, Florian Naudet, J. Hascoet, Charlène Brochard, Nelly Senal, M. Jezequel, Quentin Alimi, Zine-eddine KheneAbstract:AIMS To assess the predictive values of six urinary markers (nerve growth factor [NGF], brain-derived neurotrophic factor [BDNF], matrix metalloproteinase 2 [MMP-2], tissue inhibitor metalloproteinase 2 [TIMP-2], transformation growth factor β-1 [TGF-B1], and prostaglandin 2 [PGE2]) for adverse urodynamic features and for upper urinary tract damage in adult patients with spina bifida. MATERIALS AND METHODS A single-center prospective trial was conducted from March 2015 to March 2017 including all consecutive adult patients with spina bifida seen for urodynamic testing. The urine was collected and stored at -80°C. A urodynamic and an upper urinary tract were systematically performed. At the end of the inclusion period, urines were defrosted and urinary nerve growth factor, BDNF, TIMP-2, and TGF-B1 were assessed using validated ELISA kits. The urinary markers levels were adjusted on the urinary creatinine level. Urinary MMP-2 levels were assessed by zymography. RESULTS Fourty patients were included. Only TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance (P = .043 and P = .039, respectively). TIMP-2 was also the only urinary marker significantly associated with upper urinary tract damage on imaging (OR = 19.81; P = .02). Of all urodynamic parameters, Bladder Compliance and maximum detrusor pressure were the only ones associated with upper urinary tract damage on imaging (P = .01 and P = .02), The diagnostic performances of urinary TIMP-2 for upper urinary tract damage were slightly superior to PdetMax and Bladder Compliance with an area under the curve of 0.72. CONCLUSION Urinary TIMP-2 and MMP-2 were significantly associated with poor Bladder Compliance and urinary TIMP-2 was significantly associated with upper urinary tract damage. These findings support a pathophysiological role of extracellular matrix remodeling in poor Bladder Compliance of adult patients with spina bifida.