The Experts below are selected from a list of 14880 Experts worldwide ranked by ideXlab platform
Helena Öborn - One of the best experts on this subject based on the ideXlab platform.
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Urinary tract infections and Bladder Dysfunction after renal transplantation in children.
The Journal of urology, 2007Co-Authors: Maria Herthelius, Helena ÖbornAbstract:Purpose: Urinary tract infection remains a major cause of morbidity in pediatric renal transplant recipients. In otherwise healthy children Bladder Dysfunction increases the susceptibility to urinary tract infection. The aims of this study were to determine whether Bladder Dysfunction affects the incidence of urinary tract infection after renal transplantation, and to assess the impact of recurrent urinary tract infections on graft function.Materials and Methods: We evaluated Bladder function with a questionnaire, uroflowmetry and Bladder ultrasound, and renal function with clearance of inulin or iohexol (glomerular filtration rate) in 68 recipients of renal transplants 5 to 20 years old, at 1 to 15 years after transplantation, with and without recurrent urinary tract infections.Results: Bladder Dysfunction was equally common in children with and without recurrent urinary tract infections (68% vs 74%, not significant). Therefore, it had no effect on the incidence of recurrent urinary tract infections. Gra...
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Bladder Dysfunction in children and adolescents after renal transplantation
Pediatric Nephrology, 2006Co-Authors: Maria Herthelius, Helena ÖbornAbstract:The underlying mechanisms of urinary-tract infections (UTI) in renal transplant recipients are still not fully understood. In otherwise healthy children, Bladder Dysfunction increases the susceptibility to UTI. The aim of this study was to evaluate lower-urinary-tract function in children and adolescents after renal transplantation. Sixty-eight recipients of renal transplants, 5–20 years of age and 1–15 years after transplantation, were evaluated for their Bladder function with a questionnaire, uroflowmetry and Bladder ultrasound, and for renal function (glomerular filtration rate) by measuring clearance of inulin or iohexol. Forty-nine patients (72%) had some type of abnormality of Bladder function. Abnormal Bladder capacity was found in 26%, abnormal urinary flow in 50% and residual urine in 32% of the patients. There was no significant difference in Bladder or renal function in children with urinary-tract malformations compared with those with normal urinary tract. Furthermore, there was no significant difference in renal function in patients with Bladder Dysfunction compared with those without. The incidence of Bladder Dysfunction is high in children and adolescents after renal transplantation, but the clinical significance of this finding and whether there is a correlation between Bladder Dysfunction and UTI in these patients need to be clarified further.
Yun Seob Song - One of the best experts on this subject based on the ideXlab platform.
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treatment of Bladder Dysfunction using stem cell or tissue engineering technique
Korean Journal of Urology, 2014Co-Authors: Yun Seob SongAbstract:Tissue engineering and stem cell transplantation are two important options that may help overcome limitations in the current treatment strategy for Bladder Dysfunction. Stem cell therapy holds great promise for treating pathophysiology, as well as for urological tissue engineering and regeneration. To date, stem cell therapy in urology has mainly focused on oncology and erectile Dysfunction. The therapeutic potency of stem cells (SCs) was originally thought to derive from their ability to differentiate into various cell types including smooth muscle. The main mechanisms of SCs in reconstituting or restoring Bladder function are migration, differentiation, and paracrine effects. Nowadays, paracrine effects of stem cells are thought to be more prominent because of their stimulating effects on stem cells and adjacent cells. Studies of stem cell therapy for Bladder Dysfunction have been limited to experimental models and have been less focused on tissue engineering for Bladder regeneration. Bladder outlet obstruction is a representative model. Adipose-derived stem cells, bone marrow stem cells (BMSCs), and skeletal muscle-derived stem cells or muscle precursor cells are used for transplantation to treat Bladder Dysfunction. The aim of this study is to review stem cell therapy and updated tissue regeneration as treatments for Bladder Dysfunction and to provide the current status of stem cell therapy and tissue engineering for Bladder Dysfunction including its mechanisms and limitations.
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Stem Cell Therapy in Bladder Dysfunction: Where Are We? And Where Do We Have to Go?
BioMed research international, 2013Co-Authors: Jae Heon Kim, Sang-rae Lee, Yun Seob Song, Hong Jun LeeAbstract:To date, stem cell therapy for the Bladder has been conducted mainly on an experimental basis in the areas of Bladder Dysfunction. The therapeutic efficacy of stem cells was originally thought to be derived from their ability to differentiate into various cell types. Studies about stem cell therapy for Bladder Dysfunction have been limited to an experimental basis and have been less focused than Bladder regeneration. Bladder Dysfunction was listed in MESH as “urinary Bladder neck obstruction”, “urinary Bladder, overactive”, and “urinary Bladder, neurogenic”. Using those keywords, several articles were searched and studied. The Bladder Dysfunction model includes Bladder outlet obstruction, cryoinjured, diabetes, ischemia, and spinal cord injury. Adipose derived stem cells (ADSCs), bone marrow stem cells (BMSCs), and skeletal muscle derived stem cells (SkMSCs) are used for transplantation to treat Bladder Dysfunction. The main mechanisms of stem cells to reconstitute or restore Bladder Dysfunction are migration, differentiation, and paracrine effects. The aim of this study is to review the stem cell therapy for Bladder Dysfunction and to provide the status of stem cell therapy for Bladder Dysfunction.
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stem cell therapy in Bladder Dysfunction where are we and where do we have to go
BioMed Research International, 2013Co-Authors: Jae Heon Kim, Sang-rae Lee, Yun Seob Song, Hong Jun LeeAbstract:To date, stem cell therapy for the Bladder has been conducted mainly on an experimental basis in the areas of Bladder Dysfunction. The therapeutic efficacy of stem cells was originally thought to be derived from their ability to differentiate into various cell types. Studies about stem cell therapy for Bladder Dysfunction have been limited to an experimental basis and have been less focused than Bladder regeneration. Bladder Dysfunction was listed in MESH as “urinary Bladder neck obstruction”, “urinary Bladder, overactive”, and “urinary Bladder, neurogenic”. Using those keywords, several articles were searched and studied. The Bladder Dysfunction model includes Bladder outlet obstruction, cryoinjured, diabetes, ischemia, and spinal cord injury. Adipose derived stem cells (ADSCs), bone marrow stem cells (BMSCs), and skeletal muscle derived stem cells (SkMSCs) are used for transplantation to treat Bladder Dysfunction. The main mechanisms of stem cells to reconstitute or restore Bladder Dysfunction are migration, differentiation, and paracrine effects. The aim of this study is to review the stem cell therapy for Bladder Dysfunction and to provide the status of stem cell therapy for Bladder Dysfunction.
Christopher Gonzalez - One of the best experts on this subject based on the ideXlab platform.
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Urethral Reconstruction in Patients with Neurogenic Bladder Dysfunction
Current Bladder Dysfunction Reports, 2010Co-Authors: Jessica T. Casey, Christopher GonzalezAbstract:Prolonged urethral catheterization can lead to significant urethral defects, including strictures, diverticula, erosions, and fistulas. Although it is a potentially challenging procedure, urethral reconstruction can allow patients with neurogenic Bladder Dysfunction to continue clean intermittent catheterization, improve or maintain their cosmetic appearance, and improve sexual function. There is a paucity of literature focusing specifically on urethral reconstruction in patients with neurogenic Bladder Dysfunction, with most studies involving small, heterogeneous populations. This article reviews published outcomes of urethral reconstruction and comments on the technical aspects of repair in patients with neurogenic Bladder Dysfunction.
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Urethral Reconstruction in Patients With Neurogenic Bladder Dysfunction
The Journal of urology, 2008Co-Authors: Jessica T. Casey, Bradley A. Erickson, Neema Navai, Lee C. Zhao, Joshua J. Meeks, Christopher GonzalezAbstract:Purpose: There is limited literature examining urethral reconstruction in patients with neurogenic Bladder Dysfunction. We describe our experience of urethral reconstruction in men with concurrent neurogenic Bladder.Materials and Methods: A prospectively maintained database of all urethral reconstruction procedures performed by 1 surgeon was analyzed for patients with neurogenic Bladder Dysfunction. Patient characteristics including the etiology of neurogenic Bladder, urethral pathology, urethral reconstructive technique, complications and recurrences were evaluated.Results: A total of 23 patients were included in the analysis. Urethral pathology included erosions (10), strictures (7), diverticula (3), urethrocutaneous fistulas (2), and a combination of diverticular and stricture disease (1). Median length of the urethral pathology was 5.0 cm (range 2.0 to 10.0). Overall urethral reconstruction was successful in 16 of 23 patients (69.6%) at a mean followup of 24.7 months (range 2 to 79). Success rates dif...
Maria Herthelius - One of the best experts on this subject based on the ideXlab platform.
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Urinary tract infections and Bladder Dysfunction after renal transplantation in children.
The Journal of urology, 2007Co-Authors: Maria Herthelius, Helena ÖbornAbstract:Purpose: Urinary tract infection remains a major cause of morbidity in pediatric renal transplant recipients. In otherwise healthy children Bladder Dysfunction increases the susceptibility to urinary tract infection. The aims of this study were to determine whether Bladder Dysfunction affects the incidence of urinary tract infection after renal transplantation, and to assess the impact of recurrent urinary tract infections on graft function.Materials and Methods: We evaluated Bladder function with a questionnaire, uroflowmetry and Bladder ultrasound, and renal function with clearance of inulin or iohexol (glomerular filtration rate) in 68 recipients of renal transplants 5 to 20 years old, at 1 to 15 years after transplantation, with and without recurrent urinary tract infections.Results: Bladder Dysfunction was equally common in children with and without recurrent urinary tract infections (68% vs 74%, not significant). Therefore, it had no effect on the incidence of recurrent urinary tract infections. Gra...
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Bladder Dysfunction in children and adolescents after renal transplantation
Pediatric Nephrology, 2006Co-Authors: Maria Herthelius, Helena ÖbornAbstract:The underlying mechanisms of urinary-tract infections (UTI) in renal transplant recipients are still not fully understood. In otherwise healthy children, Bladder Dysfunction increases the susceptibility to UTI. The aim of this study was to evaluate lower-urinary-tract function in children and adolescents after renal transplantation. Sixty-eight recipients of renal transplants, 5–20 years of age and 1–15 years after transplantation, were evaluated for their Bladder function with a questionnaire, uroflowmetry and Bladder ultrasound, and for renal function (glomerular filtration rate) by measuring clearance of inulin or iohexol. Forty-nine patients (72%) had some type of abnormality of Bladder function. Abnormal Bladder capacity was found in 26%, abnormal urinary flow in 50% and residual urine in 32% of the patients. There was no significant difference in Bladder or renal function in children with urinary-tract malformations compared with those with normal urinary tract. Furthermore, there was no significant difference in renal function in patients with Bladder Dysfunction compared with those without. The incidence of Bladder Dysfunction is high in children and adolescents after renal transplantation, but the clinical significance of this finding and whether there is a correlation between Bladder Dysfunction and UTI in these patients need to be clarified further.
J. Simón - One of the best experts on this subject based on the ideXlab platform.
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RENAL TRANSPLANTATION IN CHILDREN WITH SEVERE Bladder Dysfunction
The Journal of urology, 2005Co-Authors: Santiago Mendizábal, F. Estornell, I. Zamora, A. Sabater, F. García Ibarra, J. SimónAbstract:ABSTRACTPurpose: Renal transplantation in children with Bladder Dysfunction carries a risk for the renal graft. We report our experience with transplantation in 15 patients 6 to 18 years old with severe abnormalities of the lower urinary tract.Materials and Methods: A total of 18 renal transplants were performed in 15 children with Bladder Dysfunction secondary to myelomeningocele (3), occult spina bifida (1), malformation/agenesis of the sacrum (5), posterior urethral valves (4), female hypospadias (1) and Bladder exstrophy (1) between 1979 and 2003. Urological surgery was performed before transplantation in 14 cases—7 Bladder augmentations, 5 incontinent urinary conduits/reservoirs and 2 vesicostomies. Voiding was maintained by intermittent catheterization in 9 cases and incontinent ostomies in 6. Graft implantation was performed by extraperitoneal route with ureteral anastomosis to the native Bladder in cases of Bladder augmentation. Immunosuppression consisted of triple therapy with polyclonal/monoclo...