The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Richard J Landis - One of the best experts on this subject based on the ideXlab platform.
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painful bladder filling and painful urgency are distinct characteristics in men and women with Urological chronic pelvic pain syndromes a mapp research network study
The Journal of Urology, 2015Co-Authors: John N Krieger, Dedra Buchwald, Michel A Pontari, Richard J LandisAbstract:Purpose: We describe bladder associated symptoms in patients with Urological chronic pelvic pain syndromes. We correlated these symptoms with Urological, nonUrological, psychosocial and quality of life measures.Materials and Methods: Study participants included 233 women and 191 men with interstitial cystitis/bladder pain syndrome or chronic prostatitis/chronic pelvic pain syndrome in a multicenter study. They completed a battery of measures, including items asking whether pain worsened with bladder filling (painful filling) or whether the urge to urinate was due to pain, pressure or discomfort (painful urgency). Participants were categorized into 3 groups, including group 1—painful filling and painful urgency (both), 2—painful filling or painful urgency (either) and 3—no painful filling or painful urgency (neither).Results: Of the men 75% and of the women 88% were categorized as both or either. These bladder characteristics were associated with more severe Urological symptoms (increased pain, frequency a...
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relationship between chronic nonUrological associated somatic syndromes and symptom severity in Urological chronic pelvic pain syndromes baseline evaluation of the mapp study
The Journal of Urology, 2015Co-Authors: John N Krieger, Alisa Stephens, Richard J Landis, Quentin J Clemens, Karl Kreder, Niloofar Afari, Larissa Rodriguez, Anthony Schaeffer, Sean Mackey, Gerald L AndrioleAbstract:Purpose: We used MAPP data to identify participants with Urological chronic pelvic pain syndromes only or a chronic functional nonUrological associated somatic syndrome in addition to Urological chronic pelvic pain syndromes. We characterized these 2 subgroups and explored them using 3 criteria, including 1) MAPP eligibility criteria, 2) self-reported medical history or 3) RICE criteria.Materials and Methods: Self-reported cross-sectional data were collected on men and women with Urological chronic pelvic pain syndromes, including predominant symptoms, symptom duration and severity, nonUrological associated somatic syndrome symptoms and psychosocial factors.Results: Of 424 participants with Urological chronic pelvic pain syndromes 162 (38%) had a nonUrological associated somatic syndrome, including irritable bowel syndrome in 93 (22%), fibromyalgia in 15 (4%), chronic fatigue syndrome in 13 (3%) and multiple syndromes in 41 (10%). Of 233 females 103 (44%) had a nonUrological associated somatic syndrome co...
John N Krieger - One of the best experts on this subject based on the ideXlab platform.
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painful bladder filling and painful urgency are distinct characteristics in men and women with Urological chronic pelvic pain syndromes a mapp research network study
The Journal of Urology, 2015Co-Authors: John N Krieger, Dedra Buchwald, Michel A Pontari, Richard J LandisAbstract:Purpose: We describe bladder associated symptoms in patients with Urological chronic pelvic pain syndromes. We correlated these symptoms with Urological, nonUrological, psychosocial and quality of life measures.Materials and Methods: Study participants included 233 women and 191 men with interstitial cystitis/bladder pain syndrome or chronic prostatitis/chronic pelvic pain syndrome in a multicenter study. They completed a battery of measures, including items asking whether pain worsened with bladder filling (painful filling) or whether the urge to urinate was due to pain, pressure or discomfort (painful urgency). Participants were categorized into 3 groups, including group 1—painful filling and painful urgency (both), 2—painful filling or painful urgency (either) and 3—no painful filling or painful urgency (neither).Results: Of the men 75% and of the women 88% were categorized as both or either. These bladder characteristics were associated with more severe Urological symptoms (increased pain, frequency a...
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relationship between chronic nonUrological associated somatic syndromes and symptom severity in Urological chronic pelvic pain syndromes baseline evaluation of the mapp study
The Journal of Urology, 2015Co-Authors: John N Krieger, Alisa Stephens, Richard J Landis, Quentin J Clemens, Karl Kreder, Niloofar Afari, Larissa Rodriguez, Anthony Schaeffer, Sean Mackey, Gerald L AndrioleAbstract:Purpose: We used MAPP data to identify participants with Urological chronic pelvic pain syndromes only or a chronic functional nonUrological associated somatic syndrome in addition to Urological chronic pelvic pain syndromes. We characterized these 2 subgroups and explored them using 3 criteria, including 1) MAPP eligibility criteria, 2) self-reported medical history or 3) RICE criteria.Materials and Methods: Self-reported cross-sectional data were collected on men and women with Urological chronic pelvic pain syndromes, including predominant symptoms, symptom duration and severity, nonUrological associated somatic syndrome symptoms and psychosocial factors.Results: Of 424 participants with Urological chronic pelvic pain syndromes 162 (38%) had a nonUrological associated somatic syndrome, including irritable bowel syndrome in 93 (22%), fibromyalgia in 15 (4%), chronic fatigue syndrome in 13 (3%) and multiple syndromes in 41 (10%). Of 233 females 103 (44%) had a nonUrological associated somatic syndrome co...
Serge Carrier - One of the best experts on this subject based on the ideXlab platform.
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is a sexual dysfunction domain important for quality of life in men with Urological chronic pelvic pain syndrome signs upoint to yes
The Journal of Urology, 2013Co-Authors: Seth N P Davis, Yitzchak M Binik, Rhonda Amsel, Serge CarrierAbstract:Purpose: Clinical phenotyping to guide treatment for Urological chronic pelvic pain syndrome is a promising strategy. The UPOINT (urinary, psychosocial, organ specific, infection, neUrological/systemic and tenderness of the pelvic floor) phenotyping system evaluates men and women on 6 domains. However, this study focused on men only. Due to the high prevalence of sexual dysfunction in men with Urological chronic pelvic pain syndrome, debate exists about the usefulness of adding an (S) (sexual dysfunction) domain to UPOINT. We examined the usefulness in terms of quality of life and delineated Urological chronic pelvic pain syndrome subcategories using UPOINT(S) domains.Materials and Methods: We assessed 162 men using UPOINT criteria and after adding the sexual dysfunction domain. Using multiple regression analysis UPOINT(S) criteria were then compared to quality of life, as measured by the SF-36® health outcome survey and Chronic Prostatitis Symptoms Index. Sample subgroups were assessed using k-means clus...
David Guthrie - One of the best experts on this subject based on the ideXlab platform.
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genetics and phenotyping of Urological chronic pelvic pain syndrome
The Journal of Urology, 2009Co-Authors: Jordan Dimitrakov, David GuthrieAbstract:Purpose: Interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome, collectively renamed Urological chronic pelvic pain syndromes, are a group of medically unexplained physical symptoms. Diagnosis depends on excluding all possible causes of pain and treatment targets symptoms alone. An emerging body of research implicates systemic factors in the pathogenesis of Urological chronic pelvic pain syndromes including abnormal sympathetic nervous system and hypothalamic-pituitary-adrenal axis activity. Several new lines of evidence also suggest a genetic component to disease pathogenesis. Despite ongoing efforts, neither effective treatments nor mechanistic understanding of the pathogenesis of Urological chronic pelvic pain syndromes exists.Materials and Methods: We performed a survey of the available literature on Urological chronic pelvic pain syndromes. We reviewed recent research implicating genetic mechanisms in the development of Urological chronic pelvic pain synd...
David L Paterson - One of the best experts on this subject based on the ideXlab platform.
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the emerging threat of multidrug resistant gram negative bacteria in urology
Nature Reviews Urology, 2015Co-Authors: Hosam M Zowawi, Patrick N A Harris, Matthew J Roberts, Paul A Tambyah, Mark A Schembri, Diletta M Pezzani, Deborah A Williamson, David L PatersonAbstract:Urinary tract infections (UTIs) are very common and are a major contributor to global antibiotic use and resistance. Without effective antibiotics active against common uropathogens, many Urological procedures would carry excessive risk. In this article, Zowawi and coauthors describe the current global epidemiology of resistance in Gram-negative uropathogens and discuss the genetic and molecular mechanisms underlying the resistance of these phenotypes. They also examine the effect of resistance on common Urological procedures and summarize various preventive and therapeutic options.
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the emerging threat of multidrug resistant gram negative bacteria in urology
Nature Reviews Urology, 2015Co-Authors: Hosam M Zowawi, Patrick N A Harris, Matthew J Roberts, Paul A Tambyah, Mark A Schembri, Diletta M Pezzani, Deborah A Williamson, David L PatersonAbstract:Urinary tract infections (UTIs) are very common and are a major contributor to global antibiotic use and resistance. Without effective antibiotics active against common uropathogens, many Urological procedures would carry excessive risk. In this article, Zowawi and coauthors describe the current global epidemiology of resistance in Gram-negative uropathogens and discuss the genetic and molecular mechanisms underlying the resistance of these phenotypes. They also examine the effect of resistance on common Urological procedures and summarize various preventive and therapeutic options. Antibiotic resistance in Gram-negative uropathogens is a major global concern. Worldwide, the prevalence of Enterobacteriaceae that produce extended-spectrum β-lactamase or carbapenemase enzymes continues to increase at alarming rates. Likewise, resistance to other antimicrobial agents including aminoglycosides, sulphonamides and fluoroquinolones is also escalating rapidly. Bacterial resistance has major implications for Urological practice, particularly in relation to catheter-associated urinary tract infections (UTIs) and infectious complications following transrectal-ultrasonography-guided biopsy of the prostate or Urological surgery. Although some new drugs with activity against Gram-negative bacteria with highly resistant phenotypes will become available in the near future, the existence of a single agent with activity against the great diversity of resistance is unlikely. Responding to the challenges of Gram-negative resistance will require a multifaceted approach including considered use of current antimicrobial agents, improved diagnostics (including the rapid detection of resistance) and surveillance, better adherence to basic measures of infection prevention, development of new antibiotics and research into non-antibiotic treatment and preventive strategies.
