The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform

Shaozong Chen - One of the best experts on this subject based on the ideXlab platform.

  • treatment of infected soft tissue Blast Injury in swine by regulated negative pressure wound therapy
    Annals of Surgery, 2013
    Co-Authors: Jinqing Li, Morris Topaz, Yuejun Li, Wangzhou Li, Yanqin Yuan, Shaozong Chen, Xueyong Li
    Abstract:

    This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected Blast injuries in swine. Approximately 30% to 80% of Blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries. Infected soft tissue Blast injuries were treated with gauze dressings or RNPT with different pressures ranging from −5 to −35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the Blast Injury, the bacterial load, bacterial species, and several inflammatory markers were detected. Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from −10 to −25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue Blast Injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group. RNPT clearly shows beneficial effects in treating the infected soft tissue Blast Injury in comparison with the gauze dressing therapy in swine.

  • treatment of infected soft tissue Blast Injury in swine by regulated negative pressure wound therapy
    Annals of Surgery, 2013
    Co-Authors: Morris Topaz, Yanqin Yuan, Hong Tan, Wenxing Xun, Shaozong Chen
    Abstract:

    OBJECTIVE This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected Blast injuries in swine. BACKGROUND Approximately 30% to 80% of Blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries. METHODS Infected soft tissue Blast injuries were treated with gauze dressings or RNPT with different pressures ranging from -5 to -35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the Blast Injury, the bacterial load, bacterial species, and several inflammatory markers were detected. RESULTS Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from -10 to -25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue Blast Injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group. CONCLUSIONS RNPT clearly shows beneficial effects in treating the infected soft tissue Blast Injury in comparison with the gauze dressing therapy in swine.

  • New swine model of infected soft tissue Blast Injury.
    The journal of trauma and acute care surgery, 2012
    Co-Authors: Morris Topaz, Wenxing Xun, Xiaolin Wang, Haibo Liu, Yuan Yanqin, Shaozong Chen
    Abstract:

    BACKGROUND: War injuries, especially Blast injuries, have a high risk of infection. However, no animal models of infected war injuries have been built in large animals, which retards both the understanding and the treatment optimization of infected war injuries. METHODS: Soft tissue Blast injuries were created by explosion of electric detonators in white domestic pigs. The ultra structure of the tissue around the wound was determined by transmission electron microscope. To develop infection of Blast Injury wounds, the pigs were housed in a standard animal house which was disinfected periodically, and the wounds were left untreated for 3 days. Wound specimens were collected daily to determine the bacterial load and bacterial components. To determine whether infection induces tissue necrosis in infected soft tissue Blast Injury wounds, uninfected Blast Injury wounds were created as controls of infected wounds by surgical debridement daily, and the wound area and wound depth of both wounds were measured. RESULTS: The wound area and the wound depth of the soft tissue Blast Injury created in this study fell in the range of human moderate soft tissue war injuries, and the ultra structure of the wounds was comparable with that of human Blast Injury wounds. The bacterial load of uninfected wounds was under 10 colony forming unit/g during the first 3 days of Injury, while that of infected wounds was over 10 colony forming unit/g after 2 days of Injury. The infected soft tissue Blast Injury wounds contained most of the bacteria frequently isolated in battlefield wounds. In addition, infection induced evident tissue necrosis in infected Blast Injury wounds. CONCLUSION: The infected soft tissue Blast Injury wounds mimic those in human, and they can be used to address key points of treatment optimization.

Morris Topaz - One of the best experts on this subject based on the ideXlab platform.

  • treatment of infected soft tissue Blast Injury in swine by regulated negative pressure wound therapy
    Annals of Surgery, 2013
    Co-Authors: Jinqing Li, Morris Topaz, Yuejun Li, Wangzhou Li, Yanqin Yuan, Shaozong Chen, Xueyong Li
    Abstract:

    This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected Blast injuries in swine. Approximately 30% to 80% of Blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries. Infected soft tissue Blast injuries were treated with gauze dressings or RNPT with different pressures ranging from −5 to −35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the Blast Injury, the bacterial load, bacterial species, and several inflammatory markers were detected. Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from −10 to −25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue Blast Injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group. RNPT clearly shows beneficial effects in treating the infected soft tissue Blast Injury in comparison with the gauze dressing therapy in swine.

  • treatment of infected soft tissue Blast Injury in swine by regulated negative pressure wound therapy
    Annals of Surgery, 2013
    Co-Authors: Morris Topaz, Yanqin Yuan, Hong Tan, Wenxing Xun, Shaozong Chen
    Abstract:

    OBJECTIVE This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected Blast injuries in swine. BACKGROUND Approximately 30% to 80% of Blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries. METHODS Infected soft tissue Blast injuries were treated with gauze dressings or RNPT with different pressures ranging from -5 to -35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the Blast Injury, the bacterial load, bacterial species, and several inflammatory markers were detected. RESULTS Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from -10 to -25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue Blast Injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group. CONCLUSIONS RNPT clearly shows beneficial effects in treating the infected soft tissue Blast Injury in comparison with the gauze dressing therapy in swine.

  • New swine model of infected soft tissue Blast Injury.
    The journal of trauma and acute care surgery, 2012
    Co-Authors: Morris Topaz, Wenxing Xun, Xiaolin Wang, Haibo Liu, Yuan Yanqin, Shaozong Chen
    Abstract:

    BACKGROUND: War injuries, especially Blast injuries, have a high risk of infection. However, no animal models of infected war injuries have been built in large animals, which retards both the understanding and the treatment optimization of infected war injuries. METHODS: Soft tissue Blast injuries were created by explosion of electric detonators in white domestic pigs. The ultra structure of the tissue around the wound was determined by transmission electron microscope. To develop infection of Blast Injury wounds, the pigs were housed in a standard animal house which was disinfected periodically, and the wounds were left untreated for 3 days. Wound specimens were collected daily to determine the bacterial load and bacterial components. To determine whether infection induces tissue necrosis in infected soft tissue Blast Injury wounds, uninfected Blast Injury wounds were created as controls of infected wounds by surgical debridement daily, and the wound area and wound depth of both wounds were measured. RESULTS: The wound area and the wound depth of the soft tissue Blast Injury created in this study fell in the range of human moderate soft tissue war injuries, and the ultra structure of the wounds was comparable with that of human Blast Injury wounds. The bacterial load of uninfected wounds was under 10 colony forming unit/g during the first 3 days of Injury, while that of infected wounds was over 10 colony forming unit/g after 2 days of Injury. The infected soft tissue Blast Injury wounds contained most of the bacteria frequently isolated in battlefield wounds. In addition, infection induced evident tissue necrosis in infected Blast Injury wounds. CONCLUSION: The infected soft tissue Blast Injury wounds mimic those in human, and they can be used to address key points of treatment optimization.

Xueyong Li - One of the best experts on this subject based on the ideXlab platform.

  • treatment of infected soft tissue Blast Injury in swine by regulated negative pressure wound therapy
    Annals of Surgery, 2013
    Co-Authors: Jinqing Li, Morris Topaz, Yuejun Li, Wangzhou Li, Yanqin Yuan, Shaozong Chen, Xueyong Li
    Abstract:

    This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected Blast injuries in swine. Approximately 30% to 80% of Blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries. Infected soft tissue Blast injuries were treated with gauze dressings or RNPT with different pressures ranging from −5 to −35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the Blast Injury, the bacterial load, bacterial species, and several inflammatory markers were detected. Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from −10 to −25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue Blast Injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group. RNPT clearly shows beneficial effects in treating the infected soft tissue Blast Injury in comparison with the gauze dressing therapy in swine.

Wenxing Xun - One of the best experts on this subject based on the ideXlab platform.

  • treatment of infected soft tissue Blast Injury in swine by regulated negative pressure wound therapy
    Annals of Surgery, 2013
    Co-Authors: Morris Topaz, Yanqin Yuan, Hong Tan, Wenxing Xun, Shaozong Chen
    Abstract:

    OBJECTIVE This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected Blast injuries in swine. BACKGROUND Approximately 30% to 80% of Blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries. METHODS Infected soft tissue Blast injuries were treated with gauze dressings or RNPT with different pressures ranging from -5 to -35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the Blast Injury, the bacterial load, bacterial species, and several inflammatory markers were detected. RESULTS Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from -10 to -25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue Blast Injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group. CONCLUSIONS RNPT clearly shows beneficial effects in treating the infected soft tissue Blast Injury in comparison with the gauze dressing therapy in swine.

  • New swine model of infected soft tissue Blast Injury.
    The journal of trauma and acute care surgery, 2012
    Co-Authors: Morris Topaz, Wenxing Xun, Xiaolin Wang, Haibo Liu, Yuan Yanqin, Shaozong Chen
    Abstract:

    BACKGROUND: War injuries, especially Blast injuries, have a high risk of infection. However, no animal models of infected war injuries have been built in large animals, which retards both the understanding and the treatment optimization of infected war injuries. METHODS: Soft tissue Blast injuries were created by explosion of electric detonators in white domestic pigs. The ultra structure of the tissue around the wound was determined by transmission electron microscope. To develop infection of Blast Injury wounds, the pigs were housed in a standard animal house which was disinfected periodically, and the wounds were left untreated for 3 days. Wound specimens were collected daily to determine the bacterial load and bacterial components. To determine whether infection induces tissue necrosis in infected soft tissue Blast Injury wounds, uninfected Blast Injury wounds were created as controls of infected wounds by surgical debridement daily, and the wound area and wound depth of both wounds were measured. RESULTS: The wound area and the wound depth of the soft tissue Blast Injury created in this study fell in the range of human moderate soft tissue war injuries, and the ultra structure of the wounds was comparable with that of human Blast Injury wounds. The bacterial load of uninfected wounds was under 10 colony forming unit/g during the first 3 days of Injury, while that of infected wounds was over 10 colony forming unit/g after 2 days of Injury. The infected soft tissue Blast Injury wounds contained most of the bacteria frequently isolated in battlefield wounds. In addition, infection induced evident tissue necrosis in infected Blast Injury wounds. CONCLUSION: The infected soft tissue Blast Injury wounds mimic those in human, and they can be used to address key points of treatment optimization.

Yanqin Yuan - One of the best experts on this subject based on the ideXlab platform.

  • treatment of infected soft tissue Blast Injury in swine by regulated negative pressure wound therapy
    Annals of Surgery, 2013
    Co-Authors: Jinqing Li, Morris Topaz, Yuejun Li, Wangzhou Li, Yanqin Yuan, Shaozong Chen, Xueyong Li
    Abstract:

    This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected Blast injuries in swine. Approximately 30% to 80% of Blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries. Infected soft tissue Blast injuries were treated with gauze dressings or RNPT with different pressures ranging from −5 to −35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the Blast Injury, the bacterial load, bacterial species, and several inflammatory markers were detected. Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from −10 to −25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue Blast Injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group. RNPT clearly shows beneficial effects in treating the infected soft tissue Blast Injury in comparison with the gauze dressing therapy in swine.

  • treatment of infected soft tissue Blast Injury in swine by regulated negative pressure wound therapy
    Annals of Surgery, 2013
    Co-Authors: Morris Topaz, Yanqin Yuan, Hong Tan, Wenxing Xun, Shaozong Chen
    Abstract:

    OBJECTIVE This study was designed to investigate the therapeutic potential of regulated negative pressure wound therapy (RNPT) in treating infected Blast injuries in swine. BACKGROUND Approximately 30% to 80% of Blast injuries develop infection, which increases the morbidity and mortality of these casualties. RNPT has been used in US military operations in Iraq; however, no randomized controlled study has been conducted on the use of RNPT to treat infected war injuries. METHODS Infected soft tissue Blast injuries were treated with gauze dressings or RNPT with different pressures ranging from -5 to -35 kPa. To evaluate the wound healing process, the wound area, wound depth, the number of proliferative cells, and the vascular endothelial cells in the granulation tissue were measured at different time points. Furthermore, to evaluate the infection and inflammation of the Blast Injury, the bacterial load, bacterial species, and several inflammatory markers were detected. RESULTS Compared with gauze dressing treatments, RNPT reduced bacterial load more efficiently, initiated granulation tissue formation earlier, and increased the inflammation faster. Negative pressures ranging from -10 to -25 kPa applied on the RNPT group showed beneficial effects in treating the infected soft tissue Blast Injury. RNPT did not significantly change both the aerobic and anaerobic bacterial composition compared with those of the gauze dressing group. CONCLUSIONS RNPT clearly shows beneficial effects in treating the infected soft tissue Blast Injury in comparison with the gauze dressing therapy in swine.