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Gerwin Huls - One of the best experts on this subject based on the ideXlab platform.

  • Association Between Peripheral Blood Cell Count Abnormalities and Health-Related Quality of Life in the General Population
    HemaSphere, 2020
    Co-Authors: Hanneke J C M Wouters, Isabelle A Van Zeventer, Melanie M. Van Der Klauw, Bruce H. R. Wolffenbuttel, Gerwin Huls
    Abstract:

    Complete Blood Cell Counts, including differentials, are widely available and change on aging. Peripheral Blood Cell Counts outside the normal range have previously been associated with increased mortality rates and a number of comorbid conditions. However, data about the association between Blood Cell Count abnormalities, other than anemia, and health-related quality of life (HRQoL) are scarce. We investigated the association between abnormalities in (differential) Blood Cell Counts and HRQoL in 143 191 community-dwelling individuals from the prospective population-based Lifelines cohort. HRQoL was measured using the RAND 36-Item Health Survey. Logistic regression analyses were used to determine the effect of Blood Cell Count abnormalities on the odds of having a lower score than an age- and sex-specific reference value for each domain. Leukocytosis, neutrophilia, and a high neutrophil to lymphocyte ratio were associated with impaired HRQoL across multiple domains, both for younger and older (≥60 years) individuals. Using multivariable models, we confirmed that these associations were independent of the potential confounding factors obesity, smoking, alcohol use, number of medications (as a measure of comorbidity), anemia, and mean corpuscular volume. The impact on HRQoL was most pronounced for high neutrophil levels. Further, high white Blood Cell Counts proved to be a better marker for inferior HRQoL as compared to elevated high-sensitivity C-reactive protein levels. Decreased HRQoL in several domains was also observed for individuals with monocytosis, lymphocytosis, and thrombocytosis. Taken together, the present study demonstrates an association between inflammatory and myeloid-skewed Blood Cell Counts and inferior HRQoL in community-dwelling individuals.

  • prognostic impact of white Blood Cell Count in intermediate risk acute myeloid leukemia relevance of mutated npm1 and flt3 itd
    Haematologica, 2011
    Co-Authors: Hendrik J. M. De Jonge, Peter J. M. Valk, Eveline S. J. M. De Bont, Jan Jacob Schuringa, Gert J. Ossenkoppele, Edo Vellenga, Gerwin Huls
    Abstract:

    Background: High white Blood Cell Count at presentation is an unfavorable prognostic factor for treatment outcome in intermediate cytogenetic risk acute myeloid leukemia. Since the impact of white Blood Cell Count on outcome of subgroups defined by the molecular markers NPMc+and FLT3- internal tandem duplication (ITD) is unknown, we addressed this issue. Design and Methods: We studied the effect of white Blood Cell Count on outcome in a clinically and molecularly welldefined cohort of 525 patients with acute myeloid leukemia using these molecular markers. In addition, since an increased white Blood Cell Count has been associated with an increased FLT3- ITD/FLT3 (wild-type) ratio, we investigated whether the effect of white Blood Cell Count on outcome could be explained by the FLT3-ITD/FLT3 ratio. Results: This analysis revealed that white Blood Cell Count had no impact on outcome in patients with the genotypic combinations 'NPMc+without FLT3-ITD' and 'NPM1 wild-type with or without FLT3-ITD'. In contrast, white Blood Cell Count had a significant impact on complete remission rate (P=0.034), event-free survival (P=0.009) and overall survival (P<0.001) in patients with the genotypic combination 'NPMc+with FLT3-ITD'. A FLT3-ITD/FLT3 ratio greater than 1 was also associated with a reduced complete remission rate (P=0.066) and significantly reduced eventfree survival (P= 0.001) and overall survival (P=0.001) in patients with the genotypic combination 'NPMc+with FLT3-ITD'. Multivariable analysis revealed that white Blood Cell Count and FLT3-ITD/FLT3 ratio were independent prognostic indicators for outcome in the subgroup with the genotypic combination 'NPMc+with FLT3-ITD'. Conclusions: Our results demonstrate that both high white Blood Cell Count and FLT3-ITD/FLT3 ratio are prognostic factors in patients with acute myeloid leukemia with the genotypic combination 'NPMc+with FLT3-ITD'.

  • Prognostic impact of white Blood Cell Count in intermediate risk acute myeloid leukemia: relevance of mutated NPM1 and FLT3 -ITD
    Haematologica, 2011
    Co-Authors: Hendrik J. M. De Jonge, Peter J. M. Valk, Eveline S. J. M. De Bont, Jan Jacob Schuringa, Gert J. Ossenkoppele, Edo Vellenga, Gerwin Huls
    Abstract:

    Background High white Blood Cell Count at presentation is an unfavorable prognostic factor for treatment outcome in intermediate cytogenetic risk acute myeloid leukemia. Since the impact of white Blood Cell Count on outcome of subgroups defined by the molecular markers NPMc + and FLT3 -internal tandem duplication (ITD) is unknown, we addressed this issue. Design and Methods We studied the effect of white Blood Cell Count on outcome in a clinically and molecularly well-defined cohort of 525 patients with acute myeloid leukemia using these molecular markers. In addition, since an increased white Blood Cell Count has been associated with an increased FLT3 -ITD/ FLT3 (wild-type) ratio, we investigated whether the effect of white Blood Cell Count on outcome could be explained by the FLT3 -ITD/ FLT3 ratio. Results This analysis revealed that white Blood Cell Count had no impact on outcome in patients with the genotypic combinations ‘ NPMc + without FLT3 -ITD’ and ‘ NPM1 wild-type with or without FLT3- ITD’. In contrast, white Blood Cell Count had a significant impact on complete remission rate ( P =0.034), event-free survival ( P =0.009) and overall survival ( P

Hendrik J. M. De Jonge - One of the best experts on this subject based on the ideXlab platform.

  • prognostic impact of white Blood Cell Count in intermediate risk acute myeloid leukemia relevance of mutated npm1 and flt3 itd
    Haematologica, 2011
    Co-Authors: Hendrik J. M. De Jonge, Peter J. M. Valk, Eveline S. J. M. De Bont, Jan Jacob Schuringa, Gert J. Ossenkoppele, Edo Vellenga, Gerwin Huls
    Abstract:

    Background: High white Blood Cell Count at presentation is an unfavorable prognostic factor for treatment outcome in intermediate cytogenetic risk acute myeloid leukemia. Since the impact of white Blood Cell Count on outcome of subgroups defined by the molecular markers NPMc+and FLT3- internal tandem duplication (ITD) is unknown, we addressed this issue. Design and Methods: We studied the effect of white Blood Cell Count on outcome in a clinically and molecularly welldefined cohort of 525 patients with acute myeloid leukemia using these molecular markers. In addition, since an increased white Blood Cell Count has been associated with an increased FLT3- ITD/FLT3 (wild-type) ratio, we investigated whether the effect of white Blood Cell Count on outcome could be explained by the FLT3-ITD/FLT3 ratio. Results: This analysis revealed that white Blood Cell Count had no impact on outcome in patients with the genotypic combinations 'NPMc+without FLT3-ITD' and 'NPM1 wild-type with or without FLT3-ITD'. In contrast, white Blood Cell Count had a significant impact on complete remission rate (P=0.034), event-free survival (P=0.009) and overall survival (P<0.001) in patients with the genotypic combination 'NPMc+with FLT3-ITD'. A FLT3-ITD/FLT3 ratio greater than 1 was also associated with a reduced complete remission rate (P=0.066) and significantly reduced eventfree survival (P= 0.001) and overall survival (P=0.001) in patients with the genotypic combination 'NPMc+with FLT3-ITD'. Multivariable analysis revealed that white Blood Cell Count and FLT3-ITD/FLT3 ratio were independent prognostic indicators for outcome in the subgroup with the genotypic combination 'NPMc+with FLT3-ITD'. Conclusions: Our results demonstrate that both high white Blood Cell Count and FLT3-ITD/FLT3 ratio are prognostic factors in patients with acute myeloid leukemia with the genotypic combination 'NPMc+with FLT3-ITD'.

  • Prognostic impact of white Blood Cell Count in intermediate risk acute myeloid leukemia: relevance of mutated NPM1 and FLT3 -ITD
    Haematologica, 2011
    Co-Authors: Hendrik J. M. De Jonge, Peter J. M. Valk, Eveline S. J. M. De Bont, Jan Jacob Schuringa, Gert J. Ossenkoppele, Edo Vellenga, Gerwin Huls
    Abstract:

    Background High white Blood Cell Count at presentation is an unfavorable prognostic factor for treatment outcome in intermediate cytogenetic risk acute myeloid leukemia. Since the impact of white Blood Cell Count on outcome of subgroups defined by the molecular markers NPMc + and FLT3 -internal tandem duplication (ITD) is unknown, we addressed this issue. Design and Methods We studied the effect of white Blood Cell Count on outcome in a clinically and molecularly well-defined cohort of 525 patients with acute myeloid leukemia using these molecular markers. In addition, since an increased white Blood Cell Count has been associated with an increased FLT3 -ITD/ FLT3 (wild-type) ratio, we investigated whether the effect of white Blood Cell Count on outcome could be explained by the FLT3 -ITD/ FLT3 ratio. Results This analysis revealed that white Blood Cell Count had no impact on outcome in patients with the genotypic combinations ‘ NPMc + without FLT3 -ITD’ and ‘ NPM1 wild-type with or without FLT3- ITD’. In contrast, white Blood Cell Count had a significant impact on complete remission rate ( P =0.034), event-free survival ( P =0.009) and overall survival ( P

Giovanni De Gaetano - One of the best experts on this subject based on the ideXlab platform.

  • white Blood Cell Count sex and age are major determinants of heterogeneity of platelet indices in an adult general population results from the moli sani project
    Haematologica, 2011
    Co-Authors: I Santimone, Augusto Di Castelnuovo, Amalia De Curtis, Maria Spinelli, D Cugino, Francesco Gianfagna, Francesco Zito, Maria Benedetta Donati, Chiara Cerletti, Giovanni De Gaetano
    Abstract:

    Background The understanding of non-genetic regulation of platelet indices - platelet Count, plateletcrit, mean platelet volume, and platelet distribution width - is limited. The association of these platelet indices with a number of biochemical, environmental and clinical variables was studied in a large cohort of the general population. Design and Methods Men and women (n=18,097, 52% women, 56±12 years) were randomly recruited from various villages in Molise (Italy) in the framework of the population-based cohort study “Moli-sani”. Hemochromocytometric analyses were performed using an automatic analyzer (Beckman Coulter, IL, Milan, Italy). Associations of platelet indices with dependent variables were investigated by multivariable linear regression analysis. Results Full models including age, sex, body mass index, Blood pressure, smoking, menopause, white and red Blood Cell Counts, mean corpuscular volume, D-dimers, C-reactive protein, high-density lipoproteins, low-density lipoproteins, triglycerides, glucose, and drug use explained 16%, 21%, 1.9% and 4.7% of platelet Count, plateletcrit, mean platelet volume and platelet distribution width variability, respectively; variables that appeared to be most strongly associated were white Blood Cell Count, age, and sex. Platelet Count, mean platelet volume and plateletcrit were positively associated with white Blood Cell Count, while platelet distribution width was negatively associated with white Blood Cell Count. Platelet Count and plateletcrit were also positively associated with C-reactive protein and D-dimers ( P <0.0001). Each of the other variables, although associated with platelet indices in a statistically significant manner, only explained less than 0.5% of their variability. Platelet indices varied across Molise villages, independently of any other platelet Count determinant or characteristics of the villages. Conclusions The association of platelet indices with white Blood Cell Count, C-reactive protein and D-dimers in a general population underline the relation between platelets and inflammation.

  • white Blood Cell Count sex and age are major determinants of heterogeneity of platelet indices in an adult general population results from the moli sani project
    Haematologica, 2011
    Co-Authors: I Santimone, Augusto Di Castelnuovo, Amalia De Curtis, Maria Spinelli, D Cugino, Francesco Gianfagna, Francesco Zito, Maria Benedetta Donati, Chiara Cerletti, Giovanni De Gaetano
    Abstract:

    Background The understanding of non-genetic regulation of platelet indices - platelet Count, plateletcrit, mean platelet volume, and platelet distribution width - is limited. The association of these platelet indices with a number of biochemical, environmental and clinical variables was studied in a large cohort of the general population.Design and Methods Men and women (n=18,097, 52% women, 56±12 years) were randomly recruited from various villages in Molise (Italy) in the framework of the population-based cohort study “Moli-sani”. Hemochromocytometric analyses were performed using an automatic analyzer (Beckman Coulter, IL, Milan, Italy). Associations of platelet indices with dependent variables were investigated by multivariable linear regression analysis.Results Full models including age, sex, body mass index, Blood pressure, smoking, menopause, white and red Blood Cell Counts, mean corpuscular volume, D-dimers, C-reactive protein, high-density lipoproteins, low-density lipoproteins, triglycerides, glucose, and drug use explained 16%, 21%, 1.9% and 4.7% of platelet Count, plateletcrit, mean platelet volume and platelet distribution width variability, respectively; variables that appeared to be most strongly associated were white Blood Cell Count, age, and sex. Platelet Count, mean platelet volume and plateletcrit were positively associated with white Blood Cell Count, while platelet distribution width was negatively associated with white Blood Cell Count. Platelet Count and plateletcrit were also positively associated with C-reactive protein and D-dimers (P

Minoru Yamakado - One of the best experts on this subject based on the ideXlab platform.

  • Relationship between smoking, white Blood Cell Count and metabolic syndrome in Japanese women.
    Diabetes research and clinical practice, 2007
    Co-Authors: Nobukazu Ishizaka, Yuko Ishizaka, Ei-ichi Toda, Ryozo Nagai, Kazuhiko Koike, Hideki Hashimoto, Minoru Yamakado
    Abstract:

    We found that cigarette smoking increased white Blood Cell Count, and individuals which increased white Blood Cell Count more likely to have metabolic syndrome in Japanese men. We investigated whether similar relationship can be observed also in women. We analyzed the data from 16,383 Japanese women who underwent general health screening. Age-adjusted logistic regression analysis showed that current smoking was positively associated with a highest white Blood Cell Count quartile with an odds ratio of 2.40 (95% CI: 2.16-2.68, P

  • Association between white Blood Cell Count and carotid arteriosclerosis in Japanese smokers
    Atherosclerosis, 2004
    Co-Authors: Nobukazu Ishizaka, Yuko Ishizaka, Ei-ichi Toda, Ryozo Nagai, Hideki Hashimoto, Minoru Yamakado
    Abstract:

    Abstract Recent studies have shown the relationship between general inflammatory markers and ischemic heart and cerebrovascular diseases. Here we have investigated the potential association between the circulating white Blood Cell Count and carotid arteriosclerosis in apparently healthy individuals. Between 1994 and 1998, 3455 subjects who had undergone general health screening tests including carotid ultrasonography were enrolled in this study. The intertertile cutoff points for the white Blood Cell Count were 5.1×10 3 and 6.4×10 3 μL −1 in the male subjects and 4.6×10 3 and 5.7×10 3 μL −1 in the female subjects. The prevalence of carotid plaque in the first (lowest), the second, and the third tertiles was 19, 28, and 28% in the male subjects, respectively ( P

Edo Vellenga - One of the best experts on this subject based on the ideXlab platform.

  • prognostic impact of white Blood Cell Count in intermediate risk acute myeloid leukemia relevance of mutated npm1 and flt3 itd
    Haematologica, 2011
    Co-Authors: Hendrik J. M. De Jonge, Peter J. M. Valk, Eveline S. J. M. De Bont, Jan Jacob Schuringa, Gert J. Ossenkoppele, Edo Vellenga, Gerwin Huls
    Abstract:

    Background: High white Blood Cell Count at presentation is an unfavorable prognostic factor for treatment outcome in intermediate cytogenetic risk acute myeloid leukemia. Since the impact of white Blood Cell Count on outcome of subgroups defined by the molecular markers NPMc+and FLT3- internal tandem duplication (ITD) is unknown, we addressed this issue. Design and Methods: We studied the effect of white Blood Cell Count on outcome in a clinically and molecularly welldefined cohort of 525 patients with acute myeloid leukemia using these molecular markers. In addition, since an increased white Blood Cell Count has been associated with an increased FLT3- ITD/FLT3 (wild-type) ratio, we investigated whether the effect of white Blood Cell Count on outcome could be explained by the FLT3-ITD/FLT3 ratio. Results: This analysis revealed that white Blood Cell Count had no impact on outcome in patients with the genotypic combinations 'NPMc+without FLT3-ITD' and 'NPM1 wild-type with or without FLT3-ITD'. In contrast, white Blood Cell Count had a significant impact on complete remission rate (P=0.034), event-free survival (P=0.009) and overall survival (P<0.001) in patients with the genotypic combination 'NPMc+with FLT3-ITD'. A FLT3-ITD/FLT3 ratio greater than 1 was also associated with a reduced complete remission rate (P=0.066) and significantly reduced eventfree survival (P= 0.001) and overall survival (P=0.001) in patients with the genotypic combination 'NPMc+with FLT3-ITD'. Multivariable analysis revealed that white Blood Cell Count and FLT3-ITD/FLT3 ratio were independent prognostic indicators for outcome in the subgroup with the genotypic combination 'NPMc+with FLT3-ITD'. Conclusions: Our results demonstrate that both high white Blood Cell Count and FLT3-ITD/FLT3 ratio are prognostic factors in patients with acute myeloid leukemia with the genotypic combination 'NPMc+with FLT3-ITD'.

  • Prognostic impact of white Blood Cell Count in intermediate risk acute myeloid leukemia: relevance of mutated NPM1 and FLT3 -ITD
    Haematologica, 2011
    Co-Authors: Hendrik J. M. De Jonge, Peter J. M. Valk, Eveline S. J. M. De Bont, Jan Jacob Schuringa, Gert J. Ossenkoppele, Edo Vellenga, Gerwin Huls
    Abstract:

    Background High white Blood Cell Count at presentation is an unfavorable prognostic factor for treatment outcome in intermediate cytogenetic risk acute myeloid leukemia. Since the impact of white Blood Cell Count on outcome of subgroups defined by the molecular markers NPMc + and FLT3 -internal tandem duplication (ITD) is unknown, we addressed this issue. Design and Methods We studied the effect of white Blood Cell Count on outcome in a clinically and molecularly well-defined cohort of 525 patients with acute myeloid leukemia using these molecular markers. In addition, since an increased white Blood Cell Count has been associated with an increased FLT3 -ITD/ FLT3 (wild-type) ratio, we investigated whether the effect of white Blood Cell Count on outcome could be explained by the FLT3 -ITD/ FLT3 ratio. Results This analysis revealed that white Blood Cell Count had no impact on outcome in patients with the genotypic combinations ‘ NPMc + without FLT3 -ITD’ and ‘ NPM1 wild-type with or without FLT3- ITD’. In contrast, white Blood Cell Count had a significant impact on complete remission rate ( P =0.034), event-free survival ( P =0.009) and overall survival ( P