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Blood Compatibility
The Experts below are selected from a list of 327 Experts worldwide ranked by ideXlab platform
Jian Shen – 1st expert on this subject based on the ideXlab platform
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facile surface modification of silicone rubber with zwitterionic polymers for improving Blood Compatibility
Materials Science and Engineering: C, 2013Co-Authors: Qiang Chen, Bo Yuan, Mengzhou Chen, Shishan Wu, Jian ShenAbstract:A facile approach to modify silicone rubber (SR) membrane for improving the Blood Compatibility was investigated. The hydrophobic SR surface was firstly activated by air plasma, after which an initiator was immobilized on the activated surface for atom transfer radical polymerization (ATRP). Three zwitterionic polymers were then grafted from SR membrane via surface-initiated atom transfer radical polymerization (SI-ATRP). The surface composition, wettability, and morphology of the membranes before and after modification were characterized by X-ray photoelectron spectroscopy (XPS), static water contact angle (WCA) measurement, and atomic force microscopy (AFM). Results showed that zwitterionic polymers were successfully grafted from SR surfaces, which remarkably improved the wettability of the SR surface. The Blood Compatibility of the membranes was evaluated by protein adsorption and platelet adhesion tests in vitro. As observed, all the zwitterionic polymer modified surfaces have improved resistance to nonspecific protein adsorption and have excellent resistance to platelet adhesion, showing significantly improved Blood Compatibility. This work should inspire many creative uses of SR based materials for biomedical applications such as vessel, catheter, and microfluidics.
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preparation of polypropylene superhydrophobic surface and its Blood Compatibility
Colloids and Surfaces B: Biointerfaces, 2010Co-Authors: Xiaobo Wang, Jian Shen, Lancao JiangAbstract:The Blood Compatibility of the superhydrophobic polypropylene surface that prepared by Erbil’s method was preliminarily evaluated by platelet-rich plasma (PRP) adhesion study, fresh human whole Blood contacting experiments and scanning electron microscopy, using original polypropylene films as the controls. The results show that the superhydrophobic character of polymer surface was in favor of anticoagulation.
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grafting of zwitterion from cellulose membranes via atrp for improving Blood Compatibility
Biomacromolecules, 2009Co-Authors: Qiang Chen, Bo Yuan, Shishan Wu, Jian ShenAbstract:A p-vinylbenzyl sulfobetaine was grafted from cellulose membrane (CM) using surface-initiated atom transfer radical polymerization for Blood Compatibility improvement. Surface structure, wettability, morphology, and thermal stability of the CM substrates before and after modification were characterized by attenuated total reflectance Fourier transform infrared spectra, X-ray photoelectron spectroscopy measurement, water contact angle measurement, atomic force microscopy, and thermogravimetric analysis, respectively. The results showed that zwitterionic brushes were successfully fabricated on the CM surfaces, and the content of the grafted layer increased gradually with the polymerization time. The Blood Compatibility of the CM substrates was evaluated by protein adsorption tests and platelet adhesion tests in vitro. It was found that all the CMs functionalized with zwitterionic brush showed improved resistance to nonspecific protein adsorption and platelet adhesion, even though the grafting polymerization…
Changsheng Zhao – 2nd expert on this subject based on the ideXlab platform
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zwitterionic polymer functionalization of polysulfone membrane with improved antifouling property and Blood Compatibility by combination of atrp and click chemistry
Acta Biomaterialia, 2016Co-Authors: Tao Xiang, Weifeng Zhao, Ting Lu, Changsheng ZhaoAbstract:The chemical compositions are very important for designing Blood-contacting membranes with good antifouling property and Blood Compatibility. In this study, we propose a method combining ATRP and click chemistry to introduce zwitterionic polymer of poly(sulfobetaine methacrylate) (PSBMA), negatively charged polymers of poly(sodium methacrylate) (PNaMAA) and/or poly(sodium p-styrene sulfonate) (PNaSS), to improve the antifouling property and Blood Compatibility of polysulfone (PSf) membranes. Attenuated total reflectance-Fourier transform infrared spectra, X-ray photoelectron spectroscopy and water contact angle results confirmed the successful grafting of the functional polymers. The antifouling property and Blood Compatibility of the modified membranes were systematically investigated. The zwitterionic polymer (PSBMA) grafted membranes showed good resistance to protein adsorption and bacterial adhesion; the negatively charged polymer (PNaSS or PNaMAA) grafted membranes showed improved Blood Compatibility, especially the anticoagulant property. Moreover, the PSBMA/PNaMAA modified membrane showed both antifouling property and anticoagulant property, and exhibited a synergistic effect in inhibiting Blood coagulation. The functionalization of membrane surfaces by a combination of ATRP and click chemistry is demonstrated as an effective route to improve the antifouling property and Blood Compatibility of membranes in Blood-contact.
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Engineering polyethersulfone hollow fiber membrane with improved Blood Compatibility and antibacterial property
Colloid and Polymer Science, 2015Co-Authors: Haifeng Ji, Hai-chao Yu, Xuelian Huang, Weifeng Zhao, Changsheng ZhaoAbstract:Hollow fiber membranes with satisfied Blood Compatibility and antibacterial property are desired in Blood purification. Herein, a series of heparin-like copolymers of poly(methyl methacrylate-vinyl pyrrolidone -sodium styrene sulfonate-sodium acrylate) (poly(MMA-VP-SSNa-SA)) were synthesized by free radical solution polymerization. The mixture was directly blended with polyethersulfone (PES) solution to prepare hollow fiber membranes. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Blood Compatibility of the hollow fiber membranes was evaluated via protein adsorption, platelet adhesion, clotting time, and hemolysis assay. Besides, Ag nanoparticles were immobilized onto the hollow fiber membranes efficiently by a simple and green method, and the antibacterial property and Blood Compatibility of the Ag-loaded membranes were then investigated. The results indicated that the approach towards Blood compatible and antibacterial hollow fiber membrane is efficient and flexible for the modification for membrane materials.
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zwitterionic glycosyl modified polyethersulfone membranes with enhanced anti fouling property and Blood Compatibility
Journal of Colloid and Interface Science, 2015Co-Authors: Shuangsi Li, Xin Jiang, Tao Xiang, Rui Wang, Changsheng ZhaoAbstract:Abstract In this study, novel zwitterionic glycosyl modified polyethersulfone (PES) ultrafiltration membranes were prepared via in-situ cross-linking polymerization coupled with phase inversion technique, and the following reactions. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), 1HNMR spectrum, and static water contact angles (WCAs) measurements. The modified membranes showed excellent anti-fouling property, and the flux recovery ratio could reach almost 100%. Meanwhile, the Blood Compatibility of the membranes was measured by protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT), and thrombin time (TT). The results implied that the zwitterionic glycosyl modified PES membranes had good anti-fouling property and Blood Compatibility.
Xi Tingfei – 3rd expert on this subject based on the ideXlab platform
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Blood Compatibility of amorphous titanium oxide films synthesized by ion beam enhanced deposition
Biomaterials, 1998Co-Authors: Yang Ping, Zhang Feng, Cheng Xuan, Leng Yongxang, Zheng Xiaolan, Cai Guangjun, Zhen Zihong, Chen Yuanru, Liu Xianghuai, Xi TingfeiAbstract:Titanium oxide films were synthesized on titanium, cobalt alloy and low-temperature isotropic pryolytic carbon by ion beam enhanced deposition. The non-stoichiometrical titanium oxide films were obtained. Blood Compatibility of the films were evaluated by clotting time measurement, platelet adhesion investigation and hemolysis analyses. The results revealed that Blood Compatibility of the materials was improved by the coating of titanium oxide films. Semiconductor nature of non-stoichiometric titanium oxide films might be responsible for the improvement of Blood Compatibility.