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Jian Shen - One of the best experts on this subject based on the ideXlab platform.

  • facile surface modification of silicone rubber with zwitterionic polymers for improving Blood Compatibility
    Materials Science and Engineering: C, 2013
    Co-Authors: Qiang Chen, Bo Yuan, Mengzhou Chen, Shishan Wu, Jian Shen
    Abstract:

    A facile approach to modify silicone rubber (SR) membrane for improving the Blood Compatibility was investigated. The hydrophobic SR surface was firstly activated by air plasma, after which an initiator was immobilized on the activated surface for atom transfer radical polymerization (ATRP). Three zwitterionic polymers were then grafted from SR membrane via surface-initiated atom transfer radical polymerization (SI-ATRP). The surface composition, wettability, and morphology of the membranes before and after modification were characterized by X-ray photoelectron spectroscopy (XPS), static water contact angle (WCA) measurement, and atomic force microscopy (AFM). Results showed that zwitterionic polymers were successfully grafted from SR surfaces, which remarkably improved the wettability of the SR surface. The Blood Compatibility of the membranes was evaluated by protein adsorption and platelet adhesion tests in vitro. As observed, all the zwitterionic polymer modified surfaces have improved resistance to nonspecific protein adsorption and have excellent resistance to platelet adhesion, showing significantly improved Blood Compatibility. This work should inspire many creative uses of SR based materials for biomedical applications such as vessel, catheter, and microfluidics.

  • preparation of polypropylene superhydrophobic surface and its Blood Compatibility
    Colloids and Surfaces B: Biointerfaces, 2010
    Co-Authors: Xiaobo Wang, Jian Shen, Lancao Jiang
    Abstract:

    The Blood Compatibility of the superhydrophobic polypropylene surface that prepared by Erbil's method was preliminarily evaluated by platelet-rich plasma (PRP) adhesion study, fresh human whole Blood contacting experiments and scanning electron microscopy, using original polypropylene films as the controls. The results show that the superhydrophobic character of polymer surface was in favor of anticoagulation.

  • grafting of zwitterion from cellulose membranes via atrp for improving Blood Compatibility
    Biomacromolecules, 2009
    Co-Authors: Qiang Chen, Bo Yuan, Shishan Wu, Jian Shen
    Abstract:

    A p-vinylbenzyl sulfobetaine was grafted from cellulose membrane (CM) using surface-initiated atom transfer radical polymerization for Blood Compatibility improvement. Surface structure, wettability, morphology, and thermal stability of the CM substrates before and after modification were characterized by attenuated total reflectance Fourier transform infrared spectra, X-ray photoelectron spectroscopy measurement, water contact angle measurement, atomic force microscopy, and thermogravimetric analysis, respectively. The results showed that zwitterionic brushes were successfully fabricated on the CM surfaces, and the content of the grafted layer increased gradually with the polymerization time. The Blood Compatibility of the CM substrates was evaluated by protein adsorption tests and platelet adhesion tests in vitro. It was found that all the CMs functionalized with zwitterionic brush showed improved resistance to nonspecific protein adsorption and platelet adhesion, even though the grafting polymerization...

  • Modification of polyethylene with Pluronics F127 for improvement of Blood Compatibility
    Colloids and Surfaces B: Biointerfaces, 2009
    Co-Authors: Cun Xia Liang, Li Li, Jian Shen
    Abstract:

    Abstract In order to improve Blood Compatibility of polyethylene (PE) film, the Pluronics F127 additives in the PE film were then crosslinked to be stably entrapped in the PE matrix. The crosslinking was done by free radicals produced from the decomposition of dicumyl peroxide (DCP) in the film through heating (120 °C). Surface properties of the Pluronics F127 additive-containing PE films were investigated by Fourier transform infrared spectroscopy (FTIR), electron spectroscopy for chemical analysis (ESCA) and water contact angle (WCA) measurements. The Blood Compatibility of the Pluronics F127 additive-containing films was evaluated by platelet-rich plasma and Blood-cell adhesion tests, respectively. And the results were observed by scanning electron microscopy. The Blood Compatibility of the prepared Pluronics F127 additive-containing film is better than that of blank PE film. These results suggest that the Blood Compatibility of Pluronics F127 additive-containing films make them suitable biomaterials for some applications.

  • Introduction of photocrosslinkable chitosan to polyethylene film by radiation grafting and its Blood Compatibility
    Materials Science and Engineering: C, 2004
    Co-Authors: Jiang Yuan, Jian Shen
    Abstract:

    This paper describes research to improve the Blood Compatibility of polyethylene (PE) film. O-Butyrylchitosan (OBCS) was grafted to PE film by using a radiation grafting technique. The grafted sample films were verified by attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), electron spectroscopy for chemical analysis (ESCA) and the water contact angle measurements. The Blood Compatibility of the OBCS-grafted PE films was evaluated by platelet-rich plasma (PRP) contacting experiments and protein adsorption experiments that the results were described. The Blood Compatibility of OBCS-grafted PE film is better than that of blank PE film. These results suggest that the photocrosslinkable chitosan developed here has the potential of serving in Blood-contacting applications in medical use.

Changsheng Zhao - One of the best experts on this subject based on the ideXlab platform.

  • zwitterionic polymer functionalization of polysulfone membrane with improved antifouling property and Blood Compatibility by combination of atrp and click chemistry
    Acta Biomaterialia, 2016
    Co-Authors: Tao Xiang, Weifeng Zhao, Ting Lu, Changsheng Zhao
    Abstract:

    The chemical compositions are very important for designing Blood-contacting membranes with good antifouling property and Blood Compatibility. In this study, we propose a method combining ATRP and click chemistry to introduce zwitterionic polymer of poly(sulfobetaine methacrylate) (PSBMA), negatively charged polymers of poly(sodium methacrylate) (PNaMAA) and/or poly(sodium p-styrene sulfonate) (PNaSS), to improve the antifouling property and Blood Compatibility of polysulfone (PSf) membranes. Attenuated total reflectance-Fourier transform infrared spectra, X-ray photoelectron spectroscopy and water contact angle results confirmed the successful grafting of the functional polymers. The antifouling property and Blood Compatibility of the modified membranes were systematically investigated. The zwitterionic polymer (PSBMA) grafted membranes showed good resistance to protein adsorption and bacterial adhesion; the negatively charged polymer (PNaSS or PNaMAA) grafted membranes showed improved Blood Compatibility, especially the anticoagulant property. Moreover, the PSBMA/PNaMAA modified membrane showed both antifouling property and anticoagulant property, and exhibited a synergistic effect in inhibiting Blood coagulation. The functionalization of membrane surfaces by a combination of ATRP and click chemistry is demonstrated as an effective route to improve the antifouling property and Blood Compatibility of membranes in Blood-contact.

  • Engineering polyethersulfone hollow fiber membrane with improved Blood Compatibility and antibacterial property
    Colloid and Polymer Science, 2015
    Co-Authors: Haifeng Ji, Hai-chao Yu, Xuelian Huang, Weifeng Zhao, Changsheng Zhao
    Abstract:

    Hollow fiber membranes with satisfied Blood Compatibility and antibacterial property are desired in Blood purification. Herein, a series of heparin-like copolymers of poly(methyl methacrylate-vinyl pyrrolidone -sodium styrene sulfonate-sodium acrylate) (poly(MMA-VP-SSNa-SA)) were synthesized by free radical solution polymerization. The mixture was directly blended with polyethersulfone (PES) solution to prepare hollow fiber membranes. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Blood Compatibility of the hollow fiber membranes was evaluated via protein adsorption, platelet adhesion, clotting time, and hemolysis assay. Besides, Ag nanoparticles were immobilized onto the hollow fiber membranes efficiently by a simple and green method, and the antibacterial property and Blood Compatibility of the Ag-loaded membranes were then investigated. The results indicated that the approach towards Blood compatible and antibacterial hollow fiber membrane is efficient and flexible for the modification for membrane materials.

  • zwitterionic glycosyl modified polyethersulfone membranes with enhanced anti fouling property and Blood Compatibility
    Journal of Colloid and Interface Science, 2015
    Co-Authors: Shuangsi Li, Xin Jiang, Tao Xiang, Rui Wang, Changsheng Zhao
    Abstract:

    Abstract In this study, novel zwitterionic glycosyl modified polyethersulfone (PES) ultrafiltration membranes were prepared via in-situ cross-linking polymerization coupled with phase inversion technique, and the following reactions. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), 1HNMR spectrum, and static water contact angles (WCAs) measurements. The modified membranes showed excellent anti-fouling property, and the flux recovery ratio could reach almost 100%. Meanwhile, the Blood Compatibility of the membranes was measured by protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT), and thrombin time (TT). The results implied that the zwitterionic glycosyl modified PES membranes had good anti-fouling property and Blood Compatibility.

  • Blood Compatibility comparison for polysulfone membranes modified by grafting block and random zwitterionic copolymers via surface initiated atrp
    Journal of Colloid and Interface Science, 2014
    Co-Authors: Tao Xiang, Rui Wang, Lisha Zhang, Baihai Su, Changsheng Zhao
    Abstract:

    Abstract For Blood-contacting materials, good Blood Compatibility, especially good anticoagulant property is of great importance. Zwitterionic polymers have been proved to be resistant to nonspecific protein adsorption and platelet adhesion; however, their anticoagulant property is always inadequate. In this study, two kinds of zwitterionic copolymers (sulfobetaine methacrylate and sodium p-styrene sulfonate random copolymer and block copolymer) with sulfonic groups were covalently grafted from polysulfone (PSf) membranes via surface-initiated atom transfer radical polymerization (SI-ATRP) to improve Blood Compatibility. Field emission scanning electron microscopy (FE-SEM), attenuated total reflectance–Fourier transform infrared spectra (ATR–FTIR), X-ray photoelectron spectroscopy (XPS), and static water contact angle (WCA) were applied to characterize the morphologies, chemical compositions and hydrophilicity of the modified membranes. All the zwitterionic copolymer modified membranes showed improved Blood Compatibility, especially the anticoagulant property was obviously enhanced compared to the pristine PSf and simple zwitterionic polymer modified membranes. We also found that the random copolymer modified membranes showed better resistance to platelet adhesion than the block copolymer modified membranes. The zwitterionic copolymer modified membranes with integrated antifouling property and Blood Compatibility provided wide choice for specific applications such as hemodialysis, hemofiltration, and plasma separation.

  • improved Blood Compatibility of polyethersulfone membrane with a hydrophilic and anionic surface
    Colloids and Surfaces B: Biointerfaces, 2012
    Co-Authors: Yi Lu, Dongsheng Wang, Changsheng Zhao
    Abstract:

    Abstract In this study, a novel triblock copolymer of poly (styrene-co-acrylic acid)-b-poly (vinyl pyrrolidone)-b-poly(styrene-co-acrylic acid) (P(St-co-AA)-b-PVP-b-P(St-co-AA)) is synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization, and used for the modification of Blood contacting surface of polyethersulfone (PES) membrane to improve Blood Compatibility. The synthesized block copolymer can be directly blended with PES to prepare PES membranes by a liquid–liquid phase separation technique. The compositions and structure of the PES membranes are characterized by thermogravimetric analysis (TGA), ATR-FTIR, X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM); the surface charge density of the modified PES membrane was measured by Zeta-potential; the Blood Compatibility of the PES membranes was assessed by detecting bovine serum albumin (BSA) and bovine serum fibrinogen (BFG) adsorption, platelet adhesion, activated partial thromboplastin time (APTT), platelet activation, and thrombin–antithrombin III (TAT) generation. The results indicated that the Blood Compatibility of the modified PES membrane was improved due to the membrane surface modification by blending the amphiphilic block copolymer and the surface segregation of the block copolymer.

Xi Tingfei - One of the best experts on this subject based on the ideXlab platform.

Yang Ping - One of the best experts on this subject based on the ideXlab platform.

Zhang Feng - One of the best experts on this subject based on the ideXlab platform.