The Experts below are selected from a list of 282 Experts worldwide ranked by ideXlab platform

Jason P. Acker - One of the best experts on this subject based on the ideXlab platform.

  • buffy coat top bottom and whole Blood Filtration top top produced red cell concentrates differ in size of extracellular vesicles
    Vox Sanguinis, 2015
    Co-Authors: Beatriz Bicalho, Alberto Dos Santos Pereira, Jason P. Acker
    Abstract:

    Background and Objectives The influence that Blood component separation methods have on changes to the red Blood cell membrane during storage is not well understood. In Canada, red cell concentrates (RCCs) are produced using the buffy coat (BC, top/bottom) and the whole-Blood Filtration (WBF, top/top) methods, and this study aimed at comparing their influence on the characteristics of the extracellular vesicles (EV) which accumulated in the respective products during storage. Materials and Methods Using flow cytometry, dynamic light scattering and mass spectrometry, we assessed RCC EVs for concentration, size, lipid composition and correlation with supernatant haemoglobin (Hb). Results Accumulation of RBC EVs (CD235a+) with storage time was similar in WBF and BC RCCs. The size of the EVs changed from <100 nm at d5 to near 200 nm by d42, with the EVs from WBF being smaller (P < 0·001) than BC RCCs at all storage times. The amount of EV-bound Hb in the WBF and BC units was similar (about 10% of total supernatant Hb). WBF EVs and BC EVs displayed similar lipid composition. Conclusion Haemolysis and EVs increase in BC and WBF RCCs during storage. Differences in the size characteristics of the EVs in WBF and BC RCCs suggest that non-RBC EVs are more prevalent in WBF products. Understanding the impact that manufacturing has on the characteristics of the different populations of EVs in RCCs will aid quality improvement efforts.

  • Buffy coat (top/bottom)‐ and whole‐Blood Filtration (top/top)‐produced red cell concentrates differ in size of extracellular vesicles
    Vox sanguinis, 2015
    Co-Authors: Beatriz Bicalho, Alberto Dos Santos Pereira, Jason P. Acker
    Abstract:

    Background and Objectives The influence that Blood component separation methods have on changes to the red Blood cell membrane during storage is not well understood. In Canada, red cell concentrates (RCCs) are produced using the buffy coat (BC, top/bottom) and the whole-Blood Filtration (WBF, top/top) methods, and this study aimed at comparing their influence on the characteristics of the extracellular vesicles (EV) which accumulated in the respective products during storage. Materials and Methods Using flow cytometry, dynamic light scattering and mass spectrometry, we assessed RCC EVs for concentration, size, lipid composition and correlation with supernatant haemoglobin (Hb). Results Accumulation of RBC EVs (CD235a+) with storage time was similar in WBF and BC RCCs. The size of the EVs changed from

Ye Cao - One of the best experts on this subject based on the ideXlab platform.

  • Surface modification of PBT nonwoven fabrics used for Blood Filtration and their Blood compatibility study.
    Artificial cells blood substitutes and immobilization biotechnology, 2012
    Co-Authors: Ye Cao, Jiaxin Liu, Rui Zhong, Hong Wang
    Abstract:

    AbstractIt is necessary to remove residual leukocytes to prevent the Blood transfusion-related adverse reactions. This paper describes a facile approach for the surface modification of commercial PBT nonwoven fabrics (PBTNF), used for Blood Filtration, followed by immobilizing polyvinylpyrrolidone (PVP). The whole Blood Filtration results revealed that the five types of PBTNF-PVPs’ leucocytes retention rates and erythrocyte recovery rates increased to 96% and 92% compared with the untreated PBTNF. The Blood compatibilities results indicated that PVP modified PBTNFs have good Blood compatibility, suggesting that PVP-modified PBTNF is a very promising Blood filter for selective removal of leukocytes.

  • Functional groups grafted nonwoven fabrics for Blood Filtration—The effects of functional groups and wettability on the adhesion of leukocyte and platelet
    Applied Surface Science, 2011
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Ye Cao, Hong Wang
    Abstract:

    Abstract In this work, the effects of grafted functional groups and surface wettability on the adhesion of leukocyte and platelet were investigated by the method of Blood Filtration. The filter materials, poly(butylene terephthalate) nonwoven fabrics bearing different functional groups including hydroxyl (OH), carboxyl (COOH), sulfonic acid group (SO 3 H) and zwitterionic sulfobetaine group ( ⊕ N((CH 3 ) 2 )(CH 2 ) 3 SO 3 ⊖ ) with controllable wettability were prepared by UV radiation grafting vinyl monomers with these functional groups. Our results emphasized that both surface functional groups and surface wettability had significant effects on the adhesion of leukocyte and platelet. In the case of filter materials with the same wettability, leukocytes adhering to filter materials decreased in the order: the surface bearing OH only > the surface bearing both OH and COOH > the surface bearing sulfobetaine group > the surface bearing SO 3 H, while platelets adhering to filter materials decreased as the following order: the surface bearing SO 3 H > the surface bearing both OH and COOH > the surface bearing OH only > the surface bearing sulfobetaine group. As the wettability of filter materials increased, both leukocyte and platelet adhesion to filter materials declined, except that leukocyte adhesion to the surface bearing OH only remained unchanged.

  • Zwitterionic sulfobetaine‐modified non‐woven fabric for Blood Filtration
    Polymer International, 2010
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Hong Wang, Ye Cao
    Abstract:

    Blood Filtration requires a high removal ratio of leukocytes and with simultaneous high recovery ratio of platelets and other beneficial components. Problems are often encountered with Blood filter materials in terms of high platelet loss. Zwitterions such as phosphorylcholine, sulfobetaine and carboxybetaine show effective resistance against protein adsorption and platelet adhesion. The study reported was aimed at achieving surface modification of poly(butylene terephthalate) non-woven fabric (PBTNF) using UV radiation-induced graft copolymerization of a zwitterionic sulfobetaine, N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SMDB), in order to improve the wettability and platelet recovery ratio of the PBTNF. Attenuated total reflection Fourier transform infrared and X-ray photoelectron spectroscopy results showed that SMDB was successfully grafted onto the PBTNF. Photoinitiator concentration, monomer concentration and UV irradiation time affected markedly the degree of grafting. Critical wetting surface tension, water wetting time and hemolysis tests showed an improvement in wettability and Blood compatibility as a result of graft copolymerization of SMDB. A Blood filter material composed of SMDB-modified PBTNF reduced platelet adhesion and had higher platelet recovery compared to poly(acrylic acid)-modified PBTNF. It was found that SMDB monomer was successfully grafted onto PBTNF using UV radiation. The degree of grafting of SMDB could be controlled by varying the photoinitiator concentration, monomer concentration and UV irradiation time. SMDB-modified PBTNF showed significant improvement in wettability and Blood compatibility. The zwitterionic structure of SMDB is resistant to platelet adhesion. The SMDB-modified PBTNF could be a candidate for a Blood filter material and in other medical applications. Copyright © 2010 Society of Chemical Industry

  • Zwitterionic sulfobetaine-modified non-woven fabric for Blood Filtration
    Polymer International, 2010
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Hong Wang, Ye Cao
    Abstract:

    Blood Filtration requires a high removal ratio of leukocytes and with simultaneous high recovery ratio of platelets and other beneficial components. Problems are often encountered with Blood filter materials in terms of high platelet loss. Zwitterions such as phosphorylcholine, sulfobetaine and carboxybetaine show effective resistance against protein adsorption and platelet adhesion. The study reported was aimed at achieving surface modification of poly(butylene terephthalate) non-woven fabric (PBTNF) using UV radiation-induced graft copolymerization of a zwitterionic sulfobetaine, N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SMDB), in order to improve the wettability and platelet recovery ratio of the PBTNF. Attenuated total reflection Fourier transform infrared and X-ray photoelectron spectroscopy results showed that SMDB was successfully grafted onto the PBTNF. Photoinitiator concentration, monomer concentration and UV irradiation time affected markedly the degree of grafting. Critical wetting surface tension, water wetting time and hemolysis tests showed an improvement in wettability and Blood compatibility as a result of graft copolymerization of SMDB. A Blood filter material composed of SMDB-modified PBTNF reduced platelet adhesion and had higher platelet recovery compared to poly(acrylic acid)-modified PBTNF. It was found that SMDB monomer was successfully grafted onto PBTNF using UV radiation. The degree of grafting of SMDB could be controlled by varying the photoinitiator concentration, monomer concentration and UV irradiation time. SMDB-modified PBTNF showed significant improvement in wettability and Blood compatibility. The zwitterionic structure of SMDB is resistant to platelet adhesion. The SMDB-modified PBTNF could be a candidate for a Blood filter material and in other medical applications. Copyright © 2010 Society of Chemical Industry

Chao Yang - One of the best experts on this subject based on the ideXlab platform.

  • Functional groups grafted nonwoven fabrics for Blood Filtration—The effects of functional groups and wettability on the adhesion of leukocyte and platelet
    Applied Surface Science, 2011
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Ye Cao, Hong Wang
    Abstract:

    Abstract In this work, the effects of grafted functional groups and surface wettability on the adhesion of leukocyte and platelet were investigated by the method of Blood Filtration. The filter materials, poly(butylene terephthalate) nonwoven fabrics bearing different functional groups including hydroxyl (OH), carboxyl (COOH), sulfonic acid group (SO 3 H) and zwitterionic sulfobetaine group ( ⊕ N((CH 3 ) 2 )(CH 2 ) 3 SO 3 ⊖ ) with controllable wettability were prepared by UV radiation grafting vinyl monomers with these functional groups. Our results emphasized that both surface functional groups and surface wettability had significant effects on the adhesion of leukocyte and platelet. In the case of filter materials with the same wettability, leukocytes adhering to filter materials decreased in the order: the surface bearing OH only > the surface bearing both OH and COOH > the surface bearing sulfobetaine group > the surface bearing SO 3 H, while platelets adhering to filter materials decreased as the following order: the surface bearing SO 3 H > the surface bearing both OH and COOH > the surface bearing OH only > the surface bearing sulfobetaine group. As the wettability of filter materials increased, both leukocyte and platelet adhesion to filter materials declined, except that leukocyte adhesion to the surface bearing OH only remained unchanged.

  • Zwitterionic sulfobetaine‐modified non‐woven fabric for Blood Filtration
    Polymer International, 2010
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Hong Wang, Ye Cao
    Abstract:

    Blood Filtration requires a high removal ratio of leukocytes and with simultaneous high recovery ratio of platelets and other beneficial components. Problems are often encountered with Blood filter materials in terms of high platelet loss. Zwitterions such as phosphorylcholine, sulfobetaine and carboxybetaine show effective resistance against protein adsorption and platelet adhesion. The study reported was aimed at achieving surface modification of poly(butylene terephthalate) non-woven fabric (PBTNF) using UV radiation-induced graft copolymerization of a zwitterionic sulfobetaine, N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SMDB), in order to improve the wettability and platelet recovery ratio of the PBTNF. Attenuated total reflection Fourier transform infrared and X-ray photoelectron spectroscopy results showed that SMDB was successfully grafted onto the PBTNF. Photoinitiator concentration, monomer concentration and UV irradiation time affected markedly the degree of grafting. Critical wetting surface tension, water wetting time and hemolysis tests showed an improvement in wettability and Blood compatibility as a result of graft copolymerization of SMDB. A Blood filter material composed of SMDB-modified PBTNF reduced platelet adhesion and had higher platelet recovery compared to poly(acrylic acid)-modified PBTNF. It was found that SMDB monomer was successfully grafted onto PBTNF using UV radiation. The degree of grafting of SMDB could be controlled by varying the photoinitiator concentration, monomer concentration and UV irradiation time. SMDB-modified PBTNF showed significant improvement in wettability and Blood compatibility. The zwitterionic structure of SMDB is resistant to platelet adhesion. The SMDB-modified PBTNF could be a candidate for a Blood filter material and in other medical applications. Copyright © 2010 Society of Chemical Industry

  • Zwitterionic sulfobetaine-modified non-woven fabric for Blood Filtration
    Polymer International, 2010
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Hong Wang, Ye Cao
    Abstract:

    Blood Filtration requires a high removal ratio of leukocytes and with simultaneous high recovery ratio of platelets and other beneficial components. Problems are often encountered with Blood filter materials in terms of high platelet loss. Zwitterions such as phosphorylcholine, sulfobetaine and carboxybetaine show effective resistance against protein adsorption and platelet adhesion. The study reported was aimed at achieving surface modification of poly(butylene terephthalate) non-woven fabric (PBTNF) using UV radiation-induced graft copolymerization of a zwitterionic sulfobetaine, N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SMDB), in order to improve the wettability and platelet recovery ratio of the PBTNF. Attenuated total reflection Fourier transform infrared and X-ray photoelectron spectroscopy results showed that SMDB was successfully grafted onto the PBTNF. Photoinitiator concentration, monomer concentration and UV irradiation time affected markedly the degree of grafting. Critical wetting surface tension, water wetting time and hemolysis tests showed an improvement in wettability and Blood compatibility as a result of graft copolymerization of SMDB. A Blood filter material composed of SMDB-modified PBTNF reduced platelet adhesion and had higher platelet recovery compared to poly(acrylic acid)-modified PBTNF. It was found that SMDB monomer was successfully grafted onto PBTNF using UV radiation. The degree of grafting of SMDB could be controlled by varying the photoinitiator concentration, monomer concentration and UV irradiation time. SMDB-modified PBTNF showed significant improvement in wettability and Blood compatibility. The zwitterionic structure of SMDB is resistant to platelet adhesion. The SMDB-modified PBTNF could be a candidate for a Blood filter material and in other medical applications. Copyright © 2010 Society of Chemical Industry

Hong Wang - One of the best experts on this subject based on the ideXlab platform.

  • Surface modification of PBT nonwoven fabrics used for Blood Filtration and their Blood compatibility study.
    Artificial cells blood substitutes and immobilization biotechnology, 2012
    Co-Authors: Ye Cao, Jiaxin Liu, Rui Zhong, Hong Wang
    Abstract:

    AbstractIt is necessary to remove residual leukocytes to prevent the Blood transfusion-related adverse reactions. This paper describes a facile approach for the surface modification of commercial PBT nonwoven fabrics (PBTNF), used for Blood Filtration, followed by immobilizing polyvinylpyrrolidone (PVP). The whole Blood Filtration results revealed that the five types of PBTNF-PVPs’ leucocytes retention rates and erythrocyte recovery rates increased to 96% and 92% compared with the untreated PBTNF. The Blood compatibilities results indicated that PVP modified PBTNFs have good Blood compatibility, suggesting that PVP-modified PBTNF is a very promising Blood filter for selective removal of leukocytes.

  • Functional groups grafted nonwoven fabrics for Blood Filtration—The effects of functional groups and wettability on the adhesion of leukocyte and platelet
    Applied Surface Science, 2011
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Ye Cao, Hong Wang
    Abstract:

    Abstract In this work, the effects of grafted functional groups and surface wettability on the adhesion of leukocyte and platelet were investigated by the method of Blood Filtration. The filter materials, poly(butylene terephthalate) nonwoven fabrics bearing different functional groups including hydroxyl (OH), carboxyl (COOH), sulfonic acid group (SO 3 H) and zwitterionic sulfobetaine group ( ⊕ N((CH 3 ) 2 )(CH 2 ) 3 SO 3 ⊖ ) with controllable wettability were prepared by UV radiation grafting vinyl monomers with these functional groups. Our results emphasized that both surface functional groups and surface wettability had significant effects on the adhesion of leukocyte and platelet. In the case of filter materials with the same wettability, leukocytes adhering to filter materials decreased in the order: the surface bearing OH only > the surface bearing both OH and COOH > the surface bearing sulfobetaine group > the surface bearing SO 3 H, while platelets adhering to filter materials decreased as the following order: the surface bearing SO 3 H > the surface bearing both OH and COOH > the surface bearing OH only > the surface bearing sulfobetaine group. As the wettability of filter materials increased, both leukocyte and platelet adhesion to filter materials declined, except that leukocyte adhesion to the surface bearing OH only remained unchanged.

  • Zwitterionic sulfobetaine‐modified non‐woven fabric for Blood Filtration
    Polymer International, 2010
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Hong Wang, Ye Cao
    Abstract:

    Blood Filtration requires a high removal ratio of leukocytes and with simultaneous high recovery ratio of platelets and other beneficial components. Problems are often encountered with Blood filter materials in terms of high platelet loss. Zwitterions such as phosphorylcholine, sulfobetaine and carboxybetaine show effective resistance against protein adsorption and platelet adhesion. The study reported was aimed at achieving surface modification of poly(butylene terephthalate) non-woven fabric (PBTNF) using UV radiation-induced graft copolymerization of a zwitterionic sulfobetaine, N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SMDB), in order to improve the wettability and platelet recovery ratio of the PBTNF. Attenuated total reflection Fourier transform infrared and X-ray photoelectron spectroscopy results showed that SMDB was successfully grafted onto the PBTNF. Photoinitiator concentration, monomer concentration and UV irradiation time affected markedly the degree of grafting. Critical wetting surface tension, water wetting time and hemolysis tests showed an improvement in wettability and Blood compatibility as a result of graft copolymerization of SMDB. A Blood filter material composed of SMDB-modified PBTNF reduced platelet adhesion and had higher platelet recovery compared to poly(acrylic acid)-modified PBTNF. It was found that SMDB monomer was successfully grafted onto PBTNF using UV radiation. The degree of grafting of SMDB could be controlled by varying the photoinitiator concentration, monomer concentration and UV irradiation time. SMDB-modified PBTNF showed significant improvement in wettability and Blood compatibility. The zwitterionic structure of SMDB is resistant to platelet adhesion. The SMDB-modified PBTNF could be a candidate for a Blood filter material and in other medical applications. Copyright © 2010 Society of Chemical Industry

  • Zwitterionic sulfobetaine-modified non-woven fabric for Blood Filtration
    Polymer International, 2010
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Hong Wang, Ye Cao
    Abstract:

    Blood Filtration requires a high removal ratio of leukocytes and with simultaneous high recovery ratio of platelets and other beneficial components. Problems are often encountered with Blood filter materials in terms of high platelet loss. Zwitterions such as phosphorylcholine, sulfobetaine and carboxybetaine show effective resistance against protein adsorption and platelet adhesion. The study reported was aimed at achieving surface modification of poly(butylene terephthalate) non-woven fabric (PBTNF) using UV radiation-induced graft copolymerization of a zwitterionic sulfobetaine, N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SMDB), in order to improve the wettability and platelet recovery ratio of the PBTNF. Attenuated total reflection Fourier transform infrared and X-ray photoelectron spectroscopy results showed that SMDB was successfully grafted onto the PBTNF. Photoinitiator concentration, monomer concentration and UV irradiation time affected markedly the degree of grafting. Critical wetting surface tension, water wetting time and hemolysis tests showed an improvement in wettability and Blood compatibility as a result of graft copolymerization of SMDB. A Blood filter material composed of SMDB-modified PBTNF reduced platelet adhesion and had higher platelet recovery compared to poly(acrylic acid)-modified PBTNF. It was found that SMDB monomer was successfully grafted onto PBTNF using UV radiation. The degree of grafting of SMDB could be controlled by varying the photoinitiator concentration, monomer concentration and UV irradiation time. SMDB-modified PBTNF showed significant improvement in wettability and Blood compatibility. The zwitterionic structure of SMDB is resistant to platelet adhesion. The SMDB-modified PBTNF could be a candidate for a Blood filter material and in other medical applications. Copyright © 2010 Society of Chemical Industry

Jiaxin Liu - One of the best experts on this subject based on the ideXlab platform.

  • Surface modification of PBT nonwoven fabrics used for Blood Filtration and their Blood compatibility study.
    Artificial cells blood substitutes and immobilization biotechnology, 2012
    Co-Authors: Ye Cao, Jiaxin Liu, Rui Zhong, Hong Wang
    Abstract:

    AbstractIt is necessary to remove residual leukocytes to prevent the Blood transfusion-related adverse reactions. This paper describes a facile approach for the surface modification of commercial PBT nonwoven fabrics (PBTNF), used for Blood Filtration, followed by immobilizing polyvinylpyrrolidone (PVP). The whole Blood Filtration results revealed that the five types of PBTNF-PVPs’ leucocytes retention rates and erythrocyte recovery rates increased to 96% and 92% compared with the untreated PBTNF. The Blood compatibilities results indicated that PVP modified PBTNFs have good Blood compatibility, suggesting that PVP-modified PBTNF is a very promising Blood filter for selective removal of leukocytes.

  • Functional groups grafted nonwoven fabrics for Blood Filtration—The effects of functional groups and wettability on the adhesion of leukocyte and platelet
    Applied Surface Science, 2011
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Ye Cao, Hong Wang
    Abstract:

    Abstract In this work, the effects of grafted functional groups and surface wettability on the adhesion of leukocyte and platelet were investigated by the method of Blood Filtration. The filter materials, poly(butylene terephthalate) nonwoven fabrics bearing different functional groups including hydroxyl (OH), carboxyl (COOH), sulfonic acid group (SO 3 H) and zwitterionic sulfobetaine group ( ⊕ N((CH 3 ) 2 )(CH 2 ) 3 SO 3 ⊖ ) with controllable wettability were prepared by UV radiation grafting vinyl monomers with these functional groups. Our results emphasized that both surface functional groups and surface wettability had significant effects on the adhesion of leukocyte and platelet. In the case of filter materials with the same wettability, leukocytes adhering to filter materials decreased in the order: the surface bearing OH only > the surface bearing both OH and COOH > the surface bearing sulfobetaine group > the surface bearing SO 3 H, while platelets adhering to filter materials decreased as the following order: the surface bearing SO 3 H > the surface bearing both OH and COOH > the surface bearing OH only > the surface bearing sulfobetaine group. As the wettability of filter materials increased, both leukocyte and platelet adhesion to filter materials declined, except that leukocyte adhesion to the surface bearing OH only remained unchanged.

  • Zwitterionic sulfobetaine‐modified non‐woven fabric for Blood Filtration
    Polymer International, 2010
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Hong Wang, Ye Cao
    Abstract:

    Blood Filtration requires a high removal ratio of leukocytes and with simultaneous high recovery ratio of platelets and other beneficial components. Problems are often encountered with Blood filter materials in terms of high platelet loss. Zwitterions such as phosphorylcholine, sulfobetaine and carboxybetaine show effective resistance against protein adsorption and platelet adhesion. The study reported was aimed at achieving surface modification of poly(butylene terephthalate) non-woven fabric (PBTNF) using UV radiation-induced graft copolymerization of a zwitterionic sulfobetaine, N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SMDB), in order to improve the wettability and platelet recovery ratio of the PBTNF. Attenuated total reflection Fourier transform infrared and X-ray photoelectron spectroscopy results showed that SMDB was successfully grafted onto the PBTNF. Photoinitiator concentration, monomer concentration and UV irradiation time affected markedly the degree of grafting. Critical wetting surface tension, water wetting time and hemolysis tests showed an improvement in wettability and Blood compatibility as a result of graft copolymerization of SMDB. A Blood filter material composed of SMDB-modified PBTNF reduced platelet adhesion and had higher platelet recovery compared to poly(acrylic acid)-modified PBTNF. It was found that SMDB monomer was successfully grafted onto PBTNF using UV radiation. The degree of grafting of SMDB could be controlled by varying the photoinitiator concentration, monomer concentration and UV irradiation time. SMDB-modified PBTNF showed significant improvement in wettability and Blood compatibility. The zwitterionic structure of SMDB is resistant to platelet adhesion. The SMDB-modified PBTNF could be a candidate for a Blood filter material and in other medical applications. Copyright © 2010 Society of Chemical Industry

  • Zwitterionic sulfobetaine-modified non-woven fabric for Blood Filtration
    Polymer International, 2010
    Co-Authors: Chao Yang, Kang Sun, Jiaxin Liu, Hong Wang, Ye Cao
    Abstract:

    Blood Filtration requires a high removal ratio of leukocytes and with simultaneous high recovery ratio of platelets and other beneficial components. Problems are often encountered with Blood filter materials in terms of high platelet loss. Zwitterions such as phosphorylcholine, sulfobetaine and carboxybetaine show effective resistance against protein adsorption and platelet adhesion. The study reported was aimed at achieving surface modification of poly(butylene terephthalate) non-woven fabric (PBTNF) using UV radiation-induced graft copolymerization of a zwitterionic sulfobetaine, N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SMDB), in order to improve the wettability and platelet recovery ratio of the PBTNF. Attenuated total reflection Fourier transform infrared and X-ray photoelectron spectroscopy results showed that SMDB was successfully grafted onto the PBTNF. Photoinitiator concentration, monomer concentration and UV irradiation time affected markedly the degree of grafting. Critical wetting surface tension, water wetting time and hemolysis tests showed an improvement in wettability and Blood compatibility as a result of graft copolymerization of SMDB. A Blood filter material composed of SMDB-modified PBTNF reduced platelet adhesion and had higher platelet recovery compared to poly(acrylic acid)-modified PBTNF. It was found that SMDB monomer was successfully grafted onto PBTNF using UV radiation. The degree of grafting of SMDB could be controlled by varying the photoinitiator concentration, monomer concentration and UV irradiation time. SMDB-modified PBTNF showed significant improvement in wettability and Blood compatibility. The zwitterionic structure of SMDB is resistant to platelet adhesion. The SMDB-modified PBTNF could be a candidate for a Blood filter material and in other medical applications. Copyright © 2010 Society of Chemical Industry