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Shigeho Morita - One of the best experts on this subject based on the ideXlab platform.

  • the blood gas Partition Coefficient of xenon may be lower than generally accepted
    BJA: British Journal of Anaesthesia, 1998
    Co-Authors: Takahisa Goto, Kunio Suwa, Shoichi Uezono, Fumito Ichinose, M Uchiyama, Shigeho Morita
    Abstract:

    The Blood-Gas Partition Coefficients of xenon, reported more than 25 yr ago in the literature, vary considerably from 0.13 to 0.20. Consequently, we have determined this variable by directly injecting xenon-saturated blood into a gas chromatograph-mass spectrometer. This technique yielded a Blood-Gas Partition Coefficient for xenon of 0.115 (95% confidence interval 0.107-0.123). The solubility in water measured identically was 0.096, consistent with the reported value of 0.085. These data and a detailed review of the literature strongly suggest that the Blood-Gas Partition Coefficient of xenon may be lower than the generally accepted value of 0.14.

H Gehring - One of the best experts on this subject based on the ideXlab platform.

  • blood gas Partition Coefficient and pulmonary extraction ratio for propofol in goats and pigs
    Xenobiotica, 2009
    Co-Authors: M Grossherr, Andreas Hengstenberg, L Dibbelt, R Noel, A V D Knesebeck, P Schmucker, H Gehring
    Abstract:

    The interpretation of continuously measured propofol concentration in respiratory gas demands knowledge about the blood gas Partition Coefficient and pulmonary extraction ratio for propofol. In the present investigation we compared both variables for propofol between goats and pigs during a propofol anaesthesia.In ten goats and ten pigs, expired alveolar gas and arterial and mixed venous blood samples were simultaneously drawn during total intravenous anaesthesia with propofol. The blood gas Partition Coefficient and pulmonary extraction ratio were calculated for both species. Non-parametric methods were used for statistical inference.The blood gas Partition Coefficient ranged between 7000 and 646 000 for goats and between 17 000 and 267 000 for pigs. The pulmonary extraction ratio ranged between 32.9% and 98.1% for goats and was higher for pigs, which ranged between −106.0% and 39.0%.The blood gas Partition Coefficient for propofol exceeded those for other known anaesthetic compounds so that it takes lon...

Takahisa Goto - One of the best experts on this subject based on the ideXlab platform.

  • the blood gas Partition Coefficient of xenon may be lower than generally accepted
    BJA: British Journal of Anaesthesia, 1998
    Co-Authors: Takahisa Goto, Kunio Suwa, Shoichi Uezono, Fumito Ichinose, M Uchiyama, Shigeho Morita
    Abstract:

    The Blood-Gas Partition Coefficients of xenon, reported more than 25 yr ago in the literature, vary considerably from 0.13 to 0.20. Consequently, we have determined this variable by directly injecting xenon-saturated blood into a gas chromatograph-mass spectrometer. This technique yielded a Blood-Gas Partition Coefficient for xenon of 0.115 (95% confidence interval 0.107-0.123). The solubility in water measured identically was 0.096, consistent with the reported value of 0.085. These data and a detailed review of the literature strongly suggest that the Blood-Gas Partition Coefficient of xenon may be lower than the generally accepted value of 0.14.

M Grossherr - One of the best experts on this subject based on the ideXlab platform.

  • blood gas Partition Coefficient and pulmonary extraction ratio for propofol in goats and pigs
    Xenobiotica, 2009
    Co-Authors: M Grossherr, Andreas Hengstenberg, L Dibbelt, R Noel, A V D Knesebeck, P Schmucker, H Gehring
    Abstract:

    The interpretation of continuously measured propofol concentration in respiratory gas demands knowledge about the blood gas Partition Coefficient and pulmonary extraction ratio for propofol. In the present investigation we compared both variables for propofol between goats and pigs during a propofol anaesthesia.In ten goats and ten pigs, expired alveolar gas and arterial and mixed venous blood samples were simultaneously drawn during total intravenous anaesthesia with propofol. The blood gas Partition Coefficient and pulmonary extraction ratio were calculated for both species. Non-parametric methods were used for statistical inference.The blood gas Partition Coefficient ranged between 7000 and 646 000 for goats and between 17 000 and 267 000 for pigs. The pulmonary extraction ratio ranged between 32.9% and 98.1% for goats and was higher for pigs, which ranged between −106.0% and 39.0%.The blood gas Partition Coefficient for propofol exceeded those for other known anaesthetic compounds so that it takes lon...

George C Kramer - One of the best experts on this subject based on the ideXlab platform.

  • consequences of misfilling contemporary vaporizers with desflurane
    Canadian Journal of Anaesthesia-journal Canadien D Anesthesie, 1993
    Co-Authors: John Jeffrey Andrews, Robert V. Johnston, George C Kramer
    Abstract:

    Desflurane is a volatile anaesthetic that combines low blood gas solubility (blood/gas Partition Coefficient =0.42 at 37° C), moderate potency (MAC = 6–7%), and high volatility (vapour pressure =681 mmHg at 20° C, boiling point = 23.5° C). The volatility and potency of desflurane prevent its safe use in vaporizers of traditional design. We present a mathematical model which demonstrates the potential for desflurane overdose if contemporary vaporizers are misfilled with desflurane. The most hazardous filling error occurs if an enflurane vaporizer is misfilled with desflurane. The calculated desflurane output of a misfilled enflurane vaporizer at a dial setting of 1% and a temperature of 22° C is 57.8%, or 9.6 MAC. For misfilled enflurane, isoflurane, and halothane vaporizers at dial settings equivalent to one MAC at 22° C, the calculated desflurane output is 14.0, 10.2, and 7.8 MAC, respectively. We conclude that the safe delivery of desflurane will require engineering safeguards, additional monitoring, and education of the anesthesia community.