The Experts below are selected from a list of 66 Experts worldwide ranked by ideXlab platform
Christine Rouzioux - One of the best experts on this subject based on the ideXlab platform.
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A Subset of Extreme Human Immunodeficiency Virus (HIV) Controllers Is Characterized by a Small HIV Blood Reservoir and a Weak T-Cell Activation Level
Open Forum Infectious Diseases, 2017Co-Authors: Etienne Canouï, Camille Lécuroux, Véronique Avettand-fenoel, Marine Gousset, Christine Rouzioux, Asier Saez-cirion, Laurence Meyer, Faroudy Boufassa, Olivier Lambotte, Nicolas NoëlAbstract:BACKGROUND: Human immunodeficiency virus controllers (HICs) form a heterogeneous group of patients with regard to formal definitions, immunologic characteristics, and changes over time in viral load. PATIENTS AND METHODS: The HICs with undetectable viral load ([uHICs] ie, for whom a viral load had never been detected with routine assays; n = 52) were compared with 178 HICs with blips during the follow up (bHICs). Clinical characteristics, ultrasensitive HIV-ribonucleic acid (RNA) and HIV-deoxyribonucleic acid (DNA) loads, HIV1-Western blot profiles, and immune parameters were analyzed. RESULTS: Relative to bHICs, uHICs had significantly lower ultrasensitive plasma HIV-RNA loads (P < .0001) and HIV-DNA levels in peripheral Blood mononuclear cells (P = .0004), higher CD4+ T-cell count (P = .04) at enrollment, and lower T-cell activation levels. Between diagnosis and inclusion in the cohort, the CD4+ T-cell count had not changed in uHICs but had significantly decreased in bHICs. Twenty-one percent of the uHICs lacked specific anti-HIV immunoglobulin G antibodies, and these individuals also had very low levels of HIV-DNA. Half of the uHICs had a protective human leukocyte antigen (HLA) allele (-B57/58/B27), a weak CD8+ T-cell response, and very small HIV-DNA Reservoir. CONCLUSIONS: We suggest that an interesting HIC phenotype combines protective HLA alleles, low level of HIV Blood Reservoirs, and reduced immune activation. Prospective studies aimed at evaluating the benefit of combined antiretroviral therapy in HICs might take into account the identification of uHICs and bHICs.
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hiv 1 dna for the measurement of the hiv Reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is
Journal of Clinical Virology, 2008Co-Authors: Veronique Avettandfenoel, Faroudy Boufassa, Laurence Meyer, Julie Galimand, Christine RouziouxAbstract:Abstract Background HIV-1 DNA levels, reported as copies/10 6 peripheral Blood mononuclear cells (PBMC), are very predictive of disease progression in seroconverters, independently of CD4 + T cell count and HIV-RNA. Previously, HIV-DNA levels have sometimes been reported by other means: copies/10 6 CD4 + T cells, reflecting the proportion of infected cells; or copies/mL whole Blood, reflecting the global Blood Reservoir size. Objectives We investigated if the predictive value over the natural course of the disease depends on how the results are reported. Study design Results reported as HIV-DNA copies/10 6 PBMC were converted to copies/10 6 CD4 + T cells or to copies/mL whole Blood for 422 seroconverters included in the French SEROCO cohort (ANRS). Results The three methods for reporting HIV-DNA levels yielded different ranges, but these values were highly correlated. The level of HIV-DNA during the seroconversion period was strongly associated with disease progression in all three reporting methods. Conclusions This reinforces the value of HIV-DNA quantification in physiopathological and therapeutical studies, particularly in an era of research aimed at diminishing the HIV Reservoir. Even if Blood represents a small part of this Reservoir, HIV-DNA in Blood is a simple marker that provides an informative picture of the global Reservoir and is strongly predictive of disease progression.
Satoshi Masutani - One of the best experts on this subject based on the ideXlab platform.
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Blood Reservoir function in patients with Fontan circulation and asplenia syndrome.
Cardiology in the young, 2019Co-Authors: Michitaka Fuse, Kenji Sugamoto, Seiko Kuwata, Rika Sekiya, Kohei Kawada, Miku Toki, Masahiro Kaneko, Yoichi Iwamoto, Hirotaka Ishido, Satoshi MasutaniAbstract:Splanchnic circulation constitutes a major portion of the vasculature capacitance and plays an important role in maintaining Blood perfusion. Because patients with asplenia syndrome lack this vascular bed as a Blood Reservoir, they may have a unique Blood volume and distribution, which may be related to their vulnerability to the haemodynamic changes often observed in clinical practice. During cardiac catheterisation, the mean circulatory filling pressure was calculated with the Valsalva manoeuvre in 19 patients with Fontan circulation, including 5 patients with asplenia syndrome. We also measured the cardiac output index and circulatory Blood volume by using a dye dilution technique. The Blood volume and the mean circulatory filling pressure and the venous capacitance in patients with asplenia syndrome were similar to those in the remaining patients with Fontan circulation (85 ± 14 versus 77 ± 18 ml/kg, p = 0.43, 31 ± 8 versus 27 ± 5 mmHg, p = 0.19, 2.8 ± 0.6 versus 2.9 ± 0.9 ml/kg/mmHg, p = 0.86). Unexpectedly, our data indicated that patients with asplenia syndrome, who lack splanchnic capacitance circulation, have Blood volume and venous capacitance comparable to those in patients with splanchnic circulation. These data suggest that (1) there is a Blood Reservoir other than the spleen even in patients with asplenia; (2) considering the large Blood pool of the spleen, the presence of a symmetrical liver may represent the possible organ functioning as a Blood Reservoir in asplenia syndrome; and (3) if this is indeed the case, there may be a higher risk of hepatic congestion in patients with Fontan circulation with asplenia syndrome than in those without.
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abstract 14512 Blood Reservoir function in fontan patients with asplenia syndrome
Circulation, 2018Co-Authors: Shun Matsumura, Kenji Sugamoto, Seiko Kuwata, Yoichi Iwamoto, Hirotaka Ishido, Satoshi Masutani, Akiko Yana, Clara Kurishima, Hirofumi Saiki, Hideaki SenzakiAbstract:Background: The splanchnic circulation constitutes a major portion of the total vasculature capacitance and plays an important role in maintaining Blood perfusion to vital organs in cases of hemody...
Hideaki Senzaki - One of the best experts on this subject based on the ideXlab platform.
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abstract 14512 Blood Reservoir function in fontan patients with asplenia syndrome
Circulation, 2018Co-Authors: Shun Matsumura, Kenji Sugamoto, Seiko Kuwata, Yoichi Iwamoto, Hirotaka Ishido, Satoshi Masutani, Akiko Yana, Clara Kurishima, Hirofumi Saiki, Hideaki SenzakiAbstract:Background: The splanchnic circulation constitutes a major portion of the total vasculature capacitance and plays an important role in maintaining Blood perfusion to vital organs in cases of hemody...
Kenji Sugamoto - One of the best experts on this subject based on the ideXlab platform.
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Blood Reservoir function in patients with Fontan circulation and asplenia syndrome.
Cardiology in the young, 2019Co-Authors: Michitaka Fuse, Kenji Sugamoto, Seiko Kuwata, Rika Sekiya, Kohei Kawada, Miku Toki, Masahiro Kaneko, Yoichi Iwamoto, Hirotaka Ishido, Satoshi MasutaniAbstract:Splanchnic circulation constitutes a major portion of the vasculature capacitance and plays an important role in maintaining Blood perfusion. Because patients with asplenia syndrome lack this vascular bed as a Blood Reservoir, they may have a unique Blood volume and distribution, which may be related to their vulnerability to the haemodynamic changes often observed in clinical practice. During cardiac catheterisation, the mean circulatory filling pressure was calculated with the Valsalva manoeuvre in 19 patients with Fontan circulation, including 5 patients with asplenia syndrome. We also measured the cardiac output index and circulatory Blood volume by using a dye dilution technique. The Blood volume and the mean circulatory filling pressure and the venous capacitance in patients with asplenia syndrome were similar to those in the remaining patients with Fontan circulation (85 ± 14 versus 77 ± 18 ml/kg, p = 0.43, 31 ± 8 versus 27 ± 5 mmHg, p = 0.19, 2.8 ± 0.6 versus 2.9 ± 0.9 ml/kg/mmHg, p = 0.86). Unexpectedly, our data indicated that patients with asplenia syndrome, who lack splanchnic capacitance circulation, have Blood volume and venous capacitance comparable to those in patients with splanchnic circulation. These data suggest that (1) there is a Blood Reservoir other than the spleen even in patients with asplenia; (2) considering the large Blood pool of the spleen, the presence of a symmetrical liver may represent the possible organ functioning as a Blood Reservoir in asplenia syndrome; and (3) if this is indeed the case, there may be a higher risk of hepatic congestion in patients with Fontan circulation with asplenia syndrome than in those without.
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abstract 14512 Blood Reservoir function in fontan patients with asplenia syndrome
Circulation, 2018Co-Authors: Shun Matsumura, Kenji Sugamoto, Seiko Kuwata, Yoichi Iwamoto, Hirotaka Ishido, Satoshi Masutani, Akiko Yana, Clara Kurishima, Hirofumi Saiki, Hideaki SenzakiAbstract:Background: The splanchnic circulation constitutes a major portion of the total vasculature capacitance and plays an important role in maintaining Blood perfusion to vital organs in cases of hemody...
Hirotaka Ishido - One of the best experts on this subject based on the ideXlab platform.
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Blood Reservoir function in patients with Fontan circulation and asplenia syndrome.
Cardiology in the young, 2019Co-Authors: Michitaka Fuse, Kenji Sugamoto, Seiko Kuwata, Rika Sekiya, Kohei Kawada, Miku Toki, Masahiro Kaneko, Yoichi Iwamoto, Hirotaka Ishido, Satoshi MasutaniAbstract:Splanchnic circulation constitutes a major portion of the vasculature capacitance and plays an important role in maintaining Blood perfusion. Because patients with asplenia syndrome lack this vascular bed as a Blood Reservoir, they may have a unique Blood volume and distribution, which may be related to their vulnerability to the haemodynamic changes often observed in clinical practice. During cardiac catheterisation, the mean circulatory filling pressure was calculated with the Valsalva manoeuvre in 19 patients with Fontan circulation, including 5 patients with asplenia syndrome. We also measured the cardiac output index and circulatory Blood volume by using a dye dilution technique. The Blood volume and the mean circulatory filling pressure and the venous capacitance in patients with asplenia syndrome were similar to those in the remaining patients with Fontan circulation (85 ± 14 versus 77 ± 18 ml/kg, p = 0.43, 31 ± 8 versus 27 ± 5 mmHg, p = 0.19, 2.8 ± 0.6 versus 2.9 ± 0.9 ml/kg/mmHg, p = 0.86). Unexpectedly, our data indicated that patients with asplenia syndrome, who lack splanchnic capacitance circulation, have Blood volume and venous capacitance comparable to those in patients with splanchnic circulation. These data suggest that (1) there is a Blood Reservoir other than the spleen even in patients with asplenia; (2) considering the large Blood pool of the spleen, the presence of a symmetrical liver may represent the possible organ functioning as a Blood Reservoir in asplenia syndrome; and (3) if this is indeed the case, there may be a higher risk of hepatic congestion in patients with Fontan circulation with asplenia syndrome than in those without.
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abstract 14512 Blood Reservoir function in fontan patients with asplenia syndrome
Circulation, 2018Co-Authors: Shun Matsumura, Kenji Sugamoto, Seiko Kuwata, Yoichi Iwamoto, Hirotaka Ishido, Satoshi Masutani, Akiko Yana, Clara Kurishima, Hirofumi Saiki, Hideaki SenzakiAbstract:Background: The splanchnic circulation constitutes a major portion of the total vasculature capacitance and plays an important role in maintaining Blood perfusion to vital organs in cases of hemody...