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Blood Stasis

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Ke-ji Chen – One of the best experts on this subject based on the ideXlab platform.

  • Blood Stasis syndrome and its treatment with activating Blood circulation to remove Blood Stasis therapy.
    Chinese Journal of Integrative Medicine, 2012
    Co-Authors: Ke-ji Chen

    Abstract:

    Clinical and Practical Values in Diagnosis of Blood Stasis Syndrome Blood Stasis Syndrome is a diagnosis that indicates a very strong sense of traditional Chinese medicine.It can relate to a lot of diseases;therefore, it has great clinical and practical values.Traditionally, chronic diseases and slow-progressing diseases mostly involve Blood Stasis.

  • chinese herb and formulas for promoting Blood circulation and removing Blood Stasis and antiplatelet therapies
    Evidence-based Complementary and Alternative Medicine, 2012
    Co-Authors: Yue Liu, Huijun Yin, Dazhuo Shi, Ke-ji Chen

    Abstract:

    Atherothrombosis, which directly threatens people’s health and lives, is the main cause of morbidity and mortality all over the world. Platelets play a key role in the development of acute coronary syndromes (ACSs) and contribute to cardiovascular events. Oral antiplatelet drugs are a milestone in the therapy of cardiovascular atherothrombotic diseases. In recent years, many reports have shown the possibility that “resistance” to oral anti-platelet drugs and many adverse reactions, such as serious bleeding risk, which provides an impetus for developing new anti-platelet drugs possesses highly efficiency and fewer adverse effects. Study on the Blood Stasis syndrome and promoting Blood circulation and removing Blood Stasis is the most active field of research of integration of traditional and western medicine in China. BloodStasis syndrome and platelet activation have close relationship, many Chinese herb and formulas for promoting Blood circulation and removing Blood Stasis possess definite anti-platelet effect. This paper covers the progress of anti-platelet mechanism of Chinese herb and formulas for promoting Blood circulation and removing Blood Stasis and is to be deeply discussed in further research.

Aidong Wen – One of the best experts on this subject based on the ideXlab platform.

  • The effect of Blood Stasis syndrome on the pharmacokinetics of hydroxysafflower yellow A in human
    African Journal of Pharmacy and Pharmacology, 2013
    Co-Authors: Yanyan Jia, Yun Tian, Aidong Wen, Jing Yang, Jin-wen Wang, Zhifu Yang

    Abstract:

    Blood Stasis, that is, the decrease of Blood flow velocity and the increase of Blood viscosity indicates hemorheological abnormalities and pharmacokinetic difference of drugs. Therefore, it is very important to investigate the pharmacokinetics of drugs in patients with Blood Stasis syndrome, which may influence absorption, distribution, metabolism, and excretion of drugs in Blood. The aim of this study was to compare the pharmacokinetics of 140 mg hydroxysafflor yellow A (HSYA) in healthy subjects and patients with Blood Stasis syndrome due to stable angina pectoris (SAP), and indentify the therapeutic regimen for patients and promote clinical rational drug use. This study was carried out in 12 healthy volunteers and 24 patients with BloodStasis syndrome due to SAP using a single-dose of HSYA (140 mg) under fasting conditions. Venous Blood samples were drawn through indwelling cannula from each volunteer prior to drug administration and at 0.5, 1, 1.25, 1.5, 2.0, 2.5, 3, 3.5, 4, 5, 6, 8, 10, 12, and 15 h after the drug administration. Plasma obtained after centrifuge was analyzed to determine HSYA by high-performance liquid chromatography (HPLC). HSYA pharmacokinetics have a significant difference between healthy subjects and patients with BloodStasis syndrome due to SAP: ratios of Cmax and AUC(0-∞) were 116.5% (105.0 to 134.2)and 132.2% (116.5 to 153.7), respectively; mean terminal half-life (t1/2) was 4.2 h as compared to 2.5 h in healthy subjects. The Blood Stasis syndrome has an impact on the pharmacokinetic parameters including Cmax, AUC0-∞, and t1/2, and dose adjustment should be required for patients with BloodStasis syndrome.

     

    Key words: Hydroxysafflower yellow A, safflower, pharmacokinetics differences, Blood Stasis.

  • pharmacokinetic comparisons of hydroxysafflower yellow a in normal and Blood Stasis syndrome rats
    Journal of Ethnopharmacology, 2010
    Co-Authors: Yun Tian, Zhifu Yang, Yi Qiao, Jing Yang, Yanyan Jia, Aidong Wen

    Abstract:

    Abstract Ethnopharmacological relevance Safflower is a popular Traditional Chinese Medicine (TCM) to invigorate the Blood and dispel ‘Blood Stasis’, which arises from poor Blood circulation. The differences of pharmacokinetic properties between normal and Blood Stasis syndrome rats were seldom reported. Aim of the study The present study was conducted to evaluate the pharmacokinetics of hydroxysafflower yellow A (HSYA) following oral administration of hydroxysafflower yellow A and safflower extract with approximately the same dose of HSYA 100 mg/kg in both normal and acute Blood Stasis rats. Materials and methods The animals were orally administered with HYSA monomer and safflower extract. The Blood samples were collected according to the time schedule. The concentrations of HSYA in rat plasma were determined by HPLC. Various pharmacokinetic parameters were estimated from the plasma concentration versus time data using non-compartmental methods. Results It was found that AUC0–t, Cmax, Vd and CL of HSYA in both HSYA monomer and safflower extract in acute Blood Stasis rats were with significant difference (P  Conclusions The results indicated that HSYA was with high uptake and eliminated slowly in the animals with Blood Stasis syndrome, suggesting that the rate and extent of drug metabolism was altered in acute Blood Stasis animals.

Yue Liu – One of the best experts on this subject based on the ideXlab platform.

  • chinese herb and formulas for promoting Blood circulation and removing Blood Stasis and antiplatelet therapies
    Evidence-based Complementary and Alternative Medicine, 2012
    Co-Authors: Yue Liu, Huijun Yin, Dazhuo Shi, Ke-ji Chen

    Abstract:

    Atherothrombosis, which directly threatens people’s health and lives, is the main cause of morbidity and mortality all over the world. Platelets play a key role in the development of acute coronary syndromes (ACSs) and contribute to cardiovascular events. Oral antiplatelet drugs are a milestone in the therapy of cardiovascular atherothrombotic diseases. In recent years, many reports have shown the possibility that “resistance” to oral anti-platelet drugs and many adverse reactions, such as serious bleeding risk, which provides an impetus for developing new anti-platelet drugs possesses highly efficiency and fewer adverse effects. Study on the Blood Stasis syndrome and promoting Blood circulation and removing Blood Stasis is the most active field of research of integration of traditional and western medicine in China. BloodStasis syndrome and platelet activation have close relationship, many Chinese herb and formulas for promoting Blood circulation and removing Blood Stasis possess definite anti-platelet effect. This paper covers the progress of anti-platelet mechanism of Chinese herb and formulas for promoting Blood circulation and removing Blood Stasis and is to be deeply discussed in further research.