The Experts below are selected from a list of 1173 Experts worldwide ranked by ideXlab platform
Edwin S Fineberg - One of the best experts on this subject based on the ideXlab platform.
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the influence of Blood pressure and carbohydrate tolerance on vascular Compliance in humans
American Journal of Hypertension, 2002Co-Authors: Myron H Weinberger, Naomi S Fineberg, Edwin S FinebergAbstract:Abstract We conducted noninvasive measures of vascular Compliance and glucose tolerance in 275 normotensive and hypertensive subjects. Of the total, 194 (70.5%) were hypertensive, 73 (26%) diabetic, 7 (2.5%) normotensive and diabetic and 66 (24%) both hypertensive and diabetic, and 74 (27%) normotensive and nondiabetic. In addition, 57 of the nondiabetic subjects had impaired glucose tolerance based on the results of Blood glucose levels 2 h after a glucose challenge. For the entire population, large artery Compliance was correlated with systolic (P These findings confirm the close relationship between elevated Blood pressure (BP) and carbohydrate intolerance and indicate that the vascular effects of both are separate, additive, and primarily on small Blood Vessel Compliance. These findings have important implications for the preclinical detection and potential prevention of hypertension, diabetes, and associated vascular disease.
Myron H Weinberger - One of the best experts on this subject based on the ideXlab platform.
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the influence of Blood pressure and carbohydrate tolerance on vascular Compliance in humans
American Journal of Hypertension, 2002Co-Authors: Myron H Weinberger, Naomi S Fineberg, Edwin S FinebergAbstract:Abstract We conducted noninvasive measures of vascular Compliance and glucose tolerance in 275 normotensive and hypertensive subjects. Of the total, 194 (70.5%) were hypertensive, 73 (26%) diabetic, 7 (2.5%) normotensive and diabetic and 66 (24%) both hypertensive and diabetic, and 74 (27%) normotensive and nondiabetic. In addition, 57 of the nondiabetic subjects had impaired glucose tolerance based on the results of Blood glucose levels 2 h after a glucose challenge. For the entire population, large artery Compliance was correlated with systolic (P These findings confirm the close relationship between elevated Blood pressure (BP) and carbohydrate intolerance and indicate that the vascular effects of both are separate, additive, and primarily on small Blood Vessel Compliance. These findings have important implications for the preclinical detection and potential prevention of hypertension, diabetes, and associated vascular disease.
Feng Hong - One of the best experts on this subject based on the ideXlab platform.
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Potential of PVA-doped bacterial nano-cellulose tubular composites for artificial Blood Vessels
Journal of Materials Chemistry B, 2015Co-Authors: Jingyu Tang, Xue Li, Lin Chen, Feng HongAbstract:Bacterial nano-cellulose (BNC) hydrogel has been suggested as a promising biomaterial for artificial Blood Vessels. However, some properties of BNC do not achieve all of the requirements of a native Blood Vessel – Compliance, for instance. In order to improve the properties of BNC tubes, poly(vinyl alcohol) (PVA) was introduced in the BNC tubes to make composites. Two types of pristine BNC tubes with different inner structures were produced in two bioreactors. A PVA tube and PVA–BNC tubular composites were made for comparison by using a thermally-induced phase separation method. The morphology, water permeability, cytotoxicity, and mechanical properties, including the axial stretch strength, suture retention, burst pressure, and Compliance of all the tubes, were evaluated and compared. The results indicated that PVA impregnated into BNC tubes and then significantly improved the properties of BNC, especially the mechanical properties and water permeability. The BNC tube itself played a great role in the performances of the composites as the skeleton base material. The PVA–BNC composite tubes could constitute new biomaterial candidates for vascular grafts.
Hai Pengfei - One of the best experts on this subject based on the ideXlab platform.
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Photoacoustic Elastography and Next-generation Photoacoustic Tomography Techniques Towards Clinical Translation
Washington University Open Scholarship, 2018Co-Authors: Hai PengfeiAbstract:Ultrasonically probing optical absorption, photoacoustic tomography (PAT) combines rich optical contrast with high ultrasonic resolution at depths beyond the optical diffusion limit. With consistent optical absorption contrast at different scales and highly scalable spatial resolution and penetration depth, PAT holds great promise as an important tool for both fundamental research and clinical application. Despite tremendous progress, PAT still encounters certain limitations that prevent it from becoming readily adopted in the clinical settings. This dissertation aims to advance both the technical development and application of PAT towards its clinical translation. The first part of this dissertation describes the development of photoacoustic elastography techniques, which complement PAT with the capability to image the elastic properties of biological tissue and detect pathological conditions associated with its alterations. First, I demonstrated vascular-elastic PAT (VE-PAT), capable of quantifying Blood Vessel Compliance changes due to thrombosis and occlusions. Then, I developed photoacoustic elastography to noninvasively map the elasticity distribution in biological tissue. Third, I further enhanced its performance by combing conventional photoacoustic elastography with a stress sensor having known stress–strain behavior to achieve quantitative photoacoustic elastography (QPAE). QPAE can quantify the Young’s modulus of biological tissues on an absolute scale. The second part of this dissertation introduces technical improvements of photoacoustic microscopy (PAM). First, by employing near-infrared (NIR) light for illumination, a greater imaging depth and finer lateral resolution were achieved by near-infrared optical-resolution PAM (NIR-OR-PAM). In addition, NIR-OR-PAM was capable of imaging other tissue components, including lipid and melanin. Second, I upgraded a high-speed functional OR-PAM (HF-OR-PAM) system and applied it to image neurovascular coupling during epileptic seizure propagation in mouse brains in vivo with high spatio-temporal resolution. Last, I developed a single-cell metabolic PAM (SCM-PAM) system, which improves the current single-cell oxygen consumption rate (OCR) measurement throughput from ~30 cells over 15 minutes to ~3000 cells over 15 minutes. This throughput enhancement of two orders of magnitude achieves modeling of single-cell OCR distribution with a statistically meaningful cell count. SCM-PAM enables imaging of intratumoral metabolic heterogeneity with single-cell resolution. The third part of this dissertation introduces the application of linear-array-based PAT (LA-PAT) in label-free high-throughput imaging of melanoma circulating tumor cells (CTCs) in patients in vivo. Taking advantage of the strong optical absorption of melanin and the unique capability of PAT to image optical absorption, with 100% relative sensitivity, at depths with high ultrasonic spatial resolution, LA-PAT is inherently suitable for melanoma CTC imaging. First, with a center ultrasonic frequency of 21 MHz, the LA-PAT system was able to detect melanoma CTCs clusters and quantify their sizes based on the contrast-to-noise ratio (CNR). Second, I developed an LA-PAT system with a center ultrasonic frequency of 40 MHz and imaged melanoma CTCs in patients in vivo with a CNR greater than 12. We successfully imaged 16 melanoma patients and detected melanoma CTCs in 3 of them. Among the CTC-positive patients, 67% had disease progression despite systemic therapy. In contrast, only 23% of the CTC-negative patients showed disease progression. This study lays a solid foundation for translating CTC detection to bedside for clinical care and decision-making
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Photoacoustic tomography of vascular Compliance in humans
Society of Photo-Optical Instrumentation Engineers, 2015Co-Authors: Hai Pengfei, Zhou Yong, Liang Jinyang, Li Chiye, Wang LihongAbstract:Characterization of Blood Vessel elastic properties can help in detecting thrombosis and preventing life-threatening conditions such as acute myocardial infarction or stroke. Vascular elastic photoacoustic tomography (VE-PAT) is proposed to measure Blood Vessel Compliance in humans. Implemented on a linear-array-based photoacoustic computed tomography system, VE-PAT can quantify Blood Vessel Compliance changes due to simulated thrombosis and occlusion. The feasibility of the VE-PAT system was first demonstrated by measuring the strains under uniaxial loading in perfused Blood Vessel phantoms and quantifying their Compliance changes due to the simulated thrombosis. The VE-PAT system detected a decrease in the Compliances of Blood Vessel phantoms with simulated thrombosis, which was validated by a standard compression test. The VE-PAT system was then applied to assess Blood Vessel Compliance in a human subject. Experimental results showed a decrease in Compliance when an occlusion occurred downstream from the measurement point in the Blood Vessels, demonstrating VE-PAT’s potential for clinical thrombosis detection
Naomi S Fineberg - One of the best experts on this subject based on the ideXlab platform.
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the influence of Blood pressure and carbohydrate tolerance on vascular Compliance in humans
American Journal of Hypertension, 2002Co-Authors: Myron H Weinberger, Naomi S Fineberg, Edwin S FinebergAbstract:Abstract We conducted noninvasive measures of vascular Compliance and glucose tolerance in 275 normotensive and hypertensive subjects. Of the total, 194 (70.5%) were hypertensive, 73 (26%) diabetic, 7 (2.5%) normotensive and diabetic and 66 (24%) both hypertensive and diabetic, and 74 (27%) normotensive and nondiabetic. In addition, 57 of the nondiabetic subjects had impaired glucose tolerance based on the results of Blood glucose levels 2 h after a glucose challenge. For the entire population, large artery Compliance was correlated with systolic (P These findings confirm the close relationship between elevated Blood pressure (BP) and carbohydrate intolerance and indicate that the vascular effects of both are separate, additive, and primarily on small Blood Vessel Compliance. These findings have important implications for the preclinical detection and potential prevention of hypertension, diabetes, and associated vascular disease.