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Yi Guo - One of the best experts on this subject based on the ideXlab platform.
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wake promoting effect of Bloodletting puncture at hand twelve jing well points in acute stroke patients a multi center randomized controlled trial
Chinese Journal of Integrative Medicine, 2021Co-Authors: Yang Gao, Zhiliang Zhou, Xue Zhao, Dan Zhou, Zhenguo Wang, Zelin Chen, Xingfang Pan, Yi GuoAbstract:To assess the effect and safety of Bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance. In this multi-center and randomized controlled trial, 360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into Bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine, and patients in the Bloodletting group received additional Bloodletting puncture at HTWPs on admission immediately before conventional treatment. The primary outcome measure was Glasgow Coma Scale (GCS) score and the secondary outcomes included blood pressure, respiratory rate and pulse rate. All variables were evaluated at baseline (before Bloodletting), 0 (after Bloodletting immediately), 15, 30, 50 and 80 min post Bloodletting. At 80 min post Bloodletting, the proportion of patients with improved consciousness in the Bloodletting group was greater than the control group (P 0.05). The Bloodletting puncture at HTWPs was safe and could improve conscious levels of ischemic stroke patients, highlighting a first-aid intervention for acute stroke. (Registration No. ChiCTR-INR-16009530)
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Bloodletting puncture at hand twelve jing well points relieves brain edema after severe traumatic brain injury in rats via inhibiting mapk signaling pathway
Chinese Journal of Integrative Medicine, 2021Co-Authors: Baohu Liu, Dan Zhou, Yi Guo, Yinan Gong, Sai Zhang, Yongming Guo, Tongtong Guo, Xuyi Chen, Huiling TangAbstract:To investigate whether blood-brain barrier (BBB) served a key role in the edema-relief effect of Bloodletting puncture at hand twelve Jing-well points (HTWP) in traumatic brain injury (TBI) and the potential molecular signaling pathways. Adult male Sprague-Dawley rats were assigned to the sham-operated (sham), TBI, and Bloodletting puncture (Bloodletting) groups (n=24 per group) using a randomized number table. The TBI model rats were induced by cortical contusion and then Bloodletting puncture were performed at HTWP twice a day for 2 days. The neurological function and cerebral edema were evaluated by modified neurological severity score (mNSS), cerebral water content, magnetic resonance imaging and hematoxylin and eosin staining. Cerebral blood flow was measured by laser speckles. The protein levels of aquaporin 4 (AQP4), matrix metalloproteinases 9 (MMP9) and mitogen-activated protein kinase pathway (MAPK) signaling were detected by immunofluorescence staining and Western blot. Compared with TBI group, Bloodletting puncture improved neurological function at 24 and 48 h, alleviated cerebral edema at 48 h, and reduced the permeability of BBB induced by TBI (all P<0.05). The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by Bloodletting puncture (P<0.05 or P<0.01). In addition, the extracellular signal-regulated kinase (ERK) and p38 signaling pathways were inhibited by Bloodletting puncture (P<0.05). Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling pathways. Therefore, Bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema.
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Bloodletting Puncture at Hand Twelve Jing-Well Points Improves Neurological Recovery by Ameliorating Acute Traumatic Brain Injury-Induced Coagulopathy in Mice.
Frontiers in neuroscience, 2020Co-Authors: Xiu Zhou, Yi Guo, Yongming Guo, Ding-wei Peng, Cao Yulin, Lei Zhu, Sai ZhangAbstract:Traumatic brain injury (TBI) contributes to hypocoagulopathy associated with prolonged bleeding and hemorrhagic progression. Bloodletting puncture therapy at hand twelve Jing-well points (BL-HTWP) has been applied as a first aid measure in various emergent neurological diseases, but the detailed mechanisms of the modulation between the central nervous system and systemic circulation after acute TBI in rodents remain unclear. To investigate whether BL-HTWP stimulation modulates hypocoagulable state and exerts neuroprotective effect, experimental TBI model of mice was produced by the controlled cortical impactor (CCI), and treatment with BL-HTWP was immediately made after CCI. Then, the effects of BL-HTWP on the neurological function, cerebral perfusion state, coagulable state, and cerebrovascular histopathology post-acute TBI were determined, respectively. Results showed that BL-HTWP treatment attenuated cerebral hypoperfusion and improve neurological recovery post-acute TBI. Furthermore, BL-HTWP stimulation reversed acute TBI-induced hypocoagulable state, reduced vasogenic edema and cytotoxic edema by regulating multiple hallmarks of coagulopathy in TBI. Therefore, we conclude for the first time that hypocoagulopathic state occurs after acute experimental TBI, and the neuroprotective effect of BL-HTWP relies on, at least in part, the modulation of hypocoagulable state. BL-HTWP therapy may be a promising strategy for acute severe TBI in the future.
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indication of Bloodletting therapy based on multi dimensional evidence assessment
Chinese acupuncture & moxibustion, 2020Co-Authors: Yinan Gong, Zelin Chen, Yi Guo, Simin Song, Xue MengAbstract:The indication of Bloodletting therapy was determined based on the multi-dimensional evidence assessment, which could provide guidance for the clinical application of Bloodletting therapy. The literature of Bloodletting therapy was comprehensively collected by retrieval in CNKI, Wanfang and VIP databases (until February 23, 2019), modern books in Library of Tianjing University of TCM and the Chinese Medical Code (Fifth Edition). The disease spectrum of Bloodletting therapy was determined by self-designed questionnaire survey e-mailed to relevant experts. The indication of Bloodletting therapy was determined by Delphi expert meeting. As a result, 746 pieces of ancient literature and 32 775 modern literature were included. The indications of Bloodletting therapy based on the multi-dimensional evidence assessment include herpes zoster, acne, acute tonsillitis, vascular headache, varicose veins of lower extremities, acute lumbar sprain, early erysipelas, wheat swelling, exogenous fever of children, stroke, which are mainly the syndromes of blood stasis, toxin, excess and heat.
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effect of Bloodletting acupuncture at twelve jing well points of hand on microcirculatory disturbance in mice with traumatic brain injury
Chinese acupuncture & moxibustion, 2019Co-Authors: Jianping Tian, Dan Zhou, Yi Guo, Sai Zhang, Yongming Guo, Shixiang ChengAbstract:OBJECTIVE To observe the effect of Bloodletting acupuncture at twelve jing-well points of hand on microcirculatory disturbance in mice with traumatic brain injury (TBI), and to explore the protective effect of Bloodletting therapy on TBI. METHODS Sixty clean adult male C57BL/6J mice were randomly divided into a sham-operation group, a model group and a treatment group, 20 mice in each group. The TBI model was established by using electronic controlled cerebral cortex impact instrument in the model group and the treatment group. The mice in the treatment group were treated with Bloodletting acupuncture at bilateral "Shaoshang" (LU 11), "Shangyang" (LI 1), "Zhongchong" (PC 9), "Guanchong" (TE 1), "Shaochong" (HT 9) and "Shaoze" (SI 1) immediately after trauma. The mice in the sham-operation group only opened the bone window but did not receive the strike. The regional cerebral blood flow (rCBF) was monitored by laser speckle contrast analysis (LASCA) using a PeriCam PSI System before trauma, immediately after trauma and 1, 2, 12, 24, 48, 72 h after trauma. The brain water content was measured by wet-dry weight method 24 h after trauma. The severity of functional impairment at 2, 12, 24, 48 and 72 h after trauma was evaluated by modified neurological scale scores (mNSS). RESULTS ① 2 h after trauma, the mNSS in the model group and treatment group were >7 points, suggesting the successful establishment of model; compared with the sham-operation group, the mNSS was increased significantly from 12 to 72 h after trauma in the model group ( all P<0.01), but the mNSS in the treatment group was significantly lower than that in the model group from 2 to 24 h after trauma (P<0.01, P<0.05). ② Compared with the sham-operation group, rCBF in the model group was decreased significantly immediately after trauma (P<0.01), and the rCBF in the model group was lower than that in the sham-operation group from 1 to 72 h after trauma ( all P<0.01); rCBF in the treatment group began to rise and was significantly higher than that in the model group 1-2 h after trauma (P<0.01); 12-48 h after trauma, the increasing of rCBF in the two groups tended to be gentle until 72 h after injury, and rCBF in the model group was decreased while that in the treatment group continued to rise and was higher than that in the model group (P<0.01). ③ 24 h after trauma, the brain water content in the model group was significantly higher than that in the sham-operation group (P<0.01), and brain water content in the treatment group was significantly lower than that in the model group (P<0.01). CONCLUSION The Bloodletting acupuncture at twelve jing-well points of hand could improve microcirculation disturbance, increase microcirculation perfusion, alleviate secondary brain edema and promote the recovery of nerve function in mice with TBI.
Sai Zhang - One of the best experts on this subject based on the ideXlab platform.
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Bloodletting puncture at hand twelve jing well points relieves brain edema after severe traumatic brain injury in rats via inhibiting mapk signaling pathway
Chinese Journal of Integrative Medicine, 2021Co-Authors: Baohu Liu, Dan Zhou, Yi Guo, Yinan Gong, Sai Zhang, Yongming Guo, Tongtong Guo, Xuyi Chen, Huiling TangAbstract:To investigate whether blood-brain barrier (BBB) served a key role in the edema-relief effect of Bloodletting puncture at hand twelve Jing-well points (HTWP) in traumatic brain injury (TBI) and the potential molecular signaling pathways. Adult male Sprague-Dawley rats were assigned to the sham-operated (sham), TBI, and Bloodletting puncture (Bloodletting) groups (n=24 per group) using a randomized number table. The TBI model rats were induced by cortical contusion and then Bloodletting puncture were performed at HTWP twice a day for 2 days. The neurological function and cerebral edema were evaluated by modified neurological severity score (mNSS), cerebral water content, magnetic resonance imaging and hematoxylin and eosin staining. Cerebral blood flow was measured by laser speckles. The protein levels of aquaporin 4 (AQP4), matrix metalloproteinases 9 (MMP9) and mitogen-activated protein kinase pathway (MAPK) signaling were detected by immunofluorescence staining and Western blot. Compared with TBI group, Bloodletting puncture improved neurological function at 24 and 48 h, alleviated cerebral edema at 48 h, and reduced the permeability of BBB induced by TBI (all P<0.05). The AQP4 and MMP9 which would disrupt the integrity of BBB were downregulated by Bloodletting puncture (P<0.05 or P<0.01). In addition, the extracellular signal-regulated kinase (ERK) and p38 signaling pathways were inhibited by Bloodletting puncture (P<0.05). Bloodletting puncture at HTWP might play a significant role in protecting BBB through regulating the expressions of MMP9 and AQP4 as well as corresponding regulatory upstream ERK and p38 signaling pathways. Therefore, Bloodletting puncture at HTWP may be a promising therapeutic strategy for TBI-induced cerebral edema.
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Bloodletting Puncture at Hand Twelve Jing-Well Points Improves Neurological Recovery by Ameliorating Acute Traumatic Brain Injury-Induced Coagulopathy in Mice.
Frontiers in neuroscience, 2020Co-Authors: Xiu Zhou, Yi Guo, Yongming Guo, Ding-wei Peng, Cao Yulin, Lei Zhu, Sai ZhangAbstract:Traumatic brain injury (TBI) contributes to hypocoagulopathy associated with prolonged bleeding and hemorrhagic progression. Bloodletting puncture therapy at hand twelve Jing-well points (BL-HTWP) has been applied as a first aid measure in various emergent neurological diseases, but the detailed mechanisms of the modulation between the central nervous system and systemic circulation after acute TBI in rodents remain unclear. To investigate whether BL-HTWP stimulation modulates hypocoagulable state and exerts neuroprotective effect, experimental TBI model of mice was produced by the controlled cortical impactor (CCI), and treatment with BL-HTWP was immediately made after CCI. Then, the effects of BL-HTWP on the neurological function, cerebral perfusion state, coagulable state, and cerebrovascular histopathology post-acute TBI were determined, respectively. Results showed that BL-HTWP treatment attenuated cerebral hypoperfusion and improve neurological recovery post-acute TBI. Furthermore, BL-HTWP stimulation reversed acute TBI-induced hypocoagulable state, reduced vasogenic edema and cytotoxic edema by regulating multiple hallmarks of coagulopathy in TBI. Therefore, we conclude for the first time that hypocoagulopathic state occurs after acute experimental TBI, and the neuroprotective effect of BL-HTWP relies on, at least in part, the modulation of hypocoagulable state. BL-HTWP therapy may be a promising strategy for acute severe TBI in the future.
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effect of Bloodletting acupuncture at twelve jing well points of hand on microcirculatory disturbance in mice with traumatic brain injury
Chinese acupuncture & moxibustion, 2019Co-Authors: Jianping Tian, Dan Zhou, Yi Guo, Sai Zhang, Yongming Guo, Shixiang ChengAbstract:OBJECTIVE To observe the effect of Bloodletting acupuncture at twelve jing-well points of hand on microcirculatory disturbance in mice with traumatic brain injury (TBI), and to explore the protective effect of Bloodletting therapy on TBI. METHODS Sixty clean adult male C57BL/6J mice were randomly divided into a sham-operation group, a model group and a treatment group, 20 mice in each group. The TBI model was established by using electronic controlled cerebral cortex impact instrument in the model group and the treatment group. The mice in the treatment group were treated with Bloodletting acupuncture at bilateral "Shaoshang" (LU 11), "Shangyang" (LI 1), "Zhongchong" (PC 9), "Guanchong" (TE 1), "Shaochong" (HT 9) and "Shaoze" (SI 1) immediately after trauma. The mice in the sham-operation group only opened the bone window but did not receive the strike. The regional cerebral blood flow (rCBF) was monitored by laser speckle contrast analysis (LASCA) using a PeriCam PSI System before trauma, immediately after trauma and 1, 2, 12, 24, 48, 72 h after trauma. The brain water content was measured by wet-dry weight method 24 h after trauma. The severity of functional impairment at 2, 12, 24, 48 and 72 h after trauma was evaluated by modified neurological scale scores (mNSS). RESULTS ① 2 h after trauma, the mNSS in the model group and treatment group were >7 points, suggesting the successful establishment of model; compared with the sham-operation group, the mNSS was increased significantly from 12 to 72 h after trauma in the model group ( all P<0.01), but the mNSS in the treatment group was significantly lower than that in the model group from 2 to 24 h after trauma (P<0.01, P<0.05). ② Compared with the sham-operation group, rCBF in the model group was decreased significantly immediately after trauma (P<0.01), and the rCBF in the model group was lower than that in the sham-operation group from 1 to 72 h after trauma ( all P<0.01); rCBF in the treatment group began to rise and was significantly higher than that in the model group 1-2 h after trauma (P<0.01); 12-48 h after trauma, the increasing of rCBF in the two groups tended to be gentle until 72 h after injury, and rCBF in the model group was decreased while that in the treatment group continued to rise and was higher than that in the model group (P<0.01). ③ 24 h after trauma, the brain water content in the model group was significantly higher than that in the sham-operation group (P<0.01), and brain water content in the treatment group was significantly lower than that in the model group (P<0.01). CONCLUSION The Bloodletting acupuncture at twelve jing-well points of hand could improve microcirculation disturbance, increase microcirculation perfusion, alleviate secondary brain edema and promote the recovery of nerve function in mice with TBI.
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neuroprotective effects of Bloodletting at jing points combined with mild induced hypothermia in acute severe traumatic brain injury
Neural Regeneration Research, 2016Co-Authors: Xiaomei Miao, Xuyi Chen, Hongtao Sun, Shixiang Cheng, Sai ZhangAbstract:Bloodletting at Jing points has been used to treat coma in traditional Chinese medicine. Mild induced hypothermia has also been shown to have neuroprotective effects. However, the therapeutic effects of Bloodletting at Jing points and mild induced hypothermia alone are limited. Therefore, we investigated whether combined treatment might have clinical effectiveness for the treatment of acute severe traumatic brain injury. Using a rat model of traumatic brain injury, combined treatment substantially alleviated cerebral edema and blood-brain barrier dysfunction. Furthermore, neurological function was ameliorated, and cellular necrosis and the inflammatory response were lessened. These findings suggest that the combined effects of Bloodletting at Jing points (20 μL, twice a day, for 2 days) and mild induced hypothermia (6 hours) are better than their individual effects alone. Their combined application may have marked neuroprotective effects in the clinical treatment of acute severe traumatic brain injury.
Eugene H Blackstone - One of the best experts on this subject based on the ideXlab platform.
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contemporary Bloodletting in cardiac surgical care
The Annals of Thoracic Surgery, 2015Co-Authors: Colleen G Koch, Edmunds Z Reineks, Anne S Tang, Eric D Hixson, Shannon Phillips, Joseph F Sabik, Michael J Henderson, Eugene H BlackstoneAbstract:Background Health care providers are seldom aware of the frequency and volume of phlebotomy for laboratory testing, Bloodletting that often leads to hospital-acquired anemia. Our objectives were to examine the frequency of laboratory testing in patients undergoing cardiac surgery, calculate cumulative phlebotomy volume from time of initial surgical consultation to hospital discharge, and propose strategies to reduce phlebotomy volume. Methods From January 1, 2012 to June 30, 2012, 1,894 patients underwent cardiac surgery at Cleveland Clinic; 1,867 had 1 hospitalization and 27 had 2. Each laboratory test was associated with a test name and blood volume. Phlebotomy volume was estimated separately for the intensive care unit (ICU), hospital floors, and cumulatively. Results A total of 221,498 laboratory tests were performed, averaging 115 tests per patient. The most frequently performed tests were 88,068 blood gas analyses, 39,535 coagulation tests, 30,421 complete blood counts, and 29,374 metabolic panels. Phlebotomy volume differed between ICU and hospital floors, with median volumes of 332 mL and 118 mL, respectively. Cumulative median volume for the entire hospital stay was 454 mL. More complex procedures were associated with higher overall phlebotomy volume than isolated procedures; eg, combined coronary artery bypass grafting (CABG) and valve procedure median volume was 653 mL (25th/75th percentiles, 428 of 1,065 mL) versus 448 mL (284 of 658 mL) for isolated CABG and 338 mL (237 of 619) for isolated valve procedures. Conclusions We were astonished by the extent of Bloodletting, with total phlebotomy volumes approaching amounts equivalent to 1 to 2 red blood cell units. Implementation of process improvement initiatives can potentially reduce phlebotomy volumes and resource utilization.
Zelin Chen - One of the best experts on this subject based on the ideXlab platform.
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wake promoting effect of Bloodletting puncture at hand twelve jing well points in acute stroke patients a multi center randomized controlled trial
Chinese Journal of Integrative Medicine, 2021Co-Authors: Yang Gao, Zhiliang Zhou, Xue Zhao, Dan Zhou, Zhenguo Wang, Zelin Chen, Xingfang Pan, Yi GuoAbstract:To assess the effect and safety of Bloodletting puncture at hand twelve Jing-Well points (HTWPs) in acute stroke patients with conscious disturbance. In this multi-center and randomized controlled trial, 360 patients suffered from ischemic or hemorrhagic stroke with conscious disturbance within 48 h from the onset of symptom were divided into Bloodletting (180 cases) and control (180 cases) groups using a block randomization. Patients in both groups received routine Western medicine, and patients in the Bloodletting group received additional Bloodletting puncture at HTWPs on admission immediately before conventional treatment. The primary outcome measure was Glasgow Coma Scale (GCS) score and the secondary outcomes included blood pressure, respiratory rate and pulse rate. All variables were evaluated at baseline (before Bloodletting), 0 (after Bloodletting immediately), 15, 30, 50 and 80 min post Bloodletting. At 80 min post Bloodletting, the proportion of patients with improved consciousness in the Bloodletting group was greater than the control group (P 0.05). The Bloodletting puncture at HTWPs was safe and could improve conscious levels of ischemic stroke patients, highlighting a first-aid intervention for acute stroke. (Registration No. ChiCTR-INR-16009530)
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indication of Bloodletting therapy based on multi dimensional evidence assessment
Chinese acupuncture & moxibustion, 2020Co-Authors: Yinan Gong, Zelin Chen, Yi Guo, Simin Song, Xue MengAbstract:The indication of Bloodletting therapy was determined based on the multi-dimensional evidence assessment, which could provide guidance for the clinical application of Bloodletting therapy. The literature of Bloodletting therapy was comprehensively collected by retrieval in CNKI, Wanfang and VIP databases (until February 23, 2019), modern books in Library of Tianjing University of TCM and the Chinese Medical Code (Fifth Edition). The disease spectrum of Bloodletting therapy was determined by self-designed questionnaire survey e-mailed to relevant experts. The indication of Bloodletting therapy was determined by Delphi expert meeting. As a result, 746 pieces of ancient literature and 32 775 modern literature were included. The indications of Bloodletting therapy based on the multi-dimensional evidence assessment include herpes zoster, acne, acute tonsillitis, vascular headache, varicose veins of lower extremities, acute lumbar sprain, early erysipelas, wheat swelling, exogenous fever of children, stroke, which are mainly the syndromes of blood stasis, toxin, excess and heat.
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the ameliorative effect of Bloodletting puncture at hand twelve jing well points on cerebral edema induced by permanent middle cerebral ischemia via protecting the tight junctions of the blood brain barrier
BMC Complementary and Alternative Medicine, 2017Co-Authors: Zhenguo Wang, Yi Guo, Yucen Chen, Juntao Yang, Zelin ChenAbstract:Cerebral edema, erupting simultaneously with severe ischemic stroke, might lead to increased intracranial pressure, cerebral herniation, and ultimately death. Studies conducted previously by our team have demonstrated the fact that Bloodletting puncture at hand twelve Jing-well points (HTWP) could alleviate cerebral edema, which mainly results from the disruption of blood-brain barrier (BBB). The study, therefore, was first designed to demonstrate whether BBB-protection serves an important role in the edema-relief effect of HTWP Bloodletting, based on which to research the molecular mechanism underlying. The rats were made into model suffering from permanent middle cerebral artery occlusion (pMCAO) and then Bloodletting puncture were treated at HTWP once a day. Wet and dry weight method was adopted to evaluate the degree of brain edema, evans blue extravasation and electron microscopy were used to evaluate the integrity of the BBB, and RT-qPCR was carried out to analyze the expression level of occludin, claudin-5, ICAM-1, and VEGF. Results revealed that Bloodletting puncture treatment could reduce water content of brain and the permeability of BBB caused by ischemic stroke. In Bloodletting puncture group, ameliorated tight junctions could be observed under electron microscopy. It was demonstrated in further study that, in Bloodletting group, compared with pMCAO one, the expression levels of occludin and claudin-5 were up-regulated, while ICAM-1 and VEGF were down-regulated. In conclusion, Bloodletting puncture at HTWP might play a significant role in protecting the tight junctions of BBB, thus alleviating cerebral edema induced by ischemic stroke. Therefore, the therapy of Bloodletting puncture at HTWP may be a promising strategy for acute ischemic stroke in the future.
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therapeutic efficacy observation on Bloodletting and cupping for cervical radiculopathy
Journal of Acupuncture and Tuina Science, 2015Co-Authors: Mingyuan Mou, Zelin Chen, Yi Guo, Shengai Piao, Xiangwen Meng, Chenghui Zhu, Qiang Zhao, Yaowei Zhang, Junbiao Xing, Dianjun DiaoAbstract:To observe the efficacy and safety of Bloodletting and cupping for cervical radiculopathy. The randomized controlled clinical trial was conducted in five centers. A total of 183 eligible subjects were randomly allocated into a Bloodletting group (n=68), an acupuncture group (n=56) and a combined group (n=59). Patients in the Bloodletting group were treated with Bloodletting at Dazhui (GV 14) and Jianjing (GB 21) on the affected side, coupled with 5–10 min of cupping, 5 mL blood for each cup, 2–3 cups for one treatment. Patients in the acupuncture group were treated with needling cervical Jiaji (EX-B 2) points and Jianjing (GB 21) on the affected side. The needles were retained for 30 min. Patients in the combined group were treated with both methods. The treatment in all three groups were done once every three days, twice a week, 4 weeks for a course of treatment, for a total of 1–3 courses. Then the therapeutic efficacy was evaluated using scores of visual analogue scale (VAS), neck disability index (NDL) and clinical assessment scale (CAS) before treatment and after 1, 2 and 3 courses of treatment. The scores of VAS, NDI and CAS in all three groups were significantly decreased after 1, 2 and 3 courses of treatment (all P 0.05). Bloodletting and cupping share the similar effect with acupuncture in pain relief and improvement of quality of life in patients with cervical radiculopathy.
Aliki Fiska - One of the best experts on this subject based on the ideXlab platform.
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the ancient surgical Bloodletting method of arteriotomy
Journal of Vascular Surgery, 2011Co-Authors: Niki Papavramidou, Vassilios Thomaidis, Aliki FiskaAbstract:Methods of Bloodletting were widely known in antiquity and were used for the cure of numerous illnesses and symptoms, caused mainly by the supposed excess of blood in the body. This article presents and discusses arteriotomy, a surgical method of Bloodletting, appearing after the 1st century AD in the texts of Celsus, Galen, Antyllus, and Severus. The texts were studied either in their primary language or in a translation. Secondary references were only used for comparing the ancient technique to modern surgical methods.