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Klaus J. Busam - One of the best experts on this subject based on the ideXlab platform.

  • Melanoma arising in a large plaque-type Blue Nevus with subcutaneous cellular nodules.
    The American journal of surgical pathology, 2012
    Co-Authors: Iwei Yeh, Yuqiang Fang, Klaus J. Busam
    Abstract:

    Melanoma may arise in association with and/or simulate the appearance of a cellular Blue Nevus. The distinction of a cellular Blue Nevus with atypical features from Blue Nevus-like melanoma can be difficult. One rare setting, in which one may face this diagnostic challenge, is nodule formation in a

  • fluorescence in situ hybridization for distinguishing cellular Blue nevi from Blue Nevus like melanoma
    Journal of Cutaneous Pathology, 2011
    Co-Authors: Bryan Gammon, Beth Beilfuss, Joan Guitart, Klaus J. Busam, Pedram Gerami
    Abstract:

    Background: Blue Nevus-like melanomas are melanomas that arise in association with Blue nevi or closely simulate the histopathologic appearance of a Blue Nevus, usually a cellular Blue Nevus (CBN). Although the majority of CBN can be readily distinguished from Blue Nevus-like melanoma by conventional microscopy, there are a subset of cases where this distinction may be exceedingly difficult or impossible. Methods: In this study, we evaluated the ability of a fluorescence in situ hybridization (FISH) assay targeting 6p25 (RREB1), 6q23 (MYB), 11q13 (CCND1) and the centromere of chromosome 6 (Cep6) to distinguish between CBN and Blue Nevus-like melanoma. We identified five cases of Blue Nevus-like melanoma and 12 cases of CBN. Results: The FISH assay was performed with 100% sensitivity and 100% specificity. Three of five cases met the 6p25/Cep6 criteria, all five met the 6p25 gain criteria and three of five met the 6q23/Cep6 loss criteria. None of the cases met criteria for gains in 11q13. None of the 12 CBN met any criteria for melanoma. Conclusions: A combined analysis of clinical aspects, histopathologic changes and FISH analysis could potentially contribute significantly to the ability of pathologists to discriminate between Blue Nevus-like melanoma and Blue nevi in challenging cases. Gammon B, Beilfuss B, Guitart J, Busam KJ, Gerami P. Fluorescence in situ hybridization for distinguishing cellular Blue nevi from Blue Nevus-like melanoma.

  • melanoma associated with Blue Nevus and melanoma mimicking cellular Blue Nevus a clinicopathologic study of 10 cases on the spectrum of so called malignant Blue Nevus
    The American Journal of Surgical Pathology, 2001
    Co-Authors: Scott R. Granter, Phillip H. Mckee, Eduardo Calonje, Martin C. Mihm, Klaus J. Busam
    Abstract:

    The term “malignant Blue Nevus” refers to a rare and heterogeneous group of melanomas that arise in several clinical settings. This includes melanomas arising in association with a common or cellular Blue Nevus and those arising de novo and resembling cellular Blue nevi. We reviewed the clinicopatho

  • Melanoma associated with Blue Nevus and melanoma mimicking cellular Blue Nevus: a clinicopathologic study of 10 cases on the spectrum of so-called 'malignant Blue Nevus'.
    The American journal of surgical pathology, 2001
    Co-Authors: Scott R. Granter, Phillip H. Mckee, Eduardo Calonje, Martin C. Mihm, Klaus J. Busam
    Abstract:

    The term "malignant Blue Nevus" refers to a rare and heterogeneous group of melanomas that arise in several clinical settings. This includes melanomas arising in association with a common or cellular Blue Nevus and those arising de novo and resembling cellular Blue nevi. We reviewed the clinicopathologic features of 10 cases of malignant Blue nevi. Six cases proved to be de novo melanoma mimicking cellular Blue Nevus, but lacking a clear-cut benign component. Two melanomas arose in association with a common Blue Nevus, and two with a cellular Blue Nevus. The patients' (5 males, 5 females) ages ranged from 11 to 77 years (average age, 48.1 years). The head and neck was the most common location (6 of 10 patients), with five scalp tumors. Four tumors were located on the trunk; none was located on the extremities. Tumor size ranged from 0.5 to 2.2 cm (average size, 1.1cm). Most lesions had been present for many years before surgical removal. Pigmented dendritic cells were observed in 9 of 10 cases. The malignant and benign components were easily distinguished in the four cases that arose in association with a common or cellular Blue Nevus. Abrupt transition between a benign Blue Nevus and melanoma was readily recognized at scanning magnification as distinctive nodules of epithelioid to spindled cells with a sheet-like growth pattern. In all cases, malignancy was evidenced by increased mitotic rate, necrosis, nuclear atypia, pleomorphism, hyperchromasia, and prominent nucleoli. All 7 patients with follow-up information experienced recurrence (3 patients) or metastasis (4 patients). Three patients died of disease. Malignant Blue Nevus is a heterogeneous group of melanomas that are highly aggressive and often lethal, with a propensity for metastasis to the lymph nodes and lungs.

  • Large plaque-type Blue Nevus with subcutaneous cellular nodules.
    The American journal of surgical pathology, 2000
    Co-Authors: Klaus J. Busam, James M. Woodruff, Robert A. Erlandson, Mary S. Brady
    Abstract:

    Unusual or atypical melanocytic nevi can be confused with malignant melanoma. The authors present two cases of an unusual variant of Blue Nevus that were misdiagnosed initially as malignancy. Both lesions were asymptomatic and characterized clinically by childhood onset, with slow enlargement during adolescence and subsequent nodule formation. One lesion, which measured 24 cm in greatest dimension, was located on the anterior chest wall of a 53-year-old woman. The other lesion, which measured approximately 15 cm in greatest dimension, was located on the lateral abdominal wall of a 20-year-old man. Both lesions were characterized by a multifocal dermal and subcutaneous proliferation of fusiform and dendritic pigmented melanocytes. The histologic appearance of individual foci ranged from dermal melanocytosis to common Blue Nevus and cellular Blue Nevus. The cellular foci were located in the subcutis and involved, in one patient, the stroma of the breast. The cells were immunoreactive for S-100 protein, gp100 (HMB-45), and Melan-A (A103). Ultrastructural analysis revealed melanocytes typical of Blue Nevus. The woman underwent complete excision of the lesion, and the man underwent only partial excision of the lesion. On clinical follow-up of 32 and 19 months, respectively, both patients are alive and well with no evidence of recurrence or progression. Because the lesions presented clinically as large plaques and were diagnosed histologically as Blue nevi with subcutaneous foci of cellular Blue Nevus, we term this rare variant of Blue Nevus large plaque-type Blue Nevus with subcutaneous cellular nodules. Recognition of this lesion enhances our knowledge of the morphologic spectrum of melanocytic tumors and helps to avoid confusion with malignant melanoma.

Mary S. Brady - One of the best experts on this subject based on the ideXlab platform.

  • Large plaque-type Blue Nevus with subcutaneous cellular nodules.
    The American journal of surgical pathology, 2000
    Co-Authors: Klaus J. Busam, James M. Woodruff, Robert A. Erlandson, Mary S. Brady
    Abstract:

    Unusual or atypical melanocytic nevi can be confused with malignant melanoma. The authors present two cases of an unusual variant of Blue Nevus that were misdiagnosed initially as malignancy. Both lesions were asymptomatic and characterized clinically by childhood onset, with slow enlargement during adolescence and subsequent nodule formation. One lesion, which measured 24 cm in greatest dimension, was located on the anterior chest wall of a 53-year-old woman. The other lesion, which measured approximately 15 cm in greatest dimension, was located on the lateral abdominal wall of a 20-year-old man. Both lesions were characterized by a multifocal dermal and subcutaneous proliferation of fusiform and dendritic pigmented melanocytes. The histologic appearance of individual foci ranged from dermal melanocytosis to common Blue Nevus and cellular Blue Nevus. The cellular foci were located in the subcutis and involved, in one patient, the stroma of the breast. The cells were immunoreactive for S-100 protein, gp100 (HMB-45), and Melan-A (A103). Ultrastructural analysis revealed melanocytes typical of Blue Nevus. The woman underwent complete excision of the lesion, and the man underwent only partial excision of the lesion. On clinical follow-up of 32 and 19 months, respectively, both patients are alive and well with no evidence of recurrence or progression. Because the lesions presented clinically as large plaques and were diagnosed histologically as Blue nevi with subcutaneous foci of cellular Blue Nevus, we term this rare variant of Blue Nevus large plaque-type Blue Nevus with subcutaneous cellular nodules. Recognition of this lesion enhances our knowledge of the morphologic spectrum of melanocytic tumors and helps to avoid confusion with malignant melanoma.

Su Ying Wen - One of the best experts on this subject based on the ideXlab platform.

Nathaniel J. Jellinek - One of the best experts on this subject based on the ideXlab platform.

  • Subungual Blue Nevus with combined phenotypic features
    Journal of the American Academy of Dermatology, 2008
    Co-Authors: Elizabeth M. T. Naylor, Beth S. Ruben, Leslie Robinson-bostom, Gladys H. Telang, Nathaniel J. Jellinek
    Abstract:

    Blue nail dyschromia may represent melanocytic, vascular, or other etiologies. A case of a subungual Blue nodule is presented, with a pseudo-clubbed nail. On histopathologic examination, there was a combined subungual Blue Nevus, with features of a common Blue Nevus and a pigmented epithelioid melanocytoma. This unusual presentation is reviewed, with a discussion of Blue nail dyschromia and subungual Blue nevi.

Luc Thomas - One of the best experts on this subject based on the ideXlab platform.

  • Subungual Blue Nevus
    Journal of The American Academy of Dermatology, 2003
    Co-Authors: Anne Sophie Causeret, Anne Marie Viallard, François Skowron, Brigitte Balme, Luc Thomas
    Abstract:

    Junctional or compound melanocytic Nevus and melanoma may involve the nail apparatus and are usually discussed in the differential diagnosis of nail pigmentation. Blue Nevus has been very rarely reported in this location. We report the second clinicopathologic study of a subungual Blue Nevus.