The Experts below are selected from a list of 107496 Experts worldwide ranked by ideXlab platform
Xia Huang - One of the best experts on this subject based on the ideXlab platform.
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the cycloidea radialis module regulates petal shape and Pigmentation leading to bilateral corolla symmetry in torenia fournieri linderniaceae
New Phytologist, 2017Co-Authors: Shihao Su, Junqing Xiao, Keyuan Jiao, Qincheng Peng, Xiaohe Hu, Ziqing Ye, Wei Xiao, Na Wang, Xia HuangAbstract:Summary The diverse Pigmentation patterns of flower corollas probably result from pollinator-mediated selection. Previous studies demonstrated that R2R3-MYB factors may have been recruited in the regulation of corolla Pigmentation. However, how R2R3-MYBs became so diverse in their regulation of different Pigmentation patterns remains unclear. Here, we studied a Lamiales species, Torenia fournieri, which has elaborate zygomorphic flowers with dorsal–ventral asymmetries in corolla Pigmentation. We found recent gene duplication events in CYCLOIDEA-like (CYC-like) and RADIALIS-like (RAD-like) genes, and functionally analyzed three dorsal-specific expression factors: TfCYC1, TfCYC2, and TfRAD1. We found that the CYC–RAD module coordinates petal shape and corolla Pigmentation, as ectopic expression of TfCYC2 or TfRAD1 disrupted the asymmetric corolla Pigmentation pattern and produced strongly dorsalized flowers. Dorsal petal identity was lost when TfCYC2 was down-regulated or when TfRAD1 was knocked out. In T. fournieri, the diversified CYC and RAD genes have evolved regulatory loops, and TfCYC2 binds directly to the regulatory regions of an R2R3-MYB factor gene, TfMYB1, which might lead to its asymmetric expression and ultimately establish the asymmetric Pigmentation pattern. These findings support the existence of a regulatory module that integrates dorsal–ventral patterning and asymmetric corolla Pigmentation in T. fournieri.
A Mathian - One of the best experts on this subject based on the ideXlab platform.
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hydroxychloroquine induced Pigmentation in patients with systemic lupus erythematosus a case control study
JAMA Dermatology, 2013Co-Authors: M Jallouli, Camille Frances, Jeancharles Piette, Du Le Thi Huong, P Moguelet, Cecile Factor, Noel Zahr, Makoto Miyara, D Saadoun, A MathianAbstract:Importance Hydroxychloroquine-induced Pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced Pigmentation is secondary to ecchymosis or bruising. Objective To describe the clinical features and outcome of hydroxychloroquine (HCQ)-induced Pigmentation in patients with systemic lupus erythematosus (SLE). Design, Setting, and Participants In a case-control study conducted at a French referral center for SLE and antiphospholipid syndrome, 24 patients with SLE, with a diagnosis of HCQ-induced Pigmentation, were compared with 517 SLE controls treated with HCQ. Main Outcomes and Measures The primary outcome was the clinical features of HCQ-induced Pigmentation. Skin biopsies were performed on 5 patients, both in healthy skin and in the pigmented lesions. The statistical associations of HCQ-induced Pigmentation with several variables were calculated using univariate and multivariate analyses. Results Among the 24 patients, skin Pigmentation appeared after a median HCQ treatment duration of 6.1 years (range, 3 months–22 years). Twenty-two patients (92%) reported that the appearance of pigmented lesions was preceded by the occurrence of ecchymotic areas, which gave way to a localized blue-gray or brown Pigmentation that persisted. Twenty-three patients (96%) had at least 1 condition predisposing them to easy bruising. Results from skin biopsies performed on 5 patients showed that the median concentration of iron was significantly higher in biopsy specimens of pigmented lesions compared with normal skin (4115 vs 413 nmol/g; P Conclusions and Relevance Hydroxychloroquine-induced Pigmentation is not a rare adverse effect of HCQ. Our data support the hypothesis that HCQ-induced Pigmentation is secondary to ecchymosis or bruising.
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Hydroxychloroquine-induced Pigmentation in patients with systemic lupus erythematosus: a case-control study.
JAMA Dermatology, 2013Co-Authors: M Jallouli, Camille Frances, Jeancharles Piette, Du Le Thi Huong, P Moguelet, Cecile Factor, Noel Zahr, Makoto Miyara, D Saadoun, A MathianAbstract:IMPORTANCE: Hydroxychloroquine-induced Pigmentation is not a rare adverse effect. Our data support the hypothesis that hydroxychloroquine-induced Pigmentation is secondary to ecchymosis or bruising. OBJECTIVE: To describe the clinical features and outcome of hydroxychloroquine (HCQ)-induced Pigmentation in patients with systemic lupus erythematosus (SLE). DESIGN, SETTING, AND PARTICIPANTS: In a case-control study conducted at a French referral center for SLE and antiphospholipid syndrome, 24 patients with SLE, with a diagnosis of HCQ-induced Pigmentation, were compared with 517 SLE controls treated with HCQ. MAIN OUTCOMES AND MEASURES: The primary outcome was the clinical features of HCQ-induced Pigmentation. Skin biopsies were performed on 5 patients, both in healthy skin and in the pigmented lesions. The statistical associations of HCQ-induced Pigmentation with several variables were calculated using univariate and multivariate analyses. RESULTS: Among the 24 patients, skin Pigmentation appeared after a median HCQ treatment duration of 6.1 years (range, 3 months-22 years). Twenty-two patients (92%) reported that the appearance of pigmented lesions was preceded by the occurrence of ecchymotic areas, which gave way to a localized blue-gray or brown Pigmentation that persisted. Twenty-three patients (96%) had at least 1 condition predisposing them to easy bruising. Results from skin biopsies performed on 5 patients showed that the median concentration of iron was significantly higher in biopsy specimens of pigmented lesions compared with normal skin (4115 vs 413 nmol/g; P
Shihao Su - One of the best experts on this subject based on the ideXlab platform.
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the cycloidea radialis module regulates petal shape and Pigmentation leading to bilateral corolla symmetry in torenia fournieri linderniaceae
New Phytologist, 2017Co-Authors: Shihao Su, Junqing Xiao, Keyuan Jiao, Qincheng Peng, Xiaohe Hu, Ziqing Ye, Wei Xiao, Na Wang, Xia HuangAbstract:Summary The diverse Pigmentation patterns of flower corollas probably result from pollinator-mediated selection. Previous studies demonstrated that R2R3-MYB factors may have been recruited in the regulation of corolla Pigmentation. However, how R2R3-MYBs became so diverse in their regulation of different Pigmentation patterns remains unclear. Here, we studied a Lamiales species, Torenia fournieri, which has elaborate zygomorphic flowers with dorsal–ventral asymmetries in corolla Pigmentation. We found recent gene duplication events in CYCLOIDEA-like (CYC-like) and RADIALIS-like (RAD-like) genes, and functionally analyzed three dorsal-specific expression factors: TfCYC1, TfCYC2, and TfRAD1. We found that the CYC–RAD module coordinates petal shape and corolla Pigmentation, as ectopic expression of TfCYC2 or TfRAD1 disrupted the asymmetric corolla Pigmentation pattern and produced strongly dorsalized flowers. Dorsal petal identity was lost when TfCYC2 was down-regulated or when TfRAD1 was knocked out. In T. fournieri, the diversified CYC and RAD genes have evolved regulatory loops, and TfCYC2 binds directly to the regulatory regions of an R2R3-MYB factor gene, TfMYB1, which might lead to its asymmetric expression and ultimately establish the asymmetric Pigmentation pattern. These findings support the existence of a regulatory module that integrates dorsal–ventral patterning and asymmetric corolla Pigmentation in T. fournieri.
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The CYCLOIDEA–RADIALIS module regulates petal shape and Pigmentation, leading to bilateral corolla symmetry in Torenia fournieri (Linderniaceae)
New Phytologist, 2017Co-Authors: Shihao Su, Junqing Xiao, Keyuan Jiao, Ziqing Ye, Wei Xiao, Na Wang, Qincheng PengAbstract:Summary The diverse Pigmentation patterns of flower corollas probably result from pollinator-mediated selection. Previous studies demonstrated that R2R3-MYB factors may have been recruited in the regulation of corolla Pigmentation. However, how R2R3-MYBs became so diverse in their regulation of different Pigmentation patterns remains unclear. Here, we studied a Lamiales species, Torenia fournieri, which has elaborate zygomorphic flowers with dorsal–ventral asymmetries in corolla Pigmentation. We found recent gene duplication events in CYCLOIDEA-like (CYC-like) and RADIALIS-like (RAD-like) genes, and functionally analyzed three dorsal-specific expression factors: TfCYC1, TfCYC2, and TfRAD1. We found that the CYC–RAD module coordinates petal shape and corolla Pigmentation, as ectopic expression of TfCYC2 or TfRAD1 disrupted the asymmetric corolla Pigmentation pattern and produced strongly dorsalized flowers. Dorsal petal identity was lost when TfCYC2 was down-regulated or when TfRAD1 was knocked out. In T. fournieri, the diversified CYC and RAD genes have evolved regulatory loops, and TfCYC2 binds directly to the regulatory regions of an R2R3-MYB factor gene, TfMYB1, which might lead to its asymmetric expression and ultimately establish the asymmetric Pigmentation pattern. These findings support the existence of a regulatory module that integrates dorsal–ventral patterning and asymmetric corolla Pigmentation in T. fournieri.
Qincheng Peng - One of the best experts on this subject based on the ideXlab platform.
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the cycloidea radialis module regulates petal shape and Pigmentation leading to bilateral corolla symmetry in torenia fournieri linderniaceae
New Phytologist, 2017Co-Authors: Shihao Su, Junqing Xiao, Keyuan Jiao, Qincheng Peng, Xiaohe Hu, Ziqing Ye, Wei Xiao, Na Wang, Xia HuangAbstract:Summary The diverse Pigmentation patterns of flower corollas probably result from pollinator-mediated selection. Previous studies demonstrated that R2R3-MYB factors may have been recruited in the regulation of corolla Pigmentation. However, how R2R3-MYBs became so diverse in their regulation of different Pigmentation patterns remains unclear. Here, we studied a Lamiales species, Torenia fournieri, which has elaborate zygomorphic flowers with dorsal–ventral asymmetries in corolla Pigmentation. We found recent gene duplication events in CYCLOIDEA-like (CYC-like) and RADIALIS-like (RAD-like) genes, and functionally analyzed three dorsal-specific expression factors: TfCYC1, TfCYC2, and TfRAD1. We found that the CYC–RAD module coordinates petal shape and corolla Pigmentation, as ectopic expression of TfCYC2 or TfRAD1 disrupted the asymmetric corolla Pigmentation pattern and produced strongly dorsalized flowers. Dorsal petal identity was lost when TfCYC2 was down-regulated or when TfRAD1 was knocked out. In T. fournieri, the diversified CYC and RAD genes have evolved regulatory loops, and TfCYC2 binds directly to the regulatory regions of an R2R3-MYB factor gene, TfMYB1, which might lead to its asymmetric expression and ultimately establish the asymmetric Pigmentation pattern. These findings support the existence of a regulatory module that integrates dorsal–ventral patterning and asymmetric corolla Pigmentation in T. fournieri.
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The CYCLOIDEA–RADIALIS module regulates petal shape and Pigmentation, leading to bilateral corolla symmetry in Torenia fournieri (Linderniaceae)
New Phytologist, 2017Co-Authors: Shihao Su, Junqing Xiao, Keyuan Jiao, Ziqing Ye, Wei Xiao, Na Wang, Qincheng PengAbstract:Summary The diverse Pigmentation patterns of flower corollas probably result from pollinator-mediated selection. Previous studies demonstrated that R2R3-MYB factors may have been recruited in the regulation of corolla Pigmentation. However, how R2R3-MYBs became so diverse in their regulation of different Pigmentation patterns remains unclear. Here, we studied a Lamiales species, Torenia fournieri, which has elaborate zygomorphic flowers with dorsal–ventral asymmetries in corolla Pigmentation. We found recent gene duplication events in CYCLOIDEA-like (CYC-like) and RADIALIS-like (RAD-like) genes, and functionally analyzed three dorsal-specific expression factors: TfCYC1, TfCYC2, and TfRAD1. We found that the CYC–RAD module coordinates petal shape and corolla Pigmentation, as ectopic expression of TfCYC2 or TfRAD1 disrupted the asymmetric corolla Pigmentation pattern and produced strongly dorsalized flowers. Dorsal petal identity was lost when TfCYC2 was down-regulated or when TfRAD1 was knocked out. In T. fournieri, the diversified CYC and RAD genes have evolved regulatory loops, and TfCYC2 binds directly to the regulatory regions of an R2R3-MYB factor gene, TfMYB1, which might lead to its asymmetric expression and ultimately establish the asymmetric Pigmentation pattern. These findings support the existence of a regulatory module that integrates dorsal–ventral patterning and asymmetric corolla Pigmentation in T. fournieri.
Na Wang - One of the best experts on this subject based on the ideXlab platform.
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the cycloidea radialis module regulates petal shape and Pigmentation leading to bilateral corolla symmetry in torenia fournieri linderniaceae
New Phytologist, 2017Co-Authors: Shihao Su, Junqing Xiao, Keyuan Jiao, Qincheng Peng, Xiaohe Hu, Ziqing Ye, Wei Xiao, Na Wang, Xia HuangAbstract:Summary The diverse Pigmentation patterns of flower corollas probably result from pollinator-mediated selection. Previous studies demonstrated that R2R3-MYB factors may have been recruited in the regulation of corolla Pigmentation. However, how R2R3-MYBs became so diverse in their regulation of different Pigmentation patterns remains unclear. Here, we studied a Lamiales species, Torenia fournieri, which has elaborate zygomorphic flowers with dorsal–ventral asymmetries in corolla Pigmentation. We found recent gene duplication events in CYCLOIDEA-like (CYC-like) and RADIALIS-like (RAD-like) genes, and functionally analyzed three dorsal-specific expression factors: TfCYC1, TfCYC2, and TfRAD1. We found that the CYC–RAD module coordinates petal shape and corolla Pigmentation, as ectopic expression of TfCYC2 or TfRAD1 disrupted the asymmetric corolla Pigmentation pattern and produced strongly dorsalized flowers. Dorsal petal identity was lost when TfCYC2 was down-regulated or when TfRAD1 was knocked out. In T. fournieri, the diversified CYC and RAD genes have evolved regulatory loops, and TfCYC2 binds directly to the regulatory regions of an R2R3-MYB factor gene, TfMYB1, which might lead to its asymmetric expression and ultimately establish the asymmetric Pigmentation pattern. These findings support the existence of a regulatory module that integrates dorsal–ventral patterning and asymmetric corolla Pigmentation in T. fournieri.
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The CYCLOIDEA–RADIALIS module regulates petal shape and Pigmentation, leading to bilateral corolla symmetry in Torenia fournieri (Linderniaceae)
New Phytologist, 2017Co-Authors: Shihao Su, Junqing Xiao, Keyuan Jiao, Ziqing Ye, Wei Xiao, Na Wang, Qincheng PengAbstract:Summary The diverse Pigmentation patterns of flower corollas probably result from pollinator-mediated selection. Previous studies demonstrated that R2R3-MYB factors may have been recruited in the regulation of corolla Pigmentation. However, how R2R3-MYBs became so diverse in their regulation of different Pigmentation patterns remains unclear. Here, we studied a Lamiales species, Torenia fournieri, which has elaborate zygomorphic flowers with dorsal–ventral asymmetries in corolla Pigmentation. We found recent gene duplication events in CYCLOIDEA-like (CYC-like) and RADIALIS-like (RAD-like) genes, and functionally analyzed three dorsal-specific expression factors: TfCYC1, TfCYC2, and TfRAD1. We found that the CYC–RAD module coordinates petal shape and corolla Pigmentation, as ectopic expression of TfCYC2 or TfRAD1 disrupted the asymmetric corolla Pigmentation pattern and produced strongly dorsalized flowers. Dorsal petal identity was lost when TfCYC2 was down-regulated or when TfRAD1 was knocked out. In T. fournieri, the diversified CYC and RAD genes have evolved regulatory loops, and TfCYC2 binds directly to the regulatory regions of an R2R3-MYB factor gene, TfMYB1, which might lead to its asymmetric expression and ultimately establish the asymmetric Pigmentation pattern. These findings support the existence of a regulatory module that integrates dorsal–ventral patterning and asymmetric corolla Pigmentation in T. fournieri.
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Clinical characteristics of pigment dispersion syndrome in Chinese patients
Eye, 2008Co-Authors: Guoping Qing, Na Wang, X Tang, S Zhang, H ChenAbstract:To report clinical findings and characteristics of pigment dispersion syndrome (PDS) in Chinese patients. PDS suspects with any one of the following signs: corneal endothelial Pigmentation, iris transillumination defects (ITDs), pigment granule dusting on anterior iris surface, posterior iris bowing, trabecular meshwork (TM) Pigmentation, and lenticular or zonular Pigmentation were evaluated for PDS at the glaucoma specialty clinic at Beijing Tongren Eye Centre. Diagnosis of PDS required at least two of the following signs: Krukenberg spindle, moderate-to-heavy TM Pigmentation (⩾Scheie II) and any degree of lenticular and/or zonular Pigmentation. Eighteen patients (12 males and six females) were identified as having PDS during a 1-year period, with mean age of 35.5±7.0 years (range, 22–49). All but two eyes from two patients had myopia of −0.5 D or greater, with mean spherical equivalent power of −5.20±5.80 D (range, −24.75±0.5). The average IOP at initial diagnosis was 33.7±10.5 mm Hg (range, 16–56). Fifteen patients (83.3%) were found to have pigmentary glaucoma at their initial diagnosis. All patients showed homogenous increased TM Pigmentation as well as lenticular and/or zonular Pigmentation. 61.1% of patients (11 of 18) had Krukenberg spindle. None of the patients exhibited spoke-like midperipheral ITDs except for trace-isolated transillumination in both eyes of the two patients. The most common clinical findings in Chinese PDS patients include homogeneous TM Pigmentation and pigment granule dusting on lens zonules and/or posterior peripheral lens surface. ITDs are uncommon in Chinese patients with PDS.
