The Experts below are selected from a list of 288 Experts worldwide ranked by ideXlab platform
Maja Hinge - One of the best experts on this subject based on the ideXlab platform.
-
whole Body Computed Tomography versus conventional skeletal survey in patients with multiple myeloma a study of the international myeloma working group
Blood Cancer Journal, 2017Co-Authors: Jens Hillengass, Lia A. Moulopoulos, Stefan Delorme, Jennifer Mosebach, Thomas Hielscher, Matthew T. Drake, S V Rajkumar, B Oestergaard, Niels Abildgaard, Maja HingeAbstract:For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-Body Computed Tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P<0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT. In comparison, WBCT failed to detect some bone destructions in the appendicular skeleton possibly due to limitations of the field of view. Presence of lytic bone lesions in WBCT was of borderline prognostic significance (P=0.051) for SMM patients, with a median time to progression of 38 versus 82 months for those without bone destructions. In conclusion, WBCT identifies significantly more sites of bone destruction than CSS. More than 20% of patients with SMM according to CSS have in fact active MM detectable with WBCT. On the basis of this and other studies, WBCT (either Computed Tomography (CT) alone or as part of a positron emission Tomography-CT protocol) should be considered the current standard for the detection of osteolytic lesions in MM.
A. J. Van Der Molen - One of the best experts on this subject based on the ideXlab platform.
-
The influence of arm positions on abdominal image quality of whole-Body Computed Tomography in trauma: systematic review
Emergency Radiology, 2019Co-Authors: E. S. Speelman, B. Brocx, J. E. Wilbers, O. Ivashchenko, Y. Tank, A. J. Van Der MolenAbstract:Whole-Body Computed Tomography (WBCT) is the standard diagnostic method for evaluating polytrauma patients. When patients are unable to elevate their arms, the arms are placed along the Body, which affects the image quality negatively. Aim of this systematic review is to evaluate the influence of below the shoulder arm positions on image quality of WBCT. Literature in PubMed and Scopus databases was systematically searched. Results of the papers were stratified into 4 categories: arms elevated, 1 arm up 1 arm down, arms ventrally supported, arms along the Body. A qualitative analysis was performed on subjective image quality and a quantitative analysis on objective quality (image noise). Eight studies were included with 1421 participants. Various studies reported significantly higher quality scores with arms elevated, compared to arms along the Body. Significant differences in objective image quality were found between the arms elevated and the arms ventrally on support group. The arms ventrally supported group had a significantly higher image quality than the arms along the Body group. A statistically significant difference was found in objective image quality between the 1 arm up 1 arm down and arms along the Body group. No preferential below the shoulders position could be identified. Positioning the arms alongside the Body results in a poor image quality. Placing the arms on a pillow ventrally to the chest improves image quality. Interestingly, asymmetrical arm positioning has potential to improve the image quality for patients that are unable to elevate the arms.
-
The influence of arm positions on abdominal image quality of whole-Body Computed Tomography in trauma: systematic review
Emergency Radiology, 2019Co-Authors: E. S. Speelman, B. Brocx, J. E. Wilbers, O. Ivashchenko, Y. Tank, M. J. Bie, A. J. Van Der MolenAbstract:Purpose Whole-Body Computed Tomography (WBCT) is the standard diagnostic method for evaluating polytrauma patients. When patients are unable to elevate their arms, the arms are placed along the Body, which affects the image quality negatively. Aim of this systematic review is to evaluate the influence of below the shoulder arm positions on image quality of WBCT. Methods Literature in PubMed and Scopus databases was systematically searched. Results of the papers were stratified into 4 categories: arms elevated, 1 arm up 1 arm down, arms ventrally supported, arms along the Body. A qualitative analysis was performed on subjective image quality and a quantitative analysis on objective quality (image noise). Results Eight studies were included with 1421 participants. Various studies reported significantly higher quality scores with arms elevated, compared to arms along the Body. Significant differences in objective image quality were found between the arms elevated and the arms ventrally on support group. The arms ventrally supported group had a significantly higher image quality than the arms along the Body group. A statistically significant difference was found in objective image quality between the 1 arm up 1 arm down and arms along the Body group. No preferential below the shoulders position could be identified. Conclusion Positioning the arms alongside the Body results in a poor image quality. Placing the arms on a pillow ventrally to the chest improves image quality. Interestingly, asymmetrical arm positioning has potential to improve the image quality for patients that are unable to elevate the arms.
Jens Hillengass - One of the best experts on this subject based on the ideXlab platform.
-
Whole-Body Computed Tomography versus conventional skeletal survey in patients with multiple myeloma: A study of the International Myeloma Working Group
Blood Cancer Journal, 2017Co-Authors: Jens Hillengass, Lia A. Moulopoulos, Stefan Delorme, Koutoulidis, Jennifer Mosebach, Thomas Hielscher, Matthew T. Drake, S V Rajkumar, B Oestergaard, Niels AbildgaardAbstract:For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-Body Computed Tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P
-
whole Body Computed Tomography versus conventional skeletal survey in patients with multiple myeloma a study of the international myeloma working group
Blood Cancer Journal, 2017Co-Authors: Jens Hillengass, Lia A. Moulopoulos, Stefan Delorme, Jennifer Mosebach, Thomas Hielscher, Matthew T. Drake, S V Rajkumar, B Oestergaard, Niels Abildgaard, Maja HingeAbstract:For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-Body Computed Tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P<0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT. In comparison, WBCT failed to detect some bone destructions in the appendicular skeleton possibly due to limitations of the field of view. Presence of lytic bone lesions in WBCT was of borderline prognostic significance (P=0.051) for SMM patients, with a median time to progression of 38 versus 82 months for those without bone destructions. In conclusion, WBCT identifies significantly more sites of bone destruction than CSS. More than 20% of patients with SMM according to CSS have in fact active MM detectable with WBCT. On the basis of this and other studies, WBCT (either Computed Tomography (CT) alone or as part of a positron emission Tomography-CT protocol) should be considered the current standard for the detection of osteolytic lesions in MM.
J. C. Goslings - One of the best experts on this subject based on the ideXlab platform.
-
Systematic review and meta-analysis of immediate total-Body Computed Tomography compared with selective radiological imaging of injured patients.
The British journal of surgery, 2020Co-Authors: J. C. Sierink, T. P. Saltzherr, J. B. Reitsma, O. M. Van Delden, J. S. K. Luitse, J. C. GoslingsAbstract:The aim of this review was to assess the value of immediate total-Body Computed Tomography (CT) during the primary survey of injured patients compared with conventional radiographic imaging supplemented with selective CT. A systematic search of the literature was performed in MEDLINE, Embase, Web of Science and Cochrane Library databases. Reports were eligible if they contained original data comparing immediate total-Body CT with conventional imaging supplemented with selective CT in injured patients. The main outcomes of interest were overall mortality and time in the emergency room (ER). Four studies were included describing a total of 5470 patients; one study provided 4621 patients (84.5 per cent). All four studies were non-randomized cohort studies with retrospective data collection. Mortality was reported in three studies. Absolute mortality rates differed substantially between studies, but within studies mortality rates were comparable between immediate total-Body CT and conventional imaging strategies (pooled odds ratio 0.91, 95 per cent confidence interval 0.79 to 1.05). Time in the ER was described in three studies, and in two was significantly shorter in patients who underwent immediate total-Body CT: 70 versus 104 min (P = 0.025) and 47 versus 82 min (P < 0.001) respectively. This review showed differences in time in the ER in favour of immediate total-Body CT during the primary trauma survey compared with conventional radiographic imaging supplemented with selective CT. There were no differences in mortality. The substantial reduction in time in the ER is a promising feature of immediate total-Body CT but well designed and larger randomized studies are needed to see how this will translate into clinical outcomes. Copyright © 2011 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
-
systematic review and meta analysis of immediate total Body Computed Tomography compared with selective radiological imaging of injured patients
British Journal of Surgery, 2012Co-Authors: J. C. Sierink, T. P. Saltzherr, J. B. Reitsma, O. M. Van Delden, J. S. K. Luitse, J. C. GoslingsAbstract:Background: The aim of this review was to assess the value of immediate total-Body Computed Tomography (CT) during the primary survey of injured patients compared with conventional radiographic imaging supplemented with selective CT. Methods: A systematic search of the literature was performed in MEDLINE, Embase, Web of Science and Cochrane Library databases. Reports were eligible if they contained original data comparing immediate total-Body CT with conventional imaging supplemented with selective CT in injured patients. The main outcomes of interest were overall mortality and time in the emergency room (ER). Results: Four studies were included describing a total of 5470 patients; one study provided 4621 patients (84.5 per cent). All four studies were non-randomized cohort studies with retrospective data collection. Mortality was reported in three studies. Absolute mortality rates differed substantially between studies, but within studies mortality rates were comparable between immediate total-Body CT and conventional imaging strategies (pooled odds ratio 0.91, 95 per cent confidence interval 0.79 to 1.05). Time in the ER was described in three studies, and in two was significantly shorter in patients who underwent immediate total-Body CT: 70 versus 104 min (P = 0.025) and 47 versus 82 min (P <0.001) respectively. Conclusion: This review showed differences in time in the ER in favour of immediate total-Body CT during the primary trauma survey compared with conventional radiographic imaging supplemented with selective CT. There were no differences in mortality. The substantial reduction in time in the ER is a promising feature of immediate total-Body CT but well designed and larger randomized studies are needed to see how this will translate into clinical outcomes
-
Systematic review and meta-analysis of immediate total-Body Computed Tomography compared with selective radiological imaging of injured patients
British Journal of Surgery, 2011Co-Authors: J. C. Sierink, T. P. Saltzherr, J. B. Reitsma, O. M. Van Delden, J. S. K. Luitse, J. C. GoslingsAbstract:Background: The aim of this review was to assess the value of immediate total-Body Computed Tomography (CT) during the primary survey of injured patients compared with conventional radiographic imaging supplemented with selective CT. Methods: A systematic search of the literature was performed in MEDLINE, Embase, Web of Science and Cochrane Library databases. Reports were eligible if they contained original data comparing immediate total-Body CT with conventional imaging supplemented with selective CT in injured patients. The main outcomes of interest were overall mortality and time in the emergency room (ER). Results: Four studies were included describing a total of 5470 patients; one study provided 4621 patients (84.5 per cent). All four studies were non-randomized cohort studies with retrospective data collection. Mortality was reported in three studies. Absolute mortality rates differed substantially between studies, but within studies mortality rates were comparable between immediate total-Body CT and conventional imaging strategies (pooled odds ratio 0.91, 95 per cent confidence interval 0.79 to 1.05). Time in the ER was described in three studies, and in two was significantly shorter in patients who underwent immediate total-Body CT: 70 versus 104 min (P = 0.025) and 47 versus 82 min (P
Niels Abildgaard - One of the best experts on this subject based on the ideXlab platform.
-
Whole-Body Computed Tomography versus conventional skeletal survey in patients with multiple myeloma: A study of the International Myeloma Working Group
Blood Cancer Journal, 2017Co-Authors: Jens Hillengass, Lia A. Moulopoulos, Stefan Delorme, Koutoulidis, Jennifer Mosebach, Thomas Hielscher, Matthew T. Drake, S V Rajkumar, B Oestergaard, Niels AbildgaardAbstract:For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-Body Computed Tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P
-
whole Body Computed Tomography versus conventional skeletal survey in patients with multiple myeloma a study of the international myeloma working group
Blood Cancer Journal, 2017Co-Authors: Jens Hillengass, Lia A. Moulopoulos, Stefan Delorme, Jennifer Mosebach, Thomas Hielscher, Matthew T. Drake, S V Rajkumar, B Oestergaard, Niels Abildgaard, Maja HingeAbstract:For decades, conventional skeletal survey (CSS) has been the standard imaging technique for multiple myeloma (MM). However, recently whole-Body Computed Tomography (WBCT) has been implemented into the diagnostic criteria of MM. This analysis compares sensitivity and prognostic significance of WBCT and CSS in patients with smoldering MM (SMM) and MM. Fifty-four of 212 patients (25.5%) had a negative CSS and a positive WBCT for osteolytic lesions (P<0.0001). Of 66 patients with SMM based on CSS, 12 (22.2%) had osteolytic lesions on WBCT. In comparison, WBCT failed to detect some bone destructions in the appendicular skeleton possibly due to limitations of the field of view. Presence of lytic bone lesions in WBCT was of borderline prognostic significance (P=0.051) for SMM patients, with a median time to progression of 38 versus 82 months for those without bone destructions. In conclusion, WBCT identifies significantly more sites of bone destruction than CSS. More than 20% of patients with SMM according to CSS have in fact active MM detectable with WBCT. On the basis of this and other studies, WBCT (either Computed Tomography (CT) alone or as part of a positron emission Tomography-CT protocol) should be considered the current standard for the detection of osteolytic lesions in MM.
