The Experts below are selected from a list of 71451 Experts worldwide ranked by ideXlab platform

Linbo Zhang - One of the best experts on this subject based on the ideXlab platform.

  • a new nanoscale transdermal drug delivery system oil Body linked oleosin hegf improves skin regeneration to accelerate wound healing
    2018
    Co-Authors: Weidong Qiang, Xinxin Lan, Muhammad Noman, Tingting Zhou, Xiaomei Zhang, Yongxin Guo, Jie Zheng, Hongyu Wang, Lili Guan, Linbo Zhang
    Abstract:

    Background Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous proteins. The exogenous proteins were expressed in oil bodies from plant seeds. The process can reduce purification steps, thereby significantly reducing the purification cost. Mostly, the diameter of oil Body Particle ranges between 1.0 and 1.5 µm in the safflower seeds, however, it reduces to 700–1000 nm in the transgenic safflower seeds. The significant reduction of Particle size in transgenic seeds is extremely beneficial to skin absorption.

Weidong Qiang - One of the best experts on this subject based on the ideXlab platform.

  • a new nanoscale transdermal drug delivery system oil Body linked oleosin hegf improves skin regeneration to accelerate wound healing
    2018
    Co-Authors: Weidong Qiang, Xinxin Lan, Muhammad Noman, Tingting Zhou, Xiaomei Zhang, Yongxin Guo, Jie Zheng, Hongyu Wang, Lili Guan, Linbo Zhang
    Abstract:

    Background Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous proteins. The exogenous proteins were expressed in oil bodies from plant seeds. The process can reduce purification steps, thereby significantly reducing the purification cost. Mostly, the diameter of oil Body Particle ranges between 1.0 and 1.5 µm in the safflower seeds, however, it reduces to 700–1000 nm in the transgenic safflower seeds. The significant reduction of Particle size in transgenic seeds is extremely beneficial to skin absorption.

  • A new nanoscale transdermal drug delivery system: oil Body-linked oleosin-hEGF improves skin regeneration to accelerate wound healing
    2018
    Co-Authors: Weidong Qiang, Xinxin Lan, Muhammad Noman, Tingting Zhou, Xiaomei Zhang, Yongxin Guo, Jie Zheng
    Abstract:

    Abstract Background Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous proteins. The exogenous proteins were expressed in oil bodies from plant seeds. The process can reduce purification steps, thereby significantly reducing the purification cost. Mostly, the diameter of oil Body Particle ranges between 1.0 and 1.5 µm in the safflower seeds, however, it reduces to 700–1000 nm in the transgenic safflower seeds. The significant reduction of Particle size in transgenic seeds is extremely beneficial to skin absorption. Results The diameter of oil Body in the transgenic safflower seeds was recorded in the range of 700–1000 nm. The smaller Particle size improved their skin absorption. The expression level of oleosin-hEGF-hEGF in T3 transgenic seeds was highest at 69.32 mg/g of seeds. The oil Body expressing oleosin-hEGF-hEGF had significant proliferative activity on NIH/3T3 cells and improved skin regeneration thereby accelerating wound healing in rats. The wound coverage rate exceeded 98% after treatment for 14 days with oil Body expressing oleosin-hEGF-hEGF, while the saline without EGF group and wild type oil Body group both showed less than 80%. The neonatal fibroblast and collagen were found to be increased in the safflower oil Body expressing oleosin-hEGF-hEGF treatment group. TGF-β1, bFGF and VEGF were noted as important growth factors in the repair of cutaneous wounds. Their expression level increased after 4 and 7 day treatment, but decreased after 14 days. Therefore, it can promote skin regeneration to accelerate wounds healing. Conclusions The expression of oleosin-hEGF-hEGF in T3 transgenic seeds was 80.43 ng/μL oil Body. It had significant proliferative activity on NIH/3T3 cells and improved skin regeneration to accelerate wound healing in rats. The expression process of TGF-β1, bFGF and VEGF increased at first and then gradually declined

Ralph Ernstorfer - One of the best experts on this subject based on the ideXlab platform.

  • compact femtosecond electron diffractometer with 100 kev electron bunches approaching the single electron pulse duration limit
    2015
    Co-Authors: Lutz Waldecker, Roman Bertoni, Ralph Ernstorfer
    Abstract:

    We present the design and implementation of a highly compact femtosecond electron diffractometer working at electron energies up to 100 keV. We use a multi-Body Particle tracing code to simulate electron bunch propagation through the setup and to calculate pulse durations at the sample position. Our simulations show that electron bunches containing few thousands of electrons per bunch are only weakly broadened by space-charge effects and their pulse duration is thus close to the one of a single-electron wavepacket. With our compact setup, we can create electron bunches containing up to 5000 electrons with a pulse duration below 100 fs on the sample. We use the diffractometer to track the energy transfer from photoexcited electrons to the lattice in a thin film of titanium. This process takes place on the timescale of few-hundred femtoseconds and a fully equilibrated state is reached within 1 ps.

  • compact femtosecond electron diffractometer with 100 kev electron bunches approaching the single electron pulse duration limit
    2014
    Co-Authors: Lutz Waldecker, Roman Bertoni, Ralph Ernstorfer
    Abstract:

    We present the design and implementation of a highly compact femtosecond electron diffractometer working at electron energies up to 100 keV. We use a multi-Body Particle tracing code to simulate electron bunch propagation through the setup and to calculate pulse durations at the sample position. Our simulations show that electron bunches containing few thousands of electrons per bunch are only weakly broadened by space-charge effects and their pulse duration is thus close to the one of a single-electron wavepacket. With our compact setup we can create electron bunches containing up to 5000 electrons with a pulse duration below 100 femtoseconds on the sample. We use the diffractometer to track the energy transfer from photoexcited electrons to the lattice in a thin film of titanium. This process takes place on the timescale of few-hundred femtoseconds and a fully equilibrated state is reached within one picosecond.

Jie Zheng - One of the best experts on this subject based on the ideXlab platform.

  • a new nanoscale transdermal drug delivery system oil Body linked oleosin hegf improves skin regeneration to accelerate wound healing
    2018
    Co-Authors: Weidong Qiang, Xinxin Lan, Muhammad Noman, Tingting Zhou, Xiaomei Zhang, Yongxin Guo, Jie Zheng, Hongyu Wang, Lili Guan, Linbo Zhang
    Abstract:

    Background Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous proteins. The exogenous proteins were expressed in oil bodies from plant seeds. The process can reduce purification steps, thereby significantly reducing the purification cost. Mostly, the diameter of oil Body Particle ranges between 1.0 and 1.5 µm in the safflower seeds, however, it reduces to 700–1000 nm in the transgenic safflower seeds. The significant reduction of Particle size in transgenic seeds is extremely beneficial to skin absorption.

  • A new nanoscale transdermal drug delivery system: oil Body-linked oleosin-hEGF improves skin regeneration to accelerate wound healing
    2018
    Co-Authors: Weidong Qiang, Xinxin Lan, Muhammad Noman, Tingting Zhou, Xiaomei Zhang, Yongxin Guo, Jie Zheng
    Abstract:

    Abstract Background Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous proteins. The exogenous proteins were expressed in oil bodies from plant seeds. The process can reduce purification steps, thereby significantly reducing the purification cost. Mostly, the diameter of oil Body Particle ranges between 1.0 and 1.5 µm in the safflower seeds, however, it reduces to 700–1000 nm in the transgenic safflower seeds. The significant reduction of Particle size in transgenic seeds is extremely beneficial to skin absorption. Results The diameter of oil Body in the transgenic safflower seeds was recorded in the range of 700–1000 nm. The smaller Particle size improved their skin absorption. The expression level of oleosin-hEGF-hEGF in T3 transgenic seeds was highest at 69.32 mg/g of seeds. The oil Body expressing oleosin-hEGF-hEGF had significant proliferative activity on NIH/3T3 cells and improved skin regeneration thereby accelerating wound healing in rats. The wound coverage rate exceeded 98% after treatment for 14 days with oil Body expressing oleosin-hEGF-hEGF, while the saline without EGF group and wild type oil Body group both showed less than 80%. The neonatal fibroblast and collagen were found to be increased in the safflower oil Body expressing oleosin-hEGF-hEGF treatment group. TGF-β1, bFGF and VEGF were noted as important growth factors in the repair of cutaneous wounds. Their expression level increased after 4 and 7 day treatment, but decreased after 14 days. Therefore, it can promote skin regeneration to accelerate wounds healing. Conclusions The expression of oleosin-hEGF-hEGF in T3 transgenic seeds was 80.43 ng/μL oil Body. It had significant proliferative activity on NIH/3T3 cells and improved skin regeneration to accelerate wound healing in rats. The expression process of TGF-β1, bFGF and VEGF increased at first and then gradually declined

Xinxin Lan - One of the best experts on this subject based on the ideXlab platform.

  • a new nanoscale transdermal drug delivery system oil Body linked oleosin hegf improves skin regeneration to accelerate wound healing
    2018
    Co-Authors: Weidong Qiang, Xinxin Lan, Muhammad Noman, Tingting Zhou, Xiaomei Zhang, Yongxin Guo, Jie Zheng, Hongyu Wang, Lili Guan, Linbo Zhang
    Abstract:

    Background Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous proteins. The exogenous proteins were expressed in oil bodies from plant seeds. The process can reduce purification steps, thereby significantly reducing the purification cost. Mostly, the diameter of oil Body Particle ranges between 1.0 and 1.5 µm in the safflower seeds, however, it reduces to 700–1000 nm in the transgenic safflower seeds. The significant reduction of Particle size in transgenic seeds is extremely beneficial to skin absorption.

  • A new nanoscale transdermal drug delivery system: oil Body-linked oleosin-hEGF improves skin regeneration to accelerate wound healing
    2018
    Co-Authors: Weidong Qiang, Xinxin Lan, Muhammad Noman, Tingting Zhou, Xiaomei Zhang, Yongxin Guo, Jie Zheng
    Abstract:

    Abstract Background Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous proteins. The exogenous proteins were expressed in oil bodies from plant seeds. The process can reduce purification steps, thereby significantly reducing the purification cost. Mostly, the diameter of oil Body Particle ranges between 1.0 and 1.5 µm in the safflower seeds, however, it reduces to 700–1000 nm in the transgenic safflower seeds. The significant reduction of Particle size in transgenic seeds is extremely beneficial to skin absorption. Results The diameter of oil Body in the transgenic safflower seeds was recorded in the range of 700–1000 nm. The smaller Particle size improved their skin absorption. The expression level of oleosin-hEGF-hEGF in T3 transgenic seeds was highest at 69.32 mg/g of seeds. The oil Body expressing oleosin-hEGF-hEGF had significant proliferative activity on NIH/3T3 cells and improved skin regeneration thereby accelerating wound healing in rats. The wound coverage rate exceeded 98% after treatment for 14 days with oil Body expressing oleosin-hEGF-hEGF, while the saline without EGF group and wild type oil Body group both showed less than 80%. The neonatal fibroblast and collagen were found to be increased in the safflower oil Body expressing oleosin-hEGF-hEGF treatment group. TGF-β1, bFGF and VEGF were noted as important growth factors in the repair of cutaneous wounds. Their expression level increased after 4 and 7 day treatment, but decreased after 14 days. Therefore, it can promote skin regeneration to accelerate wounds healing. Conclusions The expression of oleosin-hEGF-hEGF in T3 transgenic seeds was 80.43 ng/μL oil Body. It had significant proliferative activity on NIH/3T3 cells and improved skin regeneration to accelerate wound healing in rats. The expression process of TGF-β1, bFGF and VEGF increased at first and then gradually declined