The Experts below are selected from a list of 54009 Experts worldwide ranked by ideXlab platform

Ira O Daar - One of the best experts on this subject based on the ideXlab platform.

  • early steps in primary cilium assembly require ehd1 ehd3 dependent ciliary vesicle formation
    Nature Cell Biology, 2015
    Co-Authors: Christine Insinna, Carolyn Ott, Jimmy K Stauffer, Petra Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo Seok Hwang, Ira O Daar
    Abstract:

    Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation from smaller distal appendage vesicles (DAVs). Importantly, this step functions in M-centriole to basal Body Transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle assembly. Interestingly, only after ciliary vesicle assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step, whereby EHD1 and EHD3 reorganize the M-centriole and associated DAVs before coordinated ciliary membrane and axoneme growth.

  • Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation
    Nature Cell Biology, 2015
    Co-Authors: Quanlong Lu, Christine Insinna, Petra Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo Seok Hwang, Jimmy Stauffer, Ira O Daar
    Abstract:

    Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11–Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11–Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation from smaller distal appendage vesicles (DAVs). Importantly, this step functions in M-centriole to basal Body Transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle assembly. Interestingly, only after ciliary vesicle assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step, whereby EHD1 and EHD3 reorganize the M-centriole and associated DAVs before coordinated ciliary membrane and axoneme growth. Westlake and colleagues discover that membrane shaping EHD proteins participate in ciliogenesis by taking part in ciliary vesicle formation and transition zone protein recruitment.

Christine Insinna - One of the best experts on this subject based on the ideXlab platform.

  • early steps in primary cilium assembly require ehd1 ehd3 dependent ciliary vesicle formation
    Nature Cell Biology, 2015
    Co-Authors: Christine Insinna, Carolyn Ott, Jimmy K Stauffer, Petra Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo Seok Hwang, Ira O Daar
    Abstract:

    Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation from smaller distal appendage vesicles (DAVs). Importantly, this step functions in M-centriole to basal Body Transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle assembly. Interestingly, only after ciliary vesicle assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step, whereby EHD1 and EHD3 reorganize the M-centriole and associated DAVs before coordinated ciliary membrane and axoneme growth.

  • Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation
    Nature Cell Biology, 2015
    Co-Authors: Quanlong Lu, Christine Insinna, Petra Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo Seok Hwang, Jimmy Stauffer, Ira O Daar
    Abstract:

    Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11–Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11–Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation from smaller distal appendage vesicles (DAVs). Importantly, this step functions in M-centriole to basal Body Transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle assembly. Interestingly, only after ciliary vesicle assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step, whereby EHD1 and EHD3 reorganize the M-centriole and associated DAVs before coordinated ciliary membrane and axoneme growth. Westlake and colleagues discover that membrane shaping EHD proteins participate in ciliogenesis by taking part in ciliary vesicle formation and transition zone protein recruitment.

Alain Berthoz - One of the best experts on this subject based on the ideXlab platform.

  • Behavioral Own-Body-Transformations in Children and Adolescents With Typical Development, Autism Spectrum Disorder, and Developmental Coordination Disorder.
    Frontiers in Psychology, 2018
    Co-Authors: Soizic Gauthier, Alain Berthoz, Mohamed Zaoui, Salvatore Maria Anzalone, David Cohen, Mohamed Chetouani, François Villa, Jean Xavier
    Abstract:

    Background: In motor imitation, taking a partner’s perspective often involves a mental Body Transformation from an embodied, ego-centered viewpoint, to a disembodied, hetero-centered viewpoint. Impairments of both own-Body-Transformation (OBT) and abnormalities in visual spatial processing have been reported in patients with neurodevelopmental disorders including autism spectrum disorder (ASD). In the context of a visual-motor interactive task, studying OBT impairments while disentangling the contribution of visual spatial impairments associated with motor coordination problems has not been investigated. Methods: 85 children and adolescents (39 controls with typical development, TD; 29 patients with ASD; 17 patients with developmental coordination disorder, DCD), aged 6 to 19 years, participated in a behavioral paradigm in which participants interacted with a virtual tightrope walker (TW) standing and moving with him. The protocol enables to distinguish ego-centered and hetero-centered perspectives. Results: We show that (1) OBT was possible but difficult for children with neurodevelopmental disorders, as well as for TD children, when the task required the participant to perform a mental rotation in order to adopt a hetero-centered perspective (2) Using multivariate models, hetero-centered perspective score was significantly associated with age, TW orientation, latency and diagnosis. ASD and TD group’s performances were close and significantly correlated with age. It was not the case for DCD specifically handicapped by visual spatial impairments. (3) ASD and DCD did not perform similarly: motor performance as shown by movement amplitude was better in DCD than ASD. ASD motor response were more ambiguous and hardly readable. Conclusion: Changing perspective in a spatial environment is possible for patients with ASD although delayed compared with TD children. In patients with DCD their visual spatial impairments negatively modulated performances in the experiment.

  • Taking a third-person perspective requires inhibitory control: Evidence from a developmental negative priming study.
    Child Development, 2016
    Co-Authors: Ania Aïte, Alain Berthoz, Julie Vidal, Margot Roëll, Mohamed Zaoui, Olivier Houdé, Grégoire. Borst
    Abstract:

    To determine whether the growing ability to take a third-person perspective (3PP) is explained in part by the growing ability to inhibit a first-person perspective (1PP), 10-year-old children (n = 49) and 22-year-old adults (n = 52) performed a negative priming adaptation of the own Body Transformation task. Both children and adults were less efficient in adopting a 1PP after they adopted a 3PP-with a smaller amplitude of the negative priming effect with older age-and adults' and children's performances in the own Body Transformation task were predicted in part by their Stroop interference scores. These results suggest that the growing efficiency to adopt a 3PP is rooted in part in the growing efficiency to inhibit the 1PP.

  • Mental Imagery of Self-Location during Spontaneous and Active Self–Other Interactions: An Electrical Neuroimaging Study
    Journal of Neuroscience, 2010
    Co-Authors: Bérangère Thirioux, Alain Berthoz, Manuel R. Mercier, Gérard Jorland, Olaf Blanke
    Abstract:

    Substantial data from the cognitive neurosciences point to the importance of bodily processing for the development of a comprehensive theory of the self. A key aspect of the bodily self is self-location, the experience that the self is localized at a specific position in space within one's bodily borders (embodied self-location). Although the neural mechanisms of self-location have been studied by manipulating the spatial location of one's visual perspective during mental imagery, such experiments were conducted in constrained, explicit, and unecological contexts such as explicit instructions in a prone/seated position, although most human interactions occur spontaneously while standing/walking. Using a motor paradigm, we investigated the behavioral and neural mechanisms of spontaneous self-location and mental Body Transformations during active human interaction. Using own-Body imagery using spontaneous and explicit changes in self-location in standing participants, we report that spontaneous interactions with an avatar are neurally indistinguishable from explicit own-Body Transformation with disembodied self-location but differ from explicit own-Body Transformation with embodied self-location at 400–600 ms after stimulus onset. We discuss these findings with respect to the neural mechanisms of perspective-taking and self-location in spontaneous human interaction.

  • walking on a line a motor paradigm using rotation and reflection symmetry to study mental Body Transformations
    Brain and Cognition, 2009
    Co-Authors: Gérard Jorland, Bérangère Thirioux, Michel Bret, Mariehelene Tramus, Alain Berthoz
    Abstract:

    Researchers have recently reintroduced the own-Body in the center of the social interaction theory. From the discovery of the mirror neurons in the ventral premotor cortex of the monkey’s brain, a human embodied model of interindividual relationship based on simulation processes has been advanced, according to which we tend to emBody spontaneously the other individuals’ behavior when interacting. Although the neurocognitive mechanisms of the embodiment process have started being described, the mechanisms of self-location during embodiment are still less known. Here, we designed a motor paradigm which allows investigating in ecologically more valid conditions whether we emBody another person’s intransitive action with an embodied or disembodied self-location. Accordingly, we propose a phenomenological model of self–other interaction showing how perspective-taking mechanisms may relate on mental Body Transformation and offering a promising way to investigate the different sorts of intersubjectivity.

Vijay Walia - One of the best experts on this subject based on the ideXlab platform.

  • early steps in primary cilium assembly require ehd1 ehd3 dependent ciliary vesicle formation
    Nature Cell Biology, 2015
    Co-Authors: Christine Insinna, Carolyn Ott, Jimmy K Stauffer, Petra Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo Seok Hwang, Ira O Daar
    Abstract:

    Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation from smaller distal appendage vesicles (DAVs). Importantly, this step functions in M-centriole to basal Body Transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle assembly. Interestingly, only after ciliary vesicle assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step, whereby EHD1 and EHD3 reorganize the M-centriole and associated DAVs before coordinated ciliary membrane and axoneme growth.

  • Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation
    Nature Cell Biology, 2015
    Co-Authors: Quanlong Lu, Christine Insinna, Petra Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo Seok Hwang, Jimmy Stauffer, Ira O Daar
    Abstract:

    Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11–Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11–Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation from smaller distal appendage vesicles (DAVs). Importantly, this step functions in M-centriole to basal Body Transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle assembly. Interestingly, only after ciliary vesicle assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step, whereby EHD1 and EHD3 reorganize the M-centriole and associated DAVs before coordinated ciliary membrane and axoneme growth. Westlake and colleagues discover that membrane shaping EHD proteins participate in ciliogenesis by taking part in ciliary vesicle formation and transition zone protein recruitment.

Adrian Cuenca - One of the best experts on this subject based on the ideXlab platform.

  • early steps in primary cilium assembly require ehd1 ehd3 dependent ciliary vesicle formation
    Nature Cell Biology, 2015
    Co-Authors: Christine Insinna, Carolyn Ott, Jimmy K Stauffer, Petra Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo Seok Hwang, Ira O Daar
    Abstract:

    Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11-Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11-Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation from smaller distal appendage vesicles (DAVs). Importantly, this step functions in M-centriole to basal Body Transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle assembly. Interestingly, only after ciliary vesicle assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step, whereby EHD1 and EHD3 reorganize the M-centriole and associated DAVs before coordinated ciliary membrane and axoneme growth.

  • Early steps in primary cilium assembly require EHD1/EHD3-dependent ciliary vesicle formation
    Nature Cell Biology, 2015
    Co-Authors: Quanlong Lu, Christine Insinna, Petra Pintado, Juliati Rahajeng, Ulrich Baxa, Vijay Walia, Adrian Cuenca, Yoo Seok Hwang, Jimmy Stauffer, Ira O Daar
    Abstract:

    Membrane association with mother centriole (M-centriole) distal appendages is critical for ciliogenesis initiation. How the Rab GTPase Rab11–Rab8 cascade functions in early ciliary membrane assembly is unknown. Here, we show that the membrane shaping proteins EHD1 and EHD3, in association with the Rab11–Rab8 cascade, function in early ciliogenesis. EHD1 and EHD3 localize to preciliary membranes and the ciliary pocket. EHD-dependent membrane tubulation is essential for ciliary vesicle formation from smaller distal appendage vesicles (DAVs). Importantly, this step functions in M-centriole to basal Body Transformation and recruitment of transition zone proteins and IFT20. SNAP29, a SNARE membrane fusion regulator and EHD1-binding protein, is also required for DAV-mediated ciliary vesicle assembly. Interestingly, only after ciliary vesicle assembly is Rab8 activated for ciliary growth. Our studies uncover molecular mechanisms informing a previously uncharacterized ciliogenesis step, whereby EHD1 and EHD3 reorganize the M-centriole and associated DAVs before coordinated ciliary membrane and axoneme growth. Westlake and colleagues discover that membrane shaping EHD proteins participate in ciliogenesis by taking part in ciliary vesicle formation and transition zone protein recruitment.