The Experts below are selected from a list of 321 Experts worldwide ranked by ideXlab platform

Okitsugu Kajimoto - One of the best experts on this subject based on the ideXlab platform.

Kenichiro Itami - One of the best experts on this subject based on the ideXlab platform.

Ning Jiao - One of the best experts on this subject based on the ideXlab platform.

  • Selective Dealkenylative Functionalization of Styrenes via C-C Bond Cleavage.
    Research (Washington D.C.), 2020
    Co-Authors: Jianzhong Liu, Jun Pan, Xiao Luo, Xu Qiu, Cheng Zhang, Ning Jiao
    Abstract:

    As a readily available feedstock, styrene with about 25 million tons of global annual production serves as an important building block and organic synthon for the synthesis of fine chemicals, polystyrene plastics, and elastomers. Thus, in the past decades, many direct transformations of this costless styrene feedstock were disclosed for the preparation of high-value chemicals, which to date, generally performed on the functionalization of styrenes through the allylic C-H Bond, C(sp2 )-H Bond, or the C=C double Bond Cleavage. However, the dealkenylative functionalization of styrenes via the direct C-C single Bond Cleavage is so far challenging and still unknown. Herein, we report the novel and efficient C-C amination and hydroxylation reactions of styrenes for the synthesis of valuable aryl amines and phenols via the site-selective C(Ar)-C(alkenyl) single Bond Cleavage. This chemistry unlocks the new transformation and application of the styrene feedstock and provides an efficient protocol for the late-stage modification of substituted styrenes with the site-directed dealkenylative amination and hydroxylation.

  • Electrochemical Oxidation Induced Selective C-C Bond Cleavage.
    Chemical reviews, 2020
    Co-Authors: Shi-hui Shi, Yujie Liang, Ning Jiao
    Abstract:

    Selective C-C Bond Cleavage under mild conditions can serve as a valuable tool for organic syntheses and macromolecular degradation. However, the conventional chemical methods have largely involved the use of noble transition-metal catalysts as well as the stoichiometric and perhaps environmentally unfriendly oxidants, compromising the overall sustainable nature of C-C transformation chemistry. In this regard, electrochemical C-C Bond Cleavage has been identified as a sustainable and scalable strategy that employs electricity to replace byproduct-generating chemical reagents. To date, the progress made in this area has mainly relied on Kolbe electrolysis and related processes. Encouragingly, more and more examples of the Cleavage of C-C Bonds via other maneuvers have recently been developed. This review provides an overview on the most recent and significant developments in electrochemically oxidative selective C-C Bond Cleavage, with an emphasis on both synthetic outcomes and reaction mechanisms, and it showcases the innate advantages and exciting potentials of electrochemical synthesis.

  • Electrochemically Oxidative C–C Bond Cleavage of Alkylarenes for Anilines Synthesis
    ACS Catalysis, 2019
    Co-Authors: Yeerlan Adeli, Yujie Liang, Jianzhong Liu, Kaimeng Huang, Yangye Jiang, Song Song, Cheng-chu Zeng, Ning Jiao
    Abstract:

    In contrast to the recent breakthrough in electrochemical C–H aminations, the electrochemically oxidative C–N Bond formation through a C–C Bond Cleavage is rarely studied. This work describes an el...

  • Copper-Catalyzed Aerobic Oxidative C–C Bond Cleavage of Unstrained Ketones with Air and Amines
    Organic letters, 2015
    Co-Authors: Wang Zhou, Wenyou Fan, Qijian Jiang, Yu-feng Liang, Ning Jiao
    Abstract:

    A unique copper-catalyzed aerobic oxidative C–C Bond Cleavage of simple unstrained ketones with air and amines has been developed. In this chemistry, amides and oxo amides are easily synthesized through the selective C–C Bond Cleavage of simple ketones or unstrained cycloketones. The broad substrate scopes and use of an inexpensive copper catalyst and green molecular oxygen as an oxidant as well as an O-source make this protocol very attractive for potential synthetic applications. The control experiments reveal that the present copper-catalyzed oxidative C–C Bond Cleavage of simple ketones proceeds in a novel catalytic pathway rather than through the Cleavage of a dioxetane intermediate.

Jun-ichi Yoshida - One of the best experts on this subject based on the ideXlab platform.

Koji Terakawa - One of the best experts on this subject based on the ideXlab platform.