The Experts below are selected from a list of 273 Experts worldwide ranked by ideXlab platform
J Geurts - One of the best experts on this subject based on the ideXlab platform.
-
What drives osteoarthritis?—synovial versus subchondral Bone Pathology
Rheumatology, 2017Co-Authors: Thomas Hugle, J GeurtsAbstract:Abstract Subchondral Bone and the synovium play an important role in the initiation and progression of OA. MRI often permits an early detection of synovial hypertrophy and Bone marrow lesions, both of which can precede cartilage damage. Newer imaging modalities including CT osteoabsorptiometry and hybrid SPECT-CT have underlined the importance of Bone in OA pathogenesis. The subchondral Bone in OA undergoes an uncoupled remodelling process, which is notably characterized by macrophage infiltration and osteoclast formation. Concomitant increased osteoblast activity leads to spatial remineralization and osteosclerosis in end-stage disease. A plethora of metabolic and mechanical factors can lead to synovitis in OA. Synovial tissue is highly vascularized and thus exposed to systemic influences such as hypercholesterolaemia or low grade inflammation. This review aims to describe the current understanding of synovitis and subchondral Bone Pathology and their connection in OA.
-
what drives osteoarthritis synovial versus subchondral Bone Pathology
Rheumatology, 2016Co-Authors: Thomas Hugle, J GeurtsAbstract:Abstract Subchondral Bone and the synovium play an important role in the initiation and progression of OA. MRI often permits an early detection of synovial hypertrophy and Bone marrow lesions, both of which can precede cartilage damage. Newer imaging modalities including CT osteoabsorptiometry and hybrid SPECT-CT have underlined the importance of Bone in OA pathogenesis. The subchondral Bone in OA undergoes an uncoupled remodelling process, which is notably characterized by macrophage infiltration and osteoclast formation. Concomitant increased osteoblast activity leads to spatial remineralization and osteosclerosis in end-stage disease. A plethora of metabolic and mechanical factors can lead to synovitis in OA. Synovial tissue is highly vascularized and thus exposed to systemic influences such as hypercholesterolaemia or low grade inflammation. This review aims to describe the current understanding of synovitis and subchondral Bone Pathology and their connection in OA.
Thomas Hugle - One of the best experts on this subject based on the ideXlab platform.
-
What drives osteoarthritis?—synovial versus subchondral Bone Pathology
Rheumatology, 2017Co-Authors: Thomas Hugle, J GeurtsAbstract:Abstract Subchondral Bone and the synovium play an important role in the initiation and progression of OA. MRI often permits an early detection of synovial hypertrophy and Bone marrow lesions, both of which can precede cartilage damage. Newer imaging modalities including CT osteoabsorptiometry and hybrid SPECT-CT have underlined the importance of Bone in OA pathogenesis. The subchondral Bone in OA undergoes an uncoupled remodelling process, which is notably characterized by macrophage infiltration and osteoclast formation. Concomitant increased osteoblast activity leads to spatial remineralization and osteosclerosis in end-stage disease. A plethora of metabolic and mechanical factors can lead to synovitis in OA. Synovial tissue is highly vascularized and thus exposed to systemic influences such as hypercholesterolaemia or low grade inflammation. This review aims to describe the current understanding of synovitis and subchondral Bone Pathology and their connection in OA.
-
what drives osteoarthritis synovial versus subchondral Bone Pathology
Rheumatology, 2016Co-Authors: Thomas Hugle, J GeurtsAbstract:Abstract Subchondral Bone and the synovium play an important role in the initiation and progression of OA. MRI often permits an early detection of synovial hypertrophy and Bone marrow lesions, both of which can precede cartilage damage. Newer imaging modalities including CT osteoabsorptiometry and hybrid SPECT-CT have underlined the importance of Bone in OA pathogenesis. The subchondral Bone in OA undergoes an uncoupled remodelling process, which is notably characterized by macrophage infiltration and osteoclast formation. Concomitant increased osteoblast activity leads to spatial remineralization and osteosclerosis in end-stage disease. A plethora of metabolic and mechanical factors can lead to synovitis in OA. Synovial tissue is highly vascularized and thus exposed to systemic influences such as hypercholesterolaemia or low grade inflammation. This review aims to describe the current understanding of synovitis and subchondral Bone Pathology and their connection in OA.
Haruo Saito - One of the best experts on this subject based on the ideXlab platform.
-
Gustatory Otalgia and Wet Ear Syndrome: A Possible Cross‐Innervation After Ear Surgery
Laryngoscope, 1999Co-Authors: Haruo SaitoAbstract:Hypothesis: The chorda tympani and Arnold's nerves have close approximation to each other and their cross-innervation is possible after ear surgery. Study Design: A retrospective study was performed with a temporal Bone Pathology case and two clinical cases as representatives of such a possibility. Patients had severe otalgia and wet ear during gustatory stimulation. Methods: A temporal Bone Pathology case was studied under a light microscope. Earache and/or wet ear were provoked during gustatory stimulation. Wet ear was tested with iodine-starch reaction after the subject tasted lemon juice. Results: The temporal Bone specimen has clusters of regenerated fibers in the tympanic cavity in the area of the chorda tympani and Arnold's nerves, suggesting a possibility of mixing. There are regenerated fibers in the iter chordae anterius, showing successful bridging of the chorda tympani nerves across a long gap. Detachment of the skin over the operated mastoid bowl obscured signs in one clinical case. Another clinical case of gustatory wet ear showed objective evidence of cross-innervation with iodine-starch reaction. Conclusion: The detachment procedure and iodine-starch reaction were the proofs that the signs were related to regenerated fibers. This is the first report of gustatory otalgia and wet ear after ear surgery.
-
gustatory otalgia and wet ear syndrome a possible cross innervation after ear surgery
Laryngoscope, 1999Co-Authors: Haruo SaitoAbstract:Hypothesis: The chorda tympani and Arnold's nerves have close approximation to each other and their cross-innervation is possible after ear surgery. Study Design: A retrospective study was performed with a temporal Bone Pathology case and two clinical cases as representatives of such a possibility. Patients had severe otalgia and wet ear during gustatory stimulation. Methods: A temporal Bone Pathology case was studied under a light microscope. Earache and/or wet ear were provoked during gustatory stimulation. Wet ear was tested with iodine-starch reaction after the subject tasted lemon juice. Results: The temporal Bone specimen has clusters of regenerated fibers in the tympanic cavity in the area of the chorda tympani and Arnold's nerves, suggesting a possibility of mixing. There are regenerated fibers in the iter chordae anterius, showing successful bridging of the chorda tympani nerves across a long gap. Detachment of the skin over the operated mastoid bowl obscured signs in one clinical case. Another clinical case of gustatory wet ear showed objective evidence of cross-innervation with iodine-starch reaction. Conclusion: The detachment procedure and iodine-starch reaction were the proofs that the signs were related to regenerated fibers. This is the first report of gustatory otalgia and wet ear after ear surgery.
Nogah Shabshin - One of the best experts on this subject based on the ideXlab platform.
-
Bone marrow lesions and subchondral Bone Pathology of the knee
Knee Surgery Sports Traumatology Arthroscopy, 2016Co-Authors: Mario Ronga, Giuseppe Filardo, Jack Farr, Henning Madry, Giuseppe Milano, Luca Andriolo, Nogah ShabshinAbstract:Bone marrow lesions (BMLs) around the knee are a common magnetic resonance imaging (MRI) finding. However, despite the growing interest on BMLs in multiple pathological conditions, they remain controversial not only for the still unknown role in the etiopathological processes, but also in terms of clinical impact and treatment. The differential diagnosis includes a wide range of conditions: traumatic contusion and fractures, cyst formation and erosions, hematopoietic and infiltrated marrow, developmental chondroses, disuse and overuse, transient Bone marrow oedema syndrome and, lastly, subchondral insufficiency fractures and true osteonecrosis. Regardless the heterogeneous spectrum of these pathologies, a key factor for patient management is the distinction between reversible and irreversible conditions. To this regard, MRI plays a major role, leading to the correct diagnosis based on recognizable typical patterns that have to be considered together with coexistent abnormalities, age, and clinical history. Several treatment options have been proposed, from conservative to surgical approaches. In this manuscript the main lesion patterns and their management have been analysed to provide the most updated evidence for the differential diagnosis and the most effective treatment. Level of evidence IV.
Jenny A Tyler - One of the best experts on this subject based on the ideXlab platform.
-
degenerative joint disease in the guinea pig use of magnetic resonance imaging to monitor progression of Bone Pathology
Arthritis & Rheumatism, 1996Co-Authors: Paul J Watson, Laurance D Hall, Archie Malcolm, Jenny A TylerAbstract:Objective. The suitability of magnetic resonance imaging (MRI) for serial monitoring of Bone Pathology in the guinea pig stifle joint, an in vivo model of osteoarthritis, was investigated. Methods. MR images were compared with histologic features and radiographs of 1-mm-thick sections to determine the MR correlates of the Bone changes. Ten guinea pigs were then imaged on 7 occasions over the first year of life, enabling serial measurements of subchondral Bone thickness, subchondral pseudocysts, and osteophytes. Results. The signal intensity of trabecular Bone in MR images accurately reflected the degree of osteopenia and trabecular thinning noted around the cruciate ligament insertions. The extent of subchondral sclerosis and the development of marginal osteophytes were also accurately represented. Serial observations revealed that MRI can detect highly significant progression of lytic Bone lesions, subchondral sclerosis, and osteophyte size over periods of 6 weeks. Conclusion. MRI is not only a reliable technique for the assessment of Bone Pathology but is also a useful tool for monitoring the progression of Bone damage in osteoarthritis.
