The Experts below are selected from a list of 45591 Experts worldwide ranked by ideXlab platform
Qinghua Qin - One of the best experts on this subject based on the ideXlab platform.
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thermoelectroelastic solutions for surface Bone Remodeling under axial and transverse loads
Biomaterials, 2005Co-Authors: Qinghua QinAbstract:Theoretical prediction of surface Bone Remodeling in the diaphysis of the long Bone under various external loads are made within the framework of adaptive elastic theory. These loads include external lateral pressure, electric and thermal loads. Two solutions are presented for analyzing thermoelectroelastic problems of surface Bone Remodeling. The analytical solution that gives explicit formulation is capable of modeling homogeneous Bone materials, while the semi-analytical solution is suitable for analyzing inhomogeneous cases. Numerical results are presented to verify the proposed formulation and to show the effects of mechanical, thermal and electric loads on surface Bone Remodeling process.
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thermoelectroelastic solutions for internal Bone Remodeling under axial and transverse loads
International Journal of Solids and Structures, 2004Co-Authors: Qinghua QinAbstract:Internal Bone Remodeling of inhomogeneous materials is studied both theoretically and numerically in this paper. Two solutions are presented for analyzing thermoelectroelastic problems of internal Bone Remodeling subjected to coupled axial force, external lateral pressure, electric and thermal loads. Though all Bone is heterogeneous, assumption of homogeneity is made to entail a smoothing over features such as osteons, lamellae, fibers, and other structural elements, so that a continuum representation can be obtained. A semi-analytical solution is also presented for analyzing inhomogeneous cases. Numerical results are presented to verify the proposed formulation and to show the effects of mechanical, thermal and electric loads on Bone Remodeling process.
In Gwun Jang - One of the best experts on this subject based on the ideXlab platform.
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application of design space optimization to Bone Remodeling simulation of trabecular architecture in human proximal femur for higher computational efficiency
Finite Elements in Analysis and Design, 2010Co-Authors: In Gwun Jang, Il Yong KimAbstract:Since the 1990s, topology optimization has been used to computationally investigate the Bone Remodeling under the assumption that Bone Remodeling progresses such that the Bone material is used in a structurally optimal way. The foremost concerns in applying topology optimization to Bone Remodeling include the difficulty of handling large-scale problems and associated huge computational cost. In this paper, we applied a recently developed topology optimization algorithm, design space optimization (DSO), to Bone Remodeling simulation in order to determine trabecular architecture in human proximal femur with higher computational efficiency. We represented the full trabecular architecture in human proximal femur using a two dimensional micro-FE model with 50@mm pixel resolution and performed simulation under three load cases in daily activities. From the quantitative comparison with conventional topology optimization results as well as the actual trabecular architecture, it was shown that DSO produced structurally equivalent trabecular architecture with shorter computing time and smaller memory requirement. As future research, a three-dimensional Bone Remodeling simulation will require the preparation and management of tens of millions of FE elements, and therefore DSO would be essential to handle such a massive problem as a ''more efficient'' algorithm.
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Analogy of strain energy density based Bone-Remodeling algorithm and structural topology optimization.
Journal of biomechanical engineering, 2008Co-Authors: In Gwun Jang, Il Yong Kim, Byung Man KwakAbstract:In Bone-Remodeling studies, it is believed that the morphology of Bone is affected by its internal mechanical loads. From the 1970s, high computing power enabled quantitative studies in the simulation of Bone Remodeling or Bone adaptation. Among them, Huiskes et al. (1987, "Adaptive Bone Remodeling Theory Applied to Prosthetic Design Analysis," J. Biomech. Eng., 20, pp. 1135-1150) proposed a strain energy density based approach to Bone Remodeling and used the apparent density for the characterization of internal Bone morphology. The fundamental idea was that Bone density would increase when strain (or strain energy density) is higher than a certain value and Bone resorption would occur when the strain (or strain energy density) quantities are lower than the threshold. Several advanced algorithms were developed based on these studies in an attempt to more accurately simulate physiological Bone-Remodeling processes. As another approach, topology optimization originally devised in structural optimization has been also used in the computational simulation of the Bone-Remodeling process. The topology optimization method systematically and iteratively distributes material in a design domain, determining an optimal structure that minimizes an objective function. In this paper, we compared two seemingly different approaches in different fields-the strain energy density based Bone-Remodeling algorithm (biomechanical approach) and the compliance based structural topology optimization method (mechanical approach)-in terms of mathematical formulations, numerical difficulties, and behavior of their numerical solutions. Two numerical case studies were conducted to demonstrate their similarity and difference, and then the solution convergences were discussed quantitatively.
Il Yong Kim - One of the best experts on this subject based on the ideXlab platform.
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application of design space optimization to Bone Remodeling simulation of trabecular architecture in human proximal femur for higher computational efficiency
Finite Elements in Analysis and Design, 2010Co-Authors: In Gwun Jang, Il Yong KimAbstract:Since the 1990s, topology optimization has been used to computationally investigate the Bone Remodeling under the assumption that Bone Remodeling progresses such that the Bone material is used in a structurally optimal way. The foremost concerns in applying topology optimization to Bone Remodeling include the difficulty of handling large-scale problems and associated huge computational cost. In this paper, we applied a recently developed topology optimization algorithm, design space optimization (DSO), to Bone Remodeling simulation in order to determine trabecular architecture in human proximal femur with higher computational efficiency. We represented the full trabecular architecture in human proximal femur using a two dimensional micro-FE model with 50@mm pixel resolution and performed simulation under three load cases in daily activities. From the quantitative comparison with conventional topology optimization results as well as the actual trabecular architecture, it was shown that DSO produced structurally equivalent trabecular architecture with shorter computing time and smaller memory requirement. As future research, a three-dimensional Bone Remodeling simulation will require the preparation and management of tens of millions of FE elements, and therefore DSO would be essential to handle such a massive problem as a ''more efficient'' algorithm.
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Analogy of strain energy density based Bone-Remodeling algorithm and structural topology optimization.
Journal of biomechanical engineering, 2008Co-Authors: In Gwun Jang, Il Yong Kim, Byung Man KwakAbstract:In Bone-Remodeling studies, it is believed that the morphology of Bone is affected by its internal mechanical loads. From the 1970s, high computing power enabled quantitative studies in the simulation of Bone Remodeling or Bone adaptation. Among them, Huiskes et al. (1987, "Adaptive Bone Remodeling Theory Applied to Prosthetic Design Analysis," J. Biomech. Eng., 20, pp. 1135-1150) proposed a strain energy density based approach to Bone Remodeling and used the apparent density for the characterization of internal Bone morphology. The fundamental idea was that Bone density would increase when strain (or strain energy density) is higher than a certain value and Bone resorption would occur when the strain (or strain energy density) quantities are lower than the threshold. Several advanced algorithms were developed based on these studies in an attempt to more accurately simulate physiological Bone-Remodeling processes. As another approach, topology optimization originally devised in structural optimization has been also used in the computational simulation of the Bone-Remodeling process. The topology optimization method systematically and iteratively distributes material in a design domain, determining an optimal structure that minimizes an objective function. In this paper, we compared two seemingly different approaches in different fields-the strain energy density based Bone-Remodeling algorithm (biomechanical approach) and the compliance based structural topology optimization method (mechanical approach)-in terms of mathematical formulations, numerical difficulties, and behavior of their numerical solutions. Two numerical case studies were conducted to demonstrate their similarity and difference, and then the solution convergences were discussed quantitatively.
Grant P. Steven - One of the best experts on this subject based on the ideXlab platform.
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Time-dependent topology optimization of Bone plates considering Bone Remodeling
Computer Methods in Applied Mechanics and Engineering, 2020Co-Authors: Keke Zheng, Jianguang Fang, Grant P. StevenAbstract:Abstract Bone plates have been widely used for the treatment of Bone defects and trauma. These fixation plates can stabilize or replace Bone tissue to restore appropriate load-bearing functionality. Nevertheless, the use of Bone plates may lead to the stress shielding, thereby weakening prosthetic Bone substitutes (e.g. Bone graft or scaffolds) due to significant change in the biomechanical environment after implantation. To address this issue, we propose a time-dependent topology optimization procedure for the design of Bone plates by taking into account Bone Remodeling. A solid isotropic material penalization (SIMP) model is used to interpolate design variables. The objective is to maximize total Bone density within a reconstruction area at the final stage of Bone Remodeling, subject to a volume constraint of the Bone plate and maximum allowable compliance of the prosthetic system. The sensitivity of Bone density at the final stage is derived with respect to the topological variables of the plate in a step-wise manner. To facilitate sensitivity analysis, a Bone Remodeling rule is formulated in two different ways to accommodate a C 1 continuity. A jaw reconstruction problem is exemplified in this study to demonstrate the effectiveness of the proposed approach. Through this specific case, the non-differentiability issue due to the lazy zone of a Remodeling rule is smoothed; and the proposed approach is also compared with that of a time-independent design. The effects of volume fraction and compliance constraints are also investigated to gain further insights into the design of prosthetic substitutes. Together with additive manufacturing technology, the proposed time-dependent topology optimization procedure is expected to form a useful tool for the design of implantable devices ensuring favorable long-term treatment outcomes.
Byung Man Kwak - One of the best experts on this subject based on the ideXlab platform.
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Analogy of strain energy density based Bone-Remodeling algorithm and structural topology optimization.
Journal of biomechanical engineering, 2008Co-Authors: In Gwun Jang, Il Yong Kim, Byung Man KwakAbstract:In Bone-Remodeling studies, it is believed that the morphology of Bone is affected by its internal mechanical loads. From the 1970s, high computing power enabled quantitative studies in the simulation of Bone Remodeling or Bone adaptation. Among them, Huiskes et al. (1987, "Adaptive Bone Remodeling Theory Applied to Prosthetic Design Analysis," J. Biomech. Eng., 20, pp. 1135-1150) proposed a strain energy density based approach to Bone Remodeling and used the apparent density for the characterization of internal Bone morphology. The fundamental idea was that Bone density would increase when strain (or strain energy density) is higher than a certain value and Bone resorption would occur when the strain (or strain energy density) quantities are lower than the threshold. Several advanced algorithms were developed based on these studies in an attempt to more accurately simulate physiological Bone-Remodeling processes. As another approach, topology optimization originally devised in structural optimization has been also used in the computational simulation of the Bone-Remodeling process. The topology optimization method systematically and iteratively distributes material in a design domain, determining an optimal structure that minimizes an objective function. In this paper, we compared two seemingly different approaches in different fields-the strain energy density based Bone-Remodeling algorithm (biomechanical approach) and the compliance based structural topology optimization method (mechanical approach)-in terms of mathematical formulations, numerical difficulties, and behavior of their numerical solutions. Two numerical case studies were conducted to demonstrate their similarity and difference, and then the solution convergences were discussed quantitatively.