The Experts below are selected from a list of 324 Experts worldwide ranked by ideXlab platform
Todd Baldini - One of the best experts on this subject based on the ideXlab platform.
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Introducing the “Bone-Screw-Fastener” for improved Screw fixation in orthopedic surgery: a revolutionary paradigm shift?
Patient Safety in Surgery, 2017Co-Authors: Philip F. Stahel, Nicholas A. Alfonso, Corey Henderson, Todd BaldiniAbstract:Conventional Screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress Screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress Screw is prone to stripping at the Bone-Screw interface and can cause microfracturing of the surrounding Bone due to its thread design. Standard buttress Screws are therefore at risk of adverse postoperative outcomes secondary to failure of Bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the Bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” Bone cutting technology designed to maximize Bone volume, preserve Bone architecture, and create a circumferential interlocking interface between the implant and Bone that protects the thread from stripping and from failing to multiaxial forces. We hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic Screws with buttress threads by ease of insertion, improved Bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress Screws by providing better resistance to implant failure under physiological loads, preserving Bone biology, and thus potentially improving patient outcomes in the future. The presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress Screw as control. Once validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic Bone preservation for surgical applications requiring Screw fixation.
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Introducing the “Bone-Screw-Fastener” for improved Screw fixation in orthopedic surgery: a revolutionary paradigm shift?
Patient Safety in Surgery, 2017Co-Authors: Philip F. Stahel, Nicholas A. Alfonso, Corey Henderson, Todd BaldiniAbstract:Background Conventional Screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress Screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress Screw is prone to stripping at the Bone-Screw interface and can cause microfracturing of the surrounding Bone due to its thread design. Standard buttress Screws are therefore at risk of adverse postoperative outcomes secondary to failure of Bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the Bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” Bone cutting technology designed to maximize Bone volume, preserve Bone architecture, and create a circumferential interlocking interface between the implant and Bone that protects the thread from stripping and from failing to multiaxial forces. Presentation of the hypothesis We hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic Screws with buttress threads by ease of insertion, improved Bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress Screws by providing better resistance to implant failure under physiological loads, preserving Bone biology, and thus potentially improving patient outcomes in the future. Testing the hypothesis The presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress Screw as control. Implications of the hypothesis Once validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic Bone preservation for surgical applications requiring Screw fixation.
Philip F. Stahel - One of the best experts on this subject based on the ideXlab platform.
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Introducing the “Bone-Screw-Fastener” for improved Screw fixation in orthopedic surgery: a revolutionary paradigm shift?
Patient Safety in Surgery, 2017Co-Authors: Philip F. Stahel, Nicholas A. Alfonso, Corey Henderson, Todd BaldiniAbstract:Conventional Screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress Screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress Screw is prone to stripping at the Bone-Screw interface and can cause microfracturing of the surrounding Bone due to its thread design. Standard buttress Screws are therefore at risk of adverse postoperative outcomes secondary to failure of Bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the Bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” Bone cutting technology designed to maximize Bone volume, preserve Bone architecture, and create a circumferential interlocking interface between the implant and Bone that protects the thread from stripping and from failing to multiaxial forces. We hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic Screws with buttress threads by ease of insertion, improved Bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress Screws by providing better resistance to implant failure under physiological loads, preserving Bone biology, and thus potentially improving patient outcomes in the future. The presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress Screw as control. Once validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic Bone preservation for surgical applications requiring Screw fixation.
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Introducing the “Bone-Screw-Fastener” for improved Screw fixation in orthopedic surgery: a revolutionary paradigm shift?
Patient Safety in Surgery, 2017Co-Authors: Philip F. Stahel, Nicholas A. Alfonso, Corey Henderson, Todd BaldiniAbstract:Background Conventional Screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress Screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress Screw is prone to stripping at the Bone-Screw interface and can cause microfracturing of the surrounding Bone due to its thread design. Standard buttress Screws are therefore at risk of adverse postoperative outcomes secondary to failure of Bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the Bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” Bone cutting technology designed to maximize Bone volume, preserve Bone architecture, and create a circumferential interlocking interface between the implant and Bone that protects the thread from stripping and from failing to multiaxial forces. Presentation of the hypothesis We hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic Screws with buttress threads by ease of insertion, improved Bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress Screws by providing better resistance to implant failure under physiological loads, preserving Bone biology, and thus potentially improving patient outcomes in the future. Testing the hypothesis The presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress Screw as control. Implications of the hypothesis Once validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic Bone preservation for surgical applications requiring Screw fixation.
Shijing Qiu - One of the best experts on this subject based on the ideXlab platform.
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repair of microdamage in osteonal cortical Bone adjacent to Bone Screw
PLOS ONE, 2014Co-Authors: Lei Wang, Lianfu Deng, Jin Shao, Qi Zhou, Li Wei, Shijing QiuAbstract:Up to date, little is known about the repair mode of microdamage in osteonal cortical Bone resulting from Bone Screw implantation. In this study, self-tapping titanium cortical Bone Screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained Bone sections to examine the morphological characteristics of microdamage, Bone resorption activity and spatial relationship between microdamage and Bone resorption. Diffuse and linear cracks were coexisted in peri-Screw Bone. Intracortical Bone resorption was significantly increased 2 weeks after Screw installation and reach to the maximum at 1 month. There was no significant difference in Bone resorption between 1-month and 2-months groups. Microdamage was significantly decreased within 1 month after surgery. Bone resorption was predisposed to occur in the region of <100 µm from the Bone-Screw interface, where had extensive diffuse damage mixed with linear cracks. Different patterns of resorption cavities appeared in peri-Screw Bone. These data suggest that 1) the complex microdamage composed of diffuse damage and linear cracks is a strong stimulator for initiating targeted Bone remodeling; 2) Bone resorption activities taking place on the surfaces of differently oriented Haversian and Volkmann canals work in a team for the repair of extensive microdamage; 3) targeted Bone remodeling is a short-term reaction to microdamage and thereby it may not be able to remove all microdamage resulting from Bone Screw insertion.
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Repair of microdamage in osteonal cortical Bone adjacent to Bone Screw.
PLOS ONE, 2014Co-Authors: Lei Wang, Lianfu Deng, Jin Shao, Qi Zhou, Li Wei, Shijing QiuAbstract:Up to date, little is known about the repair mode of microdamage in osteonal cortical Bone resulting from Bone Screw implantation. In this study, self-tapping titanium cortical Bone Screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained Bone sections to examine the morphological characteristics of microdamage, Bone resorption activity and spatial relationship between microdamage and Bone resorption. Diffuse and linear cracks were coexisted in peri-Screw Bone. Intracortical Bone resorption was significantly increased 2 weeks after Screw installation and reach to the maximum at 1 month. There was no significant difference in Bone resorption between 1-month and 2-months groups. Microdamage was significantly decreased within 1 month after surgery. Bone resorption was predisposed to occur in the region of
Nicholas A. Alfonso - One of the best experts on this subject based on the ideXlab platform.
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Introducing the “Bone-Screw-Fastener” for improved Screw fixation in orthopedic surgery: a revolutionary paradigm shift?
Patient Safety in Surgery, 2017Co-Authors: Philip F. Stahel, Nicholas A. Alfonso, Corey Henderson, Todd BaldiniAbstract:Conventional Screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress Screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress Screw is prone to stripping at the Bone-Screw interface and can cause microfracturing of the surrounding Bone due to its thread design. Standard buttress Screws are therefore at risk of adverse postoperative outcomes secondary to failure of Bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the Bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” Bone cutting technology designed to maximize Bone volume, preserve Bone architecture, and create a circumferential interlocking interface between the implant and Bone that protects the thread from stripping and from failing to multiaxial forces. We hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic Screws with buttress threads by ease of insertion, improved Bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress Screws by providing better resistance to implant failure under physiological loads, preserving Bone biology, and thus potentially improving patient outcomes in the future. The presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress Screw as control. Once validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic Bone preservation for surgical applications requiring Screw fixation.
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Introducing the “Bone-Screw-Fastener” for improved Screw fixation in orthopedic surgery: a revolutionary paradigm shift?
Patient Safety in Surgery, 2017Co-Authors: Philip F. Stahel, Nicholas A. Alfonso, Corey Henderson, Todd BaldiniAbstract:Background Conventional Screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress Screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress Screw is prone to stripping at the Bone-Screw interface and can cause microfracturing of the surrounding Bone due to its thread design. Standard buttress Screws are therefore at risk of adverse postoperative outcomes secondary to failure of Bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the Bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” Bone cutting technology designed to maximize Bone volume, preserve Bone architecture, and create a circumferential interlocking interface between the implant and Bone that protects the thread from stripping and from failing to multiaxial forces. Presentation of the hypothesis We hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic Screws with buttress threads by ease of insertion, improved Bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress Screws by providing better resistance to implant failure under physiological loads, preserving Bone biology, and thus potentially improving patient outcomes in the future. Testing the hypothesis The presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress Screw as control. Implications of the hypothesis Once validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic Bone preservation for surgical applications requiring Screw fixation.
Corey Henderson - One of the best experts on this subject based on the ideXlab platform.
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Introducing the “Bone-Screw-Fastener” for improved Screw fixation in orthopedic surgery: a revolutionary paradigm shift?
Patient Safety in Surgery, 2017Co-Authors: Philip F. Stahel, Nicholas A. Alfonso, Corey Henderson, Todd BaldiniAbstract:Conventional Screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress Screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress Screw is prone to stripping at the Bone-Screw interface and can cause microfracturing of the surrounding Bone due to its thread design. Standard buttress Screws are therefore at risk of adverse postoperative outcomes secondary to failure of Bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the Bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” Bone cutting technology designed to maximize Bone volume, preserve Bone architecture, and create a circumferential interlocking interface between the implant and Bone that protects the thread from stripping and from failing to multiaxial forces. We hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic Screws with buttress threads by ease of insertion, improved Bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress Screws by providing better resistance to implant failure under physiological loads, preserving Bone biology, and thus potentially improving patient outcomes in the future. The presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress Screw as control. Once validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic Bone preservation for surgical applications requiring Screw fixation.
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Introducing the “Bone-Screw-Fastener” for improved Screw fixation in orthopedic surgery: a revolutionary paradigm shift?
Patient Safety in Surgery, 2017Co-Authors: Philip F. Stahel, Nicholas A. Alfonso, Corey Henderson, Todd BaldiniAbstract:Background Conventional Screws used for fracture fixation in orthopedic surgery continue to rely on the historic buttress thread design. While buttress Screws generally provide solid resistance against unidirectional axial loading forces, their design suffers from several limitations, as the buttress thread does not adequately resist multiaxial forces. Furthermore, the buttress Screw is prone to stripping at the Bone-Screw interface and can cause microfracturing of the surrounding Bone due to its thread design. Standard buttress Screws are therefore at risk of adverse postoperative outcomes secondary to failure of Bone fixation. A new patented Bone-Screw-Fastener was recently designed that is based on an interlocking thread technology. This new fastener provides distributive forces from the threads onto the Bone and therefore resists loads in multiple directions. The underlying concept is represented by a “female thread” Bone cutting technology designed to maximize Bone volume, preserve Bone architecture, and create a circumferential interlocking interface between the implant and Bone that protects the thread from stripping and from failing to multiaxial forces. Presentation of the hypothesis We hypothesize that the new Bone-Screw-Fastener overcomes the classic shortcomings of conventional orthopedic Screws with buttress threads by ease of insertion, improved Bone preservation, increased resistance to off-axis multidirectional loading forces and to stripping of the threads. These advanced biomechanical and biological properties can potentially mitigate the classic limitations of conventional buttress Screws by providing better resistance to implant failure under physiological loads, preserving Bone biology, and thus potentially improving patient outcomes in the future. Testing the hypothesis The presumed superiority of the new fastener will require testing and validation in well-designed prospective multicenter randomized controlled trials (RCTs), using the conventional buttress Screw as control. Implications of the hypothesis Once validated in multicenter RCTs, the new Bone-Screw-Fastener may drive a change in paradigm with regard to its innovative biomechanical principles and biologic Bone preservation for surgical applications requiring Screw fixation.