The Experts below are selected from a list of 276 Experts worldwide ranked by ideXlab platform
Shannon L. Adkins - One of the best experts on this subject based on the ideXlab platform.
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Posttetanic Count Revisited: Are Measurements More Reliable Using the TOF-Watch Accelerographic Peripheral Nerve Stimulator?
Journal of Clinical Monitoring and Computing, 2004Co-Authors: Robert D. Jr. Vincent , Russell C. Brockwell, Michael C. Moreno, Shannon L. AdkinsAbstract:Objective. Measurement of profound neuromuscular block using posttetanic count is among the most subjective measurements made in clinical anesthesia. The TOF-Watch accelerographic peripheral nerve Stimulator provides objective measurements of neuromuscular block that may improve our ability to quantitate intense blockade. Methods. The TOF-Watch and Digi Stim III peripheral nerve Stimulators were used to monitor onset and early recovery of neuromuscular response induced by rocuronium 0.6 mg/kg IV in 30 patients anesthetized with general anesthesia. After induction, train-of-four count (when present) was measured at one-min intervals. Subsequently, posttetanic count was measured at three-min intervals until the first response to train-of-four stimulation reappeared. Results. Posttetanic count and train-of-four count measurements were determined to be consistently unreliable throughout the study in seven (23%) patients with the TOF-Watch Stimulator and three (10%) patients with the Digi Stim III Stimulator ( p = NS). Among Stimulators yielding reliable measurements, decreases in train-of-four count to 0/4 were noted earlier with the Digi Stim III monitor (median = 2 min) as compared with the TOF-Watch device (median = 4 min) ( p < 0.05). Also, posttetanic count decreased to zero in only 35% of patients with the TOF-Watch Stimulator versus 67% of patients with the Digi Stim III Stimulator ( p < 0.05). Conclusions. Both monitors were similar in their ability to predict return to TOFC = 1 as a function of PTC measurements. The TOF-Watch monitor is easy to apply even in inexperienced hands. However, the device yielded erroneous data in 23% of patients.
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posttetanic count revisited are measurements more reliable using the tof watch accelerographic peripheral nerve Stimulator
Journal of Clinical Monitoring and Computing, 2003Co-Authors: R D Vincent, Russell C. Brockwell, Michael C. Moreno, Shannon L. AdkinsAbstract:Objective.Measurement of profound neuromuscular block using posttetanic count is among the most subjective measurements made in clinical anesthesia. The TOF-Watch accelerographic peripheral nerve Stimulator provides objective measurements of neuromuscular block that may improve our ability to quantitate intense blockade. Methods.The TOF-Watch and Digi Stim III peripheral nerve Stimulators were used to monitor onset and early recovery of neuromuscular response induced by rocuronium 0.6 mg/kg IV in 30 patients anesthetized with general anesthesia. After induction, train-of-four count (when present) was measured at one-min intervals. Subsequently, posttetanic count was measured at three-min intervals until the first response to train-of-four stimulation reappeared. Results.Posttetanic count and train-of-four count measurements were determined to be consistently unreliable throughout the study in seven (23%) patients with the TOF-Watch Stimulator and three (10%) patients with the Digi Stim III Stimulator (p= NS). Among Stimulators yielding reliable measurements, decreases in train-of-four count to 0/4 were noted earlier with the Digi Stim III monitor (median = 2 min) as compared with the TOF-Watch device (median = 4 min) (p< 0.05). Also, posttetanic count decreased to zero in only 35% of patients with the TOF-Watch Stimulator versus 67% of patients with the Digi Stim III Stimulator (p< 0.05). Conclusions.Both monitors were similar in their ability to predict return to TOFC = 1 as a function of PTC measurements. The TOF-Watch monitor is easy to apply even in inexperienced hands. However, the device yielded erroneous data in 23% of patients.
Johannespeter Stasch - One of the best experts on this subject based on the ideXlab platform.
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soluble guanylate cyclase Stimulators in pulmonary hypertension
Handbook of experimental pharmacology, 2013Co-Authors: Johannespeter Stasch, Oleg V EvgenovAbstract:Soluble guanylate cyclase (sGC) is a key enzyme in the nitric oxide (NO) signalling pathway. On binding of NO to its prosthetic haem group, sGC catalyses the synthesis of the second messenger cyclic guanosine monophosphate (cGMP), which promotes vasodilation and inhibits smooth muscle proliferation, leukocyte recruitment, platelet aggregation and vascular remodelling through a number of downstream mechanisms. The central role of the NO–sGC–cGMP pathway in regulating pulmonary vascular tone is demonstrated by the dysregulation of NO production, sGC activity and cGMP degradation in pulmonary hypertension (PH). The sGC Stimulators are novel pharmacological agents that directly stimulate sGC, both independently of NO and in synergy with NO. Optimisation of the first sGC Stimulator, YC-1, led to the development of the more potent and more specific sGC Stimulators, BAY 41-2272, BAY 41-8543 and riociguat (BAY 63-2521). Other sGC Stimulators include CFM-1571, BAY 60-4552, vericiguat (BAY 1021189), the acrylamide analogue A-350619 and the aminopyrimidine analogues. BAY 41-2272, BAY 41-8543 and riociguat induced marked dose-dependent reductions in mean pulmonary arterial pressure and vascular resistance with a concomitant increase in cardiac output, and they also reversed vascular remodelling and right heart hypertrophy in several experimental models of PH. Riociguat is the first sGC Stimulator that has entered clinical development. Clinical trials have shown that it significantly improves pulmonary vascular haemodynamics and increases exercise ability in patients with pulmonary arterial hypertension (PAH), chronic thromboembolic PH and PH associated with interstitial lung disease. Furthermore, riociguat reduces mean pulmonary arterial pressure in patients with PH associated with chronic obstructive pulmonary disease and improves cardiac index and pulmonary vascular resistance in patients with PH associated with left ventricular systolic dysfunction. These promising results suggest that sGC Stimulators may constitute a valuable new therapy for PH. Other trials of riociguat are in progress, including a study of the haemodynamic effects and safety of riociguat in patients with PH associated with left ventricular diastolic dysfunction, and long-term extensions of the phase 3 trials investigating the efficacy and safety of riociguat in patients with PAH and chronic thromboembolic PH. Finally, sGC Stimulators may also have potential therapeutic applications in other diseases, including heart failure, lung fibrosis, scleroderma and sickle cell disease.
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the vasodilator stimulated phosphoprotein vasp target of yc 1 and nitric oxide effects in human and rat platelets
Journal of Cardiovascular Pharmacology, 2000Co-Authors: Eva Maria Becker, Peter M Schmidt, Matthias Schramm, Henning Schroder, Ulrich Walter, Markus Hoenicka, R Gerzer, Johannespeter StaschAbstract:: The effects of the different types of soluble guanylate cyclase (sGC) Stimulators on the phosphorylation status of vasodilator-stimulated phosphoprotein (VASP) in both human and rat platelets were studied under in vitro and in vivo conditions. sGC-dependent VASP phosphorylation (at Ser(239) and Ser(157)) both by the new direct sGC Stimulator YC-1 and by NO donors was examined by sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS/PAGE) with different antibodies. One antibody, which recognizes VASP independent of its phosphorylation state, was used to detect the mobility shift of VASP caused by Ser(157) phosphorylation. The other antibody was specifically directed against VASP phosphorylated at Ser(239), the cGMP-dependent protein kinase (PKG) preferred phosphorylation site of VASP. In vitro YC-1 increased both VASP phosphorylation and cyclic guanosine monophosphate (cGMP) levels as did the NO donors 2-(N,N-diethylamino)-diazenolate-2-oxide (DEA/NO) and sodium nitroprusside (SNP). The combination of both types induced a synergistic effect in both VASP phosphorylation and cGMP increase. In rat platelets, similar effects could be shown in vitro. In vivo we observed a significant increase in cGMP and a distinct effect on VASP phosphorylation in rat platelets 1 h after oral administration of YC-1. These biochemical alterations are supported by a significant prolongation in rat-tail bleeding time. Direct Stimulators of sGC like YC-1 are on the one hand direct potent Stimulators of the cGMP/PKG/VASP pathway in platelets and on the other hand synergize with NO, the physiologic Stimulator of sGC. Therefore YC-1-like substances are interesting tools for the development of new cardiovascular drugs with vasodilatory and antithrombotic properties.
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The vasodilator-stimulated phosphoprotein (VASP): target of YC-1 and nitric oxide effects in human and rat platelets.
Journal of cardiovascular pharmacology, 2000Co-Authors: Eva Maria Becker, Matthias Schramm, Henning Schroder, Ulrich Walter, Markus Hoenicka, R Gerzer, Peter Schmidt, Johannespeter StaschAbstract:Summary: The effects of the different types of soluble guanylate cyclase (sGC) Stimulators on the phosphorylation status of vasodilator-stimulated phosphoprotein (VASP) in both human and rat platelets were studied under in vitro and in vivo conditions. sGC-dependent VASP phosphorylation (at Ser239 and Ser157) both by the new direct sGC Stimulator YC-1 and by NO donors was examined by sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS/PAGE) with different antibodies. One antibody, which recognizes VASP independent of its phosphorylation state, was used to detect the mobility shift of VASP caused by Ser157 phosphorylation. The other antibody was specifically directed against VASP phosphorylated at Ser239, the cGMP-dependent protein kinase (PKG) preferred phosphorylation site of VASP. In vitro YC-1 increased both VASP phosphorylation and cyclic guanosine monophosphate (cGMP) levels as did the NO donors 2-(N,N-diethylamino)-diazenolate-2-oxide (DEA/NO) and sodium nitroprusside (SNP). The combination of both types induced a synergistic effect in both VASP phosphorylation and cGMP increase. In rat platelets, similar effects could be shown in vitro. In vivo we observed a significant increase in cGMP and a distinct effect on VASP phosphorylation in rat platelets 1 h after oral administration of YC-1. These biochemical alterations are supported by a significant prolongation in rat-tail bleeding time. Direct Stimulators of sGC like YC-1 are on the one hand direct potent Stimulators of the cGMP/PKG/VASP pathway in platelets and on the other hand synergize with NO, the physiologic Stimulator of sGC. Therefore YC-1-like substances are interesting tools for the development of new cardiovascular drugs with vasodilatory and antithrombotic properties.
Ryu Kato - One of the best experts on this subject based on the ideXlab platform.
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investigation of a cognitive strain on hand grasping induced by sensory feedback for myoelectric hand
International Conference on Robotics and Automation, 2016Co-Authors: Hiroshi Yamada, Yusuke Yamanoi, Ko Wakita, Ryu KatoAbstract:The purpose of this study is to investigate how sensory feedback affects the cognitive strain of grasping using a prosthesis and to develop an efficient method for decreasing the cognitive strain of grasping. We divided a grasping action into two phases, an “approaching phase” and a “grasping phase”, and assumed that the tactile feedback affect for the cognitive strain induced by grasping phase and the deep sensory feedback affect for cognitive strain induced by approaching phase. Using dual-task method, we compared the effect of sensory feedback method using strength-changed simulator or using spatially changed Stimulators. As a result, we concluded that the sensory feedback can decrease the cognitive strain of grasping action, and the sensory feedback from one strength-changed Stimulator is better than the one from spatially changed Stimulators to decrease a cognitive strain caused by grasping action.
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ICRA - Investigation of a cognitive strain on hand grasping induced by sensory feedback for myoelectric hand
2016 IEEE International Conference on Robotics and Automation (ICRA), 2016Co-Authors: Hiroshi Yamada, Yusuke Yamanoi, Ko Wakita, Ryu KatoAbstract:The purpose of this study is to investigate how sensory feedback affects the cognitive strain of grasping using a prosthesis and to develop an efficient method for decreasing the cognitive strain of grasping. We divided a grasping action into two phases, an “approaching phase” and a “grasping phase”, and assumed that the tactile feedback affect for the cognitive strain induced by grasping phase and the deep sensory feedback affect for cognitive strain induced by approaching phase. Using dual-task method, we compared the effect of sensory feedback method using strength-changed simulator or using spatially changed Stimulators. As a result, we concluded that the sensory feedback can decrease the cognitive strain of grasping action, and the sensory feedback from one strength-changed Stimulator is better than the one from spatially changed Stimulators to decrease a cognitive strain caused by grasping action.
J. Craig Henry - One of the best experts on this subject based on the ideXlab platform.
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New-onset partial epilepsy in adults
Current Treatment Options in Neurology, 2009Co-Authors: J. Craig HenryAbstract:Medical management, the mainstay of treatment for partial epilepsy, involves choosing from an array of antiseizure drugs, most of which have comparable efficacy against partial-onset seizures. Effective treatment strategies involve matching the characteristics of drug and patient to control seizures without adverse effects, a task that requires familiarity with the potential advantages and drawbacks of individual antiseizure drugs. For medically refractory partial epilepsy, resective surgical procedures should be considered. If the patient is not a surgical candidate, the vagus nerve Stimulator or ketogenic diet may improve seizure control in selected cases. Emerging therapies include medications with novel mechanisms of action, deep brain Stimulators, and cortical Stimulators that respond to neural patterns of seizure activity.
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New-onset partial epilepsy in adults
Current Treatment Options in Neurology, 2009Co-Authors: Lynn Liu, J. Craig HenryAbstract:Medical management, the mainstay of treatment for partial epilepsy, involves choosing from an array of antiseizure drugs, most of which have comparable efficacy against partial-onset seizures. Effective treatment strategies involve matching the characteristics of drug and patient to control seizures without adverse effects, a task that requires familiarity with the potential advantages and drawbacks of individual antiseizure drugs. For medically refractory partial epilepsy, resective surgical procedures should be considered. If the patient is not a surgical candidate, the vagus nerve Stimulator or ketogenic diet may improve seizure control in selected cases. Emerging therapies include medications with novel mechanisms of action, deep brain Stimulators, and cortical Stimulators that respond to neural patterns of seizure activity.
Hiroshi Yamada - One of the best experts on this subject based on the ideXlab platform.
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investigation of a cognitive strain on hand grasping induced by sensory feedback for myoelectric hand
International Conference on Robotics and Automation, 2016Co-Authors: Hiroshi Yamada, Yusuke Yamanoi, Ko Wakita, Ryu KatoAbstract:The purpose of this study is to investigate how sensory feedback affects the cognitive strain of grasping using a prosthesis and to develop an efficient method for decreasing the cognitive strain of grasping. We divided a grasping action into two phases, an “approaching phase” and a “grasping phase”, and assumed that the tactile feedback affect for the cognitive strain induced by grasping phase and the deep sensory feedback affect for cognitive strain induced by approaching phase. Using dual-task method, we compared the effect of sensory feedback method using strength-changed simulator or using spatially changed Stimulators. As a result, we concluded that the sensory feedback can decrease the cognitive strain of grasping action, and the sensory feedback from one strength-changed Stimulator is better than the one from spatially changed Stimulators to decrease a cognitive strain caused by grasping action.
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ICRA - Investigation of a cognitive strain on hand grasping induced by sensory feedback for myoelectric hand
2016 IEEE International Conference on Robotics and Automation (ICRA), 2016Co-Authors: Hiroshi Yamada, Yusuke Yamanoi, Ko Wakita, Ryu KatoAbstract:The purpose of this study is to investigate how sensory feedback affects the cognitive strain of grasping using a prosthesis and to develop an efficient method for decreasing the cognitive strain of grasping. We divided a grasping action into two phases, an “approaching phase” and a “grasping phase”, and assumed that the tactile feedback affect for the cognitive strain induced by grasping phase and the deep sensory feedback affect for cognitive strain induced by approaching phase. Using dual-task method, we compared the effect of sensory feedback method using strength-changed simulator or using spatially changed Stimulators. As a result, we concluded that the sensory feedback can decrease the cognitive strain of grasping action, and the sensory feedback from one strength-changed Stimulator is better than the one from spatially changed Stimulators to decrease a cognitive strain caused by grasping action.