The Experts below are selected from a list of 19785 Experts worldwide ranked by ideXlab platform

Peter Patka - One of the best experts on this subject based on the ideXlab platform.

  • Microstructure and biomechanical characteristics of Bone Substitutes for trauma and orthopaedic surgery
    Surgery and Traumatology, 2011
    Co-Authors: E.m.m. Vanlieshout, Harrie Weinans, Youssef El-massoudi, G.h. Vankralingen, Peter Patka
    Abstract:

    textabstractAbstract. BACKGROUND: Many (artificial) Bone substitute materials are currently available for use in orthopaedic trauma surgery. Objective data on their biological and biomechanical characteristics, which determine their clinical application, is mostly lacking. The aim of this study was to investigate structural and in vitro mechanical properties of nine Bone substitute cements registered for use in orthopaedic trauma surgery in the Netherlands. METHODS: Seven calcium phosphate cements (BoneSource®, Calcibon®, ChronOS®, EuroBone®, HydroSet™, Norian SRS®, and Ostim®), one calcium sulphate cement (MIIG® X3), and one bioactive glass cement (Cortoss®) were tested. Structural characteristics were measured by micro-CT scanning. Compression strength and stiffness were determined following unconfined compression tests. RESULTS: Each Bone substitute had unique characteristics. Mean total porosity ranged from 53% (Ostim®) to 0.5% (Norian SRS®). Mean pore size exceeded 100 μm only in EuroBone® and Cortoss® (162.2 ± 107.1 μm and 148.4 ± 70.6 μm, respectively). However, 230 μm pores were found in Calcibon®, Norian SRS®, HydroSet™, and MIIG® X3. Connectivity density ranged from 27/cm3 for HydroSet™ to 0.03/cm3 for Calcibon®. The ultimate compression strength was highest in Cortoss® (47.32 MPa) and lowest in Ostim® (0.24 MPa). Young's Modulus was highest in Calcibon® (790 MPa) and lowest in Ostim® (6 MPa). CONCLUSIONS: The Bone Substitutes tested display a wide range in structural properties and compression strength, indicating that they will be suitable for different clinical indications. The data outlined here will help surgeons to select the most suitable products currently available for specific clinical indications.

  • Bone Substitutes in the netherlands a systematic literature review
    Acta Biomaterialia, 2011
    Co-Authors: Johan Van Der Stok, Esther M.m. Van Lieshout, Gerdine H. Van Kralingen, Youssef Elmassoudi, Peter Patka
    Abstract:

    Autologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

  • Bone Substitutes in the Netherlands - A systematic literature review
    Surgery and Traumatology, 2011
    Co-Authors: J. Van Destok, Youssef El-massoudi, E.m.m. Vanlieshout, G.h. Vankralingen, Peter Patka
    Abstract:

    textabstractAutologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

  • Bone Substitutes in the Netherlands – A systematic literature review
    Acta biomaterialia, 2010
    Co-Authors: Johan Van Der Stok, Esther M.m. Van Lieshout, Youssef El-massoudi, Gerdine H. Van Kralingen, Peter Patka
    Abstract:

    Autologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

Johan Van Der Stok - One of the best experts on this subject based on the ideXlab platform.

  • Bone Substitutes in the netherlands a systematic literature review
    Acta Biomaterialia, 2011
    Co-Authors: Johan Van Der Stok, Esther M.m. Van Lieshout, Gerdine H. Van Kralingen, Youssef Elmassoudi, Peter Patka
    Abstract:

    Autologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

  • Bone Substitutes in the Netherlands – A systematic literature review
    Acta biomaterialia, 2010
    Co-Authors: Johan Van Der Stok, Esther M.m. Van Lieshout, Youssef El-massoudi, Gerdine H. Van Kralingen, Peter Patka
    Abstract:

    Autologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

Emeka Nkenke - One of the best experts on this subject based on the ideXlab platform.

  • clinical outcomes of sinus floor augmentation for implant placement using autogenous Bone or Bone Substitutes a systematic review
    Clinical Oral Implants Research, 2009
    Co-Authors: Emeka Nkenke, Floria Stelzle
    Abstract:

    Background: To date, there are still no clear cut guidelines for the use of autogenous Bone or Bone Substitutes. Aim: The aim of the present review was to analyze the current literature in order to determine whether there are advantages of using autogenous Bone (AB) over Bone Substitutes (BS) in sinus floor augmentation. The focused question was: is AB superior to BS for sinus floor augmentation in partially dentate or edentulous patients in terms of implant survival, patient morbidity, sinusitis, graft loss, costs, and risk of disease transmission? Materials and methods: The analysis was limited to titanium implants with modified surfaces placed in sites with 6 mm of residual Bone height and a lateral wall approach to the sinus. A literature search was performed for human studies focusing on sinus floor augmentation. Results: Twenty-one articles were included in the review. The highest level of evidence consisted of prospective cohort studies. A descriptive analysis of the constructed evidence tables indicated that the type of graft did not seem to be associated with the success of the procedure, its complications, or implant survival. Length of healing period, simultaneous implant placement or a staged approach or the height of the residual alveolar crest, sinusitis or graft loss did not modify the lack of effect of graft material on the outcomes. Three studies documented that there was donor site morbidity present after the harvest of AB. When iliac crest Bone was harvested this sometimes required hospitalization and surgery under general anesthesia. Moreover, Bone harvest extended the operating time. The assessment of disease transmission by BS was not a topic of any of the included articles. Discussion and Conclusion: The retrieved evidence provides a low level of support for selection of AB or a Bone substitute. Clear reasons could not be identified that should prompt the clinician to prefer AB or BS.

  • effects of platelet rich plasma on Bone healing in combination with autogenous Bone and Bone Substitutes in critical size defects
    Clinical Oral Implants Research, 2004
    Co-Authors: Joerg Wiltfang, Emeka Nkenke, F R Kloss, Peter Kessler, Stefan Schultzemosgau, Robert Zimmermann, K. A. Schlegel
    Abstract:

    Abstract Objectives: An animal study was carried out to investigate the influence of platelet-rich plasma (PRP) on the regeneration of bony defects. Material and methods: Critical-size defects in the forehead region of a mini-pig were filled with randomly distributed combinations of autogenous Bone, tricalcium-phosphate granules (CeraSorb™), bovine spongious blocks (BioOss™) and a bovine Bone inducing collagenous sponge (Colloss™) with and without PRP in two preparations (Cusasan, 3i). The animals were killed after 2, 4 and 12 weeks. The specimens were evaluated microradiographically and immunohistologically. Results: Autologous Bone (38±9.9%) and Colloss (52.6±4.0%) showed the highest remineralization rates at 2 weeks. The initial high expression of BMP-2 in the Colloss®-group gives evidence of an early initiation of bony regeneration. At 2 weeks PRP ad modum 3i was able to enhance Bone healing significantly (P=0.028) only when applied in combination with autogenous Bone (62.8±1.6%). Four weeks after surgery, both PRP preparations did no longer increase bony regeneration in the autogenous groups. The osteoconductive effect of Bio-Oss™ (38.7±5.5%) and CeraSorb™ (41±4.9%) was remarkable as well 4 weeks after surgery. Nevertheless, the addition of PRP hardly influenced bony regeneration, ceramic degradation or cytokine expression when Bone Substitutes were applied. At 12 weeks, the level of reossification had adjusted similarly in all groups. Conclusion: PRP did not add additional benefit when xenogenic Bone Substitutes were used. However, a significant effect on Bone regeneration was found in the autogenous group initially when PRP is added.

Gerdine H. Van Kralingen - One of the best experts on this subject based on the ideXlab platform.

  • microstructure and biomechanical characteristics of Bone Substitutes for trauma and orthopaedic surgery
    BMC Musculoskeletal Disorders, 2011
    Co-Authors: Esther M.m. Van Lieshout, Harrie Weinans, Gerdine H. Van Kralingen, Youssef Elmassoudi, P Patka
    Abstract:

    Background: Many (artificial) Bone substitute materials are currently available for use in orthopaedic trauma surgery. Objective data on their biological and biomechanical characteristics, which determine their clinical application, is mostly lacking. The aim of this study was to investigate structural and in vitro mechanical properties of nine Bone substitute cements registered for use in orthopaedic trauma surgery in the Netherlands. Methods: Seven calcium phosphate cements (BoneSource ® , Calcibon ® , ChronOS ® , EuroBone ® , HydroSet™, Norian SRS ® , and Ostim ® ), one calcium sulphate cement (MIIG ® X3), and one bioactive glass cement (Cortoss ® ) were tested. Structural characteristics were measured by micro-CT scanning. Compression strength and stiffness were determined following unconfined compression tests. Results: Each Bone substitute had unique characteristics. Mean total porosity ranged from 53% (Ostim ® ) to 0.5% (Norian SRS ® ). Mean pore size exceeded 100 μm only in EuroBone ® and Cortoss ® (162.2 ± 107.1 μm and 148.4 ± 70.6 μm, respectively). However, 230 μm pores were found in Calcibon ® , Norian SRS ® , HydroSet™, and MIIG ® X3. Connectivity density ranged from 27/cm 3 for HydroSet™ to 0.03/cm 3 for Calcibon ® . The ultimate compression strength was highest in Cortoss ® (47.32 MPa) and lowest in Ostim ® (0.24 MPa). Young’s Modulus was highest in Calcibon ® (790 MPa) and lowest in Ostim ® (6 MPa). Conclusions: The Bone Substitutes tested display a wide range in structural properties and compression strength, indicating that they will be suitable for different clinical indications. The data outlined here will help surgeons to select the most suitable products currently available for specific clinical indications.

  • Bone Substitutes in the netherlands a systematic literature review
    Acta Biomaterialia, 2011
    Co-Authors: Johan Van Der Stok, Esther M.m. Van Lieshout, Gerdine H. Van Kralingen, Youssef Elmassoudi, Peter Patka
    Abstract:

    Autologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

  • Bone Substitutes in the Netherlands – A systematic literature review
    Acta biomaterialia, 2010
    Co-Authors: Johan Van Der Stok, Esther M.m. Van Lieshout, Youssef El-massoudi, Gerdine H. Van Kralingen, Peter Patka
    Abstract:

    Autologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

Esther M.m. Van Lieshout - One of the best experts on this subject based on the ideXlab platform.

  • microstructure and biomechanical characteristics of Bone Substitutes for trauma and orthopaedic surgery
    BMC Musculoskeletal Disorders, 2011
    Co-Authors: Esther M.m. Van Lieshout, Harrie Weinans, Gerdine H. Van Kralingen, Youssef Elmassoudi, P Patka
    Abstract:

    Background: Many (artificial) Bone substitute materials are currently available for use in orthopaedic trauma surgery. Objective data on their biological and biomechanical characteristics, which determine their clinical application, is mostly lacking. The aim of this study was to investigate structural and in vitro mechanical properties of nine Bone substitute cements registered for use in orthopaedic trauma surgery in the Netherlands. Methods: Seven calcium phosphate cements (BoneSource ® , Calcibon ® , ChronOS ® , EuroBone ® , HydroSet™, Norian SRS ® , and Ostim ® ), one calcium sulphate cement (MIIG ® X3), and one bioactive glass cement (Cortoss ® ) were tested. Structural characteristics were measured by micro-CT scanning. Compression strength and stiffness were determined following unconfined compression tests. Results: Each Bone substitute had unique characteristics. Mean total porosity ranged from 53% (Ostim ® ) to 0.5% (Norian SRS ® ). Mean pore size exceeded 100 μm only in EuroBone ® and Cortoss ® (162.2 ± 107.1 μm and 148.4 ± 70.6 μm, respectively). However, 230 μm pores were found in Calcibon ® , Norian SRS ® , HydroSet™, and MIIG ® X3. Connectivity density ranged from 27/cm 3 for HydroSet™ to 0.03/cm 3 for Calcibon ® . The ultimate compression strength was highest in Cortoss ® (47.32 MPa) and lowest in Ostim ® (0.24 MPa). Young’s Modulus was highest in Calcibon ® (790 MPa) and lowest in Ostim ® (6 MPa). Conclusions: The Bone Substitutes tested display a wide range in structural properties and compression strength, indicating that they will be suitable for different clinical indications. The data outlined here will help surgeons to select the most suitable products currently available for specific clinical indications.

  • Bone Substitutes in the netherlands a systematic literature review
    Acta Biomaterialia, 2011
    Co-Authors: Johan Van Der Stok, Esther M.m. Van Lieshout, Gerdine H. Van Kralingen, Youssef Elmassoudi, Peter Patka
    Abstract:

    Autologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.

  • Bone Substitutes in the Netherlands – A systematic literature review
    Acta biomaterialia, 2010
    Co-Authors: Johan Van Der Stok, Esther M.m. Van Lieshout, Youssef El-massoudi, Gerdine H. Van Kralingen, Peter Patka
    Abstract:

    Autologous Bone grafting is currently considered as the gold standard to restore Bone defects. However, clinical benefit is not guaranteed and there is an associated 8-39% complication rate. This has resulted in the development of alternative (synthetic) Bone Substitutes. The aim of this systematic literature review was to provide a comprehensive overview of literature data of Bone Substitutes registered in the Netherlands for use in trauma and orthopedic surgery. Brand names of selected products were used as search terms in three available databases: Embase, PubMed and Cochrane. Manuscripts written in English, German or Dutch that reported on structural, biological or biomechanical properties of the pure product or on its use in trauma and orthopedic surgery were included. The primary search resulted in 475 manuscripts from PubMed, 653 from Embase and 10 from Cochrane. Of these, 218 met the final inclusion criteria. Of each product, structural, biological and biomechanical characteristics as well as their clinical indications in trauma and orthopedic surgery are provided. All included products possess osteoconductive properties but differ in resorption time and biomechanical properties. They have been used for a wide range of clinical applications; however, the overall level of clinical evidence is low. The requirements of an optimal Bone substitute are related to the size and location of the defect. Calcium phosphate grafts have been used for most trauma and orthopedic surgery procedures. Calcium sulphates were mainly used to restore Bone defects after tumour resection surgery but offer minimal structural support. Bioactive glass remains a potential alternative; however, its use has only been studied to a limited extent.