The Experts below are selected from a list of 318 Experts worldwide ranked by ideXlab platform
Maisoon Al-jawad - One of the best experts on this subject based on the ideXlab platform.
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Recovery of Crystallographic Texture in Remineralized Dental Enamel
2016Co-Authors: Samera Siddiqui, Paul Anderson, Maisoon Al-jawadAbstract:Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and Remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and Remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that Remineralization promotes ordered formation of new crystallites and growth of pre-existin
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Recovery of crystallographic texture in remineralized dental enamel.
PLOS ONE, 2014Co-Authors: Samera Siddiqui, Paul H. Anderson, Maisoon Al-jawadAbstract:Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and Remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and Remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that Remineralization promotes ordered formation of new crystallites and growth of pre-existing crystallites which match the preferred orientation of healthy enamel. Combining microstructural and crystallographic characterization aids the understanding of caries and erosion processes and assists in the progress towards developing therapeutic treatments to allow affected enamel to regain structural integrity.
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Recovery of crystallographic texture in remineralized dental enamel.
PLOS ONE, 2014Co-Authors: Samera Siddiqui, Paul H. Anderson, Maisoon Al-jawadAbstract:Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and Remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and Remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that Remineralization promotes ordered formation of new crystallites and growth of pre-existing crystallites which match the preferred orientation of healthy enamel. Combining microstructural and crystallographic characterization aids the understanding of caries and erosion processes and assists in the progress towards developing therapeutic treatments to allow affected enamel to regain structural integrity.
Li Wei-xin - One of the best experts on this subject based on the ideXlab platform.
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A study of the demineralization and Remineralization on enamel of young permanent teeth
Journal of Xinjiang Medical University, 2005Co-Authors: Li Wei-xinAbstract:Objective: To study the effect of Remineralization of three caries-preparative reagent on artificial demineralization lesion of young permanent teeth enamel caries. Methods: 60 nocaries young premolars were selected from orthodontic teeth extraction and artificial caries lesion were formed with lactic acid gel. Then all speciments were divided into 3 groups, each group had 20 teeth, every tooth was divided into two parts, one part was experimental group, the rest was control group. Experimental group were treated with NaF, fluorid protector and Remineralization solution containing trace elements respectively, and the control group were not processed. The hardness of enamel were measured by microhardness detected. Results: Compared with the control group, all the experimental group had significant differences (P0.01), especially the Remineralization solution group. Compared with NaF and fluoride protector, the Remineralization solution group had significant difference (P0.001), but there was no significant difference between the NaF and fluoride protector(P0.05). Conclusion: The three caries-preparative reagent have Remineralization effect on young permanent teeth, especially the Remineralization solution containing trace elements.
Samera Siddiqui - One of the best experts on this subject based on the ideXlab platform.
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Recovery of Crystallographic Texture in Remineralized Dental Enamel
2016Co-Authors: Samera Siddiqui, Paul Anderson, Maisoon Al-jawadAbstract:Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and Remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and Remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that Remineralization promotes ordered formation of new crystallites and growth of pre-existin
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Recovery of crystallographic texture in remineralized dental enamel.
PLOS ONE, 2014Co-Authors: Samera Siddiqui, Paul H. Anderson, Maisoon Al-jawadAbstract:Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and Remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and Remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that Remineralization promotes ordered formation of new crystallites and growth of pre-existing crystallites which match the preferred orientation of healthy enamel. Combining microstructural and crystallographic characterization aids the understanding of caries and erosion processes and assists in the progress towards developing therapeutic treatments to allow affected enamel to regain structural integrity.
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Recovery of crystallographic texture in remineralized dental enamel.
PLOS ONE, 2014Co-Authors: Samera Siddiqui, Paul H. Anderson, Maisoon Al-jawadAbstract:Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and Remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and Remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that Remineralization promotes ordered formation of new crystallites and growth of pre-existing crystallites which match the preferred orientation of healthy enamel. Combining microstructural and crystallographic characterization aids the understanding of caries and erosion processes and assists in the progress towards developing therapeutic treatments to allow affected enamel to regain structural integrity.
Frank Lippert - One of the best experts on this subject based on the ideXlab platform.
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Bleaching of simulated stained-remineralized caries lesions in vitro
Clinical Oral Investigations, 2019Co-Authors: Sarah S. Al-angari, Frank Lippert, George J. Eckert, Jeffrey A. Platt, Carlos González-cabezas, Anderson T HaraAbstract:Objective Non-invasive esthetic treatment options for stained arrested caries lesions have not been explored. This study aimed to develop laboratory models to create stained-remineralized caries-like lesions (s-RCLs) and to test the efficacy of bleaching on their esthetic treatment. Materials and methods One hundred twelve enamel/dentin specimens were prepared from human molars, embedded, and had their color measured spectrophotometrically at baseline and after demineralization. They were randomly divided into four groups ( n = 14) based on the staining/Remineralization protocols for a total of 5 days: G1, no staining/no Remineralization; G2, no staining/Remineralization in artificial saliva (AS); G3, non-metallic staining/Remineralization with sodium fluoride/AS; and G4, metallic staining/Remineralization with silver diamine fluoride/AS. The lesion mineral loss (Δ Z ) and depth ( L ) were measured using transverse microradiography along with color change (Δ E ). Specimens were bleached and color was re-evaluated. Data were analyzed using ANOVA models followed by Fisher’s PLSD tests ( α = 0.05). Results s-RCLs in G4 were significantly ( p
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The influence of hardness and chemical composition on enamel demineralization and subsequent Remineralization
Journal of Dentistry, 2018Co-Authors: Rana Alkattan, Frank Lippert, George J. Eckert, Qing Tang, Masatoshi AndoAbstract:Objectives: The objectives were to investigate the hardness and chemical composition of sound, demineralized and pH-cycled bovine enamel and determine their influence on demineralization and Remineralization behavior. Methods: Ninety-four, 5 × 5 × 2-mm bovine enamel specimens were demineralized using three different times [(24 h (n = 33), 48 h (n = 30), 96 h (n = 31)]. The specimens were then pH-cycled using either 367 ppm F sodium fluoride or deionized water. Knoop hardness (HK) and energy-dispersive X-ray spectroscopy (measured elements: Ca, P, F, C, Mg, N) were performed at three stages (sound, after demineralization, after pH-cycling) and transverse microradiography was performed after demineralization and pH-cycling. Comparisons were determined by ANOVA. Results: Results showed that HK, integrated mineral loss and lesion depth were significantly different between stages, demineralization times and treatments. The weight% of F at the surface was significantly affected by treatment, irrespective of demineralization time, while the Ca:P ratio of the enamel remained stable even after de- and Remineralization protocols. The F in fluoride groups and the artificial saliva in non-fluoride groups were both able to induce enamel Remineralization, indicating the protective effect of salivary pellicle against demineralization even in the absence of fluoride. Conclusions: Harder specimens and those with greater surface F weight% were less susceptible to demineralization and were more likely to remineralize. However, the amount of surface Ca and P did not influence de- or Remineralization behavior. Clinical Significance: This in vitro study can help clinicians better understand the caries process and the impact of the physical and chemical characteristics of enamel on its behavior during de- and Remineralization. The over-the-counter fluoride toothpaste containing 1100 ppm-F was used, and was able to produce a mineralized enamel surface layer.
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Dose-Response Effects of Zinc and Fluoride on Caries Lesion Remineralization
Caries research, 2012Co-Authors: Frank LippertAbstract:The present mechanistic in vitro study aimed to investigate dose-response effects of zinc and fluoride on caries lesion Remineralization and subsequent protection from demineralization. Artificial caries lesions were created using a methylcellulose acid gel system. Lesions were remineralized for 2 weeks using citrate-containing artificial saliva which was supplemented with zinc (0–153 µmol/l) and fluoride (1.1 or 52.6 µmol/l) in a 7 × 2 factorial design. Lesions were also remineralized in the absence of zinc and citrate, but in the presence of fluoride. After Remineralization, all lesions were demineralized for 1 day under identical conditions. Changes in mineral distribution characteristics of caries lesions after Remineralization and secondary demineralization were studied using transverse microradiography. At 1.1 µmol/l fluoride, zinc exhibited detrimental effects on Remineralization in a dose-response manner and mainly by preventing Remineralization near the lesion surface. At 52.6 µmol/l fluoride, zinc retarded Remineralization only at the highest concentration tested. Zinc enhanced overall Remineralization at 3.8–15.3 µmol/l. At 76.5 and less so at 153 µmol/l, zinc showed extensive Remineralization of deeper parts within the lesions at the expense of Remineralization near the surface. Citrate did not interfere with Remineralization at 1.1 µmol/l fluoride, but enhanced Remineralization at 52.6 µmol/l fluoride. Lesions exhibiting preferential Remineralization in deeper parts showed higher mineral loss after secondary demineralization, suggesting the formation of more soluble mineral phases during Remineralization. In summary, zinc and fluoride showed synergistic effects in enhancing lesion Remineralization, however only at elevated fluoride concentrations.
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in vitro demineralization Remineralization cycles at human tooth enamel surfaces investigated by afm and nanoindentation
Journal of Colloid and Interface Science, 2004Co-Authors: Frank Lippert, D M Parker, Klaus D JandtAbstract:The early stages of enamel surface dissolution (erosion) are of high scientific relevance; however, little is known about if and to what extent these early stages, which result in the softening of the enamel surface, are reversible. The present study investigated the possible rehardening of surface softened enamel in two separate experiments in vitro, employing physiologically relevant demineralization and Remineralization times and remineralizing solutions possessing chemical properties close to those of human saliva. Atomic force microscopy (AFM) based nanoindentation has been used to study the nanomechanical properties and the ultrastructure of polished enamel samples as affected by demineralization/Remineralization cycles. In contradiction to previous studies employing microhardness techniques, no enamel rehardening has been observed after Remineralization; however, the demineralization schemes used in the present study (short treatments with a citric acid buffer) are not comparable to the ones used in previous studies, making a comparison difficult. A mineral deposition after Remineralization on softened enamel samples has been observed by AFM; however, a protective effect of this deposited layer could not be revealed. The exposure of softened enamel samples to either a remineralizing solution or a mineral water led to an improved acid resistance of these samples as shown in a demineralization/Remineralization cycle. The present study has demonstrated that AFM based nanoindentation is a useful tool to investigate the demineralization and Remineralization of surface softened enamel with high accuracy.
Paul H. Anderson - One of the best experts on this subject based on the ideXlab platform.
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Recovery of crystallographic texture in remineralized dental enamel.
PLOS ONE, 2014Co-Authors: Samera Siddiqui, Paul H. Anderson, Maisoon Al-jawadAbstract:Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and Remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and Remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that Remineralization promotes ordered formation of new crystallites and growth of pre-existing crystallites which match the preferred orientation of healthy enamel. Combining microstructural and crystallographic characterization aids the understanding of caries and erosion processes and assists in the progress towards developing therapeutic treatments to allow affected enamel to regain structural integrity.
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Recovery of crystallographic texture in remineralized dental enamel.
PLOS ONE, 2014Co-Authors: Samera Siddiqui, Paul H. Anderson, Maisoon Al-jawadAbstract:Dental caries is the most prevalent disease encountered by people of all ages around the world. Chemical changes occurring in the oral environment during the caries process alter the crystallography and microstructure of dental enamel resulting in loss of mechanical function. Little is known about the crystallographic effects of demineralization and Remineralization. The motivation for this study was to develop understanding of the caries process at the crystallographic level in order to contribute towards a long term solution. In this study synchrotron X-ray diffraction combined with scanning electron microscopy and scanning microradiography have been used to correlate enamel crystallography, microstructure and mineral concentration respectively in enamel affected by natural caries and following artificial demineralization and Remineralization regimes. In particular, the extent of destruction and re-formation of this complex structure has been measured. 2D diffraction patterns collected at the European Synchrotron Radiation Facility were used to quantify changes in the preferred orientation (crystallographic texture) and position of the (002) Bragg reflection within selected regions of interest in each tooth slice, and then correlated with the microstructure and local mineral mass. The results revealed that caries and artificial demineralization cause a large reduction in crystallographic texture which is coupled with the loss of mineral mass. Remineralization restores the texture to the original level seen in healthy enamel and restores mineral density. The results also showed that Remineralization promotes ordered formation of new crystallites and growth of pre-existing crystallites which match the preferred orientation of healthy enamel. Combining microstructural and crystallographic characterization aids the understanding of caries and erosion processes and assists in the progress towards developing therapeutic treatments to allow affected enamel to regain structural integrity.
