The Experts below are selected from a list of 64560 Experts worldwide ranked by ideXlab platform
Su Hee Kim - One of the best experts on this subject based on the ideXlab platform.
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self assembling peptide nanofibers coupled with neuropeptide substance p for Bone tissue engineering
Tissue Engineering Part A, 2015Co-Authors: Su Hee Kim, Woojune Hur, Ji Eun Kim, Hye Jeong Min, Suk Wha Kim, Hye Sook Min, Byeung Kyu Kim, Soohyun KimAbstract:The number of patients requiring flat Bone Transplantation continues to increase worldwide. Cell Transplantation has been successfully applied clinically; however, it causes another defect site and the time requirements to harvest cells and expand them are considerable. In this study, KLD12/KLD12-SP (KLD12+KLD12-substance P [SP]) was designed to mimic endogenous tissue-healing processes. The structures of KLD12, KLD12-SP, and KLD12/KLD12-SP were observed by transmission electron microscopy and circular dichroism spectra. KLD12/KLD12-SP nanofibers (5–10 nm) were created under physiological conditions by formation of a β-sheet structure. The ability of mesenchymal stem cells (MSCs) to recruit KLD12/KLD12-SP was observed by using an in vivo fluorescence imaging system. Labeled human Bone marrow stromal cells supplied via an intravenous injection were recruited to the scaffold containing KLD12/KLD12-SP. Polylactic acid/beta-tricalcium phosphate (PLA/β-TCP) scaffolds filled with KLD12/KLD12-SP were applied to ...
Michael J Yaszemski - One of the best experts on this subject based on the ideXlab platform.
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evolution of Bone Transplantation molecular cellular and tissue strategies to engineer human Bone
Biomaterials, 1996Co-Authors: Michael J Yaszemski, Richard G Payne, Wilson C Hayes, Robert Langer, Antonios G MikosAbstract:Bone defects occur in a wide variety of clinical situations, and their reconstruction to provide mechanical integrity to the skeleton is a necessary step in the patient's rehabilitation. The current gold standard for Bone reconstruction, the autogenous Bone graft, works well in many circumstances. However, autograft reconstruction, along with the available alternatives of allogenous Bone graft or poly(methylmethacrylate) Bone cement, do not solve all instances of Bone deficiency. Novel materials, cellular Transplantation and bioactive molecule delivery are being explored alone and in various combinations to address the problem of Bone deficiency. The goal of these strategies is to exploit the body's natural ability to repair injured Bone with new Bone tissue, and to then remodel that new Bone in response to the local stresses it experiences. In general, the strategies discussed in this paper attempt to provide the reconstructed region with appropriate initial mechanical properties, encourage new Bone to form in the region, and then gradually degrade to allow the new Bone to remodel and assume the mechanical support function. Several of the concepts presented below are already finding clinical applications in early patient trials.
Joseph M Lane - One of the best experts on this subject based on the ideXlab platform.
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the biology of Bone grafting
Journal of The American Academy of Orthopaedic Surgeons, 2005Co-Authors: Safdar N Khan, Frank P Cammisa, Harvinder S Sandhu, Ashish D Diwan, Federico P Girardi, Joseph M LaneAbstract:Many approaches are used to repair skeletal defects in reconstructive orthopaedic surgery, and Bone grafting is involved in virtually every procedure. The type of Bone graft used depends on the clinical scenario and the anticipated final outcome. Autogenous cancellous Bone graft, with its osteogenic, osteoinductive, and osteoconductive properties, remains the standard for grafting. However, the high incidence of morbidity during autogenous graft harvest may make the acquisition of grafts from other sources desirable. The clinical applications for each type of Bone graft are dictated by the structure and biochemical properties of the graft. An elegant cellular and molecular cascade follows Bone Transplantation. Bone graft incorporation within the host, whether autogenous or allogeneic, depends on many factors: type of graft (autogenous versus allogeneic, vascular versus nonvascular), site of transplant, quality of transplanted Bone and host Bone, host bed preparation, preservation techniques, systemic and local disease, and mechanical properties of the graft. J Am Acad Orthop Surg 2005;13:77-86
Soohyun Kim - One of the best experts on this subject based on the ideXlab platform.
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self assembling peptide nanofibers coupled with neuropeptide substance p for Bone tissue engineering
Tissue Engineering Part A, 2015Co-Authors: Su Hee Kim, Woojune Hur, Ji Eun Kim, Hye Jeong Min, Suk Wha Kim, Hye Sook Min, Byeung Kyu Kim, Soohyun KimAbstract:The number of patients requiring flat Bone Transplantation continues to increase worldwide. Cell Transplantation has been successfully applied clinically; however, it causes another defect site and the time requirements to harvest cells and expand them are considerable. In this study, KLD12/KLD12-SP (KLD12+KLD12-substance P [SP]) was designed to mimic endogenous tissue-healing processes. The structures of KLD12, KLD12-SP, and KLD12/KLD12-SP were observed by transmission electron microscopy and circular dichroism spectra. KLD12/KLD12-SP nanofibers (5–10 nm) were created under physiological conditions by formation of a β-sheet structure. The ability of mesenchymal stem cells (MSCs) to recruit KLD12/KLD12-SP was observed by using an in vivo fluorescence imaging system. Labeled human Bone marrow stromal cells supplied via an intravenous injection were recruited to the scaffold containing KLD12/KLD12-SP. Polylactic acid/beta-tricalcium phosphate (PLA/β-TCP) scaffolds filled with KLD12/KLD12-SP were applied to ...
Antonios G Mikos - One of the best experts on this subject based on the ideXlab platform.
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evolution of Bone Transplantation molecular cellular and tissue strategies to engineer human Bone
Biomaterials, 1996Co-Authors: Michael J Yaszemski, Richard G Payne, Wilson C Hayes, Robert Langer, Antonios G MikosAbstract:Bone defects occur in a wide variety of clinical situations, and their reconstruction to provide mechanical integrity to the skeleton is a necessary step in the patient's rehabilitation. The current gold standard for Bone reconstruction, the autogenous Bone graft, works well in many circumstances. However, autograft reconstruction, along with the available alternatives of allogenous Bone graft or poly(methylmethacrylate) Bone cement, do not solve all instances of Bone deficiency. Novel materials, cellular Transplantation and bioactive molecule delivery are being explored alone and in various combinations to address the problem of Bone deficiency. The goal of these strategies is to exploit the body's natural ability to repair injured Bone with new Bone tissue, and to then remodel that new Bone in response to the local stresses it experiences. In general, the strategies discussed in this paper attempt to provide the reconstructed region with appropriate initial mechanical properties, encourage new Bone to form in the region, and then gradually degrade to allow the new Bone to remodel and assume the mechanical support function. Several of the concepts presented below are already finding clinical applications in early patient trials.