The Experts below are selected from a list of 2448 Experts worldwide ranked by ideXlab platform
Muralithran G. Kutty - One of the best experts on this subject based on the ideXlab platform.
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using calcium sulfate cement hydroxypropyl methyl cellulose sodium alginate composites as substitutes of Bone Wax
International Journal of Applied Ceramic Technology, 2018Co-Authors: Huan Zhou, Lei Yang, Mengmeng Yang, Muralithran G. KuttyAbstract:Development of alternatives of Bone Wax to stop blood transfusion occurred in cancellous Bone injury is highly deserved clinically. An ideal candidate is supposed to be not only biodegradable, biocompatible, malleable, and cost-effective, but also have comparable mechanical strength to cancellous Bone. In the present work, calcium sulfate cement (CSC) based composites modified with hydroxypropyl methyl cellulose (HPMC) or sodium alginate (SA) were prepared. In brief, CSC was combined with 2, 4, 6 wt.% of HPMC or SA, respectively, followed by setting behavior evaluation, compressive strength and degradation testing, XRD, and SEM characterizations, as well as blood clotting induction study. Both additives improved the hemostatic performance of CSC, but CSC with 2% wt. SA exhibited the optimum setting time, mechanical strength, stability, and blood clotting ability. These results reveal the feasibility of using CSC–SA based composite as a substitute for Bone Wax.
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Using calcium sulfate cement—Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of Bone Wax
International Journal of Applied Ceramic Technology, 2017Co-Authors: Huan Zhou, Lei Yang, Mengmeng Yang, Muralithran G. KuttyAbstract:Development of alternatives of Bone Wax to stop blood transfusion occurred in cancellous Bone injury is highly deserved clinically. An ideal candidate is supposed to be not only biodegradable, biocompatible, malleable, and cost-effective, but also have comparable mechanical strength to cancellous Bone. In the present work, calcium sulfate cement (CSC) based composites modified with hydroxypropyl methyl cellulose (HPMC) or sodium alginate (SA) were prepared. In brief, CSC was combined with 2, 4, 6 wt.% of HPMC or SA, respectively, followed by setting behavior evaluation, compressive strength and degradation testing, XRD, and SEM characterizations, as well as blood clotting induction study. Both additives improved the hemostatic performance of CSC, but CSC with 2% wt. SA exhibited the optimum setting time, mechanical strength, stability, and blood clotting ability. These results reveal the feasibility of using CSC–SA based composite as a substitute for Bone Wax.
Huan Zhou - One of the best experts on this subject based on the ideXlab platform.
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Translation of Bone Wax and its substitutes: History, clinical status and future directions.
Journal of Orthopaedic Translation, 2019Co-Authors: Huan Zhou, Yanjie Bai, Chunyong Liang, Lei YangAbstract:Abstract Bone Wax, primarily composed of beesWax and softening agent, is a century-old material used to control bleeding of disrupted Bone surfaces by acting as a mechanical barrier to seal the wound. The current Bone Wax products are commonly packed in easy-to-open foil in the form of sterile sticks or plates, with excellent malleability and smooth consistency, enabling cost-effective and easy handling approach for bleeding control. It has also been reported that the inert nature of Bone Wax causes complications including foreign body reaction, infection promotion and Bone healing inhibition. With the advances in biomaterials and the market boost of Bone haemostatic materials, the arena of Bone Wax substitute research has expanded to a wide spectrum of material formulations and forms. However, the development of substitutes of Bone Wax for translation is a pivotal yet challenging topic because currently a potential candidate is recommended to be just as simple to use, effective and inexpensive to produce as traditional Bone Wax but also be absorbable and osteogenic. This review provides an overview of Bone Wax including its history, clinical applications and associated complication. In addition, emerging substitutes of Bone Wax and outlooks of future directions including the standardised evaluation methods are also discussed as an effort to catalyse the innovation and translation of Bone haemostatic agents in the near future. The translational potential of this article: Occurrence of osseous haemorrhage is common in surgically incised or traumatically fractured Bone. It is essential to stop Bone bleeding to avoid further pathologic consequences such as tissue necrosis and eventually mortalities due to blood loss. Medical sterile Bone Wax is a classical material for haemostasis of Bone during orthopaedic surgeries, thoracic surgeries, neurological surgeries and so on. Along with its widespread use, complications such as foreign body reaction, Bone healing inhibition and infection promotion associated with Bone Wax are observed. With the growing knowledge in biomaterials and the boost of market of Bone haemostatic materials, Bone Wax substitute research is thriving. An overview of Bone and its substitutes together with evolution of their design criteria is carried out in this work, providing information for the innovation and translation of Bone haemostatic agents in the near future.
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using calcium sulfate cement hydroxypropyl methyl cellulose sodium alginate composites as substitutes of Bone Wax
International Journal of Applied Ceramic Technology, 2018Co-Authors: Huan Zhou, Lei Yang, Mengmeng Yang, Muralithran G. KuttyAbstract:Development of alternatives of Bone Wax to stop blood transfusion occurred in cancellous Bone injury is highly deserved clinically. An ideal candidate is supposed to be not only biodegradable, biocompatible, malleable, and cost-effective, but also have comparable mechanical strength to cancellous Bone. In the present work, calcium sulfate cement (CSC) based composites modified with hydroxypropyl methyl cellulose (HPMC) or sodium alginate (SA) were prepared. In brief, CSC was combined with 2, 4, 6 wt.% of HPMC or SA, respectively, followed by setting behavior evaluation, compressive strength and degradation testing, XRD, and SEM characterizations, as well as blood clotting induction study. Both additives improved the hemostatic performance of CSC, but CSC with 2% wt. SA exhibited the optimum setting time, mechanical strength, stability, and blood clotting ability. These results reveal the feasibility of using CSC–SA based composite as a substitute for Bone Wax.
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Using calcium sulfate cement—Hydroxypropyl methyl cellulose/sodium alginate composites as substitutes of Bone Wax
International Journal of Applied Ceramic Technology, 2017Co-Authors: Huan Zhou, Lei Yang, Mengmeng Yang, Muralithran G. KuttyAbstract:Development of alternatives of Bone Wax to stop blood transfusion occurred in cancellous Bone injury is highly deserved clinically. An ideal candidate is supposed to be not only biodegradable, biocompatible, malleable, and cost-effective, but also have comparable mechanical strength to cancellous Bone. In the present work, calcium sulfate cement (CSC) based composites modified with hydroxypropyl methyl cellulose (HPMC) or sodium alginate (SA) were prepared. In brief, CSC was combined with 2, 4, 6 wt.% of HPMC or SA, respectively, followed by setting behavior evaluation, compressive strength and degradation testing, XRD, and SEM characterizations, as well as blood clotting induction study. Both additives improved the hemostatic performance of CSC, but CSC with 2% wt. SA exhibited the optimum setting time, mechanical strength, stability, and blood clotting ability. These results reveal the feasibility of using CSC–SA based composite as a substitute for Bone Wax.
P. Rukskul - One of the best experts on this subject based on the ideXlab platform.
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In vivo assessment of new resorbable PEG–PPG–PEG copolymer/starch Bone Wax in Bone healing and tissue reaction of Bone defect in rabbit model
Journal of Materials Science: Materials in Medicine, 2014Co-Authors: J. Suwanprateeb, S. Kiertkrittikhoon, J. Kintarak, W. Suvannapruk, F. Thammarakcharoen, P. RukskulAbstract:In this study, in vivo performance of novel resorbable Bone Wax based on a miscible blend between PEG–PPG–PEG copolymer mixtures and pregelatinized starch at 0 and 25 percent by weight including hemostasis, tissue reaction and Bone healing in a non-critical size tibia defect model were assessed and compared with commercial non-resorbable Bone Wax. Systemic reaction was evaluated by blood chemistry while local reaction, Bone quantity and quality were evaluated by microcomputed tomography (microCT) and histology analyses. It was observed that the resorbable Bone Waxes did not show any adverse systemic reaction and resorbed from the defects within approximately 2 days after application. They were as effective as the commercial Bone Wax in hemostasis, but provided better adherence to the Bone surface. The incorporation of pre-gelatinized starch in the formulation could further help in improved molding texture and decreased glove adherence. MicroCT and histology analyses showed that the resorbable Bone Waxes did not inhibit the osteogenesis whereas commercial Bone Wax impaired Bone healing and displayed inflammation and foreign body reactions.
S. Kiertkrittikhoon - One of the best experts on this subject based on the ideXlab platform.
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In vivo assessment of new resorbable PEG–PPG–PEG copolymer/starch Bone Wax in Bone healing and tissue reaction of Bone defect in rabbit model
Journal of Materials Science: Materials in Medicine, 2014Co-Authors: J. Suwanprateeb, S. Kiertkrittikhoon, J. Kintarak, W. Suvannapruk, F. Thammarakcharoen, P. RukskulAbstract:In this study, in vivo performance of novel resorbable Bone Wax based on a miscible blend between PEG–PPG–PEG copolymer mixtures and pregelatinized starch at 0 and 25 percent by weight including hemostasis, tissue reaction and Bone healing in a non-critical size tibia defect model were assessed and compared with commercial non-resorbable Bone Wax. Systemic reaction was evaluated by blood chemistry while local reaction, Bone quantity and quality were evaluated by microcomputed tomography (microCT) and histology analyses. It was observed that the resorbable Bone Waxes did not show any adverse systemic reaction and resorbed from the defects within approximately 2 days after application. They were as effective as the commercial Bone Wax in hemostasis, but provided better adherence to the Bone surface. The incorporation of pre-gelatinized starch in the formulation could further help in improved molding texture and decreased glove adherence. MicroCT and histology analyses showed that the resorbable Bone Waxes did not inhibit the osteogenesis whereas commercial Bone Wax impaired Bone healing and displayed inflammation and foreign body reactions.
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in vivo assessment of new resorbable peg ppg peg copolymer starch Bone Wax in Bone healing and tissue reaction of Bone defect in rabbit model
Journal of Materials Science: Materials in Medicine, 2014Co-Authors: Jintamai Suwanprateeb, Waraporn Suvannapruk, Faungchat Thammarakcharoen, S. Kiertkrittikhoon, J. Kintarak, Pattaravit RukskulAbstract:In this study, in vivo performance of novel resorbable Bone Wax based on a miscible blend between PEG–PPG–PEG copolymer mixtures and pregelatinized starch at 0 and 25 percent by weight including hemostasis, tissue reaction and Bone healing in a non-critical size tibia defect model were assessed and compared with commercial non-resorbable Bone Wax. Systemic reaction was evaluated by blood chemistry while local reaction, Bone quantity and quality were evaluated by microcomputed tomography (microCT) and histology analyses. It was observed that the resorbable Bone Waxes did not show any adverse systemic reaction and resorbed from the defects within approximately 2 days after application. They were as effective as the commercial Bone Wax in hemostasis, but provided better adherence to the Bone surface. The incorporation of pre-gelatinized starch in the formulation could further help in improved molding texture and decreased glove adherence. MicroCT and histology analyses showed that the resorbable Bone Waxes did not inhibit the osteogenesis whereas commercial Bone Wax impaired Bone healing and displayed inflammation and foreign body reactions.
J. Kintarak - One of the best experts on this subject based on the ideXlab platform.
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In vivo assessment of new resorbable PEG–PPG–PEG copolymer/starch Bone Wax in Bone healing and tissue reaction of Bone defect in rabbit model
Journal of Materials Science: Materials in Medicine, 2014Co-Authors: J. Suwanprateeb, S. Kiertkrittikhoon, J. Kintarak, W. Suvannapruk, F. Thammarakcharoen, P. RukskulAbstract:In this study, in vivo performance of novel resorbable Bone Wax based on a miscible blend between PEG–PPG–PEG copolymer mixtures and pregelatinized starch at 0 and 25 percent by weight including hemostasis, tissue reaction and Bone healing in a non-critical size tibia defect model were assessed and compared with commercial non-resorbable Bone Wax. Systemic reaction was evaluated by blood chemistry while local reaction, Bone quantity and quality were evaluated by microcomputed tomography (microCT) and histology analyses. It was observed that the resorbable Bone Waxes did not show any adverse systemic reaction and resorbed from the defects within approximately 2 days after application. They were as effective as the commercial Bone Wax in hemostasis, but provided better adherence to the Bone surface. The incorporation of pre-gelatinized starch in the formulation could further help in improved molding texture and decreased glove adherence. MicroCT and histology analyses showed that the resorbable Bone Waxes did not inhibit the osteogenesis whereas commercial Bone Wax impaired Bone healing and displayed inflammation and foreign body reactions.
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in vivo assessment of new resorbable peg ppg peg copolymer starch Bone Wax in Bone healing and tissue reaction of Bone defect in rabbit model
Journal of Materials Science: Materials in Medicine, 2014Co-Authors: Jintamai Suwanprateeb, Waraporn Suvannapruk, Faungchat Thammarakcharoen, S. Kiertkrittikhoon, J. Kintarak, Pattaravit RukskulAbstract:In this study, in vivo performance of novel resorbable Bone Wax based on a miscible blend between PEG–PPG–PEG copolymer mixtures and pregelatinized starch at 0 and 25 percent by weight including hemostasis, tissue reaction and Bone healing in a non-critical size tibia defect model were assessed and compared with commercial non-resorbable Bone Wax. Systemic reaction was evaluated by blood chemistry while local reaction, Bone quantity and quality were evaluated by microcomputed tomography (microCT) and histology analyses. It was observed that the resorbable Bone Waxes did not show any adverse systemic reaction and resorbed from the defects within approximately 2 days after application. They were as effective as the commercial Bone Wax in hemostasis, but provided better adherence to the Bone surface. The incorporation of pre-gelatinized starch in the formulation could further help in improved molding texture and decreased glove adherence. MicroCT and histology analyses showed that the resorbable Bone Waxes did not inhibit the osteogenesis whereas commercial Bone Wax impaired Bone healing and displayed inflammation and foreign body reactions.