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Dipak K Majumdar - One of the best experts on this subject based on the ideXlab platform.

  • linum usitatissimum linseed flaxseed fixed oil antimicrobial activity and efficacy in Bovine Mastitis
    Inflammopharmacology, 2011
    Co-Authors: Gaurav Kaithwas, Alok Mukerjee, Pradeep Kumar, Dipak K Majumdar
    Abstract:

    Purpose In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in Bovine Mastitis were investigated.

  • linum usitatissimum linseed flaxseed fixed oil antimicrobial activity and efficacy in Bovine Mastitis
    Inflammopharmacology, 2011
    Co-Authors: Gaurav Kaithwas, Alok Mukerjee, Pradeep Kumar, Dipak K Majumdar
    Abstract:

    In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in Bovine Mastitis were investigated. In vitro antimicrobial activity of L. usitatissimum fixed oil was evaluated against a number of microorganisms by disc diffusion method and MIC determination. The in vivo efficacy of the oil was evaluated in nine Mastitis-affected cows divided into three groups (three in each group), following once-a-day intramammary infusion of oil, cefoperazone or an oil-cefoperazone combination for 7 days and by monitoring the California Mastitis test score, somatic cell count and microbial count in milk samples. The in vitro antimicrobial activity of the oil against Staphylococcus aureus, Streptococcus agalactiae and Escherichia coli was comparable to that of cefoperazone while the antimicrobial activity against Enterococcus faecalis, Micrococcus luteus and Candida albicans, was greater than that of cefoperazone. In the in vivo study, the oil exhibited significant reduction in the California Mastitis test score and somatic cell count in milk samples from infected udders following 7 days of intramammary administration suggesting its anti-inflammatory effect. The microbial count in milk samples was also reduced significantly following oil treatment. The effects were comparable to the treatment by cefoperazone (Mastiwock) alone or in combination with the oil. Apparently, the anti-inflammatory and antimicrobial properties of the oil contribute to its therapeutic efficacy in Mastitis; the oil could be used as an alternative treatment for Bovine Mastitis The results suggest possible therapeutic potential of L. usitatissimum fixed oil in Bovine Mastitis.

Gaurav Kaithwas - One of the best experts on this subject based on the ideXlab platform.

  • linum usitatissimum linseed flaxseed fixed oil antimicrobial activity and efficacy in Bovine Mastitis
    Inflammopharmacology, 2011
    Co-Authors: Gaurav Kaithwas, Alok Mukerjee, Pradeep Kumar, Dipak K Majumdar
    Abstract:

    Purpose In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in Bovine Mastitis were investigated.

  • linum usitatissimum linseed flaxseed fixed oil antimicrobial activity and efficacy in Bovine Mastitis
    Inflammopharmacology, 2011
    Co-Authors: Gaurav Kaithwas, Alok Mukerjee, Pradeep Kumar, Dipak K Majumdar
    Abstract:

    In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in Bovine Mastitis were investigated. In vitro antimicrobial activity of L. usitatissimum fixed oil was evaluated against a number of microorganisms by disc diffusion method and MIC determination. The in vivo efficacy of the oil was evaluated in nine Mastitis-affected cows divided into three groups (three in each group), following once-a-day intramammary infusion of oil, cefoperazone or an oil-cefoperazone combination for 7 days and by monitoring the California Mastitis test score, somatic cell count and microbial count in milk samples. The in vitro antimicrobial activity of the oil against Staphylococcus aureus, Streptococcus agalactiae and Escherichia coli was comparable to that of cefoperazone while the antimicrobial activity against Enterococcus faecalis, Micrococcus luteus and Candida albicans, was greater than that of cefoperazone. In the in vivo study, the oil exhibited significant reduction in the California Mastitis test score and somatic cell count in milk samples from infected udders following 7 days of intramammary administration suggesting its anti-inflammatory effect. The microbial count in milk samples was also reduced significantly following oil treatment. The effects were comparable to the treatment by cefoperazone (Mastiwock) alone or in combination with the oil. Apparently, the anti-inflammatory and antimicrobial properties of the oil contribute to its therapeutic efficacy in Mastitis; the oil could be used as an alternative treatment for Bovine Mastitis The results suggest possible therapeutic potential of L. usitatissimum fixed oil in Bovine Mastitis.

Pradeep Kumar - One of the best experts on this subject based on the ideXlab platform.

  • linum usitatissimum linseed flaxseed fixed oil antimicrobial activity and efficacy in Bovine Mastitis
    Inflammopharmacology, 2011
    Co-Authors: Gaurav Kaithwas, Alok Mukerjee, Pradeep Kumar, Dipak K Majumdar
    Abstract:

    Purpose In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in Bovine Mastitis were investigated.

  • linum usitatissimum linseed flaxseed fixed oil antimicrobial activity and efficacy in Bovine Mastitis
    Inflammopharmacology, 2011
    Co-Authors: Gaurav Kaithwas, Alok Mukerjee, Pradeep Kumar, Dipak K Majumdar
    Abstract:

    In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in Bovine Mastitis were investigated. In vitro antimicrobial activity of L. usitatissimum fixed oil was evaluated against a number of microorganisms by disc diffusion method and MIC determination. The in vivo efficacy of the oil was evaluated in nine Mastitis-affected cows divided into three groups (three in each group), following once-a-day intramammary infusion of oil, cefoperazone or an oil-cefoperazone combination for 7 days and by monitoring the California Mastitis test score, somatic cell count and microbial count in milk samples. The in vitro antimicrobial activity of the oil against Staphylococcus aureus, Streptococcus agalactiae and Escherichia coli was comparable to that of cefoperazone while the antimicrobial activity against Enterococcus faecalis, Micrococcus luteus and Candida albicans, was greater than that of cefoperazone. In the in vivo study, the oil exhibited significant reduction in the California Mastitis test score and somatic cell count in milk samples from infected udders following 7 days of intramammary administration suggesting its anti-inflammatory effect. The microbial count in milk samples was also reduced significantly following oil treatment. The effects were comparable to the treatment by cefoperazone (Mastiwock) alone or in combination with the oil. Apparently, the anti-inflammatory and antimicrobial properties of the oil contribute to its therapeutic efficacy in Mastitis; the oil could be used as an alternative treatment for Bovine Mastitis The results suggest possible therapeutic potential of L. usitatissimum fixed oil in Bovine Mastitis.

Alok Mukerjee - One of the best experts on this subject based on the ideXlab platform.

  • linum usitatissimum linseed flaxseed fixed oil antimicrobial activity and efficacy in Bovine Mastitis
    Inflammopharmacology, 2011
    Co-Authors: Gaurav Kaithwas, Alok Mukerjee, Pradeep Kumar, Dipak K Majumdar
    Abstract:

    Purpose In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in Bovine Mastitis were investigated.

  • linum usitatissimum linseed flaxseed fixed oil antimicrobial activity and efficacy in Bovine Mastitis
    Inflammopharmacology, 2011
    Co-Authors: Gaurav Kaithwas, Alok Mukerjee, Pradeep Kumar, Dipak K Majumdar
    Abstract:

    In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in Bovine Mastitis were investigated. In vitro antimicrobial activity of L. usitatissimum fixed oil was evaluated against a number of microorganisms by disc diffusion method and MIC determination. The in vivo efficacy of the oil was evaluated in nine Mastitis-affected cows divided into three groups (three in each group), following once-a-day intramammary infusion of oil, cefoperazone or an oil-cefoperazone combination for 7 days and by monitoring the California Mastitis test score, somatic cell count and microbial count in milk samples. The in vitro antimicrobial activity of the oil against Staphylococcus aureus, Streptococcus agalactiae and Escherichia coli was comparable to that of cefoperazone while the antimicrobial activity against Enterococcus faecalis, Micrococcus luteus and Candida albicans, was greater than that of cefoperazone. In the in vivo study, the oil exhibited significant reduction in the California Mastitis test score and somatic cell count in milk samples from infected udders following 7 days of intramammary administration suggesting its anti-inflammatory effect. The microbial count in milk samples was also reduced significantly following oil treatment. The effects were comparable to the treatment by cefoperazone (Mastiwock) alone or in combination with the oil. Apparently, the anti-inflammatory and antimicrobial properties of the oil contribute to its therapeutic efficacy in Mastitis; the oil could be used as an alternative treatment for Bovine Mastitis The results suggest possible therapeutic potential of L. usitatissimum fixed oil in Bovine Mastitis.

Ulrich Dobrindt - One of the best experts on this subject based on the ideXlab platform.

  • No evidence for a Bovine Mastitis Escherichia coli pathotype
    BMC Genomics, 2017
    Co-Authors: Andreas Leimbach, Anja Poehlein, John Vollmers, Dennis Görlich, Rolf Daniel, Ulrich Dobrindt
    Abstract:

    Background Escherichia coli Bovine Mastitis is a disease of significant economic importance in the dairy industry. Molecular characterization of Mastitis-associated E. coli (MAEC) did not result in the identification of common traits. Nevertheless, a mammary pathogenic E. coli (MPEC) pathotype has been proposed suggesting virulence traits that differentiate MAEC from commensal E. coli . The present study was designed to investigate the MPEC pathotype hypothesis by comparing the genomes of MAEC and commensal Bovine E. coli . Results We sequenced the genomes of eight E. coli isolated from Bovine Mastitis cases and six fecal commensal isolates from udder-healthy cows. We analyzed the phylogenetic history of Bovine E. coli genomes by supplementing this strain panel with eleven Bovine-associated E. coli from public databases. The majority of the isolates originate from phylogroups A and B1, but neither MAEC nor commensal strains could be unambiguously distinguished by phylogenetic lineage. The gene content of both MAEC and commensal strains is highly diverse and dominated by their phylogenetic background. Although individual strains carry some typical E. coli virulence-associated genes, no traits important for pathogenicity could be specifically attributed to MAEC. Instead, both commensal strains and MAEC have very few gene families enriched in either pathotype. Only the aerobactin siderophore gene cluster was enriched in commensal E. coli within our strain panel. Conclusions This is the first characterization of a phylogenetically diverse strain panel including several MAEC and commensal isolates. With our comparative genomics approach we could not confirm previous studies that argue for a positive selection of specific traits enabling MAEC to elicit Bovine Mastitis. Instead, MAEC are facultative and opportunistic pathogens recruited from the highly diverse Bovine gastrointestinal microbiota. Virulence-associated genes implicated in Mastitis are a by-product of commensalism with the primary function to enhance fitness in the Bovine gastrointestinal tract. Therefore, we put the definition of the MPEC pathotype into question and suggest to designate corresponding isolates as MAEC.

  • no evidence for a Bovine Mastitis escherichia coli pathotype
    BMC Genomics, 2017
    Co-Authors: Andreas Leimbach, Anja Poehlein, John Vollmers, Dennis Görlich, Rolf Daniel, Ulrich Dobrindt
    Abstract:

    Escherichia coli Bovine Mastitis is a disease of significant economic importance in the dairy industry. Molecular characterization of Mastitis-associated E. coli (MAEC) did not result in the identification of common traits. Nevertheless, a mammary pathogenic E. coli (MPEC) pathotype has been proposed suggesting virulence traits that differentiate MAEC from commensal E. coli. The present study was designed to investigate the MPEC pathotype hypothesis by comparing the genomes of MAEC and commensal Bovine E. coli. We sequenced the genomes of eight E. coli isolated from Bovine Mastitis cases and six fecal commensal isolates from udder-healthy cows. We analyzed the phylogenetic history of Bovine E. coli genomes by supplementing this strain panel with eleven Bovine-associated E. coli from public databases. The majority of the isolates originate from phylogroups A and B1, but neither MAEC nor commensal strains could be unambiguously distinguished by phylogenetic lineage. The gene content of both MAEC and commensal strains is highly diverse and dominated by their phylogenetic background. Although individual strains carry some typical E. coli virulence-associated genes, no traits important for pathogenicity could be specifically attributed to MAEC. Instead, both commensal strains and MAEC have very few gene families enriched in either pathotype. Only the aerobactin siderophore gene cluster was enriched in commensal E. coli within our strain panel. This is the first characterization of a phylogenetically diverse strain panel including several MAEC and commensal isolates. With our comparative genomics approach we could not confirm previous studies that argue for a positive selection of specific traits enabling MAEC to elicit Bovine Mastitis. Instead, MAEC are facultative and opportunistic pathogens recruited from the highly diverse Bovine gastrointestinal microbiota. Virulence-associated genes implicated in Mastitis are a by-product of commensalism with the primary function to enhance fitness in the Bovine gastrointestinal tract. Therefore, we put the definition of the MPEC pathotype into question and suggest to designate corresponding isolates as MAEC.