The Experts below are selected from a list of 79884 Experts worldwide ranked by ideXlab platform

Hailong Yuan - One of the best experts on this subject based on the ideXlab platform.

  • Formulation and optimization of a novel oral fast dissolving film containing drug nanoparticles by Box–Behnken Design–response surface methodology
    Drug development and industrial pharmacy, 2014
    Co-Authors: Cheng-ying Shen, Bao-de Shen, Jin-xia Bai, Ling Dai, Jin Han, Hailong Yuan
    Abstract:

    AbstractObjective: The purpose of this study was to Design and optimize a novel drug nanoparticles-loaded oral fast dissolving film (NP-OFDF) using Box–Behnken Design–response surface methodology.Methods: Drug nanosuspensions produced from high pressure homogenization were transformed into oral fast dissolving film containing drug nanoparticles by casting methods. Herpetrione (HPE), a novel and potent antiviral agent with poor water solubility that was extracted from Herpetospermum caudigerum, was studied as the model drug. The formulations of oral fast dissolving film containing HPE nanoparticles (HPE-NP-OFDF) were optimized by employing Box-Behnken Design–response surface methodology and then systematically characterized.Results: The optimized HPE-NP-OFDF was disintegrated in water within 20 s with reconstituted nanosuspensions particle size of 299.31 nm. Scanning electron microscopy (SEM) images showed that well-dispersed HPE nanoparticles with slight adhesion to each other were exposed on the surface ...

Zhen Zhang - One of the best experts on this subject based on the ideXlab platform.

  • Optimization of the preparation of pectin from Aloe using a Box–Behnken Design
    Carbohydrate polymers, 2014
    Co-Authors: Lijing Geng, Wei Zhou, Qu Xingyuan, Weijie Chen, Chang Liu, Jing Sun, Hui Wang, Zhen Zhang
    Abstract:

    Abstract The extraction condition of pectin from Aloe vera barbadensis Mill was optimized by a Box–Behnken Design. The effect of parameters of extraction water proportion (EWP), extraction pH (EpH), extraction temperature (ETe), extraction time (ETi), alcohol precipitation pH (APpH)and alcohol precipitation temperature (APTe) on the extraction yield of pectin was investigated by a software of Design Export 8.0.5b. The maximum extraction yield was obtained with the EWP of 20:1, EpH of 1.5, ETe of 90 °C, ETi of 120 min, APpH of 3.0 and APTe of 50 °C, which was consistent with the experimental value. We also found out that the pectin content decreased gradually during storage and sucrose concentration had a significant impact on the viscosity of pectin.

Gautam Majumdar - One of the best experts on this subject based on the ideXlab platform.

  • Prediction and parametric optimization of surface roughness of electroless Ni-Co-P coating using Box-Behnken Design
    Journal of the Mechanical Behavior of Materials, 2019
    Co-Authors: Subhasish Sarkar, Arghya Mukherjee, Rishav Kumar Baranwal, Chanchal Biswas, Gautam Majumdar
    Abstract:

    AbstractThe current study focuses on the parametric optimization of electroless Ni-Co-P coating considering surface roughness as a response using Box-Behnken Design (BBD) of experiment. The two bath parameters namely the concentration of cobalt sulphate and sodium hypophosphite were varied along with the bath temperature to predict the variation in surface roughness. Analysis of variance (ANOVA) method has been applied to determine the interactions of the substantial factors which dominate the surface roughness of the coating. The process parameters for surface roughness of the coating were optimized by successfully utilizing the statistical model of Box-Behnken Design (BBD) of experiment. From the BBD model, the optimum condition for the deposition of the coating has been evaluated. In that specific condition, the surface roughness of the as-deposited coating is found to be 0.913μm. Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), and X-Ray Diffraction (XRD) study have been utilized to characterize the electroless Ni-Co-P coating deposited in optimized condition.

Cheng-ying Shen - One of the best experts on this subject based on the ideXlab platform.

  • Formulation and optimization of a novel oral fast dissolving film containing drug nanoparticles by Box–Behnken Design–response surface methodology
    Drug development and industrial pharmacy, 2014
    Co-Authors: Cheng-ying Shen, Bao-de Shen, Jin-xia Bai, Ling Dai, Jin Han, Hailong Yuan
    Abstract:

    AbstractObjective: The purpose of this study was to Design and optimize a novel drug nanoparticles-loaded oral fast dissolving film (NP-OFDF) using Box–Behnken Design–response surface methodology.Methods: Drug nanosuspensions produced from high pressure homogenization were transformed into oral fast dissolving film containing drug nanoparticles by casting methods. Herpetrione (HPE), a novel and potent antiviral agent with poor water solubility that was extracted from Herpetospermum caudigerum, was studied as the model drug. The formulations of oral fast dissolving film containing HPE nanoparticles (HPE-NP-OFDF) were optimized by employing Box-Behnken Design–response surface methodology and then systematically characterized.Results: The optimized HPE-NP-OFDF was disintegrated in water within 20 s with reconstituted nanosuspensions particle size of 299.31 nm. Scanning electron microscopy (SEM) images showed that well-dispersed HPE nanoparticles with slight adhesion to each other were exposed on the surface ...

Ali A. Dadkhah - One of the best experts on this subject based on the ideXlab platform.

  • Optimization of Supercritical Extraction of Linalyl Acetate from Lavender via Box‐Behnken Design
    Chemical Engineering & Technology, 2012
    Co-Authors: Seyyed M. Ghoreishi, Hossein Kamali, H.s. Ghaziaskar, Ali A. Dadkhah
    Abstract:

    Essential oil was extracted from lavender using supercritical carbon dioxide by means of a newly developed periodic static-dynamic (PSD) procedure and the conventional semicontinuous (SC) technique. Applying GC-FID analysis in conjunction with Box-Behnken Design, an optimum overall extraction yield (94.4 %) was obtained via PSD in contrast to 90 % for the SC method. The results indicate that supercritical fluid extraction is a viable technique for separation of constituents such as linalyl acetate, linalool, fenchone, and camphor for pharmaceutical and medicinal applications. Furthermore, a substantial reduction of energy consumption and solvent consumption is achieved with the developed PSD process compared to the conventional SC method.