The Experts below are selected from a list of 1299 Experts worldwide ranked by ideXlab platform
Kathryn M. Meurs - One of the best experts on this subject based on the ideXlab platform.
-
Arrhythmogenic Right Ventricular Cardiomyopathy in the Boxer Dog: An Update
The Veterinary clinics of North America. Small animal practice, 2017Co-Authors: Kathryn M. MeursAbstract:Arrhythmogenic right ventricular cardiomyopathy is an inheritable form of myocardial disease characterized most commonly by ventricular tachycardias, syncope, and sometimes systolic dysfunction and heart failure. A genetic mutation in the striatin gene has been identified in many affected Dogs. Dogs with only one copy of the mutation (heterozygous) have a variable prognosis, with many Dogs remaining asymptomatic or being successfully managed on antiarrhythmic drugs for years. Dogs that are homozygous for the mutation seem to have a worse prognosis.
-
Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs
Journal of veterinary internal medicine, 2013Co-Authors: Kathryn M. Meurs, Joshua A. Stern, D. David Sisson, Mark D Kittleson, Suzanne M. Cunningham, Marisa K. Ames, Clarke E. Atkins, Teresa C. Defrancesco, Timothy E. Hodge, Bruce W. KeeneAbstract:Myocardial disease in the Boxer Dog is characterized by 1 of 2 clinical presentations, dilated cardiomyopathy (DCM) characterized by ventricular systolic dysfunction, dilatation and tachyarrhythmias, and arrhythmogenic right ventricular cardiomyopathy (ARVC) characterized by ventricular tachyarrhythmias, syncope, and sudden death. Boxer ARVC has been associated with a deletion in the striatin gene in some families. We hypothesized that both presentations represent a single disease, and the development of DCM in the Boxer is associated with the striatin deletion. Thirty-three adult Boxer Dogs with DCM, 29 adult Boxer Dogs with the striatin deletion and ARVC, and 16 Boxers without cardiac disease. DNA samples were evaluated for the striatin deletion. Association of the deletion with the DCM phenotype was tested by a Fisher's exact test. T-tests were used to evaluate potential differences between the positive heterozygous and positive homozygous groups with DCM with regard to age, LVIDD, LVIDS, and FS%. Thirty of 33 Dogs with DCM were positive for the striatin deletion. The striatin mutation and the homozygous genotype were strongly associated with the DCM phenotype (P < .001 and P = .005). There was no statistical difference between the heterozygous and homozygous groups with regard to age and echocardiographic measurements. This study demonstrates an association between DCM in the Boxer Dog and the striatin mutation, particularly with the homozygous genotype. The observation that 3/33 Dogs developed DCM and lacked the striatin mutation suggests that there is at least 1 other cause of DCM in the Boxer Dog.
-
Genome-wide association identifies a deletion in the 3′ untranslated region of Striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy
Human Genetics, 2010Co-Authors: Kathryn M. Meurs, Evan Mauceli, Sunshine Lahmers, Gregory M Acland, Stephen N White, Kerstin Lindblad-tohAbstract:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease characterized by ventricular arrhythmias and sudden cardiac death. It is most frequently inherited as an autosomal dominant trait with incomplete and age-related penetrance and variable clinical expression. The human disease is most commonly associated with a causative mutation in one of several genes encoding desmosomal proteins. We have previously described a spontaneous canine model of ARVC in the Boxer Dog. We phenotyped adult Boxer Dogs for ARVC by performing physical examination, echocardiogram and ambulatory electrocardiogram. Genome-wide association using the canine 50k SNP array identified several regions of association, of which the strongest resided on chromosome 17. Fine mapping and direct DNA sequencing identified an 8-bp deletion in the 3′ untranslated region (UTR) of the Striatin gene on chromosome 17 in association with ARVC in the Boxer Dog. Evaluation of the secondary structure of the 3′ UTR demonstrated that the deletion affects a stem loop structure of the mRNA and expression analysis identified a reduction in Striatin mRNA. Dogs that were homozygous for the deletion had a more severe form of disease based on a significantly higher number of ventricular premature complexes. Immunofluorescence studies localized Striatin to the intercalated disc region of the cardiac myocyte and co-localized it to three desmosomal proteins, Plakophilin-2, Plakoglobin and Desmoplakin, all involved in the pathogenesis of ARVC in human beings. We suggest that Striatin may serve as a novel candidate gene for human ARVC.
-
genome wide association identifies a deletion in the 3 untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy
Human Genetics, 2010Co-Authors: Kathryn M. Meurs, Evan Mauceli, Sunshine Lahmers, Gregory M Acland, Stephen N White, Kerstin LindbladtohAbstract:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease characterized by ventricular arrhythmias and sudden cardiac death. It is most frequently inherited as an autosomal dominant trait with incomplete and age-related penetrance and variable clinical expression. The human disease is most commonly associated with a causative mutation in one of several genes encoding desmosomal proteins. We have previously described a spontaneous canine model of ARVC in the Boxer Dog. We phenotyped adult Boxer Dogs for ARVC by performing physical examination, echocardiogram and ambulatory electrocardiogram. Genome-wide association using the canine 50k SNP array identified several regions of association, of which the strongest resided on chromosome 17. Fine mapping and direct DNA sequencing identified an 8-bp deletion in the 3′ untranslated region (UTR) of the Striatin gene on chromosome 17 in association with ARVC in the Boxer Dog. Evaluation of the secondary structure of the 3′ UTR demonstrated that the deletion affects a stem loop structure of the mRNA and expression analysis identified a reduction in Striatin mRNA. Dogs that were homozygous for the deletion had a more severe form of disease based on a significantly higher number of ventricular premature complexes. Immunofluorescence studies localized Striatin to the intercalated disc region of the cardiac myocyte and co-localized it to three desmosomal proteins, Plakophilin-2, Plakoglobin and Desmoplakin, all involved in the pathogenesis of ARVC in human beings. We suggest that Striatin may serve as a novel candidate gene for human ARVC.
-
Boxer Dog cardiomyopathy: an update.
The Veterinary clinics of North America. Small animal practice, 2004Co-Authors: Kathryn M. MeursAbstract:Boxer Dog cardiomyopathy is an inheritable form of myocardial disease characterized most commonly by ventricular tachycardias, syncope, and, sometimes, systolic dysfunction and heart failure. Careful evaluation of Boxer Dog cardiomyopathy by several investigators has demonstrated that the disease may be best classified as arrhythmogenic right ventricular cardiomyopathy. Affected Dogs have a variable prognosis; although some succumb to sudden cardiac death, many can remain asymptomatic or be successfully managed on antiarrhythmics for years.
Anna Oevermann - One of the best experts on this subject based on the ideXlab platform.
-
Cerebral High‐grade Oligodendroglioma with Sarcomatous Transdifferentiation (“Oligosarcoma”) in a Boxer Dog
Journal of veterinary internal medicine, 2014Co-Authors: Angela Fadda, Istvan Vajtai, Johann Lang, Diana Henke, Anna OevermannAbstract:A 9-year-old Boxer Dog was referred to the Veterinary Teaching Hospital of the University of Bern for a history of chronic neck pain and gait problems, which rapidly progressed to a non-ambulatory status. Magnetic resonance imaging (MRI) examination of the head revealed a large intra-axial space-occupying lesion that was divided in two portions interconnected by a thin isthmus at the level of the cerebellar tentorium. Histopathology revealed a biphasic malignant neoplasm composed of neuroepithelial and mesenchymal elements. The former displayed characteristics of conventional anaplastic oligodendroglioma involving brisk mitotic activity and glomeruloid microvascular proliferation on a background of a fibrillary round cells with "honeycomb-like" perinuclear vacuolation. Conversely, the sarcomatous moiety exhibited haphazard fascicles of spindle cells amidst an intricate mesh of pericellular basal lamina and broad bands of collagen. Both tumor cell populations immunoreacted for Olig-2 and – to a lesser extent – GFAP. In addition, the sarcomatous areas focally expressed vimentin, muscular actin, and smooth muscle actin. "Oligosarcoma" - an exquisitely uncommon pattern of oligodendroglial malignancy in humans - has not previously been reported to affect Dogs, although oligodendroglioma is a common CNS tumor in this species. Whether canine oligosarcoma shares with its human counterpart not only morphological aspects, but also molecular signatures, clinical behavior and responsiveness to therapy merits further investigation. In humans, oligodendroglial differentiation tends to confer significant clinical advantage with respect to prognosis and adjuvant treatment options. The awareness of such hallmarks and the investigation of their impact on prognosis are crucial for improved therapeutical strategies in Dogs.
-
cerebral high grade oligodendroglioma with sarcomatous transdifferentiation oligosarcoma in a Boxer Dog
Journal of Veterinary Internal Medicine, 2014Co-Authors: Angela Fadda, Istvan Vajtai, Johann Lang, Diana Henke, Anna OevermannAbstract:A 9-year-old Boxer Dog was referred to the Veterinary Teaching Hospital of the University of Bern for a history of chronic neck pain and gait problems, which rapidly progressed to a non-ambulatory status. Magnetic resonance imaging (MRI) examination of the head revealed a large intra-axial space-occupying lesion that was divided in two portions interconnected by a thin isthmus at the level of the cerebellar tentorium. Histopathology revealed a biphasic malignant neoplasm composed of neuroepithelial and mesenchymal elements. The former displayed characteristics of conventional anaplastic oligodendroglioma involving brisk mitotic activity and glomeruloid microvascular proliferation on a background of a fibrillary round cells with "honeycomb-like" perinuclear vacuolation. Conversely, the sarcomatous moiety exhibited haphazard fascicles of spindle cells amidst an intricate mesh of pericellular basal lamina and broad bands of collagen. Both tumor cell populations immunoreacted for Olig-2 and – to a lesser extent – GFAP. In addition, the sarcomatous areas focally expressed vimentin, muscular actin, and smooth muscle actin. "Oligosarcoma" - an exquisitely uncommon pattern of oligodendroglial malignancy in humans - has not previously been reported to affect Dogs, although oligodendroglioma is a common CNS tumor in this species. Whether canine oligosarcoma shares with its human counterpart not only morphological aspects, but also molecular signatures, clinical behavior and responsiveness to therapy merits further investigation. In humans, oligodendroglial differentiation tends to confer significant clinical advantage with respect to prognosis and adjuvant treatment options. The awareness of such hallmarks and the investigation of their impact on prognosis are crucial for improved therapeutical strategies in Dogs.
Angela Fadda - One of the best experts on this subject based on the ideXlab platform.
-
Cerebral High‐grade Oligodendroglioma with Sarcomatous Transdifferentiation (“Oligosarcoma”) in a Boxer Dog
Journal of veterinary internal medicine, 2014Co-Authors: Angela Fadda, Istvan Vajtai, Johann Lang, Diana Henke, Anna OevermannAbstract:A 9-year-old Boxer Dog was referred to the Veterinary Teaching Hospital of the University of Bern for a history of chronic neck pain and gait problems, which rapidly progressed to a non-ambulatory status. Magnetic resonance imaging (MRI) examination of the head revealed a large intra-axial space-occupying lesion that was divided in two portions interconnected by a thin isthmus at the level of the cerebellar tentorium. Histopathology revealed a biphasic malignant neoplasm composed of neuroepithelial and mesenchymal elements. The former displayed characteristics of conventional anaplastic oligodendroglioma involving brisk mitotic activity and glomeruloid microvascular proliferation on a background of a fibrillary round cells with "honeycomb-like" perinuclear vacuolation. Conversely, the sarcomatous moiety exhibited haphazard fascicles of spindle cells amidst an intricate mesh of pericellular basal lamina and broad bands of collagen. Both tumor cell populations immunoreacted for Olig-2 and – to a lesser extent – GFAP. In addition, the sarcomatous areas focally expressed vimentin, muscular actin, and smooth muscle actin. "Oligosarcoma" - an exquisitely uncommon pattern of oligodendroglial malignancy in humans - has not previously been reported to affect Dogs, although oligodendroglioma is a common CNS tumor in this species. Whether canine oligosarcoma shares with its human counterpart not only morphological aspects, but also molecular signatures, clinical behavior and responsiveness to therapy merits further investigation. In humans, oligodendroglial differentiation tends to confer significant clinical advantage with respect to prognosis and adjuvant treatment options. The awareness of such hallmarks and the investigation of their impact on prognosis are crucial for improved therapeutical strategies in Dogs.
-
cerebral high grade oligodendroglioma with sarcomatous transdifferentiation oligosarcoma in a Boxer Dog
Journal of Veterinary Internal Medicine, 2014Co-Authors: Angela Fadda, Istvan Vajtai, Johann Lang, Diana Henke, Anna OevermannAbstract:A 9-year-old Boxer Dog was referred to the Veterinary Teaching Hospital of the University of Bern for a history of chronic neck pain and gait problems, which rapidly progressed to a non-ambulatory status. Magnetic resonance imaging (MRI) examination of the head revealed a large intra-axial space-occupying lesion that was divided in two portions interconnected by a thin isthmus at the level of the cerebellar tentorium. Histopathology revealed a biphasic malignant neoplasm composed of neuroepithelial and mesenchymal elements. The former displayed characteristics of conventional anaplastic oligodendroglioma involving brisk mitotic activity and glomeruloid microvascular proliferation on a background of a fibrillary round cells with "honeycomb-like" perinuclear vacuolation. Conversely, the sarcomatous moiety exhibited haphazard fascicles of spindle cells amidst an intricate mesh of pericellular basal lamina and broad bands of collagen. Both tumor cell populations immunoreacted for Olig-2 and – to a lesser extent – GFAP. In addition, the sarcomatous areas focally expressed vimentin, muscular actin, and smooth muscle actin. "Oligosarcoma" - an exquisitely uncommon pattern of oligodendroglial malignancy in humans - has not previously been reported to affect Dogs, although oligodendroglioma is a common CNS tumor in this species. Whether canine oligosarcoma shares with its human counterpart not only morphological aspects, but also molecular signatures, clinical behavior and responsiveness to therapy merits further investigation. In humans, oligodendroglial differentiation tends to confer significant clinical advantage with respect to prognosis and adjuvant treatment options. The awareness of such hallmarks and the investigation of their impact on prognosis are crucial for improved therapeutical strategies in Dogs.
Kerstin Lindbladtoh - One of the best experts on this subject based on the ideXlab platform.
-
genome wide association identifies a deletion in the 3 untranslated region of striatin in a canine model of arrhythmogenic right ventricular cardiomyopathy
Human Genetics, 2010Co-Authors: Kathryn M. Meurs, Evan Mauceli, Sunshine Lahmers, Gregory M Acland, Stephen N White, Kerstin LindbladtohAbstract:Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease characterized by ventricular arrhythmias and sudden cardiac death. It is most frequently inherited as an autosomal dominant trait with incomplete and age-related penetrance and variable clinical expression. The human disease is most commonly associated with a causative mutation in one of several genes encoding desmosomal proteins. We have previously described a spontaneous canine model of ARVC in the Boxer Dog. We phenotyped adult Boxer Dogs for ARVC by performing physical examination, echocardiogram and ambulatory electrocardiogram. Genome-wide association using the canine 50k SNP array identified several regions of association, of which the strongest resided on chromosome 17. Fine mapping and direct DNA sequencing identified an 8-bp deletion in the 3′ untranslated region (UTR) of the Striatin gene on chromosome 17 in association with ARVC in the Boxer Dog. Evaluation of the secondary structure of the 3′ UTR demonstrated that the deletion affects a stem loop structure of the mRNA and expression analysis identified a reduction in Striatin mRNA. Dogs that were homozygous for the deletion had a more severe form of disease based on a significantly higher number of ventricular premature complexes. Immunofluorescence studies localized Striatin to the intercalated disc region of the cardiac myocyte and co-localized it to three desmosomal proteins, Plakophilin-2, Plakoglobin and Desmoplakin, all involved in the pathogenesis of ARVC in human beings. We suggest that Striatin may serve as a novel candidate gene for human ARVC.
Joseph Hillebrandt - One of the best experts on this subject based on the ideXlab platform.
-
Zinc Toxicosis in a Boxer Dog Secondary to Ingestion of Holiday Garland
Journal of Medical Toxicology, 2017Co-Authors: Karyn Bischoff, Anne Chiapella, Jaime Weisman, Lisa M. Crofton, Joseph HillebrandtAbstract:Introduction Increased admissions occur in small animal veterinary emergency clinics during some holidays, and some of the increased caseload is due to ingestion of toxic substances. This report documents zinc toxicosis contributing to the death of a Dog after ingestion of holiday tinsel garland. Case study A mature Boxer Dog presented with a 4-day history of vomiting and diarrhea. Radiodense foreign material was detected in the stomach and removed via gastrotomy. The patient clinically worsened over the next several days with evidence of hemolytic anemia, severe hypernatremia, and an elevated WBC count with a suspected dehiscence of the surgical site and acute renal failure. The serum zinc concentration was moderately elevated. Postmortem findings included surgical dehiscence from the gastrotomy and enterotomy sites, hepatic extramedullary hematopoiesis, hemoglobinuric nephrosis, and pancreatic fibrosis. The foreign material removed from the stomach also contained zinc. Discussion Ingestion of holiday tinsel garland made from metal-coated plastic film has not previously been implicated in zinc toxicosis. Zinc toxicosis has a good prognosis in veterinary medicine when diagnosed and treated promptly, but the unique source of zinc in this Dog contributed to the delay in diagnosis and grave outcome in this case.
-
Zinc Toxicosis in a Boxer Dog Secondary to Ingestion of Holiday Garland
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2017Co-Authors: Karyn Bischoff, Anne Chiapella, Jaime Weisman, Lisa M. Crofton, Joseph HillebrandtAbstract:Introduction Increased admissions occur in small animal veterinary emergency clinics during some holidays, and some of the increased caseload is due to ingestion of toxic substances. This report documents zinc toxicosis contributing to the death of a Dog after ingestion of holiday tinsel garland.